DK2556055T3 - Ship-hæmmere og anvendelser deraf - Google Patents
Ship-hæmmere og anvendelser deraf Download PDFInfo
- Publication number
- DK2556055T3 DK2556055T3 DK11766857.4T DK11766857T DK2556055T3 DK 2556055 T3 DK2556055 T3 DK 2556055T3 DK 11766857 T DK11766857 T DK 11766857T DK 2556055 T3 DK2556055 T3 DK 2556055T3
- Authority
- DK
- Denmark
- Prior art keywords
- applications
- ship inhibitors
- ship
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0007—Androstane derivatives not substituted in position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0027—Azides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32237810P | 2010-04-09 | 2010-04-09 | |
| PCT/US2011/031930 WO2011127465A2 (en) | 2010-04-09 | 2011-04-11 | Ship inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2556055T3 true DK2556055T3 (da) | 2019-08-19 |
Family
ID=44763588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11766857.4T DK2556055T3 (da) | 2010-04-09 | 2011-04-11 | Ship-hæmmere og anvendelser deraf |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9447139B2 (da) |
| EP (2) | EP3581563B1 (da) |
| DK (1) | DK2556055T3 (da) |
| ES (1) | ES2742213T3 (da) |
| WO (1) | WO2011127465A2 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9447139B2 (en) | 2010-04-09 | 2016-09-20 | The Research Foundation Of State University Of New York | Ship inhibitors and uses thereof |
| CN104072564B (zh) * | 2013-03-28 | 2016-08-17 | 广州市赛普特医药科技股份有限公司 | 2β,3α,5α-三羟基-雄甾-6-酮及其制备方法与用途 |
| EP3016660B1 (en) * | 2013-07-01 | 2020-06-10 | The Research Foundation for the State University of New York | Ship inhibition to combat obesity |
| EP3157530A4 (en) * | 2014-06-17 | 2018-01-17 | The Research Foundation for The State University of New York | Ship inhibition to induce expression of granulocyte colony stimulating factor in a subject |
| AU2016381509A1 (en) | 2015-12-31 | 2018-07-19 | Syracuse University | Tryptamine-based SHIP inhibitors for the treatment of cancer |
| JP2019535826A (ja) * | 2016-11-16 | 2019-12-12 | アイコア，エルエルシー． | 心血管疾患及び肺疾患を治療するためのグルコース−６−リン酸デヒドロゲナーゼの阻害剤 |
| WO2019234189A1 (en) * | 2018-06-06 | 2019-12-12 | Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) | Enhanced trained immunity in myeloid cells by ship-1 inhibition |
| US20220023315A1 (en) * | 2018-07-31 | 2022-01-27 | The Research Foundation For The State University Of New York | Methods of activating microglial cells |
| CN112315964B (zh) * | 2020-12-07 | 2024-01-26 | 中国医科大学附属盛京医院 | 环戊基菲啶苯类化合物在制备tln1蛋白抑制剂中的应用 |
| CN114716499B (zh) * | 2022-04-24 | 2023-05-23 | 浙江工商大学 | 生物甾醇胍基化修饰的胆酸螯合剂及制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU35817A1 (da) * | 1957-09-27 | |||
| GB1033520A (en) * | 1962-03-30 | 1966-06-22 | Sterling Drug Inc | 3-amino steroids |
| CS126738B5 (da) * | 1965-08-31 | 1968-03-15 | ||
| BE702699A (da) * | 1967-08-16 | 1968-01-15 | ||
| DE69721304T2 (de) | 1996-12-20 | 2004-03-04 | Novo Nordisk A/S | Verbindungen zur Regulierung der Meiose |
| WO2004032880A2 (en) | 2002-10-11 | 2004-04-22 | Isis Pharmaceuticals, Inc. | Method for inhibiting angiogenesis with ship-1 inhibitors |
| AU2004222540B2 (en) | 2003-03-11 | 2009-10-01 | Trophos | Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof |
| EP1789056A1 (en) | 2004-06-29 | 2007-05-30 | Jado Technologies GmbH | Use of steroid-derived pharmaceutical compositions for treating disorders relating to pathological processes in lipid rafts |
| WO2008068037A1 (en) * | 2006-12-08 | 2008-06-12 | Jado Technologies Gmbh | Cholesterylamines for the treatment and prevention of infectious diseases |
| WO2010045199A2 (en) * | 2008-10-13 | 2010-04-22 | University Of South Florida | Method of modulating ship activity |
| US8101605B2 (en) | 2009-12-04 | 2012-01-24 | Aquinox Pharmaceuticals Inc. | SHIP1 modulators and methods related thereto |
| US9447139B2 (en) | 2010-04-09 | 2016-09-20 | The Research Foundation Of State University Of New York | Ship inhibitors and uses thereof |
| EP3016660B1 (en) | 2013-07-01 | 2020-06-10 | The Research Foundation for the State University of New York | Ship inhibition to combat obesity |
-
2011
- 2011-04-11 US US13/640,162 patent/US9447139B2/en active Active
- 2011-04-11 DK DK11766857.4T patent/DK2556055T3/da active
- 2011-04-11 EP EP19189158.9A patent/EP3581563B1/en active Active
- 2011-04-11 EP EP11766857.4A patent/EP2556055B1/en active Active
- 2011-04-11 ES ES11766857T patent/ES2742213T3/es active Active
- 2011-04-11 WO PCT/US2011/031930 patent/WO2011127465A2/en not_active Ceased
-
2016
- 2016-09-19 US US15/269,209 patent/US11319336B2/en active Active
-
2021
- 2021-12-03 US US17/542,090 patent/US20220162254A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170051006A1 (en) | 2017-02-23 |
| EP2556055B1 (en) | 2019-07-31 |
| WO2011127465A3 (en) | 2012-03-15 |
| US20220162254A1 (en) | 2022-05-26 |
| EP3581563A1 (en) | 2019-12-18 |
| EP3581563B1 (en) | 2023-06-28 |
| US11319336B2 (en) | 2022-05-03 |
| WO2011127465A2 (en) | 2011-10-13 |
| ES2742213T3 (es) | 2020-02-13 |
| EP3581563C0 (en) | 2023-06-28 |
| EP2556055A4 (en) | 2014-02-19 |
| EP2556055A2 (en) | 2013-02-13 |
| US9447139B2 (en) | 2016-09-20 |
| US20130102577A1 (en) | 2013-04-25 |
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