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DK2588164T3 - Medikamentafgivelsesindretning omfattende et manuelt aktiveringselement med forbedrede gribe- og aktiveringsegenskaber - Google Patents

Medikamentafgivelsesindretning omfattende et manuelt aktiveringselement med forbedrede gribe- og aktiveringsegenskaber Download PDF

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Publication number
DK2588164T3
DK2588164T3 DK11783825.0T DK11783825T DK2588164T3 DK 2588164 T3 DK2588164 T3 DK 2588164T3 DK 11783825 T DK11783825 T DK 11783825T DK 2588164 T3 DK2588164 T3 DK 2588164T3
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Denmark
Prior art keywords
dose
gears
drug delivery
delivery device
housing
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DK11783825.0T
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English (en)
Inventor
Anders Holmqvist
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Shl Group Ab
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/586—Ergonomic details therefor, e.g. specific ergonomics for left or right-handed users
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (10)

1. Medikamentafgivelsesindretning omfattende: - et hus (10) med modstående distal (18) og proximal (24) ende, som er indrettet til at rumme et medikamentbeholderaggregat (12), hvortil et afgivelsesorgan kan fastgøres; - et drivorgan (14), der er interaktivt forbundet til medikamentbeholderaggregatet til uddrivelse af en dosis medikament; - et dosisaktiveringsaggregat, som er driftforbundet til drivorganet; og - et aktiveringselement (26), der er interaktivt forbundet til huset såvel som til dosisaktiveringsaggregatet via et gearaggregat; hvor aktiveringselementet (26) omfatter tandstænger (54), der strækker sig i retning hovedsageligt vinkelret på indretningens længderetning og er anbragt i indgreb med gearaggregatet (32), hvorved aktiveringselementet er indrettet til at kunne bevæge sig i en retning (28) hovedsageligt vinkelret på en længdeakse (30) gennem indretningen fra en startposition, hvori aktiveringselementet befinder sig i huset (10), til en dosisindstillingsposition, hvori en del af aktiveringselementet (26) rager et bestemt stykke, proportionalt med den indstillede dosis, ud fra husets langsgående overflade, når dosisaktiveringsaggregatet betjenes manuelt til indstilling af en dosis, og hvor aktiveringselementet er indrettet til at blive manuelt betjent i en retning hovedsageligt vinkelret på indretningens længdeakse fra dosisindstillingspositionen til startpositionen til fremdrivning af dosisaktiveringsaggregatet og derved drivorganet (14), kendetegnet ved, at gearaggregatet (32) omfatter første tandhjul (36) og andre tandhjul (38), der er fast knyttet til de første tandhjul (36); hvor det første og andet tandhjul er drejeligt forbundet til huset (10), og hvor de første tandhjul (36) har en delecirkeldiameter, som er større end de andre tandhjuls (38) delecirkeldiameter, til tilvejebringelse af et udvekslingsforhold; dosisaktiveringsaggregatet omfatter et rørformet dosisaktiveringselement (20) og et dosisindstillingsgreb (34), som er forbundet til hinanden; det rørformede dosisaktiveringselement (20) omfatter en tandstang (22) på sin ydre rundgående overflade, og tandstangen (22) er indrettet til at interagere med de andre tandhjul (38); aktiveringselementets (26) tandstænger (54), der strækker sig i den hovedsageligt vinkelrette retning, er anbragt i indgreb med de første tandhjul (36) således, at når dosisindstillingsgrebet drejes til indstilling af en dosis, bevæger det rørformede dosisaktiveringselement (20) sig i distal retning som følge af gevindforbindelsen med drivorganet, og aktiveringselementet (26) bevæges ud af huset (10) fra startpositionen til dosisindstillingspositionen.
2. Medikamentafgivelsesindretning ifølge krav 1, hvor aktivering af aktiveringselementet (26) er konfigureret til at tillade en trykkraft fra alle fingre på den ene hånd.
3. Medikamentafgivelsesindretning ifølge krav 1, hvor det rørformede dosisaktiveringselement (20) og drivorganet er forbundet interaktivt til hinanden via gevind, som er tilvejebragt på ydersiden af drivorganet og på indersiden af det rørformede dosisaktiveringselement (20).
4. Medikamentafgivelsesindretning ifølge ethvert af de foregående krav 1 til 3, hvor huset omfatter et dosismængdevindue (40), hvori der er vist markeringer (42), og hver markering (42) svarer til bestemte dosismængder.
5. Medikamentafgivelsesindretning ifølge krav 4, hvor markeringerne (42) er anbragt på en sideflade af aktiveringselementet (26).
6. Medikamentafgivelsesindretning ifølge krav 4, hvor markeringerne (42) er anbragt på en rundgående overflade af en tromle (44), hvilken tromle (44) er interaktivt forbundet til de første tandhjul (36) via tredje (60) og fjerde (62) tandhjul.
7. Medikamentafgivelsesindretning ifølge krav 6, hvor de tredje tandhjul (60) er fast knyttet til de første tandhjul (36), og hvor de fjerde tandhjul (62) er fast knyttet til tromlen (44).
8. Medikamentafgivelsesindretning ifølge ethvert af de foregående krav, hvor indretningen yderligere omfatter føringer (46) indrettet til at styre på i længderetningen gående riller (48), som er tilvejebragt på ydersiden af drivorganet for at tillade en langsgående bevægelse, men hindre drejning af drivorganet.
9. Medikamentafgivelsesindretning ifølge ethvert af de foregående krav, hvor indretningen yderligere omfatter et énvejslåseorgan (50), der er indrettet til at interagere med drivorganet for at tillade langsgående bevægelse af drivorganet i kun proximal retning.
10. Medikamentafgivelsesindretning ifølge ethvert af de foregående krav, hvor indretningen er en injektionssprøjte.
DK11783825.0T 2010-05-20 2011-05-09 Medikamentafgivelsesindretning omfattende et manuelt aktiveringselement med forbedrede gribe- og aktiveringsegenskaber DK2588164T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34668210P 2010-05-20 2010-05-20
SE1050501 2010-05-20
PCT/SE2011/050577 WO2011145998A1 (en) 2010-05-20 2011-05-09 A medicament delivery device comprising a manual activation member with improved gripping and activation abilities.

Publications (1)

Publication Number Publication Date
DK2588164T3 true DK2588164T3 (da) 2015-05-11

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US (1) US8926568B2 (da)
EP (1) EP2588164B1 (da)
DK (1) DK2588164T3 (da)
TW (1) TWI484936B (da)
WO (1) WO2011145998A1 (da)

Families Citing this family (6)

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CN104136058A (zh) * 2011-11-29 2014-11-05 赛诺菲-安万特德国有限公司 用于药剂递送装置的操作辅件和包括操作辅件的药剂递送装置
CN105102031B (zh) * 2013-04-10 2019-01-18 赛诺菲 用于药物输送装置的驱动机构
USD755372S1 (en) * 2013-12-12 2016-05-03 Daicel Corporation Needleless syringe
CN104740729B (zh) * 2013-12-26 2019-02-22 上海微创生命科技有限公司 一种胰岛素注射器
NL2012054C2 (nl) * 2014-01-07 2015-07-08 Sharpsight B V Inrichting voor het doseren van een substantie, in het bijzonder een medicijn.
JP2017536958A (ja) * 2014-12-08 2017-12-14 サノフイ プリズムを含む薬物送達デバイス

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US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5645534A (en) * 1994-06-24 1997-07-08 Becton Dickinson And Company Time of last injection indicator for medication delivery pen
SE9901736D0 (sv) 1999-05-12 1999-05-12 Pharmacia & Upjohn Ab Injectino device and method for ITS operation
TW453884B (en) * 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
US6692472B2 (en) * 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
WO2003057286A1 (en) * 2001-12-13 2003-07-17 Matsushita Electric Industrial Co., Ltd. Administration instrument for medical use
FR2850286B1 (fr) 2003-01-27 2005-12-16 Sedat Dispositif de gonflage de ballonnet
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FR2953415B1 (fr) * 2009-12-09 2012-12-28 Primequal Sa Dispositif d'ejection pour ejecter de faibles doses

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Publication number Publication date
US8926568B2 (en) 2015-01-06
WO2011145998A1 (en) 2011-11-24
US20130211336A1 (en) 2013-08-15
TW201201765A (en) 2012-01-16
TWI484936B (zh) 2015-05-21
EP2588164A4 (en) 2014-03-12
EP2588164B1 (en) 2015-04-15
EP2588164A1 (en) 2013-05-08

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