DK2358373T3 - Injicerbar polydeoxyribonukleotidsammensætning til behandling af osteoartikulære sygdomme - Google Patents
Injicerbar polydeoxyribonukleotidsammensætning til behandling af osteoartikulære sygdomme Download PDFInfo
- Publication number
- DK2358373T3 DK2358373T3 DK09764046.0T DK09764046T DK2358373T3 DK 2358373 T3 DK2358373 T3 DK 2358373T3 DK 09764046 T DK09764046 T DK 09764046T DK 2358373 T3 DK2358373 T3 DK 2358373T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- composition according
- polydeoxyribonucleotides
- pdrn
- composition
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 4
- 201000010099 disease Diseases 0.000 title description 3
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
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- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 208000003947 Knee Osteoarthritis Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
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- OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 101710108470 Hyalin Proteins 0.000 description 1
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- 241000124008 Mammalia Species 0.000 description 1
- 102000055008 Matrilin Proteins Human genes 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
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- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 230000037023 motor activity Effects 0.000 description 1
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- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
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- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (9)
1. Sammensætning på basis af polydeoxyribonukleotider, ekstraheret fra naturlige kilder, til anvendelse ved hjælp af intraartikulær indgivelse i den terapeutiske behandling og eller som terapeutisk co-adjuvans i behandlingen af en degenerativ eller post-traumatisk tilstand af leddene, hvor polydeoxyribonukleotider har molekylvægte på mellem 70 kDalton og 240 kDalton.
2. Sammensætning ifølge krav 1 i form af en injicerbar vandig opløsning, som indeholder fra 1 til 100 mg/ml, fortrinsvis fra 5 til 30 mg/ml af polydeoxyribonukleotider i et saltholdigt vandigt opløsningsmiddel.
3. Sammensætning ifølge krav 1 eller 2 til behandling af osteoarthritis.
4. Sammensætning ifølge et af kravene 1 til 3, omfattende en polydeoxyribo-nukleotidfraktion, der er ekstraheret fra fiskesperm, hvor polydeoxyribonu-kleotiderne har polymerkæder med forskellige molekylvægte på mellem 70 kDalton og 240 kDalton.
5. Sammensætning ifølge et af kravene 1 til 4, som har en pH-værdi fra 6,5 til 7,5.
6. Sammensætning ifølge et af kravene 1 til 4, som indeholder natriumchlorid og natriumphosphatsalte.
7. Sammensætning ifølge et af kravene 1 til 6 til anvendelse i behandlingen af smerte i en patient, der lider af en smertefuld degenerativ eller posttraumatisk tilstand af leddene.
8. Anvendelse af en sammensætning ifølge et af kravene 1 til 6 til fremstilling af et farmaceutisk produkt eller en medicinsk indretning, der kan anvendes som en terapeutisk co-adjuvans i behandlingen af osteoartikulære patologier, især osteoarthritis ved hjælp af intraartikulær injektion af sammensætningen.
9. Anvendelse af en sammensætning ifølge krav 8, hvor det farmaceutiske produkt eller medicinske indretning til indgivelse ved hjælp af injektion er i form af en lille flaske, medicinflaske eller ampul eller i form af en forfyldt sprøjte.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITTO2008A000804A IT1391866B1 (it) | 2008-10-30 | 2008-10-30 | Composizione iniettabile di polinucleotidi per il trattamento di patologie osteoarticolari. |
| PCT/IB2009/054776 WO2010049898A1 (en) | 2008-10-30 | 2009-10-28 | Injectable polydeoxyribonucleotide composition for the treatment of osteoarticular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2358373T3 true DK2358373T3 (da) | 2015-11-02 |
Family
ID=40903256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09764046.0T DK2358373T3 (da) | 2008-10-30 | 2009-10-28 | Injicerbar polydeoxyribonukleotidsammensætning til behandling af osteoartikulære sygdomme |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9220734B2 (da) |
| EP (1) | EP2358373B1 (da) |
| CN (1) | CN102238953B (da) |
| BR (1) | BRPI0914410A2 (da) |
| DK (1) | DK2358373T3 (da) |
| ES (1) | ES2552651T3 (da) |
| IT (1) | IT1391866B1 (da) |
| PL (1) | PL2358373T3 (da) |
| PT (1) | PT2358373E (da) |
| RU (1) | RU2508115C2 (da) |
| WO (1) | WO2010049898A1 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1401218B1 (it) * | 2010-07-14 | 2013-07-12 | Mastelli S R L | Composizione ad attivita' bio-rigenerativa, riparativa ed eutrofizzante. |
| IT1406068B1 (it) | 2010-07-22 | 2014-02-06 | Medestea Int Spa | Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego |
| KR101739409B1 (ko) | 2011-10-21 | 2017-05-25 | 주식회사 파마리서치프로덕트 | 어류 정소로부터 분리된 디엔에이 단편 혼합물을 포함하는 연골 재생용 조성물 |
| ITUB20153110A1 (it) * | 2015-08-13 | 2017-02-13 | Alfakjn S R L | Composizione liquida iniettabile per uso nella terapia infiltrativa intra-articolare |
| ITUB20159447A1 (it) * | 2015-12-28 | 2017-06-28 | Mastelli S R L | Composizione per il trattamento e prevenzione dell?osteoporosi. |
| CN107287186A (zh) * | 2016-04-05 | 2017-10-24 | 达特珂贝怡股份有限公司 | 从鱼类的精液分离多脱氧核糖核苷酸的方法、由所述方法获得的多脱氧核糖核苷酸及其用途 |
| KR102410132B1 (ko) * | 2018-02-26 | 2022-06-17 | 주식회사 뉴온 | 조직 수복용 히알루론산 피부 충진제 조성물 |
| KR102056144B1 (ko) * | 2018-03-08 | 2019-12-16 | 주식회사 파마리서치프로덕트 | Dna 단편 혼합물이 고농도로 함유된 유동성을 갖는 액제 조성물 및 이의 제조방법 |
| KR102285724B1 (ko) * | 2018-04-05 | 2021-08-03 | 김석순 | Dna 단편 혼합물 및 히알루론산을 포함하는 연골 재생용 조성물 |
| KR20190140654A (ko) | 2018-06-12 | 2019-12-20 | 주식회사 비알팜 | Dna 단편 혼합물 및 매트릭스 메탈로프로테아제 생성 억제제를 포함하는 관절염 예방 및 치료용 조성물 |
| KR102242840B1 (ko) * | 2019-04-04 | 2021-04-23 | 주식회사 비알팜 | 탈모 방지 또는 발모 촉진용 조성물 |
| CN111214694B (zh) * | 2020-03-31 | 2022-04-22 | 山东大鱼生物技术有限公司 | 一种具有止血和加速伤口愈合功能的敷料及其制备方法 |
| KR102234367B1 (ko) * | 2020-09-07 | 2021-03-31 | 바이오메디팜 어업회사법인 주식회사 | 연어의 정소로부터 고순도 피디알엔의 추출 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899481A (en) * | 1970-11-03 | 1975-08-12 | Crinos Industria Farmaco | Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs |
| IT1187833B (it) | 1985-12-12 | 1987-12-23 | Farmigea Spa | Procedimento per l ottenimento di polidesossiribonucleotidi non informazionali sostanzialmente puri e dotati di attivita biologiche e prodotto relativo |
| FR2676926B1 (fr) * | 1991-05-30 | 1993-10-01 | Pierre Flecchia | Compositions pharmaceutiques a base de polydesoxyribonucleotides et leur procede de preparation. |
| US5977083A (en) * | 1991-08-21 | 1999-11-02 | Burcoglu; Arsinur | Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states |
| EP0786522A2 (en) * | 1992-07-17 | 1997-07-30 | Ribozyme Pharmaceuticals, Inc. | Enzymatic RNA molecules for treatment of stenotic conditions |
| AU7319994A (en) * | 1993-06-30 | 1995-01-24 | Board Of Regents, The University Of Texas System | Nucleotide preparation and uses thereof in wound healing |
| US6737271B1 (en) * | 2000-03-24 | 2004-05-18 | Biocell Laboratories | Compound, composition and method for the treatment of inflammatory and inflammatory-related disorders |
| EP1442132A2 (en) * | 2001-10-26 | 2004-08-04 | Novartis AG | Methods for the treatment of osteoarthritis and compositions thereof |
-
2008
- 2008-10-30 IT ITTO2008A000804A patent/IT1391866B1/it active
-
2009
- 2009-10-28 ES ES09764046.0T patent/ES2552651T3/es active Active
- 2009-10-28 RU RU2011121612/15A patent/RU2508115C2/ru active
- 2009-10-28 PL PL09764046T patent/PL2358373T3/pl unknown
- 2009-10-28 BR BRPI0914410A patent/BRPI0914410A2/pt not_active Application Discontinuation
- 2009-10-28 PT PT97640460T patent/PT2358373E/pt unknown
- 2009-10-28 DK DK09764046.0T patent/DK2358373T3/da active
- 2009-10-28 CN CN200980143593.4A patent/CN102238953B/zh active Active
- 2009-10-28 EP EP09764046.0A patent/EP2358373B1/en active Active
- 2009-10-28 US US13/125,572 patent/US9220734B2/en active Active
- 2009-10-28 WO PCT/IB2009/054776 patent/WO2010049898A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011121612A (ru) | 2012-12-10 |
| RU2508115C2 (ru) | 2014-02-27 |
| WO2010049898A1 (en) | 2010-05-06 |
| EP2358373A1 (en) | 2011-08-24 |
| PT2358373E (pt) | 2015-11-13 |
| ES2552651T3 (es) | 2015-12-01 |
| ITTO20080804A1 (it) | 2010-04-30 |
| US20110196024A1 (en) | 2011-08-11 |
| US9220734B2 (en) | 2015-12-29 |
| CN102238953B (zh) | 2015-11-25 |
| EP2358373B1 (en) | 2015-09-09 |
| PL2358373T3 (pl) | 2016-02-29 |
| CN102238953A (zh) | 2011-11-09 |
| BRPI0914410A2 (pt) | 2016-08-16 |
| IT1391866B1 (it) | 2012-01-27 |
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