DK2176220T3 - Pyrrolidin-2-on-derivater som androgenreceptormodulatorer. - Google Patents

Pyrrolidin-2-on-derivater som androgenreceptormodulatorer.

Info

Publication number: DK2176220T3
Authority: DK; Denmark
Prior art keywords: pyrrolidin; derivatives; androgen receptor; receptor modulators; modulators
Prior art date: 2007-08-07

Application number

DK08792430.4T

Other languages

English (en)

Inventor

Atsushi Hasuoka

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-07

Filing date

2008-08-06

Publication date

2013-06-10

2008-08-06 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2013-06-10 Application granted granted Critical

2013-06-10 Publication of DK2176220T3 publication Critical patent/DK2176220T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

DK08792430.4T 2007-08-07 2008-08-06 Pyrrolidin-2-on-derivater som androgenreceptormodulatorer. DK2176220T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2007205966		2007-08-07
JP2007299658		2007-11-19
PCT/JP2008/064500 WO2009020234A2 (en)	2007-08-07	2008-08-06	Pyrrolidin-2 -one derivatives as androgen receptor modulator

Publications (1)

Publication Number	Publication Date
DK2176220T3 true DK2176220T3 (da)	2013-06-10

Family

ID=40329363

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08792430.4T DK2176220T3 (da)	2007-08-07	2008-08-06	Pyrrolidin-2-on-derivater som androgenreceptormodulatorer.

Country Status (34)

Country	Link
US (2)	US8420694B2 (da)
EP (1)	EP2176220B1 (da)
JP (1)	JP5292390B2 (da)
KR (1)	KR20100049644A (da)
CN (1)	CN101821235B (da)
AR (1)	AR067823A1 (da)
AU (1)	AU2008284662B2 (da)
BR (1)	BRPI0814957B8 (da)
CA (1)	CA2695852C (da)
CL (1)	CL2008002313A1 (da)
CO (1)	CO6160326A2 (da)
CR (1)	CR11266A (da)
CY (1)	CY1114067T1 (da)
DK (1)	DK2176220T3 (da)
DO (1)	DOP2010000053A (da)
EA (1)	EA017429B1 (da)
ES (1)	ES2406685T3 (da)
GE (1)	GEP20125571B (da)
HR (1)	HRP20130374T1 (da)
JO (1)	JO2864B1 (da)
MA (1)	MA31639B1 (da)
ME (1)	ME01579B (da)
MX (1)	MX2010001484A (da)
MY (1)	MY159910A (da)
NZ (1)	NZ583624A (da)
PE (1)	PE20090899A1 (da)
PL (1)	PL2176220T3 (da)
PT (1)	PT2176220E (da)
RS (1)	RS52812B (da)
SI (1)	SI2176220T1 (da)
TN (1)	TN2010000062A1 (da)
TW (1)	TWI418543B (da)
WO (1)	WO2009020234A2 (da)
ZA (1)	ZA201001289B (da)

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AR067823A1 (es) *	2007-08-07	2009-10-21	Takeda Pharmaceutical	Compuestos de amina ciclica
MX2010009162A (es)	2008-02-22	2010-12-21	Radius Health Inc	Moduladores selectivos del receptor de androgeno.
US8268872B2 (en) *	2008-02-22	2012-09-18	Radius Health, Inc.	Selective androgen receptor modulators
US20090270361A1 (en) *	2008-03-26	2009-10-29	Takeda Pharmaceutical Company Limited	Substituted pyrazole derivatives and use thereof
MX338831B (es)	2010-02-04	2016-05-03	Radius Health Inc	Moduladores selectivos de receptores de androgenos.
ME02474B (me)	2010-05-12	2017-02-20	Radius Health Inc	Terapijski režimi
US8642632B2 (en)	2010-07-02	2014-02-04	Radius Health, Inc.	Selective androgen receptor modulators
EP2621901B1 (en)	2010-09-28	2015-07-29	Radius Health, Inc	Selective androgen receptor modulators
EP2834216A1 (en) *	2012-04-04	2015-02-11	Catylix Inc.	Selective androgen receptor modulators
EP3158995B1 (en)	2012-08-09	2018-05-23	Dynamis Therapeutics, Inc.	Meglumine for reducing high triglyceride levels
CN104662124B (zh) *	2012-09-21	2017-06-16	默克专利股份有限公司	具有c‑c三键的化合物及其在液晶混合物中的用途
SMT202300072T1 (it)	2014-03-28	2023-05-12	Univ Duke	Cancro della mammella mediante l'utilizzo di modulatori selettivi del recetiore degli estrogeni
US9421264B2 (en)	2014-03-28	2016-08-23	Duke University	Method of treating cancer using selective estrogen receptor modulators
KR101597327B1 (ko) *	2014-04-24	2016-02-24	동아에스티 주식회사	옥사졸리딘계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제
CN103951688B (zh) *	2014-05-06	2016-04-20	成都安斯利生物医药有限公司	一种制备3,5-二氟-4-甲基苯硼酸的方法
RU2022108295A (ru)	2016-06-22	2022-04-06	Эллипсес Фарма Лтд	Способы лечения ar+ рака молочной железы
CN117417263A (zh)	2017-01-05	2024-01-19	雷迪厄斯制药公司	Rad1901-2hcl的多晶型形式
CN112423844B (zh)	2018-07-04	2024-08-13	雷迪厄斯制药公司	Rad1901-2hcl的多晶型形式
JP7446316B2 (ja)	2019-01-11	2024-03-08	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	置換ピロリジンアミドｉｉｉ
MA54946A (fr)	2019-02-12	2021-12-22	Radius Pharmaceuticals Inc	Procédés et composés
CN110204505B (zh) *	2019-05-31	2023-02-03	荆门医药工业技术研究院	(s)-3-苄氧羰基-4-异丙基-2,5-恶唑烷二酮的制备工艺
US20230012570A1 (en) *	2019-11-20	2023-01-19	Medshine Discovery Inc.	Bicyclic compound used as selective androgen receptor modulator

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BR9914018A (pt) *	1998-09-22	2001-07-03	Yamanouchi Pharmaceuticals Co	Derivado de cianofenila
US6258833B1 (en)	1999-12-23	2001-07-10	Icos Corporation	Cyclic AMP-specific phosphodiesterase inhibitors
US7026500B2 (en)	2000-08-24	2006-04-11	University Of Tennessee Research Foundation	Halogenated selective androgen receptor modulators and methods of use thereof
JP2002088073A (ja)	2000-09-08	2002-03-27	Yamanouchi Pharmaceut Co Ltd	抗アンドロゲン剤
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DK2289872T3 (da)	2004-06-07	2017-10-09	Univ Tennessee Res Found	Medicinsk anvendelse af en selektiv androgen receptor-modulator
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TW200724139A (en) *	2005-05-05	2007-07-01	Warner Lambert Co	Androgen modulators
PL1891038T3 (pl)	2005-05-13	2009-04-30	Lilly Co Eli	Podstawione n-arylopirolidyny jako selektywne modulatory receptora androgenowego
WO2007015567A1 (ja)	2005-08-01	2007-02-08	Takeda Pharmaceutical Company Limited	環状アミン化合物
WO2007097289A1 (ja)	2006-02-20	2007-08-30	Takeda Pharmaceutical Company Limited	新規医薬
AU2007275736A1 (en)	2006-07-19	2008-01-24	Osurf (Ohio State University Research Foundation)	Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof
CN101516365A (zh)	2006-07-26	2009-08-26	诺瓦提斯公司	十一异戊二烯基焦磷酸酯合酶的抑制剂
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AR067823A1 (es)	2007-08-07	2009-10-21	Takeda Pharmaceutical	Compuestos de amina ciclica

2008
- 2008-08-06 AR ARP080103428A patent/AR067823A1/es unknown
- 2008-08-06 KR KR1020107005062A patent/KR20100049644A/ko not_active Abandoned
- 2008-08-06 HR HRP20130374AT patent/HRP20130374T1/hr unknown
- 2008-08-06 AU AU2008284662A patent/AU2008284662B2/en not_active Ceased
- 2008-08-06 GE GEAP200811715A patent/GEP20125571B/en unknown
- 2008-08-06 RS RS20130235A patent/RS52812B/sr unknown
- 2008-08-06 EA EA201070246A patent/EA017429B1/ru unknown
- 2008-08-06 US US12/672,516 patent/US8420694B2/en not_active Expired - Fee Related
- 2008-08-06 MX MX2010001484A patent/MX2010001484A/es active IP Right Grant
- 2008-08-06 PL PL08792430T patent/PL2176220T3/pl unknown
- 2008-08-06 NZ NZ583624A patent/NZ583624A/en not_active IP Right Cessation
- 2008-08-06 CL CL2008002313A patent/CL2008002313A1/es unknown
- 2008-08-06 CN CN2008801105925A patent/CN101821235B/zh not_active Expired - Fee Related
- 2008-08-06 ME MEP-2013-64A patent/ME01579B/me unknown
- 2008-08-06 BR BRPI0814957A patent/BRPI0814957B8/pt not_active IP Right Cessation
- 2008-08-06 CA CA2695852A patent/CA2695852C/en active Active
- 2008-08-06 ES ES08792430T patent/ES2406685T3/es active Active
- 2008-08-06 DK DK08792430.4T patent/DK2176220T3/da active
- 2008-08-06 EP EP08792430A patent/EP2176220B1/en active Active
- 2008-08-06 PT PT87924304T patent/PT2176220E/pt unknown
- 2008-08-06 WO PCT/JP2008/064500 patent/WO2009020234A2/en not_active Ceased
- 2008-08-06 PE PE2008001314A patent/PE20090899A1/es not_active Application Discontinuation
- 2008-08-06 MY MYPI2010000564A patent/MY159910A/en unknown
- 2008-08-06 US US12/221,739 patent/US7834051B2/en active Active
- 2008-08-06 TW TW097129774A patent/TWI418543B/zh not_active IP Right Cessation
- 2008-08-06 JP JP2010504096A patent/JP5292390B2/ja not_active Expired - Fee Related
- 2008-08-06 SI SI200830941T patent/SI2176220T1/sl unknown
- 2008-08-09 JO JO2008353A patent/JO2864B1/en active
2010
- 2010-02-05 DO DO2010000053A patent/DOP2010000053A/es unknown
- 2010-02-05 TN TNP2010000062A patent/TN2010000062A1/fr unknown
- 2010-02-12 CR CR11266A patent/CR11266A/es unknown
- 2010-02-23 ZA ZA2010/01289A patent/ZA201001289B/en unknown
- 2010-02-26 MA MA32657A patent/MA31639B1/fr unknown
- 2010-03-05 CO CO10026475A patent/CO6160326A2/es unknown
2013
- 2013-06-21 CY CY20131100507T patent/CY1114067T1/el unknown

Also Published As

Publication number	Publication date
JP2010535704A (ja)	2010-11-25
GEP20125571B (en)	2012-07-10
JP5292390B2 (ja)	2013-09-18
US7834051B2 (en)	2010-11-16
PT2176220E (pt)	2013-04-09
CA2695852C (en)	2017-01-03
BRPI0814957A2 (pt)	2015-02-03
CN101821235A (zh)	2010-09-01
EP2176220A2 (en)	2010-04-21
RS52812B (sr)	2013-10-31
BRPI0814957B8 (pt)	2021-05-25
TWI418543B (zh)	2013-12-11
ZA201001289B (en)	2011-04-28
US8420694B2 (en)	2013-04-16
US20090042967A1 (en)	2009-02-12
KR20100049644A (ko)	2010-05-12
WO2009020234A2 (en)	2009-02-12
MA31639B1 (fr)	2010-08-02
AU2008284662A1 (en)	2009-02-12
CO6160326A2 (es)	2010-05-20
MX2010001484A (es)	2010-03-04
ES2406685T3 (es)	2013-06-07
CR11266A (es)	2010-03-22
JO2864B1 (en)	2015-03-15
EP2176220B1 (en)	2013-03-27
CA2695852A1 (en)	2009-02-12
TW200916439A (en)	2009-04-16
HK1143972A1 (en)	2011-01-21
EA017429B1 (ru)	2012-12-28
ME01579B (me)	2014-09-20
US20110098336A1 (en)	2011-04-28
MY159910A (en)	2017-02-15
TN2010000062A1 (en)	2011-09-26
CY1114067T1 (el)	2016-07-27
AR067823A1 (es)	2009-10-21
HRP20130374T1 (en)	2013-05-31
SI2176220T1 (sl)	2013-05-31
WO2009020234A3 (en)	2009-04-16
BRPI0814957B1 (pt)	2019-12-03
EA201070246A1 (ru)	2010-08-30
DOP2010000053A (es)	2010-07-15
CL2008002313A1 (es)	2009-05-15
AU2008284662B2 (en)	2013-07-25
CN101821235B (zh)	2012-11-14
NZ583624A (en)	2012-06-29
PE20090899A1 (es)	2009-08-06
PL2176220T3 (pl)	2013-08-30

Publication	Publication Date	Title
DK2176220T3 (da)	2013-06-10	Pyrrolidin-2-on-derivater som androgenreceptormodulatorer.
DK2144897T3 (da)	2011-02-07	8-Oxy-quinolinderivater som bradykinin B2-receptormodulatorer
DK2094658T3 (da)	2012-02-13	Tetrahydrocyclopenta[B]indolforbindelser som androgenreceptormodulatorer
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