DK2298278T3 - Forebyggelse og reduktion af blodtab og inflammatorisk respons - Google Patents
Forebyggelse og reduktion af blodtab og inflammatorisk respons Download PDFInfo
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- DK2298278T3 DK2298278T3 DK10180486.2T DK10180486T DK2298278T3 DK 2298278 T3 DK2298278 T3 DK 2298278T3 DK 10180486 T DK10180486 T DK 10180486T DK 2298278 T3 DK2298278 T3 DK 2298278T3
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Claims (25)
1. Polypeptid, der omfatter aminosyresekvensen: Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (aminosyreresterne 3-60 af SEQ ID NO: 2), hvor polypeptidet hæmmer kallikrein, til anvendelse til behandling eller forebyggelse af en systemisk inflammatorisk respons hos en person.
2. Polypeptid til anvendelse ifølge krav 1, hvor personen har omfattende kapillærlækage, bløddelstraume eller knoglevævstraume.
3. Polypeptid til anvendelse ifølge krav 1, hvor anvendelsen behandler eller forebygger skade på lungesystemet hos personen.
4. Polypeptid til anvendelse ifølge krav 1, hvor anvendelsen behandler eller forebygger ARDS (adult respiratory distress syndrome) hos personen.
5. Polypeptid til anvendelse ifølge krav 1, hvor anvendelsen behandler eller forebygger nedsat blodgennemstrømning af nyrer eller indvolde hos personen.
6. Polypeptid til anvendelse ifølge krav 1, hvor anvendelsen behandler eller forebygger en koagulopati hos personen.
7. Polypeptid til anvendelse ifølge krav 1, hvor anvendelsen behandler eller forebygger en nedsat neurokognitiv funktion hos personen.
8. Polypeptid til anvendelse ifølge krav 1, hvor anvendelsen behandler eller forebygger apopleksi hos personen.
9. Polypeptid til anvendelse ifølge krav 1, hvor anvendelsen behandler eller forebygger nyresvigt hos personen.
10. Polypeptid til anvendelse ifølge krav 1, hvor anvendelsen behandler eller forebygger et akut myokardieinfarkt eller en skade på hjertevæv hos personen.
11. Polypeptid, der omfatter aminosyresekvensen: Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (aminosyreresterne 3-60 af SEQ ID NO: 2), hvor polypeptidet hæmmer kallikrein, til anvendelse til behandling eller forebyggelse af perioperativt blodtab.
12. Polypeptid til anvendelse ifølge krav 2 eller krav 11, hvor personen har gennemgået en kardiotorakal operation.
13. Polypeptid til anvendelse ifølge krav 2 eller krav 11, hvor personen har gennemgået en koronararteriebypass-transplantationsprocedure.
14. Polypeptid til anvendelse ifølge krav 2 eller krav 11, hvor personen har fået foretaget en kardiopulmonal bypass.
15. Polypeptid til anvendelse ifølge krav 2 eller krav 11, hvor personen har fået indsat en kunstig hofte eller foretaget en sternal spaltning.
16. Polypeptid til anvendelse ifølge et hvilket som helst af kravene 12 til 15 til anvendelse i kombination med en blodtransfusion.
17. Polypeptid, der omfatter aminosyresekvensen: Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (aminosyreresterne 3-60 af SEQ ID NO: 2), hvor polypeptidet hæmmer kallikrein, til anvendelse til behandling eller forebyggelse af iskæmi.
18. Polypeptid til anvendelse ifølge et hvilket som helst af kravene 1 til 17, hvor polypeptidet består af aminosyresekvensen: Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (aminosyreresterne 3-60 af SEQ ID NO: 2).
19. Polypeptid til anvendelse ifølge et hvilket som helst af kravene 1 til 17, hvor polypeptidet består af aminosyresekvensen: Glu Ala Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gin Cys Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gin Asn Arg Phe Glu Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp (SEQ ID NO: 2) .
20. Farmaceutisk præparat, der omfatter et polypeptid til anvendelse ifølge et hvilket som helst af kravene 1 til 19 og en/et eller flere farmaceutisk acceptable buffere, bærematerialer og excipienser, hvor det farmaceutiske præparat er til anvendelse ifølge et hvilket som helst af kravene 1 til 17 .
21. Farmaceutisk præparat ifølge krav 20, hvor præparatet er et tørt, lyofiliseret pulver.
22. Farmaceutisk præparat ifølge krav 20, hvor præparatet omfatter bufferet saltvand.
23. Farmaceutisk præparat ifølge krav 22, hvor præparatet omfatter phosphatbufferet saltvand.
24. Farmaceutisk præparat ifølge et hvilket som helst af kravene 20 til 23, hvor det farmaceutiske præparat omfatter en eller flere andre farmaceutisk aktive forbindelser.
25. Beholder, der omfatter det farmaceutiske præparat ifølge et hvilket som helst af kravene 20 til 24, hvor det farmaceutiske præparat er til anvendelse ifølge et hvilket som helst af kravene 1 til 17.
Applications Claiming Priority (3)
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| US38723902P | 2002-06-07 | 2002-06-07 | |
| US40700302P | 2002-08-28 | 2002-08-28 | |
| EP07023364A EP1941867B1 (en) | 2002-06-07 | 2003-06-06 | Modified kunitz domain polypeptide |
Publications (1)
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| DK2298278T3 true DK2298278T3 (da) | 2016-02-01 |
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| DK03757339.1T DK1531791T3 (da) | 2002-06-07 | 2003-06-06 | Forebyggelse og begrænsning af iskæmi |
| DK10180484.7T DK2311432T3 (da) | 2002-06-07 | 2003-06-06 | Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure |
| DK07023364.8T DK1941867T3 (da) | 2002-06-07 | 2003-06-06 | Polypeptid med modificeret Kunitz domæne |
| DK10180486.2T DK2298278T3 (da) | 2002-06-07 | 2003-06-06 | Forebyggelse og reduktion af blodtab og inflammatorisk respons |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
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| DK03757339.1T DK1531791T3 (da) | 2002-06-07 | 2003-06-06 | Forebyggelse og begrænsning af iskæmi |
| DK10180484.7T DK2311432T3 (da) | 2002-06-07 | 2003-06-06 | Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure |
| DK07023364.8T DK1941867T3 (da) | 2002-06-07 | 2003-06-06 | Polypeptid med modificeret Kunitz domæne |
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| CY (1) | CY1112228T1 (da) |
| DE (1) | DE60333758D1 (da) |
| DK (4) | DK1531791T3 (da) |
| ES (4) | ES2348230T3 (da) |
| PT (4) | PT1531791E (da) |
| WO (1) | WO2003103475A2 (da) |
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| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| AU2001279203A1 (en) | 2000-07-31 | 2002-02-13 | Harman International Industries Inc. | Loudspeaker coil suspension system |
| US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| ATE477020T1 (de) * | 2002-06-07 | 2010-08-15 | Dyax Corp | Prevention und verringerung von ischemia |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ES2709103T3 (es) * | 2002-08-28 | 2019-04-15 | Dyax Corp | Métodos para conservar órganos y tejidos |
| US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| WO2005021557A2 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| ATE489062T1 (de) * | 2003-09-12 | 2010-12-15 | Z Medica Corp | Teilweise hydriertes hämostatisches mittel |
| US20060177971A1 (en) * | 2004-01-13 | 2006-08-10 | Jsr Corporation | Anisotropically conductive connector, production process thereof and application product thereof |
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| JP5118492B2 (ja) * | 2004-12-23 | 2013-01-16 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 血栓の形成の防止および／または安定化の防止 |
| US20060178609A1 (en) | 2005-02-09 | 2006-08-10 | Z-Medica, Llc | Devices and methods for the delivery of molecular sieve materials for the formation of blood clots |
| EP1853326B1 (en) | 2005-02-15 | 2016-06-15 | Virginia Commonwealth University | Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers |
| WO2007062676A1 (en) | 2005-12-01 | 2007-06-07 | B.R.A.H.M.S. Aktiengesellschaft | Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists |
| JP2009529542A (ja) * | 2006-03-10 | 2009-08-20 | ダイアックス コーポレーション | エカランチドに関する配合物 |
| LT1854477T (lt) * | 2006-03-16 | 2016-12-12 | Dyax Corp. | Peptidai, slopinantys plazmos kalikreiną, skirti naudoti oftalmologinių sutrikimų gydymui |
| EP2374472B9 (en) * | 2006-03-16 | 2019-06-12 | Dyax Corp. | Compositions and methods for treating ophthalmic disorders |
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| EP2347778A1 (de) | 2010-01-25 | 2011-07-27 | ECP Entwicklungsgesellschaft mbH | Fluidpumpe mit einem radial komprimierbaren Rotor |
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2016
- 2016-06-07 US US15/175,644 patent/US10245307B2/en not_active Expired - Lifetime
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2019
- 2019-02-21 US US16/281,276 patent/US11344610B2/en not_active Expired - Lifetime
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