[go: up one dir, main page]

DK2411043T3 - Behandling af cancer med immunostimulatorisk hiv tat derivat-polypeptider - Google Patents

Behandling af cancer med immunostimulatorisk hiv tat derivat-polypeptider

Info

Publication number
DK2411043T3
DK2411043T3 DK10712217.8T DK10712217T DK2411043T3 DK 2411043 T3 DK2411043 T3 DK 2411043T3 DK 10712217 T DK10712217 T DK 10712217T DK 2411043 T3 DK2411043 T3 DK 2411043T3
Authority
DK
Denmark
Prior art keywords
derivate
polypeptides
cancer
treatment
hiv tat
Prior art date
Application number
DK10712217.8T
Other languages
English (en)
Inventor
David I Cohen
Original Assignee
Pin Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pin Pharma Inc filed Critical Pin Pharma Inc
Application granted granted Critical
Publication of DK2411043T3 publication Critical patent/DK2411043T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK10712217.8T 2009-03-23 2010-03-23 Behandling af cancer med immunostimulatorisk hiv tat derivat-polypeptider DK2411043T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16260509P 2009-03-23 2009-03-23
US30627810P 2010-02-19 2010-02-19
US31022110P 2010-03-03 2010-03-03
PCT/US2010/028347 WO2010111292A1 (en) 2009-03-23 2010-03-23 Treatment of cancer with immunostimulatory hiv tat derivative polypeptides

Publications (1)

Publication Number Publication Date
DK2411043T3 true DK2411043T3 (da) 2013-10-21

Family

ID=42246045

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10712217.8T DK2411043T3 (da) 2009-03-23 2010-03-23 Behandling af cancer med immunostimulatorisk hiv tat derivat-polypeptider

Country Status (12)

Country Link
US (2) US8530431B2 (da)
EP (1) EP2411043B1 (da)
JP (1) JP5692933B2 (da)
CN (1) CN102405057B (da)
AU (1) AU2010230073B2 (da)
BR (1) BRPI1009215B1 (da)
CA (1) CA2755897C (da)
DK (1) DK2411043T3 (da)
ES (1) ES2432863T3 (da)
IL (1) IL215316A (da)
NZ (1) NZ595060A (da)
WO (1) WO2010111292A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2411043T3 (da) 2009-03-23 2013-10-21 Pin Pharma Inc Behandling af cancer med immunostimulatorisk hiv tat derivat-polypeptider
WO2012031262A1 (en) * 2010-09-02 2012-03-08 Visa International Service Association Social retail referral control apparatuses, methods and systems
EP2928910B1 (en) * 2012-12-06 2019-09-04 PIN Pharma, Inc. Treatment of inflammation, autoimmune, and neurodegenerative disorders with immunosuppressive tat derivative polypeptides
CN105705164A (zh) 2013-10-04 2016-06-22 品诺制药公司 用于癌症治疗的免疫刺激性hiv tat衍生多肽

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2631355B1 (fr) 1988-05-13 1990-09-07 Doris Engineering Dispositif de protection pour ouvrages en mer et procede pour la mise en oeuvre dudit dispositif
US5652122A (en) 1989-12-21 1997-07-29 Frankel; Alan Nucleic acids encoding and methods of making tat-derived transport polypeptides
US6316003B1 (en) 1989-12-21 2001-11-13 Whitehead Institute For Biomedical Research Tat-derived transport polypeptides
US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
JPH05506031A (ja) 1990-03-30 1993-09-02 スミスクライン・ビーチャム・コーポレイション 免疫不全ウイルス感染に伴う疾病の抑制
WO1991018454A1 (en) 1990-05-18 1991-11-28 Centre National De La Recherche Scientifique Compositions capable of blocking cytotoxicity of viral regulatory proteins and neurotoxic symptoms associated with retroviral infection
US5219990A (en) 1991-01-28 1993-06-15 Biogen, Inc. Papillomavirus e2 trans-activation repressors
CA2113720A1 (en) 1991-07-25 1993-02-04 Syamal Raychaudhuri Induction of cytotoxic t-lymphocyte responses
US5350835A (en) 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
WO1994015634A1 (en) 1992-12-30 1994-07-21 Matthias Rath Tat and rev oligopeptides in hiv treatment
FR2700169B1 (fr) 1993-01-04 1995-03-24 Transgene Sa Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine.
US5981258A (en) 1993-12-13 1999-11-09 Transgene S.A. Composition of trans-dominant variants of viral proteins for obtaining an antiviral effect
US6228369B1 (en) 1993-12-13 2001-05-08 Transgene S.A. Composition of trans-dominant variants of viral proteins for obtaining an anti-viral effect
US5817308A (en) 1994-02-14 1998-10-06 University Of Rochester Tolerogenic fusion proteins of immunoglobulins and methods for inducing and maintaining tolerance
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
CA2190972A1 (en) 1994-05-23 1995-11-30 Gideon Goldstein Compositions of transactivating proteins of human immunodeficiency virus
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
ES2366201T3 (es) 1994-07-15 2011-10-18 University Of Iowa Research Foundation Oligonucleótidos inmunmoduladores.
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
DE69610295T3 (de) 1995-03-08 2009-10-08 Neovacs Von einem retroviralen regulationsprotein abstammende, detoxifierte immunogene, dagegen gerichtete antikörper, verfahren zur deren herstellung und diese immunogene oder antikörper enthaltende, pharmazeutische zusammensetzungen.
US6846493B2 (en) 1995-09-01 2005-01-25 Millenium Biologix Inc. Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity
US5976786A (en) 1995-12-29 1999-11-02 National Jewish Medical And Research Center Screening methods for the identification of compounds that modulate apoptosis in immunodeficiency virus infected cells
US6200575B1 (en) 1996-03-07 2001-03-13 Neovacs Non-toxic immunogens derived from a retroviral regulatory protein antibodies preparation process and pharmaceutical compositions comprising them
EP0834569A1 (en) 1996-10-03 1998-04-08 Roche Diagnostics GmbH Thermostable DNA polymerase from carboxydothermus hydrogenoformans
US6686333B1 (en) 1996-10-04 2004-02-03 The United States Of America As Represented By The Department Of Health And Human Resources Inhibition of HIV replication using soluble Tat peptide analogs
US6024965A (en) 1996-10-18 2000-02-15 Erasums University Rotterdam Induction of REV and TAT specific cytotoxic T-cells for prevention and treatment of human immunodeficiency virus (HIV) infection
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6271354B1 (en) 1997-04-03 2001-08-07 Thomas Jefferson University Chimeric viral proteins
US20010007659A1 (en) 1997-04-17 2001-07-12 The University Of California Use of lentiviral vectors for antigen presentation in dendritic cells
WO1998052581A1 (en) 1997-05-20 1998-11-26 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
GB2341390B (en) 1997-05-21 2000-11-08 Univ Leland Stanford Junior Composition and method for enhancing transport across biological membranes
US5891994A (en) 1997-07-11 1999-04-06 Thymon L.L.C. Methods and compositions for impairing multiplication of HIV-1
PL196805B1 (pl) 1997-08-05 2008-02-29 Nventa Biopharma Corp Białko fuzyjne, kompozycja, cząsteczka kwasu nukleinowego, zastosowanie białka fuzyjnego, zastosowanie kwasu nukleinowego, komórka oraz sposób wytwarzania białka fuzyjnego
GB9720585D0 (en) 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
IT1297090B1 (it) 1997-12-01 1999-08-03 Barbara Ensoli Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le
FR2773156B1 (fr) 1997-12-26 2000-03-31 Biovacs Inc Nouveaux immunogenes anti-retroviraux (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida
FR2781158B1 (fr) 1998-07-15 2002-12-13 Vacs Internat Nouvelles proteines modifiees immunogenes non immunosuppressives, leur procede de preparation et leurs applications
US6497880B1 (en) 1998-12-08 2002-12-24 Stressgen Biotechnologies Corporation Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus
WO2000059935A1 (en) 1999-04-05 2000-10-12 Mayo Foundation For Medical Education And Research Anti-apoptotic fusion polypeptide
FR2792206B1 (fr) * 1999-04-13 2006-08-04 Centre Nat Rech Scient Vaccin anti-vih-1 comprenant tout ou partie de la proteine tat de vih-1
WO2000078969A1 (en) 1999-06-21 2000-12-28 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hiv tat peptides and multiple peptide conjugate system
AU5821000A (en) 1999-06-29 2001-01-31 Smithkline Beecham Biologicals (Sa) Vaccine
CA2378097A1 (en) 1999-07-08 2001-01-18 Stressgen Biotechnologies Corporation Induction of a th1-like response in vitro
US20050244434A1 (en) 1999-08-12 2005-11-03 Cohen David I Tat-based tolerogen compositions and methods of making and using same
EP1246647B1 (en) 1999-08-12 2010-04-28 InIst, Inc. Non-immunosuppressant hiv tat
CA2381425A1 (en) 1999-08-24 2001-03-01 Cellgate, Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
AT408721B (de) 1999-10-01 2002-02-25 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung enthaltend ein antigen
FR2802426B1 (fr) 1999-12-15 2004-04-02 Neovacs Utilisation de proteines immunogenes immunosuppressives et/ou angiogeniques rendues inactives, pour la production d'iga secretoires
AT409085B (de) 2000-01-28 2002-05-27 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen
BR0107972A (pt) 2000-01-31 2002-11-05 Smithkline Beecham Biologicals Uso de uma proteìna ou polinucleotìdeo tat do hiv, nef do hiv, ou tat do hiv ligado(a) a uma proteìna ou polinucleotìdeo nef do hiv (nef-tat), e de uma proteìna ou polinucleotìdeo gp120 do hiv, método para imunizar um ser humano contra o hiv, e, composição de vacina para o uso humano
AU2001256999A1 (en) 2000-04-12 2001-10-30 Wisconsin Alumni Research Foundation. A method for making an hiv vaccine
US6399067B1 (en) 2000-04-28 2002-06-04 Thymon L.L.C. Methods and compositions for impairing multiplication of HIV-1
AUPQ776100A0 (en) 2000-05-26 2000-06-15 Australian National University, The Synthetic molecules and uses therefor
US6544780B1 (en) 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
US20020110566A1 (en) 2000-06-26 2002-08-15 Neefe John R. Human papilloma virus treatment
US20070248618A1 (en) 2004-03-16 2007-10-25 Cohen David I Tat-Based vaccine Compositions and Methods of Making and Using Same
ATE493495T1 (de) 2000-09-08 2011-01-15 Univ Maryland Biotech Inst Genmanipulierte dna-vakzine zur co-expression, methoden zu deren herstellung und deren verwendungen
FR2814958B1 (fr) 2000-10-06 2003-03-07 Aventis Pasteur Composition vaccinale
US20040034209A1 (en) 2001-01-26 2004-02-19 David Ho Vaccination of hiv infected persons following highly active antiretrovial therapy
KR100465589B1 (ko) * 2001-04-20 2005-01-13 허만욱 비만 억제 폴리펩타이드
EP1279404A1 (en) 2001-07-26 2003-01-29 Istituto Superiore di Sanità Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases
AUPR842501A0 (en) * 2001-10-23 2001-11-15 Epipop Pty Ltd A method for identification and development of therapeutic agents
EP1458750A2 (en) 2001-12-11 2004-09-22 Aventis Pasteur Mutated hiv tat
NZ573064A (en) 2002-04-04 2011-02-25 Coley Pharm Gmbh Immunostimulatory G,U-containing oligoribonucleotides
WO2003103586A2 (en) 2002-06-05 2003-12-18 Coley Pharmaceutical Group, Inc. Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids
US6786160B1 (en) 2003-05-02 2004-09-07 Zeftek, Inc. Beam isolator
WO2004108753A1 (en) * 2003-06-10 2004-12-16 The University Of Melbourne Immunomodulating compositions, uses therefor and processes for their production
US20050203041A1 (en) 2003-09-23 2005-09-15 Mourich Dan V. Antisense compound and method for selectively killing activated T cells
GB2407500A (en) * 2003-11-03 2005-05-04 Ist Superiore Sanita Use of microparticles for antigen delivery
US7927580B2 (en) 2004-03-16 2011-04-19 Nanirx, Inc. Tat-based immunomodulatory compositions and methods of their discovery and use
FR2868318B1 (fr) * 2004-04-01 2012-11-16 Commissariat Energie Atomique Antigene tat stabilise et ses applications pour la vaccination anti-vih
FR2868319B1 (fr) * 2004-04-01 2006-07-07 Commissariat Energie Atomique Antigene tat dimerique et ses applications pour la vaccination anti-vih
DK2411043T3 (da) 2009-03-23 2013-10-21 Pin Pharma Inc Behandling af cancer med immunostimulatorisk hiv tat derivat-polypeptider

Also Published As

Publication number Publication date
ES2432863T3 (es) 2013-12-05
BRPI1009215B1 (pt) 2019-10-29
CA2755897C (en) 2020-01-28
US20110009336A1 (en) 2011-01-13
IL215316A (en) 2015-06-30
IL215316A0 (en) 2011-12-29
WO2010111292A1 (en) 2010-09-30
EP2411043A1 (en) 2012-02-01
AU2010230073A1 (en) 2011-09-29
CA2755897A1 (en) 2010-09-30
US8530431B2 (en) 2013-09-10
US20130331335A1 (en) 2013-12-12
EP2411043B1 (en) 2013-07-31
AU2010230073B2 (en) 2016-05-26
JP2012521986A (ja) 2012-09-20
JP5692933B2 (ja) 2015-04-01
CN102405057A (zh) 2012-04-04
US9206239B2 (en) 2015-12-08
BRPI1009215A2 (pt) 2016-03-15
CN102405057B (zh) 2016-05-25
NZ595060A (en) 2013-05-31

Similar Documents

Publication Publication Date Title
HUS2400017I1 (hu) Dolutegravir és lamivudin kombinációi HIV-fertõzés kezelésére
PL2324831T3 (pl) Terapia pirfenidonem z wykluczeniem fluwoksaminy
BR112012005594A2 (pt) tratamento de câncer
DK4104848T3 (da) Sikker indgivelse af desmopressin
PL2552438T3 (pl) Sposoby leczenia raka wątrobowokomórkowego
DK2785349T3 (da) Kombinationsbehandling af cancer
DK2435432T6 (da) Apoptose-inducerende midler til behandling af cancer og immune og autoimmune sygdomme
DK2511264T3 (da) Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme
DK3517534T3 (da) Forbindelser, der er anvendelige til behandling af cancer
DK2507211T3 (da) Apoptosefremkaldende midler til behandling af cancer og immun- og autoimmun-sygdomme
DK2498756T3 (da) Tabletformuleringer af neratinibmaleat
EP2498844A4 (en) IMPFSPRITZE
DK2451482T3 (da) Kombinationsterapi til behandlingen af diabetes
DK2493466T3 (da) Hidtil ukendt antitumoral anvendelse af cabazitaxel
DK3246042T3 (da) Lægemiddelresistent immunterapi til behandling af cancer
BRPI1014688A2 (pt) aplicações terapêuticas de derivados de quinazolinadiona
EP2407493A4 (en) SILICONE MONOMER
DK2501381T3 (da) Behandling af atrieflimmer
DK2802351T3 (da) Midler til behandling af triple-negativ brystkræft
EP2827061A4 (en) CERAMIC GLOW CANDLE
BRPI1011318A2 (pt) derivados de triazina e suas aplicações terapêuticas
DK2411043T3 (da) Behandling af cancer med immunostimulatorisk hiv tat derivat-polypeptider
DK2295521T3 (da) Fremgangsmåde til sulfurisering af katalysatorer til behandling af carbonhydrid
EP2539356A4 (en) MODULATION OF SMAD3 EXPRESSION
ES1070559Y (es) Urna cineraria