DK2083890T3 - Doserings- og drivmekanisme til lægemiddeladministrationsanordning - Google Patents
Doserings- og drivmekanisme til lægemiddeladministrationsanordning Download PDFInfo
- Publication number
- DK2083890T3 DK2083890T3 DK07819684.7T DK07819684T DK2083890T3 DK 2083890 T3 DK2083890 T3 DK 2083890T3 DK 07819684 T DK07819684 T DK 07819684T DK 2083890 T3 DK2083890 T3 DK 2083890T3
- Authority
- DK
- Denmark
- Prior art keywords
- drive sleeve
- drug delivery
- delivery device
- piston rod
- housing
- Prior art date
Links
- 230000007246 mechanism Effects 0.000 title claims description 30
- 238000012377 drug delivery Methods 0.000 claims description 38
- 239000003814 drug Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 3
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
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- 229920000669 heparin Polymers 0.000 description 1
- 229940025708 injectable product Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (10)
1. Drivmekanisme til anvendelse i en lægemiddeladministrationsanordning, der omfatter: et hus (3, 7) med et spiralformet gevind, fortrinsvis et indvendigt spiralformet gevind; et aktiveringsmiddel (16), der er ikke-roterbart i forhold til huset (3, 7); en drivmuffe (14), hvor aktiveringsmidlet (16) er udformet til at overføre kraft fra en bruger til drivmuffen (14), og hvor drivmuffen (14) er koblet sammen med aktiveringsmidlet (16) til længdegående vandring ved muliggørelse af relativ rotation mellem drivmuffen (14) og aktiveringsmidlet (16); en stempelstang (10), der omfatter en distal gevinddel og en proksimal gevinddel; der er kendetegnet ved, at a) den distale gevinddel (9) af stempelstangen (10) er i gevindindgreb med huset (3, 7); b) den proksimale gevinddel (12) af stempelstangen (10) er i gevindindgreb med drivmuffen (14); hvor huset (3, 7) danner et spor (30), der omfatter en spiralformet gevinddel og en lineær del, der strækker sig i længderetningen, hvor drivmuffen (14) er i indgreb med sporet (30); således at c) når aktiveringsmidlet (16) bevæges i en proksimal retning væk fra en distal ende af lægemiddeladministrationsanordningen (1), er drivmuffen (14) i indgreb med den spiralformede del af sporet (30), således at drivmuffen (14) roterer i forhold til aktiveringsmidlet (16) og bevæges i den proksimale retning; og d) når aktiveringsmidlet (16) bevæges i en distal retning mod en distal ende af lægemiddeladministrationsanordningen (1), er drivmuffen (14) i indgreb med den lineære del af sporet (30), således at drivmuffen (14) bevæges i den distale retning og forhindres i at rotere i forhold til huset (3, 7), og stempelstangen (10) drives til at rotere i forhold til huset (3, 7) på grund af dens indgreb med huset (3, 7) og drivmuffen (14), således at en kraft overføres i længderetningen til den distale ende af lægemiddeladministrationsanordningen (1).
2. Drivmekanisme ifølge krav 1, hvor stempelstangen (10) har et i det væsentlige cirkulært tværsnit.
3. Drivmekanisme ifølge krav 1 eller krav 2, hvor den distale gevinddel (9) og den proksimale gevinddel (12) af stempelstangen (10) er modsat disponeret.
4. Drivmekanisme ifølge et hvilkset som helst af kravene 1 til 3, hvor stigningen af det andet gevind på stempelstangen (10) er i det væsentlige lig med stigningen af den spiralformede del af sporet (30) .
5. Lægemiddeladministrationsanordning, der omfatter drivmekanismen ifølge et hvilket som helst af kravene 1 til 4.
6. Lægemiddeladministrationsanordning ifølge krav 5, som er en pentype anordning.
7. Lægemiddeladministrationsanordning ifølge et hvilket som helst af kravene 5 til 6, som er an injektortype anordning.
8. Lægemiddeladministrationsanordning ifølge et hvilket som helst af kravene 5 til 7, som omfatter en kanyle.
9. Lægemiddeladministrationsanordning ifølge et hvilket som helst af kravene 5 til 7, som er en kanylefri anordning.
10. Lægemiddeladministrationsanordning ifølge et hvilket som helst af kravene 5 til 9, som er konfigureret til at dispensere et lægemiddel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06023955A EP1923084A1 (en) | 2006-11-17 | 2006-11-17 | Dosing and drive mechanism for drug delivery device |
| PCT/EP2007/009675 WO2008058667A1 (en) | 2006-11-17 | 2007-11-08 | Dosing and drive mechanism for drug delivery device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2083890T3 true DK2083890T3 (da) | 2019-04-08 |
Family
ID=37714720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07819684.7T DK2083890T3 (da) | 2006-11-17 | 2007-11-08 | Doserings- og drivmekanisme til lægemiddeladministrationsanordning |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8226631B2 (da) |
| EP (2) | EP1923084A1 (da) |
| JP (1) | JP5286274B2 (da) |
| KR (1) | KR101425393B1 (da) |
| CN (1) | CN101583392B (da) |
| AR (1) | AR063837A1 (da) |
| AU (1) | AU2007321448B2 (da) |
| BR (1) | BRPI0718749A2 (da) |
| CA (1) | CA2669376A1 (da) |
| DK (1) | DK2083890T3 (da) |
| IL (1) | IL198749A (da) |
| MX (1) | MX2009005094A (da) |
| MY (1) | MY149419A (da) |
| NO (1) | NO20092323L (da) |
| TR (1) | TR201903693T4 (da) |
| TW (1) | TWI434712B (da) |
| WO (1) | WO2008058667A1 (da) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1476210B1 (en) | 2002-02-11 | 2008-09-24 | Antares Pharma, Inc. | Intradermal injector |
| CN101132820B (zh) | 2005-01-24 | 2010-05-19 | 安塔雷斯制药公司 | 预充式针辅助喷射注入器 |
| US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
| EP1923084A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
| ES2752152T3 (es) | 2008-03-10 | 2020-04-03 | Antares Pharma Inc | Dispositivo de seguridad para inyector |
| CA2724641C (en) | 2008-05-20 | 2020-03-24 | Avant Medical Corp. | Autoinjector system |
| US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
| CN102112165B (zh) * | 2008-06-11 | 2013-05-29 | Shl集团有限责任公司 | 药物输送设备 |
| WO2010017285A2 (en) | 2008-08-05 | 2010-02-11 | Antares Pharma, Inc. | Multiple dosage injector |
| EP2201967A1 (en) | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Drug delivery device |
| EP2201972A1 (en) * | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Fixed dose injection device with resettable drive mechanism |
| EP2201973A1 (en) | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Drug delivery device with piston rod carrying dose markings |
| EP2201971A1 (en) | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Drug delivery device |
| EP2201970A1 (en) | 2008-12-23 | 2010-06-30 | Sanofi-Aventis Deutschland GmbH | Drug delivery device |
| US8827964B2 (en) | 2009-03-05 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
| AU2010226442A1 (en) | 2009-03-20 | 2011-10-13 | Antares Pharma, Inc. | Hazardous agent injection system |
| RU2545417C2 (ru) * | 2009-03-30 | 2015-03-27 | Санофи-Авентис Дойчланд Гмбх | Устройство для доставки лекарственных средств с усовершенствованным стержнем поршня |
| WO2010112558A1 (en) | 2009-03-31 | 2010-10-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with dose indication window |
| US9463283B2 (en) | 2009-06-01 | 2016-10-11 | Sanofi-Aventis Deutschland Gmbh | Dosing mechanism for a drug deliver device |
| US8974423B2 (en) | 2009-06-01 | 2015-03-10 | Sanofi-Aventis Deutschland Gmbh | Resettable drug delivery device |
| US9345840B2 (en) | 2009-06-01 | 2016-05-24 | Sanofi-Aventis Deutschland Gmbh | Drug delivery dose setting mechanism with variable maximum dose |
| US8672896B2 (en) | 2009-06-01 | 2014-03-18 | Sanofi-Aventis Deutschland Gmbh | Inner housing for a drug delivery device |
| US9125994B2 (en) | 2009-06-01 | 2015-09-08 | Sanofi—Aventis Deutschland GmbH | Drug delivery device with dose dial sleeve rotational stop |
| US9950116B2 (en) | 2009-06-01 | 2018-04-24 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism for priming a drug delivery device |
| US8257319B2 (en) | 2009-06-01 | 2012-09-04 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device inner housing having helical spline |
| US9623187B2 (en) | 2009-06-01 | 2017-04-18 | Sanofi-Aventis Deutschland Gmbh | Resettable drug delivery device |
| US10034982B2 (en) * | 2009-06-01 | 2018-07-31 | Sanofi-Aventis Deutschland Gmbh | Spindle for a drug delivery device |
| US8585656B2 (en) | 2009-06-01 | 2013-11-19 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism for priming a drug delivery device |
| US8728043B2 (en) | 2009-06-01 | 2014-05-20 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device |
| US9457150B2 (en) | 2009-06-01 | 2016-10-04 | Sanofi-Aventis Deutschland Gmbh | Biasing mechanism for a drug delivery device |
| US9108007B2 (en) | 2009-06-01 | 2015-08-18 | Sanofi-Aventis Deutschland Gmbh | Spindle and bearing combination and drug delivery device |
| US9199040B2 (en) | 2009-06-01 | 2015-12-01 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device last dose lock-out mechanism |
| US9238106B2 (en) | 2009-06-01 | 2016-01-19 | Sanofi-Aventis Deutschland Gmbh | Dose setting mechanism for priming a drug delivery device |
| EP2275159A1 (en) | 2009-07-14 | 2011-01-19 | Sanofi-Aventis Deutschland GmbH | Drug delivery device |
| EP2292286A1 (en) * | 2009-09-07 | 2011-03-09 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a medication delivery device and medication delivery device |
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-
2006
- 2006-11-17 EP EP06023955A patent/EP1923084A1/en not_active Ceased
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2007
- 2007-11-08 CN CN2007800500250A patent/CN101583392B/zh active Active
- 2007-11-08 WO PCT/EP2007/009675 patent/WO2008058667A1/en not_active Ceased
- 2007-11-08 TR TR2019/03693T patent/TR201903693T4/tr unknown
- 2007-11-08 CA CA002669376A patent/CA2669376A1/en not_active Abandoned
- 2007-11-08 MX MX2009005094A patent/MX2009005094A/es active IP Right Grant
- 2007-11-08 JP JP2009536637A patent/JP5286274B2/ja active Active
- 2007-11-08 MY MYPI20091859A patent/MY149419A/en unknown
- 2007-11-08 KR KR1020097012441A patent/KR101425393B1/ko not_active Expired - Fee Related
- 2007-11-08 DK DK07819684.7T patent/DK2083890T3/da active
- 2007-11-08 BR BRPI0718749-1A2A patent/BRPI0718749A2/pt not_active IP Right Cessation
- 2007-11-08 EP EP07819684.7A patent/EP2083890B1/en active Active
- 2007-11-08 AU AU2007321448A patent/AU2007321448B2/en not_active Ceased
- 2007-11-15 TW TW096143139A patent/TWI434712B/zh not_active IP Right Cessation
- 2007-11-15 AR ARP070105081A patent/AR063837A1/es unknown
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2009
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- 2009-05-15 US US12/466,590 patent/US8226631B2/en active Active
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Also Published As
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|---|---|
| KR20090082490A (ko) | 2009-07-30 |
| AU2007321448A1 (en) | 2008-05-22 |
| KR101425393B1 (ko) | 2014-08-01 |
| IL198749A (en) | 2012-12-31 |
| CA2669376A1 (en) | 2008-05-22 |
| JP2010509957A (ja) | 2010-04-02 |
| TWI434712B (zh) | 2014-04-21 |
| IL198749A0 (en) | 2010-02-17 |
| TW200836787A (en) | 2008-09-16 |
| NO20092323L (no) | 2009-07-15 |
| HK1138527A1 (en) | 2010-08-27 |
| EP2083890B1 (en) | 2018-12-26 |
| EP2083890A1 (en) | 2009-08-05 |
| US20100094253A1 (en) | 2010-04-15 |
| BRPI0718749A2 (pt) | 2013-12-03 |
| WO2008058667A1 (en) | 2008-05-22 |
| MY149419A (en) | 2013-08-30 |
| AU2007321448B2 (en) | 2013-02-14 |
| TR201903693T4 (tr) | 2019-04-22 |
| MX2009005094A (es) | 2009-05-27 |
| EP1923084A1 (en) | 2008-05-21 |
| CN101583392B (zh) | 2013-05-29 |
| US8226631B2 (en) | 2012-07-24 |
| AR063837A1 (es) | 2009-02-25 |
| CN101583392A (zh) | 2009-11-18 |
| JP5286274B2 (ja) | 2013-09-11 |
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