[go: up one dir, main page]

DK2001990T3 - Integreret system til bearbejdning af mikrofluidiske prøver og fremgangsmåde til anvendelse heraf - Google Patents

Integreret system til bearbejdning af mikrofluidiske prøver og fremgangsmåde til anvendelse heraf Download PDF

Info

Publication number
DK2001990T3
DK2001990T3 DK07754084.7T DK07754084T DK2001990T3 DK 2001990 T3 DK2001990 T3 DK 2001990T3 DK 07754084 T DK07754084 T DK 07754084T DK 2001990 T3 DK2001990 T3 DK 2001990T3
Authority
DK
Denmark
Prior art keywords
sample
cartridge
microfluidic
liquid
polynucleotide
Prior art date
Application number
DK07754084.7T
Other languages
English (en)
Inventor
Kalyan Handique
Sundaresh N Brahmasandra
Karthik Ganesan
Betty Wu
Nikhil Phadke
Gene Parunak
Jeff Williams
Original Assignee
Handylab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Handylab Inc filed Critical Handylab Inc
Application granted granted Critical
Publication of DK2001990T3 publication Critical patent/DK2001990T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/003—Valves for single use only
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0032—Constructional types of microvalves; Details of the cutting-off member using phase transition or influencing viscosity
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0044—Electric operating means therefor using thermo-electric means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0061—Operating means specially adapted for microvalves actuated by fluids actuated by an expanding gas or liquid volume
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B01L2400/0611—Valves, specific forms thereof check valves duck bill valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
    • G01N2035/00881—Communications between instruments or with remote terminals network configurations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Claims (15)

1. Apparat (981), omfattende: en modtagebås (992, 2014), som er konfigureret til at modtage en indførlig flersporet mikrofluidikpatron (994), hvor hvert spor omfatter en PCR-reak-tionszone (1001), som er konfigureret til at optage en polynucleotid-indehol-dende prøve (996), et antal sæt af opvarmningsindretninger, hvor hvert sæt af opvarmningsindretninger er koblet termisk sammen med en PCR-reaktionszone i flerspors-patronen, idet hvert sæt af opvarmningsindretninger omfatter et antal opvarmningsindretninger (1003,1005,1007,1009), som tilsammen er konfigureret til cyklisk at opvarme PCR-reaktionszonen under termiske cyklingstilstande, hvilket antal af opvarmningsindretninger er yderligere konfigureret til at opretholde en i alt væsentligt ensartet temperatur over PCR-reaktionszonen under hver fase af den termiske cykling, en detektor (999, 2009), som er konfigureret til at detektere tilstedeværelsen af en eller flere forstærkede polynucleotider i flersporspatronen, og en processor (980), som er konfigureret til uafhængigt at styre hver varme-indretning med henblik på cyklisk at opvarme hver PCR-reaktionszone i flersporspatronen, hvilken processor er yderligere konfigureret til at udøve uafhængige PCR-reaktioner på polynucleotid-indeholdende prøver i flerspors-patronens PCR-reaktionszoner.
2. Apparat (981) ifølge krav 1, hvorved detektoren (999, 2009) er en optisk detektor, som omfatter en lyskilde (2850), som er konfigureret til at udsende lys i en fluorescerende farves absorptionsbånd, og hvorved den optiske detektor yderligere omfatter en lysdetektor (2852), som er konfigureret til at detektere lys i den fluorescerende farves emissionsbånd, hvorved den fluorescerende farve svarer til en fluorescerende polynucleotidprøve eller et fragment heraf.
3. Apparat (981) ifølge krav 1, hvorved antallet af varmeindretninger omfatter i det mindste to kontaktvarmekilder, hvorved de i det mindste to kontaktvarmekilder hver er konfigureret til at blive koblet uafhængigt termisk til et andet udvalgt område af mikrofluidikpatronen (994), hvorved forskellige valgte områder opvarmes uafhængigt.
4. Apparat (981) ifølge krav 3, og som yderligere omfatter et eftergivende lag ved de i det mindste to kontaktvarmekilder, hvorved det eftergivende lag er konfigureret til termisk at koble de i det mindste to kontaktvarmekilder sammen med et eller flere af de valgte områder af mikrofluidikpatronen.
5. Apparat (981) ifølge krav 1, og som yderligere omfatter et låg (2010) ved modtagebåsen (992, 2014), idet låget er indrettet til i det mindste delvis at udelukke omgivende lys fra modtagebåsen.
6. Apparat (981) ifølge krav 1, og som yderligere omfatter en eller flere kraftindretninger, som er konfigureret til at påføre i det mindste en del af mikrofluidikpatronen (994) en kraft.
7. Apparat ifølge krav 6, hvorved den ene eller de flere kraftindretninger (1214) er konfigureret til at påføre kraft med henblik på termisk at koble de i det mindste to kontaktvarmekilder til i det mindste en del af mikrofluidikpatronen (994).
8. Apparat (981) ifølge krav 1, hvorved detektoren (999, 2009) er konfigureret til at detektere tilstedeværelsen af en eller flere forstærkede polynucleotider, som forstærkes ved hjælp af en fremgangsmåde valgt fra gruppen bestående af: po-lymerasekædereaktion, PMA, SDA, NASBA, LCR og Rolling-Cycle-amplifikatio-ner.
9. Apparat (981) ifølge krav 1, hvorved antallet af opvarmningsindretninger omfatter fire opvarmningsindretninger (1003,1005,1007,1009), som er konfigureret til termisk at koble til fire sider af PCR-reaktionszonen (1001).
10. Apparat (981) ifølge krav 9, hvorved de fire opvarmningsindretninger (1003, 1005, 1007, 1009) omfatter en første opvarmningsindretning (1005), som er adskilt fra en anden opvarmningsindretning (1003) ved hjælp af en spalte, hvor spalten er lille nok til at opretholde en temperaturgradient på mindre end 1 °C hen over bredden af en PCR-reaktionszone (1001) i flersporspatronen (994) på et hvilket som helst punkt langs en længde af PCR-reaktionszonen, idet de fire opvarmningsindretninger yderligere omfatter en tredje opvarmningsindretning (1007) og en fjerde opvarmningsindretning (1009), hvor længden af den tredje og den fjerde opvarmningsindretning er mindre end længden af den første og anden opvarmningsindretning.
11. Apparat (981) ifølge krav 1, hvorved hvert sæt af opvarmningsindretninger yderligere omfatter en eller flere temperaturfølere (1011, 1013, 1015), som er konfigureret til at styre energien, som leveres til antallet af opvarmningsindretninger (1003,1005,1007,1009), idet de en eller flere temperaturfølere yderligere er konfigureret til at overføre temperaturinformation til processoren (980).
12. Apparat (981) ifølge krav 3, hvorved de i det mindste to kontaktvarmekilder er konfigureret til at være i direkte fysisk kontakt med en af PCR-reaktionszo-nerne (1001) i flersporspatronen (994).
13. Apparat (981) ifølge krav 1, og som yderligere omfatter en patron (994) i kombination med apparatet, hvorved patronen omfatter: en eller flere mikroflui-dikkomponenter, som er konfigureret til at virke på mikrofluidikvolumener af po-lynucleotidindeholdende prøver før, under og efter forstærkning af en eller flere polynucleotider fra prøven, hvilke en eller flere mikrofluidikkomponenter er udvalgt fra gruppen bestående af: en eller flere kanaler (204, 214, 228, 230, 240, 246, 256, 257, 261), som er konfigureret til at tillade passage af mikrofluidikvolumener, en eller flere aktuatorer (244, 248, 254), som er konfigureret til at bevæge mikrofluidikvolumenerne, et eller flere kamre (220), som er konfigureret til at indeholde mikrofluidikvolumenerne, og en eller flere komponenter (206, 208, 210, 234, 242, 246, 250, 252, 258), som er konfigureret til at forhindre bevægelse af mikrofluidikvolumenerne.
14. Apparat (981) ifølge krav 13, hvorved de en eller flere komponenter, som er konfigureret til at forhindre bevægelse af mikrofluidikvolumener, omfatter: en mikrofluidikventil (206, 208, 210, 234), som er konfigureret til at transformere fra en åben til en lukket tilstand, og en mikrofluidikgate (242, 246, 250, 252, 258), som er konfigureret til at transformere fra en lukket til en åben tilstand.
15. Apparat (981) ifølge krav 2, hvorved den optiske detektor (999, 2009) er konfigureret til uafhængigt at detektere et antal af fluorescerende farver på et antal forskellige steder på mikrofluidikpatronen (984), hvorved hver fluorescerende farve svarer til en fluorescerende polynucleotid eller et fragment heraf.
DK07754084.7T 2006-03-24 2007-03-26 Integreret system til bearbejdning af mikrofluidiske prøver og fremgangsmåde til anvendelse heraf DK2001990T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78600706P 2006-03-24 2006-03-24
US85928406P 2006-11-14 2006-11-14
PCT/US2007/007513 WO2007112114A2 (en) 2006-03-24 2007-03-26 Integrated system for processing microfluidic samples, and method of using same

Publications (1)

Publication Number Publication Date
DK2001990T3 true DK2001990T3 (da) 2016-10-03

Family

ID=38541746

Family Applications (2)

Application Number Title Priority Date Filing Date
DK16174452.9T DK3088083T3 (da) 2006-03-24 2007-03-26 Fremgangsmåde til udøvelse af PCR ned eb flersporet patron
DK07754084.7T DK2001990T3 (da) 2006-03-24 2007-03-26 Integreret system til bearbejdning af mikrofluidiske prøver og fremgangsmåde til anvendelse heraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK16174452.9T DK3088083T3 (da) 2006-03-24 2007-03-26 Fremgangsmåde til udøvelse af PCR ned eb flersporet patron

Country Status (6)

Country Link
US (10) US9040288B2 (da)
EP (2) EP2001990B1 (da)
JP (4) JP5415253B2 (da)
DK (2) DK3088083T3 (da)
ES (2) ES2587007T3 (da)
WO (1) WO2007112114A2 (da)

Families Citing this family (301)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
EP1631496B1 (en) 2003-04-28 2014-02-26 Medical Instill Technologies, Inc. Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US7731906B2 (en) 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP5344817B2 (ja) 2004-05-03 2013-11-20 ハンディーラブ インコーポレイテッド ポリヌクレオチド含有サンプルの処理
US20070137062A1 (en) * 2005-07-05 2007-06-21 Eck Gary A Increased Negative Static Pressure Drying
KR20080096567A (ko) 2006-02-03 2008-10-30 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 장치
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DK3088083T3 (da) * 2006-03-24 2018-11-26 Handylab Inc Fremgangsmåde til udøvelse af PCR ned eb flersporet patron
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7966746B2 (en) * 2006-04-24 2011-06-28 Medical Instill Technologies, LLC Needle penetrable and laser resealable lyophilization method
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
JP2008167722A (ja) * 2007-01-15 2008-07-24 Konica Minolta Medical & Graphic Inc 磁性支持体上での加熱による核酸単離方法
US20080212643A1 (en) * 2007-03-02 2008-09-04 Mcgahhey D David Temperature monitoring device
US20090011417A1 (en) * 2007-03-07 2009-01-08 George Maltezos Testing Device
US20090042241A1 (en) 2007-04-06 2009-02-12 California Institute Of Technology Microfluidic device
EP2425894B1 (en) 2007-06-21 2016-12-28 Gen-Probe Incorporated Instruments and method for exposing a receptacle to multiple thermal zones
EP2171460B1 (en) 2007-07-13 2017-08-30 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
GB0715170D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
WO2009019452A1 (en) * 2007-08-03 2009-02-12 Enigma Diagnostics Limited Reaction vessel
GB0715171D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
EP3756767B1 (en) * 2007-10-02 2024-05-01 Labrador Diagnostics LLC Modular point-of-care devices and uses thereof
GB2466398B (en) * 2007-10-17 2012-09-05 Agilent Technologies Inc Measurement device with motion-triggered data exchange
US8021039B2 (en) * 2007-11-07 2011-09-20 Frank Amato Quality control material monitor
JP5311801B2 (ja) * 2007-11-09 2013-10-09 キヤノン株式会社 浸透圧ポンプを用いた送液駆動機構および該送液駆動機構を有するマイクロチップ
US7847932B2 (en) * 2007-12-28 2010-12-07 Morpho Detection, Inc. System and method for improved biodetection
US7852470B2 (en) * 2007-12-28 2010-12-14 Morpho Detection, Inc. System and method for improved biodetection
US20090168592A1 (en) * 2007-12-28 2009-07-02 Michael Craig Burrell Agitator for portable substance identification system and method
US8152494B2 (en) * 2008-02-12 2012-04-10 Gene Parunak Methods and systems for fluid control
CN102112625B (zh) * 2008-03-03 2013-11-20 学校法人埼玉医科大学 造成急性呼吸道感染的炎性病原体的鉴别方法
WO2010005444A1 (en) * 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide capture materials, and methods of using same
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US11235323B2 (en) 2008-08-27 2022-02-01 Life Technologies Corporation Apparatus for and method of processing biological samples
JP5492207B2 (ja) 2008-08-27 2014-05-14 ライフ テクノロジーズ コーポレーション 生物学的サンプルの処理装置および処理方法
BRPI0919285A2 (pt) * 2008-10-06 2015-08-18 Ulrich Mohr Dispositivo para cultivo/exposição, especialmente para culturas de células e/ou de bactérias.
US8247191B2 (en) * 2008-11-13 2012-08-21 Ritzen Kalle Disposable cassette and method of use for blood analysis on blood analyzer
JP5245788B2 (ja) * 2008-12-12 2013-07-24 株式会社島津製作所 反応処理装置
US20100159498A1 (en) * 2008-12-19 2010-06-24 Ritzen Kalle Blood analyzer with a blood cell sedimentation control mechanism and method of use
EP2391452B1 (en) * 2009-01-30 2015-06-17 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
WO2010091246A2 (en) * 2009-02-06 2010-08-12 Northwestern University Burstable liquid packaging and uses thereof
US20100213063A1 (en) * 2009-02-09 2010-08-26 Frederic Zenhausern Analysis
US9057064B1 (en) * 2009-02-25 2015-06-16 Ag-Defense Systems, Inc. Method and apparatus for extracting DNA from a biological sample
CN101881782B (zh) * 2009-05-08 2016-02-24 深圳迈瑞生物医疗电子股份有限公司 生化分析仪样本装载装置及方法
EP2437887B1 (en) 2009-06-04 2016-05-11 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
EP3586945A3 (en) 2009-06-05 2020-03-04 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
US8273300B2 (en) * 2009-07-09 2012-09-25 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
US8435454B2 (en) * 2009-07-09 2013-05-07 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
EP2475987B1 (en) * 2009-09-12 2021-12-15 Azure Vault Ltd Identifying transition points in chemical reactions
US8696991B1 (en) * 2010-01-04 2014-04-15 Harold W. Howe Field deployable surface plasmon resonance based biosensor
US9329173B2 (en) * 2010-01-07 2016-05-03 Sensor-Kinesis Corporation Method and apparatus for forming of an automated sampling device for the detection of Salmonella enterica utilizing an electrochemical aptamer biosensor
US9310363B2 (en) * 2010-01-07 2016-04-12 Sensor-Kinesis Corporation Method and apparatus for forming of an automated sampling device for the detection of salmonella enterica utilizing an electrochemical aptamer biosensor
EP2534494A4 (en) * 2010-02-12 2016-05-04 Univ Northwestern ASSAY CARD FOR SAMPLING, PROCESSING AND REACTION
EP2539719B1 (en) 2010-02-23 2019-12-25 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
US8720036B2 (en) 2010-03-09 2014-05-13 Netbio, Inc. Unitary biochip providing sample-in to results-out processing and methods of manufacture
AU2011224387B2 (en) * 2010-03-09 2015-12-24 Ande Corporation Unitary biochip providing sample-in to results-out processing and methods of manufacture
AU2016200080B2 (en) * 2010-03-09 2017-10-26 Ande Corporation Unitary biochip providing sample-in to results-out processing and methods of manufacture
KR101368463B1 (ko) * 2010-04-23 2014-03-03 나노바이오시스 주식회사 2개의 열 블록을 포함하는 ｐｃｒ 장치
EP2409765A1 (en) * 2010-07-21 2012-01-25 F. Hoffmann-La Roche AG Microfluidic system and process for mixing liquid fluids
CN103540517B (zh) * 2010-07-23 2017-05-24 贝克曼考尔特公司 处理样本的系统及方法
CA2807381A1 (en) 2010-08-03 2012-02-09 Drexel University Materials for disinfection produced by non-thermal plasma
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
GB201016014D0 (en) * 2010-09-24 2010-11-10 Epistem Ltd Thermal cycler
WO2012051529A1 (en) 2010-10-15 2012-04-19 Lockheed Martin Corporation Micro fluidic optic design
GB2484735B (en) * 2010-10-22 2014-12-31 Fathy A A Hasan Blood typing instrument and method
WO2012058420A1 (en) * 2010-10-27 2012-05-03 The Board Of Trustees Of The University Of Illinois Health diagnostic compact disc
US8663974B2 (en) 2010-12-23 2014-03-04 Claremont Biosolutions Llc Compositions and methods for capture and elution of biological materials via particulates
CA3177188A1 (en) * 2011-01-06 2012-07-12 Meso Scale Technologies, Llc. Assay cartridges for pcr analysis and methods of use thereof
RU2620922C2 (ru) 2011-01-21 2017-05-30 Теранос, Инк. Системы и методы оптимизации использования образца
AU2012211141B2 (en) 2011-01-27 2016-11-03 Invisible Sentinel, Inc. Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof
US9469871B2 (en) * 2011-04-14 2016-10-18 Corporos Inc. Methods and apparatus for point-of-care nucleic acid amplification and detection
ES2617599T3 (es) * 2011-04-15 2017-06-19 Becton, Dickinson And Company Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración
EP2527814A1 (en) * 2011-04-27 2012-11-28 Koninklijke Philips Electronics N.V. Sensor system with an exchangeable cartridge and a reader
US8470153B2 (en) * 2011-07-22 2013-06-25 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
US9435765B2 (en) 2011-07-22 2016-09-06 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
US9857332B2 (en) 2011-07-22 2018-01-02 Tecan Trading Ag System for manipulating samples in liquid droplets
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
KR20140070649A (ko) 2011-09-30 2014-06-10 라이프 테크놀로지스 코포레이션 생물학적 분석을 위한 시스템 및 방법
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
EP2761305B1 (en) 2011-09-30 2017-08-16 Becton, Dickinson and Company Unitized reagent strip
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
US8911949B2 (en) 2011-11-11 2014-12-16 Icubate, Inc. Systems and methods for performing amplicon rescue multiplex polymerase chain reaction (PCR)
WO2013086230A1 (en) * 2011-12-06 2013-06-13 Edan Diagnostics In vitro medical diagnostic device, cartridge, and systems and methods
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
WO2013119719A1 (en) * 2012-02-06 2013-08-15 Ludwig, Lester, F. Microprocessor-controlled microfluidic platform for pathogen, toxin, biomarker, and chemical detection with removable updatable sensor array for food and water safety, medical, and laboratory apllications
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US11648561B2 (en) 2012-02-13 2023-05-16 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
CN114134029A (zh) 2012-02-13 2022-03-04 纽莫德克斯莫勒库拉尔公司 用于处理和检测核酸的微流体盒
US20150038361A1 (en) * 2012-02-14 2015-02-05 Cornell University Apparatus, methods, and applications for point of care multiplexed diagnostics
ITUD20120028A1 (it) * 2012-02-21 2013-08-22 Sedicidodici S R L Camera di perfusione, relativa apparecchiatura utilizzante tale camera di perfusione e procedimento per l'analisi della patologia trombotico-ischemica ed emorragica
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
CA2866379C (en) 2012-03-09 2020-10-13 Invisible Sentinel, Inc. Methods and compositions for detecting multiple analytes with a single signal
US8804105B2 (en) * 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
US11360076B2 (en) 2012-03-30 2022-06-14 Weavr Health Corp. Methods and systems to collect a biological sample
US9354159B2 (en) 2012-05-02 2016-05-31 Nanoscopia (Cayman), Inc. Opto-fluidic system with coated fluid channels
US9186670B2 (en) * 2012-05-09 2015-11-17 Wisconsin Alumni Research Foundation Functionalized microfluidic device and method
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US8735853B2 (en) * 2012-06-09 2014-05-27 E.I. Spectra, Llc Fluorescence flow cytometry
GB201210403D0 (en) * 2012-06-13 2012-07-25 Ffei Ltd Mircoscope colour chart
AU2013279833B2 (en) * 2012-06-22 2018-07-19 Zoetis Denmark Aps A method and a system for quantitative or qualitative determination of a target component
US20150259671A1 (en) * 2012-07-31 2015-09-17 General Electric Company Devices and systems for isolating biomolecules and associated methods thereof
EP2881457B1 (en) * 2012-08-03 2019-04-24 Sony Corporation Nucleic acid analyzer, microchip for nucleic acid analysis, and method for mounting microchip in device
CN104684645B (zh) 2012-08-30 2017-03-08 生命技术公司 竖直夹具装置
EP2893356B1 (en) * 2012-09-05 2022-04-27 Cepheid Universal docking bay and data door in a fluidic analysis system
EP2965817B1 (en) 2012-10-24 2017-09-27 Genmark Diagnostics Inc. Integrated multiplex target analysis
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
WO2014066376A1 (en) 2012-10-25 2014-05-01 Neumodx Molecular, Inc. Method and materials for isolation of nucleic acid materials
WO2014097287A1 (en) 2012-12-17 2014-06-26 Leukodx, Ltd. Systems and methods for detecting a biological condition
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
WO2014108184A1 (en) * 2013-01-09 2014-07-17 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
EP2951593B1 (en) 2013-01-31 2018-09-19 Luminex Corporation Fluid retention plates and analysis cartridges
JP2016510418A (ja) * 2013-02-18 2016-04-07 セラノス， インコーポレイテッド 多重分析のためのシステム及び方法
CN104707674B (zh) 2013-03-11 2018-06-15 克忧公司 用于检测和量化分析物的系统和方法
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
AU2013202805B2 (en) * 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
US9416776B2 (en) * 2013-03-15 2016-08-16 Siemens Healthcare Diagnostics Inc. Microfluidic distributing device
US10220392B2 (en) 2013-03-15 2019-03-05 Becton, Dickinson And Company Process tube and carrier tray
US11865544B2 (en) 2013-03-15 2024-01-09 Becton, Dickinson And Company Process tube and carrier tray
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
CA2905204C (en) 2013-03-15 2021-08-10 Becton, Dickinson And Company Process tube and carrier tray
WO2014160861A1 (en) 2013-03-29 2014-10-02 6SensorLabs, Inc. A portable device for detection of harmful substances
US10466236B2 (en) 2013-03-29 2019-11-05 Nima Labs, Inc. System and method for detecting target substances
US10254279B2 (en) 2013-03-29 2019-04-09 Nima Labs, Inc. System and method for detection of target substances
SG11201508882PA (en) * 2013-04-29 2015-11-27 Becton Dickinson Co Imaging cartridge, pipette, and method of use for direct sputum smear microscopy
US11358138B2 (en) 2013-07-19 2022-06-14 Boston Microfluidics Inc. Fluid sample collection device
US10422806B1 (en) 2013-07-25 2019-09-24 Theranos Ip Company, Llc Methods for improving assays of biological samples
US9347962B2 (en) 2013-08-05 2016-05-24 Nanoscopia (Cayman), Inc. Handheld diagnostic system with chip-scale microscope and automated image capture mechanism
JP6427753B2 (ja) 2013-09-11 2018-11-28 国立大学法人大阪大学 熱対流生成用チップ、熱対流生成装置、及び熱対流生成方法
WO2015051347A2 (en) * 2013-10-04 2015-04-09 Avansci Bio, L.L.C. Liquid dispensing device
EP3760703A1 (en) 2013-10-22 2021-01-06 Berkeley Lights, Inc. Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
CN110560187B (zh) 2013-11-18 2022-01-11 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
US20150166326A1 (en) * 2013-12-18 2015-06-18 Berkeley Lights, Inc. Capturing Specific Nucleic Acid Materials From Individual Biological Cells In A Micro-Fluidic Device
US9243222B2 (en) * 2014-01-06 2016-01-26 Lawrence Livermore National Security, Llc Compositions and methods for pathogen transport
US10559864B2 (en) 2014-02-13 2020-02-11 Birmingham Technologies, Inc. Nanofluid contact potential difference battery
WO2015138343A1 (en) 2014-03-10 2015-09-17 Click Diagnostics, Inc. Cartridge-based thermocycler
ES2887222T3 (es) 2014-04-24 2021-12-22 Lucira Health Inc Detección colorimétrica de amplificación de ácido nucleico
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
GB2544198B (en) 2014-05-21 2021-01-13 Integenx Inc Fluidic cartridge with valve mechanism
EP2950076B1 (en) * 2014-05-26 2017-06-28 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Portable system for automated preparation of liquid and/or solid samples
US11291992B2 (en) 2014-08-05 2022-04-05 Sanwa Biotech Ltd On-site diagnostic system and the method thereof
US10141166B2 (en) * 2014-08-15 2018-11-27 Applied Materials, Inc. Method of real time in-situ chamber condition monitoring using sensors and RF communication
WO2016065073A1 (en) 2014-10-22 2016-04-28 Integenx Inc. Systems and methods for sample preparation, processing and analysis
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
ES3038141T3 (en) * 2014-11-11 2025-10-09 Hoffmann La Roche Fluid sample processing cartridge
JP2016094238A (ja) * 2014-11-17 2016-05-26 セイコーエプソン株式会社 容器収納体
USD794817S1 (en) * 2014-11-18 2017-08-15 Illumina, Inc. Analysis cartridge
USD794818S1 (en) * 2014-11-18 2017-08-15 Illumina, Inc. Analysis cartridge
USD794819S1 (en) * 2014-11-18 2017-08-15 Illumina, Inc. Analysis cartridge
US9623415B2 (en) 2014-12-31 2017-04-18 Click Diagnostics, Inc. Devices and methods for molecular diagnostic testing
CN107209181A (zh) * 2015-01-22 2017-09-26 日本电气方案创新株式会社 靶分析工具和靶分析方法
GB2531615B (en) * 2015-02-02 2017-11-22 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
GB201501705D0 (en) 2015-02-02 2015-03-18 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
WO2016172454A1 (en) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Microfluidic cell structure
US10233491B2 (en) 2015-06-19 2019-03-19 IntegenX, Inc. Valved cartridge and system
DK3132264T3 (da) 2015-06-29 2019-05-06 Cell Id Pte Ltd Fremgangsmåde og anordning til indsamling af testdata fra anvendelse af et engangstestkit
AU2016294420B2 (en) 2015-07-15 2019-04-18 Hycor Biomedical, Llc Customizable instrument
CN111487423B (zh) 2015-07-17 2023-09-01 克忧健康公司 用于增强检测和分析物定量的系统及方法
EP3124118B1 (en) * 2015-07-28 2018-02-28 Panasonic Intellectual Property Management Co., Ltd. Microchannel apparatus and pcr method
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
AU2016361413B2 (en) 2015-11-23 2022-04-14 Berkeley Lights, Inc. In situ-generated microfluidic isolation structures, kits and methods of use thereof
KR20230042540A (ko) 2015-12-30 2023-03-28 버클리 라잇츠, 인크. 광학적으로 구동되는 대류 및 변위를 위한 미세유체 디바이스들, 키트들 및 그 방법들
WO2017127570A1 (en) * 2016-01-20 2017-07-27 Triv Tech, Llc Point-of-care nucleic acid amplification and detection
WO2017160838A1 (en) 2016-03-14 2017-09-21 Diassess Inc. Devices and methods for biological assay sample preparation and delivery
US11123736B2 (en) 2016-03-14 2021-09-21 Lucira Health, Inc. Systems and methods for performing biological assays
US10730041B2 (en) * 2016-03-14 2020-08-04 Helixbind, Inc. Integrated fluidic devices and related methods
EP3430378B1 (en) 2016-03-14 2022-08-10 Lucira Health, Inc. Devices and methods for modifying optical properties
JP2019509740A (ja) 2016-03-14 2019-04-11 ディアスセス インコーポレイテッド 選択的に通気される生物学的アッセイ装置および関連の方法
FR3049060B1 (fr) * 2016-03-21 2018-04-20 Commissariat A L'energie Atomique Et Aux Energies Alternatives Dispositif de preparation d'un echantillon sanguin
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
WO2017201049A1 (en) 2016-05-17 2017-11-23 Integrated Nano-Technologies, Inc. Flow control system for diagnostic assay system
CN109689213B (zh) 2016-05-26 2022-10-14 伯克利之光生命科技公司 共价修饰的表面、试剂盒及制备方法和用途
WO2017210556A1 (en) * 2016-06-02 2017-12-07 Integrated Nano-Technologies, Inc. System and method for optimizing heat transfer for target amplification within a diagnostic assay system
CN110325652A (zh) 2016-06-29 2019-10-11 易捷仪器诊断股份有限公司 使用流动池检测分子的装置和方法
GB201611442D0 (en) * 2016-06-30 2016-08-17 Lumiradx Tech Ltd Fluid control
CN106047661B (zh) * 2016-07-06 2020-03-24 上海宏石医疗科技有限公司 一种pcr检测试剂容器及pcr前处理系统
JP6738428B2 (ja) 2016-08-31 2020-08-12 京セラ株式会社 センサ装置およびそれを用いた検出方法
JP6609530B2 (ja) * 2016-09-05 2019-11-20 株式会社日立製作所 単一細胞解析用システム
US10227633B2 (en) * 2016-10-07 2019-03-12 Bigtec Private Limited Portable device for purifying biological sample and a method thereof
CA3037221A1 (en) * 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Method for controlling an analysis device and analysis system
US11364495B2 (en) 2016-12-01 2022-06-21 Novel Microdevices, Llc Automated point-of-care devices for complex sample processing and methods of use thereof
JP7099961B2 (ja) * 2016-12-06 2022-07-12 日本板硝子株式会社 反応処理装置
US10427162B2 (en) * 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
US11213819B2 (en) * 2017-01-30 2022-01-04 Noavaran Payesh Ani Salamat (AZSense) Integrated patient monitor system
CN106680474A (zh) * 2017-02-04 2017-05-17 上海为然环保科技有限公司 一种家用餐具大肠杆菌快速检测仪
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
WO2018195107A1 (en) * 2017-04-17 2018-10-25 MedCision, Inc. Systems, devices, and methods for automated large gauge sample thawing
US11865535B2 (en) * 2017-04-20 2024-01-09 Hewlett-Packard Development Company, L.P. Microfluidic reaction system
US10598637B2 (en) * 2017-07-18 2020-03-24 Perkinelmer Health Sciences, Inc. Automated thermal desorption systems configured to determine sample tube orientation and/or cap presence, and related methods
CA3070455A1 (en) 2017-07-19 2019-01-24 Evanostics, Llc Cartridges for oral fluid analysis and methods of use
JP6904131B2 (ja) * 2017-07-21 2021-07-14 株式会社島津製作所 遺伝子測定装置
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
JP7046166B2 (ja) 2017-09-14 2022-04-01 ルシラ ヘルス インコーポレイテッド 電子読み出しを用いる多重化バイオアッセイデバイス
CN111801577A (zh) 2017-10-27 2020-10-20 波士顿微流控公司 流体样本收集装置
AU2018364741B2 (en) 2017-11-09 2021-03-25 Visby Medical, Inc. Portable molecular diagnostic device and methods for the detection of target viruses
EP3724636A4 (en) 2017-12-15 2021-08-18 Evanostics, LLC OPTICAL READER FOR ANALYTE TEST
JP2021515899A (ja) * 2018-03-02 2021-06-24 テレフレックス メディカル インコーポレイテッド 感染検出システムおよび方法
CN112400015A (zh) * 2018-03-15 2021-02-23 克里普托斯生物技术有限公司 进行热辅助的生化反应的方法和系统
US10816516B2 (en) 2018-03-28 2020-10-27 Perkinelmer Health Sciences, Inc. Autosamplers and gas chromatographic systems and methods including same
US20210008564A1 (en) * 2018-04-06 2021-01-14 Boehringer Ingelheim Vetmedica Gmbh Analysis device, cartridge, analysis system and method for testing a sample
KR102533782B1 (ko) * 2018-04-18 2023-05-17 엘지전자 주식회사 공기조화기
WO2019209290A1 (en) 2018-04-25 2019-10-31 Hewlett-Packard Development Company, L.P. Selective release of material in thermally degradable capsule
US11484877B2 (en) 2018-05-29 2022-11-01 Weavr Health Corp. Blood metering device with desiccant and support for storage media and inlay with flange
WO2019231837A1 (en) * 2018-05-29 2019-12-05 Boston Microfluidics, Inc. Blood metering device with desiccant and support for storage media and inlay with flange
US20200041418A1 (en) * 2018-07-31 2020-02-06 The Texas A&M University System Nanoplasmonic paper substrate for identification of fentanyl and fentanyl-related compounds
BR112021003395A2 (pt) * 2018-08-23 2021-05-18 Sanwa Biotech Ltd aparelho de diagnóstico portátil e método do mesmo
CN113272065A (zh) * 2018-08-27 2021-08-17 新型微装置有限责任公司（Dba新型装置） 包括竖直微流体设备和自动致动机构的样品-应答微流体系统和方法
CA3111751A1 (en) 2018-09-03 2020-03-12 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
US11772097B2 (en) 2018-10-19 2023-10-03 Renegadexbio, Pbc Simultaneous spot test and storage of blood samples
US11490839B2 (en) 2018-10-23 2022-11-08 Weavr Health Corp. Funnel with extension tube to augment blood collection device
CN111175481B (zh) * 2018-11-09 2025-03-04 广州万孚生物技术股份有限公司 血气生化测试卡、血气分析仪及血气分析仪的控制方法
KR102146299B1 (ko) * 2018-11-14 2020-08-20 바디텍메드(주) 다중진단 기능을 갖는 일체형 면역진단 형광 리더기
US12066383B2 (en) 2018-12-18 2024-08-20 Aspida Dx Inc. Optical analyte detection
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
CN111378557B (zh) 2018-12-26 2023-06-06 财团法人工业技术研究院 用于产生液珠的管状结构及液珠产生方法
WO2020168258A1 (en) 2019-02-15 2020-08-20 Berkeley Lights, Inc. Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment
US11479748B2 (en) * 2019-03-28 2022-10-25 The Regents Of The University Of California Methods and device for stimulating DNA repair
KR20220005009A (ko) 2019-04-28 2022-01-12 비스비 메디컬, 인코포레이티드 디지털 검출 능력 및 무선 연결성을 갖는 분자 진단 디바이스
CN114126762B (zh) 2019-04-30 2023-01-03 伯克利之光生命科技公司 用于包封和测定细胞的方法
TWI715997B (zh) 2019-06-13 2021-01-11 新加坡商克雷多生物醫學私人有限公司 一種可即時偵測一種以上螢光訊號之聚合酶鏈式反應裝置
US11061014B2 (en) * 2019-06-25 2021-07-13 Hemex Health, Inc. Malaria species detection
WO2021002941A1 (en) * 2019-07-03 2021-01-07 Siemens Healthcare Diagnostics Inc. Multi-well tray for cell lysing and purification and method of use
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
WO2021046336A1 (en) * 2019-09-06 2021-03-11 Teleflex Medical Incorporated Oligonucleotides for real-time determining the identification and antibiotic resistance of pathogenic microorganisms
DE102019124588A1 (de) 2019-09-12 2021-03-18 Biometra GmbH Temperiervorrichtung
WO2021066744A1 (en) * 2019-09-30 2021-04-08 Illumina Singapore Pte. Ltd. Test cartridge for analysis instruments
USD979092S1 (en) 2019-10-02 2023-02-21 Becton, Dickinson And Company Microfluidic cartridge
EP4085149A4 (en) 2020-01-03 2024-03-06 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
US10953404B1 (en) * 2020-04-24 2021-03-23 Pattern Bioscience, Inc. Apparatuses for contactless loading and imaging of microfluidic chips and related methods
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
CN113773942A (zh) * 2020-06-10 2021-12-10 北京百康芯生物科技有限公司 一种核酸检测卡盒
CN216978837U (zh) 2020-09-11 2022-07-15 贝克顿·迪金森公司 一种用于检测流体样品中的分析物的检测装置和测试系统
CN114308147A (zh) * 2020-09-30 2022-04-12 富佳生技股份有限公司 检测芯片、核酸检测盒及核酸检测设备
TW202215293A (zh) * 2020-09-30 2022-04-16 富佳生技股份有限公司 核酸檢測儀及基於影像的核酸檢測方法
EP3978128A1 (en) * 2020-09-30 2022-04-06 iCare Diagnostics International Co. Ltd. Nucleic acid detection kit and nucleic acid detection device
US20220099624A1 (en) * 2020-09-30 2022-03-31 Icare Diagnostics International Co. Ltd. Nucleic acid detection host and nucleic acid detection device
JP2022058248A (ja) * 2020-09-30 2022-04-11 富佳生技股▲ふん▼有限公司 核酸検出キット及び核酸検出装置
TWD218529S (zh) * 2020-09-30 2022-05-01 富佳生技股份有限公司 核酸檢測儀之圖形化使用者介面
KR102875461B1 (ko) 2020-11-09 2025-10-24 삼성전자주식회사 전자 장치 및 그의 연락처를 관리하는 방법
CN112629997B (zh) * 2020-12-15 2023-11-14 宁波爱基因科技有限公司 微流控检测仪加热保温系统
US12228514B1 (en) 2021-01-08 2025-02-18 A9.Com, Inc. Systems, devices, and methods for virus detection via fluorescence emission
US12115530B2 (en) * 2021-03-19 2024-10-15 Lost Arrow Bio On-board reagent storage in a fluid processing device
US11891671B1 (en) * 2021-03-24 2024-02-06 A9.Com, Inc. Virus detection system
GB2605956A (en) * 2021-04-14 2022-10-26 Univ Of South Eastern Norway Systems, apparatus and methods for extracting and analysing cellular material
DE102021109852A1 (de) 2021-04-19 2022-10-20 Ist Innuscreen Gmbh Verfahren zur automatisierten Online-Detektion mindestens einer biologischen Zielsubstanz in einer Flüssigkeit und Online-Analysegerät
EP4326849A1 (en) * 2021-04-22 2024-02-28 Baebies, Inc. Culture monitoring system and methods
US12216053B1 (en) 2021-06-22 2025-02-04 Amazon Technologies, Inc. System and methods for detecting pathogens using multi-wavelength sensing
US20240335836A1 (en) * 2021-07-30 2024-10-10 Cue Health Inc. An analyte detection system cartridge with improved phase changeable valves
CN113877239B (zh) * 2021-09-30 2023-07-25 浙江扬清芯片技术有限公司 一种集成纺织品超声提取及检测的微流控芯片
US12090483B2 (en) * 2021-10-12 2024-09-17 Amazon Technologies, Inc. Diagnostic sample collection system
US12415183B1 (en) * 2021-12-09 2025-09-16 Amazon Technologies, Inc. Microfluidic systems and methods
US20250065334A1 (en) * 2021-12-29 2025-02-27 Memorial Sloan-Kettering Cancer Center Vessels, devices, processes, and systems for tracking and managing items with circuitous custody chains
CN114308179A (zh) * 2022-01-06 2022-04-12 洛阳师范学院 一种数字化产品设计教学试验台
US12453967B2 (en) 2022-01-11 2025-10-28 GE Precision Healthcare LLC Closed system centrifuge tube for performing sample transfer
US12383895B2 (en) * 2022-01-24 2025-08-12 Siphox, Inc. Optical reader device for multiplexed diagnostic systems and methods of use
WO2023164613A2 (en) * 2022-02-24 2023-08-31 Denver Health and Hospital Authority Methods for diagnosing and/or treating otitis media
KR102814100B1 (ko) * 2022-08-02 2025-05-28 주식회사 아이젠텍 질병의 진단을 위한 올인원 카트리지 및 진단기기
WO2024102748A1 (en) * 2022-11-07 2024-05-16 Kephera Diagnostics, Llc Methods, diagnostic instruments, and kits for detecting diseases
EP4389887A1 (en) * 2022-12-21 2024-06-26 Mobidiag Oy Isolating and lysing cells
US20240321410A1 (en) * 2023-03-20 2024-09-26 Fluidion US Inc. High-throughput Training Data Generation System for Machine Learning-based Fluid Composition Monitoring Approaches
JP1762420S (ja) * 2023-03-31 2024-01-29 検査装置
WO2025034518A1 (en) * 2023-08-04 2025-02-13 Mammoth Biosciences, Inc. Instrumentation and methods for analysis of nucleic acids
DE102023129147A1 (de) 2023-10-24 2025-04-24 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Fluidische Vorrichtung und Verfahren zur Probenvorbereitung mit einer fluidischen Vorrichtung
WO2025090803A1 (en) 2023-10-26 2025-05-01 Pacesetter, Inc. Improved communication between medical devices
CN117686670B (zh) * 2024-02-02 2024-05-03 内蒙古蒙牛乳业（集团）股份有限公司 样品自动检测系统与智慧实验室
WO2025193617A1 (en) * 2024-03-11 2025-09-18 Biological Mimetics, Inc. Multi-chamber devices for detecting pathogens/molecules and methods of using same
CN119714840B (zh) * 2024-12-13 2025-09-05 汉江国家实验室 气液孔腔特征频率校核方法、装置及设备

Family Cites Families (1073)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1434314A (en) 1921-08-04 1922-10-31 Raich Anthony Lunch pail
US1616419A (en) 1925-04-03 1927-02-01 Everlasting Valve Co Automatic shut-off device for gas in case of fire
US1733401A (en) 1928-03-29 1929-10-29 Christman Matthias Journal box
NL109202C (da) 1959-11-20
GB1095429A (da) 1965-05-17
US3444742A (en) 1965-12-06 1969-05-20 Univ Of Kentucky Research Foun Multiple-unit pipetting assembly and pipette for use therein
US3528449A (en) 1968-02-27 1970-09-15 Trw Inc Fluid flow control apparatus
US3813316A (en) 1972-06-07 1974-05-28 Gen Electric Microorganisms having multiple compatible degradative energy-generating plasmids and preparation thereof
US4038192A (en) 1973-12-03 1977-07-26 International Biomedical Laboratories, Inc. Device for exchange between fluids suitable for treatment of blood
US3985649A (en) 1974-11-25 1976-10-12 Eddelman Roy T Ferromagnetic separation process and material
JPS5255578A (en) * 1975-10-31 1977-05-07 Hitachi Ltd Analyzing apparatus
US4018652A (en) 1976-01-09 1977-04-19 Mcdonnell Douglas Corporation Process and apparatus for ascertaining the concentration of microorganism in a water specimen
US4018089A (en) 1976-05-05 1977-04-19 Beckman Instruments, Inc. Fluid sampling apparatus
USD249706S (en) 1976-12-17 1978-09-26 Eastman Kodak Company Sample cup tray for chemical analysis of biological fluids
USD252157S (en) 1977-04-14 1979-06-19 Warner-Lambert Company Diagnostic device for measuring biochemical characteristics of microorganisms and the like
USD252341S (en) 1977-05-12 1979-07-10 Ryder International Corporation Testing tray
JPS5416896A (en) 1977-06-21 1979-02-07 Asahi Medical Co Blood dialyser
US4139005A (en) 1977-09-01 1979-02-13 Dickey Gilbert C Safety release pipe cap
USD254687S (en) 1979-01-25 1980-04-08 Mcdonnell Douglas Corporation Biochemical card for use with an automated microbial identification machine
USD261173S (en) 1979-02-05 1981-10-06 American Optical Corporation Bilirubinometer
USD261033S (en) 1979-02-05 1981-09-29 American Optical Corporation Bilirubin concentration analyzer
US4301412A (en) 1979-10-29 1981-11-17 United States Surgical Corporation Liquid conductivity measuring system and sample cards therefor
JPS5766361A (en) 1980-10-09 1982-04-22 Olympus Optical Co Ltd Plate-shaped apparatus for judging cohesion of particle
US4472357A (en) 1981-11-18 1984-09-18 Medical Laboratory Automation, Inc. Blood bank cuvette cassette and label therefor
US4457329A (en) 1981-12-04 1984-07-03 Air Products And Chemicals, Inc. Safety pressure regulator
JPS58212921A (ja) 1982-06-04 1983-12-10 Aron Kasei Co Ltd プラスチツクス中空成形物の成形方法
USD279817S (en) 1982-07-19 1985-07-23 Daryl Laboratories, Inc. Immunoassay test slide
US4504582A (en) 1982-07-20 1985-03-12 Genex Corporation Vermiculite as a carrier support for immobilized biological materials
US4439526A (en) 1982-07-26 1984-03-27 Eastman Kodak Company Clustered ingress apertures for capillary transport devices and method of use
EP0105194B1 (de) 1982-09-02 1988-05-25 Firma Andreas Hettich Zentrifugationskammern zur zytodiagnostischen Präparation von Epithelzellen und deren Verwendung
US4647432A (en) 1982-11-30 1987-03-03 Japan Tectron Instruments Corporation Tokuyama Soda Kabushiki Kaisha Automatic analysis apparatus
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
USD282208S (en) 1983-02-07 1986-01-14 Data Packaging Corporation Pipetter tip cartridge
US4698302A (en) 1983-05-12 1987-10-06 Advanced Magnetics, Inc. Enzymatic reactions using magnetic particles
US4522786A (en) 1983-08-10 1985-06-11 E. I. Du Pont De Nemours And Company Multilayered test device for detecting analytes in liquid test samples
US4673657A (en) 1983-08-26 1987-06-16 The Regents Of The University Of California Multiple assay card and system
CA1220168A (en) 1983-09-09 1987-04-07 Henry J. Rahn Magnetic separator for solid phase immunoassays
US4599315A (en) 1983-09-13 1986-07-08 University Of California Regents Microdroplet test apparatus
USD292735S (en) 1983-11-02 1987-11-10 A/S Nunc Tube for the immunological adsorption analysis
US4724207A (en) 1984-02-02 1988-02-09 Cuno Incorporated Modified siliceous chromatographic supports
US4654127A (en) 1984-04-11 1987-03-31 Sentech Medical Corporation Self-calibrating single-use sensing device for clinical chemistry and method of use
JP2502961B2 (ja) 1984-04-26 1996-05-29 日本碍子株式会社 電気化学的装置の製造方法
USD288478S (en) 1984-06-21 1987-02-24 Sentech Medical Corporation Clinical chemistry analyzer
WO1986005410A1 (en) 1985-03-13 1986-09-25 Baxter Travenol Laboratories, Inc. Platelet collection system
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4612959A (en) 1985-05-07 1986-09-23 Mobil Oil Corporation Valveless shut-off and transfer device
US4720374A (en) 1985-07-22 1988-01-19 E. I. Du Pont De Nemours And Company Container having a sonication compartment
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4678752A (en) 1985-11-18 1987-07-07 Becton, Dickinson And Company Automatic random access analyzer
US4871779A (en) 1985-12-23 1989-10-03 The Dow Chemical Company Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
DE3614955C1 (de) 1986-05-02 1987-08-06 Schulz Peter Proben-Verteiler-System
US4978622A (en) 1986-06-23 1990-12-18 Regents Of The University Of California Cytophaga-derived immunopotentiator
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5763262A (en) 1986-09-18 1998-06-09 Quidel Corporation Immunodiagnostic device
USD302294S (en) 1986-10-03 1989-07-18 Biotrack, Inc. Reagent cartridge for blood analysis
US4935342A (en) 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
US4978502A (en) 1987-01-05 1990-12-18 Dole Associates, Inc. Immunoassay or diagnostic device and method of manufacture
US5004583A (en) 1987-01-29 1991-04-02 Medtest Systems, Inc. Universal sensor cartridge for use with a universal analyzer for sensing components in a multicomponent fluid
US4946562A (en) 1987-01-29 1990-08-07 Medtest Systems, Inc. Apparatus and methods for sensing fluid components
US4997772A (en) 1987-09-18 1991-03-05 Eastman Kodak Company Water-insoluble particle and immunoreactive reagent, analytical elements and methods of use
US5599667A (en) 1987-03-02 1997-02-04 Gen-Probe Incorporated Polycationic supports and nucleic acid purification separation and hybridization
PT86881A (pt) 1987-03-02 1989-03-30 Lyle J Arnold Jr Metodo para a purificacao, separacao e hibridacao de acidos nucleicos utilizando suportes policationicos
US4855110A (en) 1987-05-06 1989-08-08 Abbott Laboratories Sample ring for clinical analyzer network
US5001417A (en) 1987-06-01 1991-03-19 Abbott Laboratories Apparatus for measuring electrolytes utilizing optical signals related to the concentration of the electrolytes
US5192507A (en) 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
JPH01503808A (ja) 1987-07-16 1989-12-21 イー・アイ・デユポン・ド・ネモアース・アンド・コンパニー（インコーポレイテツド） 固定化された凝集剤を用いるアフイニテイ分離
US4827944A (en) 1987-07-22 1989-05-09 Becton, Dickinson And Company Body fluid sample collection tube composite
GB8720470D0 (en) 1987-08-29 1987-10-07 Emi Plc Thorn Sensor arrangements
US4921809A (en) 1987-09-29 1990-05-01 Findley Adhesives, Inc. Polymer coated solid matrices and use in immunoassays
USD312692S (en) 1987-10-09 1990-12-04 Bradley Marshall C Pipette holder
US4914710A (en) 1987-11-20 1990-04-03 Storage Technology Corporation MICR document smear test machine
US4902624A (en) 1987-11-23 1990-02-20 Eastman Kodak Company Temperature cycling cuvette
USD310413S (en) 1987-12-17 1990-09-04 Miles Inc. Sample processor
US4895650A (en) 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays
JPH01219669A (ja) 1988-02-29 1989-09-01 Shimadzu Corp 液体試料容器の類別検出方法
US5503803A (en) 1988-03-28 1996-04-02 Conception Technologies, Inc. Miniaturized biological assembly
DE3811713A1 (de) 1988-04-08 1989-10-19 Bosch Gmbh Robert Planare polarographische sonde zur bestimmung des (lambda)-wertes von gasgemischen
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5096669A (en) 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US6147198A (en) 1988-09-15 2000-11-14 New York University Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
US5060823A (en) 1988-09-15 1991-10-29 Brandeis University Sterile transfer system
DE8813340U1 (de) 1988-10-24 1988-12-08 Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad Probenrack für Probengefäße
JPH0814337B2 (ja) 1988-11-11 1996-02-14 株式会社日立製作所 流体自体の相変化を利用した流路の開閉制御弁及び開閉制御方法
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US4919829A (en) 1988-12-30 1990-04-24 The United States Of America As Represented By The Secretary Of Commerce Aluminum hydroxides as solid lubricants
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US4948561A (en) 1989-02-09 1990-08-14 Eastman Kodak Company Multiple level filter device and kit containing same
US5053199A (en) 1989-02-21 1991-10-01 Boehringer Mannheim Corporation Electronically readable information carrier
US5416000A (en) 1989-03-16 1995-05-16 Chemtrak, Inc. Analyte immunoassay in self-contained apparatus
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US6610256B2 (en) 1989-04-05 2003-08-26 Wisconsin Alumni Research Foundation Image processing and analysis of individual nucleic acid molecules
FI86229C (fi) 1989-04-10 1992-07-27 Niilo Kaartinen Foerfarande foer formning av ett uppvaermbart och nedkylbart element vid ett system behandlande smao vaetskemaengder samt ett medelst foerfarandet framstaellt element.
US5334499A (en) 1989-04-17 1994-08-02 Eastman Kodak Company Methods of extracting, amplifying and detecting a nucleic acid from whole blood or PBMC fraction
US4949742A (en) 1989-04-26 1990-08-21 Spectra-Physics, Inc. Temperature operated gas valve
US5135872A (en) 1989-04-28 1992-08-04 Sangstat Medical Corporation Matrix controlled method of delayed fluid delivery for assays
US5071531A (en) 1989-05-01 1991-12-10 Soane Technologies, Inc. Casting of gradient gels
US5061336A (en) 1989-05-01 1991-10-29 Soane Technologies, Inc. Gel casting method and apparatus
AU109440S (en) 1989-05-03 1990-10-31 Bayer Diagnostic G M B H Diagnostic working station evaluation device
US5089233A (en) 1989-06-12 1992-02-18 Eastman Kodak Company Processing apparatus for a chemical reaction pack
US5173269A (en) 1989-06-15 1992-12-22 At&T Bell Laboratories Apparatus for reducing the reactivity of articles destined for disposal
USD325638S (en) 1989-07-10 1992-04-21 Hach Company Microtester or the like
USD328794S (en) 1989-07-19 1992-08-18 Pb Diagnostic Systems, Inc. Diagnostic instrument or similar article
AU635314B2 (en) 1989-09-08 1993-03-18 Terumo Kabushiki Kaisha Measuring apparatus
DE69004652T2 (de) 1989-09-29 1994-05-11 Glory Kogyo Kk Vorrichtung zum Bündeln von Papierblättern.
US5275787A (en) 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
LU87601A1 (fr) 1989-10-05 1990-02-07 Ceodeux Sa Robinet pour bouteille de gaz
US5231015A (en) 1989-10-18 1993-07-27 Eastman Kodak Company Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme
USD324426S (en) 1989-10-20 1992-03-03 Pacific Biotech, Inc. Reaction unit for use in analyzing biological fluids
US4967950A (en) 1989-10-31 1990-11-06 International Business Machines Corporation Soldering method
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5091328A (en) 1989-11-21 1992-02-25 National Semiconductor Corporation Method of late programming MOS devices
JP2731613B2 (ja) 1989-12-12 1998-03-25 株式会社クラレ 酵素免疫測定用カートリツジ、それを用いた測定方法及び測定装置
US5279936A (en) 1989-12-22 1994-01-18 Syntex (U.S.A.) Inc. Method of separation employing magnetic particles and second medium
USD328135S (en) 1990-01-12 1992-07-21 Pacific Biotech, Inc. Reaction unit for use in analyzing biological fluids
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US6054034A (en) 1990-02-28 2000-04-25 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5935401A (en) 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
ATE154981T1 (de) 1990-04-06 1997-07-15 Perkin Elmer Corp Automatisiertes labor für molekularbiologie
GB9007791D0 (en) 1990-04-06 1990-06-06 Foss Richard C High voltage boosted wordline supply charge pump and regulator for dram
EP0481068A4 (en) 1990-05-01 1993-02-24 Autogen Instruments, Inc. Integral biomolecule preparation device
US5667976A (en) 1990-05-11 1997-09-16 Becton Dickinson And Company Solid supports for nucleic acid hybridization assays
US5252296A (en) 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
US5935522A (en) 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US5155166A (en) 1990-06-18 1992-10-13 Eastman Kodak Company Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to carboxylated particles and a kit containing same
US5147777A (en) 1990-06-18 1992-09-15 Eastman Kodak Company Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use
DE4023194A1 (de) 1990-07-20 1992-01-23 Kodak Ag Vorrichtung mit mehreren einreihig angeordneten aufnahmen fuer mit fluessigkeit gefuellte behaelter
US5208163A (en) 1990-08-06 1993-05-04 Miles Inc. Self-metering fluid analysis device
US5147606A (en) 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
JPH0734375Y2 (ja) 1990-09-11 1995-08-02 株式会社シノテスト 被検体物質の反応測定検出器具
WO1992005443A1 (en) 1990-09-15 1992-04-02 Medical Research Council Reagent separation
US5135627A (en) 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
US5652141A (en) 1990-10-26 1997-07-29 Oiagen Gmbh Device and process for isolating nucleic acids from cell suspension
US5141718A (en) 1990-10-30 1992-08-25 Millipore Corporation Test plate apparatus
DE59105165D1 (de) 1990-11-01 1995-05-18 Ciba Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse.
DE59104604D1 (de) 1990-11-26 1995-03-23 Ciba Geigy Ag Detektorzelle.
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5273716A (en) 1991-01-14 1993-12-28 Electric Power Research Institute, Inc. pH optrode
FR2672301A1 (fr) 1991-02-01 1992-08-07 Larzul Daniel Procede et dispositif pour amplifier le nombre d'une sequence definie d'acide nucleique dans un echantillon biologique.
US5466574A (en) 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
US5384499A (en) 1991-04-25 1995-01-24 Altera Corporation High-density erasable programmable logic device architecture using multiplexer interconnections
US5327038A (en) 1991-05-09 1994-07-05 Rockwell International Corporation Walking expansion actuator
JPH05345900A (ja) 1991-07-08 1993-12-27 Fuji Oil Co Ltd 硬質油脂の製造法
DE4123348A1 (de) 1991-07-15 1993-01-21 Boehringer Mannheim Gmbh Elektrochemisches analysesystem
USD333522S (en) 1991-07-23 1993-02-23 P B Diagnostic Systems, Inc. Sample tube holder
IT1249433B (it) 1991-08-06 1995-02-23 Pompeo Moscetta Procedimento per il dosaggio di analiti in campioni liquidi e relativaapparecchiatura.
US7297313B1 (en) 1991-08-31 2007-11-20 The Regents Of The University Of California Microfabricated reactor, process for manufacturing the reactor, and method of amplification
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5256376A (en) 1991-09-12 1993-10-26 Medical Laboratory Automation, Inc. Agglutination detection apparatus
CA2118912C (en) 1991-10-04 1999-04-06 Melville Douglas Ball Peelable laminated structures and process for production thereof
CA2074671A1 (en) 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
USD347478S (en) 1991-11-05 1994-05-31 Hybaid Ltd. Laboratory instrument for handling bimolecular samples
EP0620822B1 (en) 1991-11-07 2001-05-30 Nanotronics, Inc. Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5787032A (en) 1991-11-07 1998-07-28 Nanogen Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
USD351475S (en) 1992-01-30 1994-10-11 Jan Gerber Skin patch for testing allergic reactions
US5559432A (en) 1992-02-27 1996-09-24 Logue; Delmar L. Joystick generating a polar coordinates signal utilizing a rotating magnetic field within a hollow toroid core
US5217694A (en) 1992-03-25 1993-06-08 Gibler W Brian Holder for evacuated test tubes
US5646049A (en) 1992-03-27 1997-07-08 Abbott Laboratories Scheduling operation of an automated analytical system
CA2133643A1 (en) 1992-04-06 1993-10-14 Stanley R. Bouma Method and device for detection of nucleic acid or analyte using total internal reflectance
US5223226A (en) 1992-04-14 1993-06-29 Millipore Corporation Insulated needle for forming an electrospray
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US6953676B1 (en) * 1992-05-01 2005-10-11 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5744366A (en) 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5401465A (en) 1992-05-05 1995-03-28 Chiron Corporation Luminometer with reduced sample crosstalk
US5364591A (en) 1992-06-01 1994-11-15 Eastman Kodak Company Device for moving a target-bearing solid through a liquid for detection while being contained
US5414245A (en) 1992-08-03 1995-05-09 Hewlett-Packard Corporation Thermal-ink heater array using rectifying material
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
DE4231966A1 (de) 1992-09-24 1994-03-31 Bosch Gmbh Robert Planare polarograhische Sonde zur Bestimmung des Lambda-Wertes von Gasgemischen
US5338671A (en) 1992-10-07 1994-08-16 Eastman Kodak Company DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
US5422271A (en) 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
US5569364A (en) 1992-11-05 1996-10-29 Soane Biosciences, Inc. Separation media for electrophoresis
US5885432A (en) 1992-11-05 1999-03-23 Soane Biosciences Un-crosslinked polymeric media for electrophoresis
GB9223334D0 (en) 1992-11-06 1992-12-23 Hybaid Ltd Magnetic solid phase supports
US5500187A (en) 1992-12-08 1996-03-19 Westinghouse Electric Corporation Disposable optical agglutination assay device and method for use
US5302348A (en) 1992-12-10 1994-04-12 Itc Corporation Blood coagulation time test apparatus and method
US5311996A (en) 1993-01-05 1994-05-17 Duffy Thomas J Edge protector
DE4334834A1 (de) 1993-10-13 1995-04-20 Andrzej Dr Ing Grzegorzewski Biosensor zum Messen von Viskositäts- und/oder Dichteänderungen
FI932866A0 (fi) 1993-06-21 1993-06-21 Labsystems Oy Separeringsfoerfarande
JPH0664156U (ja) 1993-02-16 1994-09-09 株式会社ニッテク 血液容器の保持構造
USD351913S (en) 1993-02-25 1994-10-25 Diametrics Medical, Inc. Disposable electrochemical measurement cartridge for a portable medical analyzer
US5339486A (en) 1993-03-10 1994-08-23 Persic Jr William V Golf ball cleaner
DE4316023A1 (de) 1993-05-13 1994-11-17 Basf Ag Verfahren zur Herstellung von niedrigmolekularen Polymerisaten des 1-Vinylimidazols
US5565171A (en) 1993-05-28 1996-10-15 Governors Of The University Of Alberta Continuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules
US6203759B1 (en) 1996-05-31 2001-03-20 Packard Instrument Company Microvolume liquid handling system
JP3339650B2 (ja) 1993-07-02 2002-10-28 和光純薬工業株式会社 液体分注装置
EP0636413B1 (en) 1993-07-28 2001-11-14 PE Corporation (NY) Nucleic acid amplification reaction apparatus and method
USD356232S (en) 1993-08-20 1995-03-14 Flair Communications Agency, Inc. Dual vesselled beverage container
US5397709A (en) 1993-08-27 1995-03-14 Becton Dickinson And Company System for detecting bacterial growth in a plurality of culture vials
JP2948069B2 (ja) 1993-09-20 1999-09-13 株式会社日立製作所 化学分析装置
US5374395A (en) 1993-10-14 1994-12-20 Amoco Corporation Diagnostics instrument
US5415839A (en) 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
US5645801A (en) 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
EP0653631B1 (de) 1993-11-11 2003-05-14 Aclara BioSciences, Inc. Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
DE4343089A1 (de) 1993-12-17 1995-06-29 Bosch Gmbh Robert Planares Sensorelement auf Festelektrolytbasis
ATE169521T1 (de) 1994-01-11 1998-08-15 Abbott Lab Vorrichtung und verfahren zur durchführung von nukleinsäueretests mittels temperaturzyklen
CA2143365A1 (en) 1994-03-14 1995-09-15 Hugh V. Cottingham Nucleic acid amplification method and apparatus
DE4408361C2 (de) 1994-03-14 1996-02-01 Bosch Gmbh Robert Elektrochemischer Sensor zur Bestimmung der Sauerstoffkonzentration in Gasgemischen
US5725831A (en) 1994-03-14 1998-03-10 Becton Dickinson And Company Nucleic acid amplification apparatus
KR970702375A (ko) 1994-03-24 1997-05-13 알렉미안 Dna 멜토메터 및 이것의 사용방법(a dna meltometer and methods of use thereof)
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5475487A (en) 1994-04-20 1995-12-12 The Regents Of The University Of California Aqueous carrier waveguide in a flow cytometer
USD366116S (en) 1994-05-03 1996-01-09 Thomas Biskupski Electrical box for storing dental wax
DE69527585T2 (de) 1994-06-08 2003-04-03 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
DE4420732A1 (de) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
US5514343A (en) 1994-06-22 1996-05-07 Nunc, As Microtitration system
WO1996000228A1 (en) 1994-06-23 1996-01-04 Dade International Inc. Method for the rapid isolation of nucleic acid
FR2722294B1 (fr) 1994-07-07 1996-10-04 Lyon Ecole Centrale Procede d'analyse qualitative et/ou quantitative de substances biologiques presentes dans un milieu liquide conducteur et capteurs biochimiques d'affinite utilises pour la mise en oeuvre de ce procede
US5800600A (en) 1994-07-14 1998-09-01 Tonejet Corporation Pty Ltd Solid ink jet ink
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
CA2156226C (en) 1994-08-25 1999-02-23 Takayuki Taguchi Biological fluid analyzing device and method
US5627041A (en) 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
JP3652424B2 (ja) 1994-10-27 2005-05-25 日本政策投資銀行 自動分析装置及びその方法
JP3403839B2 (ja) 1994-10-27 2003-05-06 プレシジョン・システム・サイエンス株式会社 カートリッジ容器
US5721136A (en) 1994-11-09 1998-02-24 Mj Research, Inc. Sealing device for thermal cycling vessels
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5846396A (en) 1994-11-10 1998-12-08 Sarnoff Corporation Liquid distribution system
US5654141A (en) 1994-11-18 1997-08-05 Thomas Jefferson University Amplification based detection of bacterial infection
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
US5731212A (en) 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
US5846493A (en) 1995-02-14 1998-12-08 Promega Corporation System for analyzing a substance from a solution following filtering of the substance from the solution
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
US5683659A (en) 1995-02-22 1997-11-04 Hovatter; Kenneth R. Integral assembly of microcentrifuge strip tubes and strip caps
US5579928A (en) 1995-03-06 1996-12-03 Anukwuem; Chidi I. Test tube holder with lock down clamp
US6967088B1 (en) 1995-03-16 2005-11-22 Allergan, Inc. Soluble recombinant botulinum toxin proteins
US5578270A (en) 1995-03-24 1996-11-26 Becton Dickinson And Company System for nucleic acid based diagnostic assay
US5674394A (en) 1995-03-24 1997-10-07 Johnson & Johnson Medical, Inc. Single use system for preparation of autologous plasma
DE19512368A1 (de) 1995-04-01 1996-10-02 Boehringer Mannheim Gmbh System zur Freisetzung und Isolierung von Nukleinsäuren
US5700429A (en) 1995-04-19 1997-12-23 Roche Diagnostic Systems, Inc. Vessel holder for automated analyzer
USD382346S (en) 1995-04-19 1997-08-12 Roche Diagnostic Systems, Inc. Vessel holder
US5578818A (en) 1995-05-10 1996-11-26 Molecular Dynamics LED point scanning system
US5771902A (en) 1995-09-25 1998-06-30 Regents Of The University Of California Micromachined actuators/sensors for intratubular positioning/steering
DE19519015C1 (de) 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
WO1996039547A2 (en) 1995-06-01 1996-12-12 The Regents Of The University Of California Multiple source deposition of shape-memory alloy thin films
ATE224774T1 (de) 1995-06-06 2002-10-15 Orchid Biosciences Inc Herstellung elektrischer leitungen durch löcher
CA2222506C (en) 1995-06-06 2007-07-24 Quantic Biomedical Partners Device and method for concentrating plasma
US6228635B1 (en) * 1995-06-07 2001-05-08 Aastrom Bioscience, Inc. Portable cell growth cassette for use in maintaining and growing biological cells
JP3554612B2 (ja) 1995-06-12 2004-08-18 マツダ株式会社 車両用ロールカーテン
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US6524532B1 (en) 1995-06-20 2003-02-25 The Regents Of The University Of California Microfabricated sleeve devices for chemical reactions
US6521181B1 (en) 1995-06-20 2003-02-18 The Regents Of The University Of Calfornia Microfabricated electrochemiluminescence cell for chemical reaction detection
US5968745A (en) 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US6066300A (en) 1995-07-07 2000-05-23 Bayer Corporation Reagent handling system and configurable vial carrier for use therein
US6158269A (en) 1995-07-13 2000-12-12 Bayer Corporation Method and apparatus for aspirating and dispensing sample fluids
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
EP0843176B1 (en) 1995-07-31 2013-06-12 Precision System Science Co., Ltd. Analysis system comprising a container and a liquid sucking/discharging line
JP3923968B2 (ja) 1995-07-31 2007-06-06 プレシジョン・システム・サイエンス株式会社 容器使用方法
JP3927570B2 (ja) 1995-07-31 2007-06-13 プレシジョン・システム・サイエンス株式会社 容器
US5849208A (en) 1995-09-07 1998-12-15 Microfab Technoologies, Inc. Making apparatus for conducting biochemical analyses
KR970706902A (ko) 1995-09-12 1997-12-01 로드릭 리차드 제이 Dna 증폭 및 검정 방법 및 장치(device and method for dna amplification and assay)
US6057149A (en) 1995-09-15 2000-05-02 The University Of Michigan Microscale devices and reactions in microscale devices
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6911183B1 (en) 1995-09-15 2005-06-28 The Regents Of The University Of Michigan Moving microdroplets
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
GB9519346D0 (en) 1995-09-22 1995-11-22 English Glass Company The Limi Dispensing systems
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5628890A (en) 1995-09-27 1997-05-13 Medisense, Inc. Electrochemical sensor
US6132580A (en) 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
DE69513658T2 (de) 1995-09-29 2000-05-31 Stmicroelectronics S.R.L., Agrate Brianza Spannungsregler für nichtflüchtige, elektrisch programmierbare Halbleiterspeicheranordnungen
US5651839A (en) 1995-10-26 1997-07-29 Queen's University At Kingston Process for engineering coherent twin and coincident site lattice grain boundaries in polycrystalline materials
US5705813A (en) 1995-11-01 1998-01-06 Hewlett-Packard Company Integrated planar liquid handling system for maldi-TOF MS
DE19540877C2 (de) 1995-11-02 1998-02-26 Byk Sangtec Diagnostica Modulare Reagenzienkartusche
JP2000512434A (ja) 1995-11-03 2000-09-19 サーノフ コーポレイション 磁 石
US20010055812A1 (en) 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
EP0865606B1 (en) 1995-12-05 2005-03-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US6068751A (en) 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
WO1997022825A1 (en) 1995-12-18 1997-06-26 Neukermans Armand P Microfluidic valve and integrated microfluidic system
USD382647S (en) 1996-01-17 1997-08-19 Biomerieux Vitek, Inc. Biochemical test card
US5883211A (en) 1996-01-19 1999-03-16 Aclara Biosciences, Inc. Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US5631337A (en) 1996-01-19 1997-05-20 Soane Bioscience Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5726944A (en) 1996-02-05 1998-03-10 Motorola, Inc. Voltage regulator for regulating an output voltage from a charge pump and method therefor
US5981735A (en) 1996-02-12 1999-11-09 Cobra Therapeutics Limited Method of plasmid DNA production and purification
AU715627B2 (en) 1996-02-21 2000-02-03 Biomerieux Vitek, Inc. Automatic sample testing machine
US5736102A (en) 1996-02-21 1998-04-07 Biomerieux Vitek, Inc. Test sample positioning system
USD378782S (en) 1996-03-01 1997-04-08 Johnson & Johnson Clinical Diagnostics, Inc. Processor for nucleic acid detection
US5849598A (en) 1996-03-15 1998-12-15 Washington University Method for transferring micro quantities of liquid samples to discrete locations
CA2249235C (en) 1996-03-25 2002-05-07 Diasys Corporation Apparatus and method for handling fluid samples of body materials
US6114122A (en) 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
US5844238A (en) 1996-03-27 1998-12-01 David Sarnoff Research Center, Inc. Infrared imager using room temperature capacitance sensor
US7244622B2 (en) 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US7235406B1 (en) 1996-04-03 2007-06-26 Applera Corporation Nucleic acid analysis device
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5671303A (en) 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
US5948363A (en) 1996-04-22 1999-09-07 Gaillard; Patrick Micro-well strip with print tabs
US6001307A (en) 1996-04-26 1999-12-14 Kyoto Daiichi Kagaku Co., Ltd. Device for analyzing a sample
US6221672B1 (en) 1996-04-30 2001-04-24 Medtronic, Inc. Method for determining platelet inhibitor response
US6054277A (en) 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
JPH09304385A (ja) 1996-05-14 1997-11-28 Shionogi & Co Ltd 磁性粒子分離装置及び物質の分離方法
US6180950B1 (en) 1996-05-14 2001-01-30 Don Olsen Micro heating apparatus for synthetic fibers
WO1997044671A1 (fr) 1996-05-20 1997-11-27 Precision System Science Co., Ltd. Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage
US5726404A (en) 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
US6083762A (en) 1996-05-31 2000-07-04 Packard Instruments Company Microvolume liquid handling system
US5939291A (en) 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
US5914229A (en) 1996-06-14 1999-06-22 Sarnoff Corporation Method for amplifying a polynucleotide
US5912124A (en) 1996-06-14 1999-06-15 Sarnoff Corporation Padlock probe detection
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US5985651A (en) 1996-06-17 1999-11-16 The Board Of Trustees Of The Leland Stanford Junior University Thermocycling apparatus and method
CN1173776C (zh) 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US6547942B1 (en) 1996-06-28 2003-04-15 Caliper Technologies Corp. Electropipettor and compensation means for electrophoretic bias
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5699157A (en) 1996-07-16 1997-12-16 Caliper Technologies Corp. Fourier detection of species migrating in a microchannel
US20020053399A1 (en) 1996-07-30 2002-05-09 Aclara Biosciences, Inc Methods for fabricating enclosed microchannel structures
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6558916B2 (en) 1996-08-02 2003-05-06 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time measurements of patient cellular responses
US5804436A (en) 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
US6280967B1 (en) 1996-08-02 2001-08-28 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time of cellular responses
US5858187A (en) 1996-09-26 1999-01-12 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing electrodynamic focusing on a microchip
US5872623A (en) 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
US6110343A (en) 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
JP2001502319A (ja) 1996-10-15 2001-02-20 藤沢薬品工業株式会社 成長ホルモンの放出を促進するベンズオキセピン誘導体
US6500390B1 (en) 1996-10-17 2002-12-31 David A. Boulton Method for sealing and venting a microplate assembly
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
USD421653S (en) 1996-11-18 2000-03-14 Tekmar Company Housing for a laboratory instrument
US6447727B1 (en) 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
DE19749011A1 (de) 1996-11-19 1998-05-20 Lang Volker Mikroventil
US6465257B1 (en) 1996-11-19 2002-10-15 Caliper Technologies Corp. Microfluidic systems
US6379929B1 (en) 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
USD399959S (en) 1997-01-24 1998-10-20 Abbott Laboratories Housing for a device for measuring the concentration of an analyte in a sample of blood
US5772966A (en) 1997-01-24 1998-06-30 Maracas; George N. Assay dispensing apparatus
USD414271S (en) 1997-02-03 1999-09-21 Eli Lilly And Company Reaction vessel for combining chemicals
US5972694A (en) 1997-02-11 1999-10-26 Mathus; Gregory Multi-well plate
DE19707226A1 (de) 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
US5882496A (en) 1997-02-27 1999-03-16 The Regents Of The University Of California Porous silicon structures with high surface area/specific pore size
US5958349A (en) 1997-02-28 1999-09-28 Cepheid Reaction vessel for heat-exchanging chemical processes
CA2574107C (en) 1997-02-28 2011-08-16 Cepheid Heat exchanging, optically interrogated chemical reaction assembly
US5911737A (en) 1997-02-28 1999-06-15 The Regents Of The University Of California Microfabricated therapeutic actuators
DK0963545T3 (da) 1997-02-28 2011-07-25 Cepheid Kemisk reaktionsaggregat med varmeveksler og optisk inspektion og reaktionsbeholder
US5861563A (en) 1997-03-20 1999-01-19 Bayer Corporation Automatic closed tube sampler
US5964997A (en) 1997-03-21 1999-10-12 Sarnoff Corporation Balanced asymmetric electronic pulse patterns for operating electrode-based pumps
US5747666A (en) 1997-03-26 1998-05-05 Willis; John P. Point-of-care analyzer module
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US5964995A (en) 1997-04-04 1999-10-12 Caliper Technologies Corp. Methods and systems for enhanced fluid transport
US5993750A (en) 1997-04-11 1999-11-30 Eastman Kodak Company Integrated ceramic micro-chemical plant
DE19717085C2 (de) 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
JP4171075B2 (ja) 1997-04-25 2008-10-22 カリパー・ライフ・サイエンシズ・インコーポレーテッド 改良されたチャネル幾何学的形状を組み込む微小流体装置
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US5997708A (en) 1997-04-30 1999-12-07 Hewlett-Packard Company Multilayer integrated assembly having specialized intermediary substrate
ES2182299T3 (es) 1997-05-02 2003-03-01 Gen Probe Inc Dispositivo con receptaculos de reaccion.
WO1998050147A1 (en) 1997-05-09 1998-11-12 The Regents Of The University Of California Peltier-assisted microfabricated reaction chambers for thermal cycling
US5944717A (en) 1997-05-12 1999-08-31 The Regents Of The University Of California Micromachined electrical cauterizer
US5980719A (en) 1997-05-13 1999-11-09 Sarnoff Corporation Electrohydrodynamic receptor
US6106685A (en) 1997-05-13 2000-08-22 Sarnoff Corporation Electrode combinations for pumping fluids
EP0983504A2 (en) 1997-05-23 2000-03-08 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
JP3937107B2 (ja) 1997-05-23 2007-06-27 東拓工業株式会社 環状凹凸波形管用ベルマウス
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US6524790B1 (en) 1997-06-09 2003-02-25 Caliper Technologies Corp. Apparatus and methods for correcting for variable velocity in microfluidic systems
DE69831830T2 (de) 1997-06-09 2006-06-22 F. Hoffmann-La Roche Ag Einweg-Analysevorrichtung
US6190619B1 (en) 1997-06-11 2001-02-20 Argonaut Technologies, Inc. Systems and methods for parallel synthesis of compounds
US5882465A (en) 1997-06-18 1999-03-16 Caliper Technologies Corp. Method of manufacturing microfluidic devices
US5900130A (en) 1997-06-18 1999-05-04 Alcara Biosciences, Inc. Method for sample injection in microchannel device
US6425972B1 (en) 1997-06-18 2002-07-30 Calipher Technologies Corp. Methods of manufacturing microfabricated substrates
US5959291A (en) 1997-06-27 1999-09-28 Caliper Technologies Corporation Method and apparatus for measuring low power signals
JP3191150B2 (ja) 1997-06-30 2001-07-23 株式会社アステックコーポレーション 採血管ラック
US5928161A (en) 1997-07-03 1999-07-27 The Regents Of The University Of California Microbiopsy/precision cutting devices
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5985217A (en) 1997-07-17 1999-11-16 The Regents Of The University Of California Microfabricated instrument for tissue biopsy and analysis
US5932799A (en) 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US5827481A (en) 1997-07-31 1998-10-27 Hewlett-Packard Company Cartridge system for effecting sample acquisition and introduction
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5916522A (en) 1997-08-07 1999-06-29 Careside, Inc. Electrochemical analytical cartridge
US5919711A (en) 1997-08-07 1999-07-06 Careside, Inc. Analytical cartridge
US6156199A (en) 1997-08-11 2000-12-05 Zuk, Jr.; Peter Centrifugal filtration apparatus
AU4437702A (en) 1997-08-13 2002-07-11 Cepheid Microstructures for the manipulation of fluid samples
AU4437602A (en) 1997-08-13 2002-07-11 Cepheid Microstructures for the manipulation of fluid samples
US6368871B1 (en) 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
AU745989B2 (en) 1997-08-13 2002-04-11 Cepheid Microstructures for the manipulation of fluid samples
US5916776A (en) 1997-08-27 1999-06-29 Sarnoff Corporation Amplification method for a polynucleotide
US5989402A (en) 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US5965410A (en) 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
JP2001515204A (ja) 1997-09-02 2001-09-18 カリパー テクノロジーズ コーポレイション 電気流体制御および電気熱制御を有するマイクロ流体システム
US6597450B1 (en) 1997-09-15 2003-07-22 Becton, Dickinson And Company Automated Optical Reader for Nucleic Acid Assays
US6043880A (en) 1997-09-15 2000-03-28 Becton Dickinson And Company Automated optical reader for nucleic acid assays
US6284113B1 (en) 1997-09-19 2001-09-04 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
US20020092767A1 (en) 1997-09-19 2002-07-18 Aclara Biosciences, Inc. Multiple array microfluidic device units
US6902703B2 (en) 1999-05-03 2005-06-07 Ljl Biosystems, Inc. Integrated sample-processing system
US5961925A (en) 1997-09-22 1999-10-05 Bristol-Myers Squibb Company Apparatus for synthesis of multiple organic compounds with pinch valve block
US5993611A (en) 1997-09-24 1999-11-30 Sarnoff Corporation Capacitive denaturation of nucleic acid
US6012902A (en) 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
US6106784A (en) 1997-09-26 2000-08-22 Applied Chemical & Engineering Systems, Inc. Thawing station
DE69839294T2 (de) 1997-09-29 2009-04-09 F. Hoffmann-La Roche Ag Gerät zur Abscheidung magnetischer Teilchen
US5851492A (en) 1997-09-30 1998-12-22 Blattner; Frederick R. Microtiter plate sealing system
AU9673198A (en) 1997-10-02 1999-04-27 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6803019B1 (en) 1997-10-15 2004-10-12 Aclara Biosciences, Inc. Laminate microstructure device and method for making same
US5958694A (en) 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6132684A (en) 1997-10-31 2000-10-17 Becton Dickinson And Company Sample tube holder
ES2209222T3 (es) 1997-11-14 2004-06-16 Gen-Probe Incorporated Estacion de trabajo de ensayos.
US6287831B1 (en) 1997-11-14 2001-09-11 California Institute Of Technology Cell lysis device
US5992820A (en) 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6123205A (en) 1997-11-26 2000-09-26 Bayer Corporation Sample tube rack
USD413677S (en) 1997-11-26 1999-09-07 Bayer Corporation Sample tube rack
US6197503B1 (en) 1997-11-26 2001-03-06 Ut-Battelle, Llc Integrated circuit biochip microsystem containing lens
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
US5922289A (en) 1997-12-05 1999-07-13 Evergreen Industries Inc. Microtitration tray
US6914137B2 (en) 1997-12-06 2005-07-05 Dna Research Innovations Limited Isolation of nucleic acids
CN1230440C (zh) 1997-12-06 2005-12-07 Dna研究创新有限公司 核酸的分离
US6074725A (en) 1997-12-10 2000-06-13 Caliper Technologies Corp. Fabrication of microfluidic circuits by printing techniques
DE19755479A1 (de) 1997-12-13 1999-06-17 Wolfgang Prof Dr Ing Benecke Miniaturisiertes PCR-System zur Genanalyse
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
ES2309022T3 (es) 1997-12-24 2008-12-16 Cepheid Dispositivo y procedimiento para lisis.
US6430512B1 (en) 1997-12-30 2002-08-06 Caliper Technologies Corp. Software for the display of chromatographic separation data
US6167910B1 (en) 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
JP3551293B2 (ja) 1998-02-02 2004-08-04 東洋紡績株式会社 核酸抽出装置
USD413391S (en) 1998-02-05 1999-08-31 Bayer Corporation Test tube sample rack
US6420143B1 (en) 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US6100541A (en) 1998-02-24 2000-08-08 Caliper Technologies Corporation Microfluidic devices and systems incorporating integrated optical elements
US6537432B1 (en) 1998-02-24 2003-03-25 Target Discovery, Inc. Protein separation via multidimensional electrophoresis
US6756019B1 (en) 1998-02-24 2004-06-29 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6861035B2 (en) 1998-02-24 2005-03-01 Aurora Discovery, Inc. Multi-well platforms, caddies, lids and combinations thereof
US6251343B1 (en) 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6369893B1 (en) 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
USD417009S (en) 1998-03-02 1999-11-23 Bayer Corporation Sample tube rack
USD428497S (en) 1998-03-06 2000-07-18 Bayer Corporation Test tube sample rack
AU764319B2 (en) 1998-03-17 2003-08-14 Cepheid Chemical processing device
US6979424B2 (en) 1998-03-17 2005-12-27 Cepheid Integrated sample analysis device
ATE250455T1 (de) 1998-03-17 2003-10-15 Cepheid Vorrichtung zum analysieren einer probe
AU1357102A (en) 1998-03-23 2002-03-14 Cepheid Multi-site reactor system with dynamic independent control of indvidual reaction sites
US7188001B2 (en) 1998-03-23 2007-03-06 Cepheid System and method for temperature control
JPH11295323A (ja) 1998-04-13 1999-10-29 Matsushita Electric Ind Co Ltd 自動分注装置および分注方法
US6024920A (en) 1998-04-21 2000-02-15 Bio-Rad Laboratories, Inc. Microplate scanning read head
US7078224B1 (en) 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
EP1925367A1 (en) 1998-05-01 2008-05-28 Gen-Probe Incorporated System for agitating the contents of a container
JPH11316226A (ja) 1998-05-06 1999-11-16 Olympus Optical Co Ltd 自動測定用カートリッジ及び自動測定法
US6123798A (en) 1998-05-06 2000-09-26 Caliper Technologies Corp. Methods of fabricating polymeric structures incorporating microscale fluidic elements
AU759974B2 (en) 1998-05-16 2003-05-01 Applied Biosystems, Llc Instrument for monitoring polymerase chain reaction of DNA
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
WO1999060397A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
EP0964555A1 (de) 1998-06-04 1999-12-15 Siemens Aktiengesellschaft Pegelregelung und adaptive Filterung in CAP-Empfängern
US6306590B1 (en) 1998-06-08 2001-10-23 Caliper Technologies Corp. Microfluidic matrix localization apparatus and methods
US6274089B1 (en) 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6149882A (en) 1998-06-09 2000-11-21 Symyx Technologies, Inc. Parallel fixed bed reactor and fluid contacting apparatus
USD421130S (en) 1998-06-15 2000-02-22 Bayer Corporation Sample tube rack
US7799521B2 (en) 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6787111B2 (en) 1998-07-02 2004-09-07 Amersham Biosciences (Sv) Corp. Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis
USD420747S (en) 1998-07-10 2000-02-15 Bayer Corporation Sample tube rack
DE19833087A1 (de) 1998-07-23 2000-01-27 Bosch Gmbh Robert Gassensor und Verfahren zu dessen Herstellung
DE19833293C1 (de) 1998-07-24 2000-01-20 Gunther Botsch Trennvorrichtung
US6366924B1 (en) 1998-07-27 2002-04-02 Caliper Technologies Corp. Distributed database for analytical instruments
ATE303598T1 (de) 1998-07-31 2005-09-15 Tecan Trading Ag Magnetseparator
US6540896B1 (en) 1998-08-05 2003-04-01 Caliper Technologies Corp. Open-Field serial to parallel converter
US6236456B1 (en) 1998-08-18 2001-05-22 Molecular Devices Corporation Optical system for a scanning fluorometer
US6316774B1 (en) 1998-08-18 2001-11-13 Molecular Devices Corporation Optical system for a scanning fluorometer
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
USD439673S1 (en) 1998-10-06 2001-03-27 Sorenson Bioscience Multi-well microcentrifuge tube
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US6958392B2 (en) 1998-10-09 2005-10-25 Whatman, Inc. Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products
EP1125129A1 (en) 1998-10-13 2001-08-22 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6498497B1 (en) 1998-10-14 2002-12-24 Caliper Technologies Corp. Microfluidic controller and detector system with self-calibration
US6948843B2 (en) 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US6086740A (en) 1998-10-29 2000-07-11 Caliper Technologies Corp. Multiplexed microfluidic devices and systems
US5973138A (en) 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
WO2000034521A1 (en) 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
JP2000180455A (ja) 1998-12-15 2000-06-30 Sanuki Kogyo Kk フローインジェクション自動分析装置
US6062261A (en) 1998-12-16 2000-05-16 Lockheed Martin Energy Research Corporation MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs
US6887693B2 (en) 1998-12-24 2005-05-03 Cepheid Device and method for lysing cells, spores, or microorganisms
US7914994B2 (en) 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6635470B1 (en) 1999-01-08 2003-10-21 Applera Corporation Fiber array and methods for using and making same
US6150119A (en) 1999-01-19 2000-11-21 Caliper Technologies Corp. Optimized high-throughput analytical system
IT1306964B1 (it) 1999-01-19 2001-10-11 St Microelectronics Srl Circuito a boosting capacitivo per la regolazione della tensione dilettura di riga in memorie non-volatili
US6416642B1 (en) 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US20020019059A1 (en) 1999-01-28 2002-02-14 Calvin Y.H. Chow Devices, systems and methods for time domain multiplexing of reagents
MXPA01007804A (es) 1999-02-02 2003-06-09 Caliper Techn Corp Metodos, dispositivos y sistemas para caracterizar proteinas.
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
AU3372800A (en) 1999-02-23 2000-09-14 Caliper Technologies Corporation Manipulation of microparticles in microfluidic systems
US6143547A (en) 1999-03-02 2000-11-07 Academia Sinica Cell line derived from Penaeus monodon and a method of growing virus using the same
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
US6558945B1 (en) 1999-03-08 2003-05-06 Aclara Biosciences, Inc. Method and device for rapid color detection
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6326083B1 (en) 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
US6148508A (en) 1999-03-12 2000-11-21 Caliper Technologies Corp. Method of making a capillary for electrokinetic transport of materials
JP2000266760A (ja) 1999-03-17 2000-09-29 Hitachi Ltd 分注装置
EP1041386B1 (en) 1999-03-25 2007-10-17 Tosoh Corporation Analyzer
JP3988306B2 (ja) 1999-03-25 2007-10-10 東ソー株式会社 自動測定装置
US6500323B1 (en) 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
US6194563B1 (en) 1999-03-26 2001-02-27 Vysis, Inc. Solid phase nucleic acid labeling by transamination
US6783962B1 (en) 1999-03-26 2004-08-31 Upfront Chromatography Particulate material for purification of bio-macromolecules
US6303343B1 (en) 1999-04-06 2001-10-16 Caliper Technologies Corp. Inefficient fast PCR
US6306273B1 (en) 1999-04-13 2001-10-23 Aclara Biosciences, Inc. Methods and compositions for conducting processes in microfluidic devices
US6322683B1 (en) 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6605475B1 (en) 1999-04-16 2003-08-12 Perspective Biosystems, Inc. Apparatus and method for sample delivery
US20040053290A1 (en) 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
CA2270106C (en) 1999-04-23 2006-03-14 Yousef Haj-Ahmad Nucleic acid purification and process
US6773676B2 (en) 1999-04-27 2004-08-10 Agilent Technologies, Inc. Devices for performing array hybridization assays and methods of using the same
AU769571B2 (en) 1999-04-28 2004-01-29 Universitat Zurich Polyionic coatings in analytic and sensor devices
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
EP1206571B1 (en) 1999-05-04 2004-09-29 Ortho-Clinical Diagnostics, Inc. Rapid and efficient capture of dna from sample without using cell lysing reagent
US6458259B1 (en) 1999-05-11 2002-10-01 Caliper Technologies Corp. Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow
US6555389B1 (en) 1999-05-11 2003-04-29 Aclara Biosciences, Inc. Sample evaporative control
US6838680B2 (en) 1999-05-12 2005-01-04 Aclara Biosciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US6399952B1 (en) 1999-05-12 2002-06-04 Aclara Biosciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US6326147B1 (en) 1999-05-13 2001-12-04 The Perkin-Elmer Corporation Methods, apparatus, articles of manufacture, and user interfaces for performing automated biological assay preparation and macromolecule purification
US6310199B1 (en) 1999-05-14 2001-10-30 Promega Corporation pH dependent ion exchange matrix and method of use in the isolation of nucleic acids
EP1179087B1 (en) 1999-05-17 2019-03-27 Caliper Life Sciences, Inc. Focusing of microparticles in microfluidic systems
US6592821B1 (en) 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
US6472141B2 (en) 1999-05-21 2002-10-29 Caliper Technologies Corp. Kinase assays using polycations
US6287774B1 (en) 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
ATE401125T1 (de) 1999-05-28 2008-08-15 Bio Data Corp Verfahren und vorrichtung zur direkten probenahme eines fluids für die mikrofiltration
EP1181098B2 (en) 1999-05-28 2011-07-06 Cepheid Cartridge for conducting a chemical reaction
US20040200909A1 (en) 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
JP4022069B2 (ja) 1999-05-28 2007-12-12 シーフィード 細胞破壊装置および方法
AU5291600A (en) 1999-06-01 2000-12-18 Caliper Technologies Corporation Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
DE29909529U1 (de) 1999-06-01 1999-08-12 Festo AG & Co, 73734 Esslingen Fluidtechnisches Steuergerät
AU771547B2 (en) 1999-06-01 2004-03-25 Regents Of The University Of California, The Method of sterilizing
GB9913275D0 (en) 1999-06-08 1999-08-04 Dna Research Instr Limited Sample processing device
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
FR2795426A1 (fr) 1999-06-22 2000-12-29 Commissariat Energie Atomique Support d'analyse biologique a amplification
ATE395136T1 (de) 1999-06-22 2008-05-15 Tecan Trading Ag Vorrichtungen zur durchfuehrung von miniaturisierten in vitro amplifizierungsassays
ATE215673T1 (de) 1999-06-28 2002-04-15 California Inst Of Techn Elastomerische mikropumpen- und mikroventilsysteme
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
GB9915034D0 (en) 1999-06-29 1999-08-25 Cambridge Imaging Ltd Improved assay analysis
AU6068300A (en) 1999-07-06 2001-01-22 Caliper Technologies Corporation Microfluidic systems and methods for determining modulator kinetics
US6353475B1 (en) 1999-07-12 2002-03-05 Caliper Technologies Corp. Light source power modulation for use with chemical and biochemical analysis
ATE411110T1 (de) 1999-07-19 2008-10-15 Biomerieux Bv Verfahren zum mengen von magnetteilchen mit einer flüssigkeit
USD438311S1 (en) 1999-07-28 2001-02-27 Matsushita Electric Industrial Co.,Ltd. Strip for blood test
US6337435B1 (en) * 1999-07-30 2002-01-08 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
US6242188B1 (en) 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection
US6818060B2 (en) 1999-08-02 2004-11-16 Emerald Biostructures, Inc. Robot for mixing crystallization trial matrices
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
EP1077086B1 (en) 1999-08-18 2004-10-27 Becton Dickinson and Company Stopper-shield assembly
US6495104B1 (en) 1999-08-19 2002-12-17 Caliper Technologies Corp. Indicator components for microfluidic systems
WO2001014931A1 (fr) 1999-08-23 2001-03-01 Mitsubishi Chemical Corporation Composition photopolymerisable et plaque lithographique photopolymerisable
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
US6613581B1 (en) 1999-08-26 2003-09-02 Caliper Technologies Corp. Microfluidic analytic detection assays, devices, and integrated systems
US6613211B1 (en) 1999-08-27 2003-09-02 Aclara Biosciences, Inc. Capillary electrokinesis based cellular assays
US6824663B1 (en) 1999-08-27 2004-11-30 Aclara Biosciences, Inc. Efficient compound distribution in microfluidic devices
US6633785B1 (en) 1999-08-31 2003-10-14 Kabushiki Kaisha Toshiba Thermal cycler and DNA amplifier method
US6752966B1 (en) 1999-09-10 2004-06-22 Caliper Life Sciences, Inc. Microfabrication methods and devices
USD466219S1 (en) 1999-09-13 2002-11-26 Micronic B.V. Carrier for test-tubes
US6906797B1 (en) 1999-09-13 2005-06-14 Aclara Biosciences, Inc. Side light activated microfluid channels
DE19945604A1 (de) 1999-09-23 2003-08-07 Aclara Biosciences Inc Verfahren zur Verbindung von Werkstücken aus Kunststoff und seine Verwendung in der Mikro- und Nanostrukturtechnik
US6221600B1 (en) 1999-10-08 2001-04-24 Board Of Regents, The University Of Texas System Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
DE19948473A1 (de) 1999-10-08 2001-04-12 Nmi Univ Tuebingen Verfahren und Vorrichtung zum Messen an in einer flüssigen Umgebung befindlichen Zellen
AU783191B2 (en) 1999-10-08 2005-10-06 Caliper Life Sciences, Inc. Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US6287254B1 (en) 1999-11-02 2001-09-11 W. Jean Dodds Animal health diagnosis
US6232072B1 (en) 1999-10-15 2001-05-15 Agilent Technologies, Inc. Biopolymer array inspection
US6908594B1 (en) 1999-10-22 2005-06-21 Aclara Biosciences, Inc. Efficient microfluidic sealing
USD461906S1 (en) 1999-10-25 2002-08-20 Tuan Hung Pham Diagnostic test card
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
US6300124B1 (en) 1999-11-02 2001-10-09 Regents Of The University Of Minnesota Device and method to directly control the temperature of microscope slides
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
EP1237655A2 (en) 1999-12-09 2002-09-11 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
USD438632S1 (en) 1999-12-21 2001-03-06 Compucyte Corporation Multi-well reagent cartridge for treating a sample
USD438633S1 (en) 1999-12-21 2001-03-06 Compucyte Corporation Reagent cartridge for treating a sample
JP2003517842A (ja) 1999-12-21 2003-06-03 オーソ−クリニカル・ダイアグノスティックス・インコーポレイテッド 核酸の検出方法
US6936414B2 (en) 1999-12-22 2005-08-30 Abbott Laboratories Nucleic acid isolation method and kit
DE19963032A1 (de) 1999-12-24 2001-06-28 Roche Diagnostics Gmbh System zur Bearbeitung von Proben in einer Mehrkammeranordnung
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
WO2001049414A2 (en) 2000-01-06 2001-07-12 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
DE60038127T2 (de) 2000-01-06 2009-03-05 Caliper Life Sciences, Inc., Mountain View Methoden und syteme zur überwachung intrazellulärer bindereaktionen
US6468761B2 (en) 2000-01-07 2002-10-22 Caliper Technologies, Corp. Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
EP1246699B1 (en) 2000-01-11 2007-01-03 Clinical Micro Sensors, Inc. Cartridge comprising a biochip
AU2001232805A1 (en) 2000-01-12 2001-07-24 Ut-Battelle, Llc A microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US7037416B2 (en) 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
JP3397737B2 (ja) 2000-01-24 2003-04-21 倉敷紡績株式会社 核酸の抽出方法
US6556923B2 (en) 2000-01-26 2003-04-29 Caliper Technologies Corp. Software for high throughput microfluidic systems
US6589729B2 (en) 2000-02-04 2003-07-08 Caliper Technologies Corp. Methods, devices, and systems for monitoring time dependent reactions
CA2399398A1 (en) 2000-02-11 2001-08-16 Aclara Biosciences, Inc. Microfluid device with sample injector and method of use
US6685813B2 (en) 2000-02-11 2004-02-03 Aclara Biosciences, Inc. Tandem isotachophoresis/zone electrophoresis method and system
WO2001061054A2 (en) 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
JP3750460B2 (ja) 2000-02-18 2006-03-01 日立工機株式会社 分注装置及び分注方法
US6681616B2 (en) 2000-02-23 2004-01-27 Caliper Technologies Corp. Microfluidic viscometer
US7040144B2 (en) 2000-02-23 2006-05-09 Caliper Life Sciences, Inc. Microfluidic viscometer
ATE382858T1 (de) 2000-02-23 2008-01-15 Caliper Life Sciences Inc Mehrfach-reservoir-drucksteuersystem
US20020072060A1 (en) 2000-07-19 2002-06-13 Getts Robert C. Methods for detecting and assaying nucleic acid sequences
US6352673B1 (en) 2000-03-09 2002-03-05 Rainin Instrument Ergonomic return springless manual air displacement pipette
AU2001249253A1 (en) 2000-03-17 2001-10-03 Aclara Biosciences, Inc. Microfluidic device and system with improved sample handling
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
US6927851B2 (en) 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US6401552B1 (en) 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples
US6733645B1 (en) 2000-04-18 2004-05-11 Caliper Technologies Corp. Total analyte quantitation
USD446306S1 (en) 2000-04-26 2001-08-07 Matsushita Electric Industrial Co., Ltd. Medical information communication apparatus
US7160735B2 (en) 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US6787016B2 (en) 2000-05-01 2004-09-07 Aclara Biosciences, Inc. Dynamic coating with linear polymer mixture for electrophoresis
AU2001259355B2 (en) 2000-05-03 2005-09-01 Caliper Life Sciences, Inc. Multi depth substrate fabrication processes
US7578976B1 (en) 2000-05-10 2009-08-25 Lawrence Livermore National Security, Llc Sleeve reaction chamber system
AU6154101A (en) 2000-05-11 2001-11-20 Caliper Techn Corp Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
ATE409238T1 (de) 2000-05-12 2008-10-15 Caliper Life Sciences Inc Nachweis der hybridisierung von nukleinsäuren durch fluoreszenzpolarisation
ES2319101T3 (es) 2000-05-19 2009-05-04 Becton Dickinson And Company Sistema y procedimiento de manipulacion de particulas magneticamente sensibles en muestras de fluido para extraer el adn o el arn de una muestra.
DE60134849D1 (de) 2000-05-19 2008-08-28 Aclara Biosciences Inc Ausrichtung eines optischen detektionssystems mit einem kapillarkanal in einem mikrofluiden laborchip
US6672458B2 (en) 2000-05-19 2004-01-06 Becton, Dickinson And Company System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample
EP1286761A2 (en) 2000-05-24 2003-03-05 Cellular Process Chemistry Inc. Modular chemical production system incorporating a microreactor
WO2001092569A2 (en) 2000-05-31 2001-12-06 Tepnel Medical Limited Formulation for polymerase chain reaction and vessel containing same
US6520197B2 (en) 2000-06-02 2003-02-18 The Regents Of The University Of California Continuous laminar fluid mixing in micro-electromechanical systems
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6790330B2 (en) 2000-06-14 2004-09-14 Board Of Regents, The University Of Texas System Systems and methods for cell subpopulation analysis
WO2001097974A1 (en) 2000-06-19 2001-12-27 Caliper Technologies Corp. Methods and devices for enhancing bonded substrate yields and regulating temperature
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US7169618B2 (en) 2000-06-28 2007-01-30 Skold Technology Magnetic particles and methods of producing coated magnetic particles
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
FR2812088B1 (fr) 2000-07-21 2003-01-24 Abx Sa Dispositif de traitement d'echantillons de produits sanguins
EP1305615B1 (en) 2000-07-21 2004-09-29 Aclara BioSciences, Inc. Method and devices for capillary electrophoresis with a norbornene based surface coating
US7004184B2 (en) 2000-07-24 2006-02-28 The Reagents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
US7255833B2 (en) 2000-07-25 2007-08-14 Cepheid Apparatus and reaction vessel for controlling the temperature of a sample
US7169277B2 (en) 2000-08-02 2007-01-30 Caliper Life Sciences, Inc. High throughput separations based analysis systems
US20020142618A1 (en) 2000-08-04 2002-10-03 Caliper Technologies Corp. Control of operation conditions within fluidic systems
AU2001276498A1 (en) * 2000-08-04 2002-02-18 Molecular Sensing Plc Apparatus for diagnostic assays
FR2813207B1 (fr) 2000-08-28 2002-10-11 Bio Merieux Carte reactionnelle et utilisation d'une telle carte
JP3993372B2 (ja) 2000-09-13 2007-10-17 独立行政法人理化学研究所 リアクタの製造方法
DE60140553D1 (de) 2000-09-14 2009-12-31 Caliper Life Sciences Inc MIKROFLUIDISCHE VORRICHTUNGEN UND METHODEN UM TEMPERATUR-VERMITTELTE REAKTIONEN DURCHZUFüHREN
EP2299256A3 (en) 2000-09-15 2012-10-10 California Institute Of Technology Microfabricated crossflow devices and methods
US6939451B2 (en) 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
US7727479B2 (en) 2000-09-29 2010-06-01 Applied Biosystems, Llc Device for the carrying out of chemical or biological reactions
US7615340B2 (en) 2000-10-03 2009-11-10 Minerva Biotechnologies Corporation Electronic detection of interaction and detection of interaction based on the interruption of flow
WO2002028531A1 (en) 2000-10-06 2002-04-11 Protasis Corporation Fluid separation conduit cartridge with encryption capability
US6623860B2 (en) 2000-10-10 2003-09-23 Aclara Biosciences, Inc. Multilevel flow structures
USD463031S1 (en) 2000-10-11 2002-09-17 Aclara Biosciences, Inc. Microvolume sample plate
HK1052770A1 (zh) 2000-10-13 2003-09-26 Irm, Llc 高产率的加工系统及其使用方法
US6375185B1 (en) 2000-10-20 2002-04-23 Gamemax Corporation Paper currency receiving control assembly for currency-coin exchange machine
WO2002037091A1 (en) 2000-10-31 2002-05-10 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US7514046B2 (en) 2000-10-31 2009-04-07 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
CA2427669A1 (en) 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US7105304B1 (en) 2000-11-07 2006-09-12 Caliper Life Sciences, Inc. Pressure-based mobility shift assays
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
US20050202470A1 (en) 2000-11-16 2005-09-15 Caliper Life Sciences, Inc. Binding assays using molecular melt curves
US6951632B2 (en) 2000-11-16 2005-10-04 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
CH695544A5 (de) 2000-11-17 2006-06-30 Tecan Trading Ag Vorrichtung zur Abgabe bzw. Aufnahme/Abgabe von Flüssigkeitsproben.
USD468437S1 (en) 2000-11-21 2003-01-07 Acon Laboratories, Inc. Test platform
US6521188B1 (en) 2000-11-22 2003-02-18 Industrial Technology Research Institute Microfluidic actuator
SE0004296D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US20040043479A1 (en) 2000-12-11 2004-03-04 Briscoe Cynthia G. Multilayerd microfluidic devices for analyte reactions
US7024281B1 (en) 2000-12-11 2006-04-04 Callper Life Sciences, Inc. Software for the controlled sampling of arrayed materials
US6382254B1 (en) 2000-12-12 2002-05-07 Eastman Kodak Company Microfluidic valve and method for controlling the flow of a liquid
DE60142410D1 (de) 2000-12-27 2010-07-29 Dynavax Tech Corp Immunomodulatorische polynukleotide und verfahren zur deren verwendung
US6453928B1 (en) 2001-01-08 2002-09-24 Nanolab Ltd. Apparatus, and method for propelling fluids
WO2005030984A2 (en) 2003-09-26 2005-04-07 Datascope Investment Corp. Method for small volume nucleic acid synthesis
JP4505776B2 (ja) 2001-01-19 2010-07-21 凸版印刷株式会社 遺伝子検出システム、これを備えた遺伝子検出装置、検出方法、並びに遺伝子検出用チップ
JP3548858B2 (ja) 2001-01-22 2004-07-28 独立行政法人産業技術総合研究所 流量の制御方法及びそれに用いるマイクロバルブ
US6878755B2 (en) 2001-01-22 2005-04-12 Microgen Systems, Inc. Automated microfabrication-based biodetector
US6681788B2 (en) 2001-01-29 2004-01-27 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7670559B2 (en) 2001-02-15 2010-03-02 Caliper Life Sciences, Inc. Microfluidic systems with enhanced detection systems
US6509186B1 (en) * 2001-02-16 2003-01-21 Institute Of Microelectronics Miniaturized thermal cycler
US6432695B1 (en) 2001-02-16 2002-08-13 Institute Of Microelectronics Miniaturized thermal cycler
US6720148B1 (en) 2001-02-22 2004-04-13 Caliper Life Sciences, Inc. Methods and systems for identifying nucleotides by primer extension
US7867776B2 (en) 2001-03-02 2011-01-11 Caliper Life Sciences, Inc. Priming module for microfluidic chips
US7150999B1 (en) 2001-03-09 2006-12-19 Califer Life Sciences, Inc. Process for filling microfluidic channels
US7223363B2 (en) 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US6576459B2 (en) 2001-03-23 2003-06-10 The Regents Of The University Of California Sample preparation and detection device for infectious agents
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US20140227710A1 (en) 2001-03-28 2014-08-14 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
JP2002355038A (ja) 2001-03-29 2002-12-10 Japan Science & Technology Corp 遺伝子解析方法およびその解析装置
US20020143297A1 (en) 2001-03-30 2002-10-03 Becton, Dickinson And Company Adaptor for use with point-of-care testing cartridge
US6960437B2 (en) * 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
USD470595S1 (en) 2001-04-10 2003-02-18 Andrea Crisanti Assay device
USD500142S1 (en) 2001-04-10 2004-12-21 Andrea Crisanti Assay device
US7440684B2 (en) 2001-04-12 2008-10-21 Spaid Michael A Method and apparatus for improved temperature control in microfluidic devices
US6588625B2 (en) 2001-04-24 2003-07-08 Abbott Laboratories Sample handling system
US20020155010A1 (en) 2001-04-24 2002-10-24 Karp Christoph D. Microfluidic valve with partially restrained element
EP3231445A1 (en) 2001-05-18 2017-10-18 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
USD495805S1 (en) 2001-05-25 2004-09-07 Umedik, Inc. Assay device
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US20020187557A1 (en) 2001-06-07 2002-12-12 Hobbs Steven E. Systems and methods for introducing samples into microfluidic devices
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US6977163B1 (en) 2001-06-13 2005-12-20 Caliper Life Sciences, Inc. Methods and systems for performing multiple reactions by interfacial mixing
DE10128894A1 (de) 2001-06-15 2002-12-19 Basf Ag Verfahren zur schmutzablösungsfördernden Behandlung von Oberflächen textiler und nicht-textiler Materialien
US6859698B2 (en) 2001-06-21 2005-02-22 Snap-On Incorporated Detachable cartridge unit and auxiliary unit for function expansion of a data processing system
US20030211517A1 (en) 2001-06-22 2003-11-13 Carulli John P. Gp354 nucleic acids and polypeptides
US6709857B2 (en) 2001-06-26 2004-03-23 Becton, Dickinson And Company System and method for optically monitoring the concentration of a gas in a sample vial using photothermal spectroscopy to detect sample growth
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
US20030073110A1 (en) 2001-07-03 2003-04-17 Masaharu Aritomi Method for isolating nucleic acid and a cartridge for chemical reaction and for nucleic acid isolation
US6762049B2 (en) 2001-07-05 2004-07-13 Institute Of Microelectronics Miniaturized multi-chamber thermal cycler for independent thermal multiplexing
WO2003006964A1 (en) 2001-07-12 2003-01-23 Aclara Biosciences, Inc. Submersible light-directing member for material excitation in microfluidic devices
ATE522776T1 (de) * 2001-07-16 2011-09-15 Idaho Technology Inc Temperaturwechselsystem und verwendungsverfahren
US7023007B2 (en) 2001-07-17 2006-04-04 Caliper Life Sciences, Inc. Methods and systems for alignment of detection optics
US7270959B2 (en) 2001-07-25 2007-09-18 Oakville Hong Kong Company Limited Specimen collection container
SG169225A1 (en) * 2001-07-25 2011-03-30 Univ Princeton Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US6766817B2 (en) 2001-07-25 2004-07-27 Tubarc Technologies, Llc Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
JP4596776B2 (ja) * 2001-07-26 2010-12-15 ハンディラブ・インコーポレーテッド 微細流体処理方法及びシステム
AU2002367840A1 (en) 2001-07-26 2003-11-17 Motorola, Inc. System and methods for mixing within a microfluidic device
US20060062696A1 (en) 2001-07-27 2006-03-23 Caliper Life Sciences, Inc. Optimized high throughput analytical systems
US7060171B1 (en) 2001-07-31 2006-06-13 Caliper Life Sciences, Inc. Methods and systems for reducing background signal in assays
JP2003047839A (ja) 2001-08-06 2003-02-18 Yamatake Corp マイクロリアクタ
JP2003047840A (ja) 2001-08-06 2003-02-18 Yamatake Corp マイクロリアクタ
US6640981B2 (en) 2001-08-14 2003-11-04 3088081 Canada Inc. Modular test tube rack
USD482796S1 (en) 2001-09-11 2003-11-25 Sysmex Corporation Sample analyzer
USD512155S1 (en) 2001-09-12 2005-11-29 Techno Medica Co., Ltd. Automatic blood sampling tube preparation apparatus
JP3996416B2 (ja) 2001-09-21 2007-10-24 Ｊｕｋｉ株式会社 核酸ハイブリダイゼーションにおけるｂ／ｆ分離方法
US20030059823A1 (en) 2001-09-21 2003-03-27 Juki Corporation Hybridization apparatus and method for detecting nucleic acid in sample using the same
USD467349S1 (en) 2001-09-28 2002-12-17 Orasure Technologies, Inc. Analyzer
USD467348S1 (en) 2001-10-15 2002-12-17 Kimberly-Clark Worldwide, Inc. Diagnostic test carrier
AU2002364937A1 (en) * 2001-10-18 2003-06-17 The Board Of Trustees Of The University Of Illinois Hybrid microfluidic and nanofluidic system
US20030089605A1 (en) * 2001-10-19 2003-05-15 West Virginia University Research Corporation Microfluidic system for proteome analysis
US20030156991A1 (en) 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US7584240B2 (en) 2001-11-07 2009-09-01 Genvault Corporation Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients
US6750661B2 (en) 2001-11-13 2004-06-15 Caliper Life Sciences, Inc. Method and apparatus for controllably effecting samples using two signals
US7247274B1 (en) 2001-11-13 2007-07-24 Caliper Technologies Corp. Prevention of precipitate blockage in microfluidic channels
US7069952B1 (en) 2001-11-14 2006-07-04 Caliper Life Sciences, Inc. Microfluidic devices and methods of their manufacture
DE10156790A1 (de) 2001-11-19 2003-06-18 Chemagen Biopolymer Technologi Vorrichtung und Verfahren zum Behandeln von Magnetpartikeln
US20030099954A1 (en) * 2001-11-26 2003-05-29 Stefan Miltenyi Apparatus and method for modification of magnetically immobilized biomolecules
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US6960235B2 (en) 2001-12-05 2005-11-01 The Regents Of The University Of California Chemical microreactor and method thereof
JP2003185584A (ja) 2001-12-18 2003-07-03 Fuji Photo Film Co Ltd スキャナ
JP2003180350A (ja) * 2001-12-21 2003-07-02 Terumo Corp 温度制御装置
DE10163476A1 (de) 2001-12-21 2003-10-30 Siemens Ag Anordnung zur Trennung einer Komponente aus einem Fluid
US20030127327A1 (en) 2002-01-04 2003-07-10 Kurnik Ronald T. Microfluidic device and method for improved sample handling
US7410615B2 (en) 2002-01-24 2008-08-12 Perkinelmer Las, Inc. Precision liquid dispensing system
US7205154B2 (en) 2002-01-31 2007-04-17 Agilent Technologies, Inc. Calibrating array scanners
US7288228B2 (en) 2002-02-12 2007-10-30 Gilson, Inc. Sample injection system
US6819027B2 (en) 2002-03-04 2004-11-16 Cepheid Method and apparatus for controlling ultrasonic transducer
CA2477702A1 (en) 2002-03-05 2003-09-18 Caliper Life Sciences, Inc. Mixed mode microfluidic systems abstract of the disclosure
US7101467B2 (en) 2002-03-05 2006-09-05 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
US7195986B1 (en) 2002-03-08 2007-03-27 Caliper Life Sciences, Inc. Microfluidic device with controlled substrate conductivity
KR100450818B1 (ko) 2002-03-09 2004-10-01 삼성전자주식회사 다챔버 ｐｃｒ 칩
US7252928B1 (en) 2002-03-12 2007-08-07 Caliper Life Sciences, Inc. Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
US7223371B2 (en) 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
CA2422224A1 (en) 2002-03-15 2003-09-15 Affymetrix, Inc. System, method, and product for scanning of biological materials
DE10212761B4 (de) 2002-03-22 2009-12-31 Eppendorf Ag Mikrotiterplatte
AU2003218806A1 (en) 2002-03-27 2003-10-08 Jae-Chern Yoo Bio-disc, bio-driver apparatus, and assay method using the same
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
EP1490685A4 (en) 2002-04-02 2009-02-11 Caliper Life Sciences Inc METHODS, SYSTEMS AND DEVICES FOR SEPARATING AND INSULATING ONE OR MORE SPECIMEN COMPONENTS OF A BIOLOGICAL SAMPLING MATERIAL
USD472324S1 (en) 2002-04-05 2003-03-25 Charles River Laboratories, Inc. Cuvette
JP2003299485A (ja) 2002-04-10 2003-10-21 Sekisui Chem Co Ltd 温度制御型マイクロリアクター及びマイクロリアクターシステム
JP2005532043A (ja) 2002-04-11 2005-10-27 シークエノム， インコーポレイテッド 固相支持体上で化学反応を実行するための方法および装置
US8241883B2 (en) 2002-04-24 2012-08-14 Caliper Life Sciences, Inc. High throughput mobility shift
CA2483445C (en) 2002-04-26 2011-04-19 Abbott Laboratories Structure and method for handling magnetic particles in biological assays
US6905612B2 (en) 2003-03-21 2005-06-14 Hanuman Llc Plasma concentrate apparatus and method
JP3972189B2 (ja) 2002-05-10 2007-09-05 日本パルスモーター株式会社 着脱自在なカートリッジラック構造を備える分注装置
USD474279S1 (en) 2002-05-15 2003-05-06 Monogen, Inc. Specimen processing instrument
JP3839349B2 (ja) 2002-05-15 2006-11-01 株式会社堀場製作所 化学発光酵素免疫測定装置
DE60307825T2 (de) 2002-05-17 2007-03-01 Gen-Probe Inc., San Diego Probenträger mit feststelleinrichtung und zugehörige tropfschirmvorrichtung
DE60316938T2 (de) 2002-05-17 2008-07-17 Gen-Probe Inc., San Diego Probenträger mit lösbarer sperreinrichtung
US20040029260A1 (en) 2002-05-17 2004-02-12 Hansen Timothy R. Automated system for isolating, amplifying and detecting a target nucleic acid sequence
AU2003222704A1 (en) 2002-05-24 2003-12-12 Epr Labautomation Ag Method and device for dosing small volumes of liquid
US7161356B1 (en) 2002-06-05 2007-01-09 Caliper Life Sciences, Inc. Voltage/current testing equipment for microfluidic devices
USD480814S1 (en) 2002-06-11 2003-10-14 Diversa Corporation Gigamatrix holding tray
US7208125B1 (en) 2002-06-28 2007-04-24 Caliper Life Sciences, Inc Methods and apparatus for minimizing evaporation of sample materials from multiwell plates
US6679279B1 (en) 2002-07-10 2004-01-20 Motorola, Inc. Fluidic valve having a bi-phase valve element
ATE529188T1 (de) 2002-07-15 2011-11-15 Phynexus Inc Extraktionskolonnenvorrichtung
US7438857B2 (en) 2002-07-23 2008-10-21 Protedyne Corporation Liquid handling tool having porous plunger
US7041258B2 (en) 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7214348B2 (en) 2002-07-26 2007-05-08 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
CA2492613A1 (en) 2002-07-26 2004-02-05 Applera Corporation Microfluidic size-exclusion devices, systems, and methods
DE10236029A1 (de) 2002-08-02 2004-02-19 Cybio Systems Gmbh Einrichtung zum Dispensieren und Beobachten der Lumineszenz von Einzelproben in Multiprobenanordnungen
US20040053315A1 (en) 2002-08-12 2004-03-18 Caliper Technologies Corp. Methods and systems for monitoring molecular interactions
GB0219457D0 (en) 2002-08-21 2002-09-25 Amersham Biosciences Uk Ltd Fluorescence reference plate
US7001853B1 (en) 2002-08-30 2006-02-21 Caliper Life Sciences, Inc. Flow control of photo-polymerizable resin
USD516221S1 (en) 2002-09-09 2006-02-28 Meso Scale Technologies, Llc. Diagnostic instrument
JP3756477B2 (ja) 2002-09-17 2006-03-15 横河電機株式会社 デンドリマーによる核酸またはタンパク質の抽出方法およびデンドリマー組成物
ITTO20020808A1 (it) 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
USD484989S1 (en) 2002-09-20 2004-01-06 Dade Behring Inc. Multi-well liquid container
TW590982B (en) 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
US6730883B2 (en) 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
AU2003284055A1 (en) 2002-10-09 2004-05-04 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
US7932098B2 (en) 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7217542B2 (en) * 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
US7122384B2 (en) 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
EP1567638A1 (en) 2002-11-08 2005-08-31 Irm, Llc Apparatus and methods to process substrate surface features
JP2004170159A (ja) 2002-11-18 2004-06-17 Hitachi Koki Co Ltd 自動分注装置
ATE465255T1 (de) 2002-11-26 2010-05-15 Univ Massachusetts Verabreichung von sirnas
USD491276S1 (en) 2002-12-09 2004-06-08 Babette Langille Plastic diagnostic card
USD491272S1 (en) 2002-12-13 2004-06-08 Immunivest Corporation Autoprep instrument
US6905583B2 (en) 2002-12-13 2005-06-14 Aclara Biosciences, Inc. Closed-loop control of electrokinetic processes in microfluidic devices based on optical readings
ATE508368T1 (de) 2002-12-13 2011-05-15 Dhr Finland Oy Analysator, analyseverfahren und flüssigkeitskartusche
USD491273S1 (en) 2002-12-19 2004-06-08 3M Innovative Properties Company Hybridization cartridge
SE0203781D0 (sv) 2002-12-19 2002-12-19 Alphahelix Ab Holder and method for cooling or heating samples
US7850912B2 (en) 2003-05-14 2010-12-14 Dako Denmark A/S Method and apparatus for automated pre-treatment and processing of biological samples
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20050042639A1 (en) 2002-12-20 2005-02-24 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA length
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
CA2510166A1 (en) 2002-12-20 2004-09-30 Caliper Life Sciences, Inc. Single molecule amplification and detection of dna
US8676383B2 (en) 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
EP2711415B1 (en) 2002-12-26 2022-02-16 Meso Scale Technologies, LLC. Assay cartridges and methods of using the same
US20060113190A1 (en) 2002-12-27 2006-06-01 Kurnik Ronald T Microfluidic device and method for improved sample handling
JP2006512092A (ja) 2002-12-30 2006-04-13 ザ・リージェンツ・オブ・ジ・ユニバーシティ・オブ・カリフォルニア 病原体の検出および分析のための方法および装置
US20070269891A9 (en) 2003-01-13 2007-11-22 Yasunobu Tanaka Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
US6964747B2 (en) 2003-01-21 2005-11-15 Bioarray Solutions, Ltd. Production of dyed polymer microparticles
US7049558B2 (en) 2003-01-27 2006-05-23 Arcturas Bioscience, Inc. Apparatus and method for heating microfluidic volumes and moving fluids
JP4021335B2 (ja) 2003-01-31 2007-12-12 ユニバーサル・バイオ・リサーチ株式会社 監視機能付分注装置および分注装置の監視方法
US7338637B2 (en) 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
AU2004220626B2 (en) 2003-02-05 2010-07-29 Iquum Inc. Sample processing tubule
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
KR100959101B1 (ko) 2003-02-20 2010-05-25 삼성전자주식회사 Ｐｃｒ 반응기 및 ｐｃｒ 반응기의 입구와 출구의 개폐를조절하는 방법
WO2004076056A2 (en) 2003-02-26 2004-09-10 Lake Shore Cryotronics Inc. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
JP4129864B2 (ja) 2003-03-24 2008-08-06 農工大ティー・エル・オー株式会社 磁気微粒子の磁気分離装置
JP2004305009A (ja) * 2003-04-02 2004-11-04 Hitachi Ltd 核酸増幅装置及び核酸増幅方法
US20040203173A1 (en) 2003-04-08 2004-10-14 Peck Bill J. Apparatus and methods for droplet dispensing
AU2004229405A1 (en) 2003-04-08 2004-10-28 Irm, Llc Material removal and dispensing devices, systems, and methods
US9766216B2 (en) 2003-04-14 2017-09-19 Wako Pure Chemical Industries, Ltd. Reduction of migration shift assay interference
WO2004094986A2 (en) 2003-04-16 2004-11-04 Handylab, Inc. System and method for electrochemical detection of biological compounds
GB2401237A (en) 2003-04-28 2004-11-03 Hewlett Packard Development Co Data transfer arrangement for disaster recovery
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
JP4156627B2 (ja) 2003-05-09 2008-09-24 カリパー・ライフ・サイエンシズ・インコーポレーテッド 自動サンプル分析
US7038472B1 (en) 2003-05-12 2006-05-02 Caliper Life Sciences, Inc. Methods and systems for measuring internal dimensions of microscale structures
US7374949B2 (en) 2003-05-29 2008-05-20 Bayer Healthcare Llc Diagnostic test strip for collecting and detecting an analyte in a fluid sample
US7055695B2 (en) 2003-06-02 2006-06-06 Caliper Life Sciencee, Inc. Container providing a controlled hydrated environment
JP2005009870A (ja) 2003-06-16 2005-01-13 Fuji Photo Film Co Ltd 分析装置の吸引方法
EP1650570B1 (en) 2003-07-17 2021-05-26 LSI Medience Corporation Apparatus for use in measuring a component contained in a sample comprising a measuring device and a cartridge
US7381370B2 (en) 2003-07-18 2008-06-03 Dade Behring Inc. Automated multi-detector analyzer
EP1648622A4 (en) 2003-07-21 2009-11-11 Dendritic Nanotechnologies Inc STABILIZED AND CHEMICALLY FUNCTIONALIZED NANOPARTICLES
USD508999S1 (en) 2003-07-24 2005-08-30 Biomerieux, Inc. Sample testing machine
USD500363S1 (en) 2003-07-24 2004-12-28 Biomerieux Inc. Sample holder
US20070134808A1 (en) 2003-07-29 2007-06-14 Sullivan James T Simultaneous multi-column liquid chromatograph for direct sampling of an array of liquid samples
US7731906B2 (en) 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7744817B2 (en) * 2003-08-11 2010-06-29 Sakura Finetek U.S.A., Inc. Manifold assembly
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
USD499813S1 (en) 2003-08-22 2004-12-14 As.Pire Bioresearch Inc. Assay testing device
JP2005065607A (ja) 2003-08-26 2005-03-17 Hitachi Ltd 遺伝子処理チップおよび遺伝子処理装置
USD515707S1 (en) 2003-09-01 2006-02-21 Matsushita Electric Industrial Co., Ltd. Fluorescent reader
EP1660881A2 (en) 2003-09-05 2006-05-31 Caliper Life Sciences, Inc. Analyte injection system
US7501094B2 (en) 2003-09-15 2009-03-10 Syngenta Limited Preparation and characterization of formulations in a high throughput mode
US20050220675A1 (en) 2003-09-19 2005-10-06 Reed Mark T High density plate filler
AU2004273996A1 (en) 2003-09-19 2005-03-31 University Of Rochester Biagnostic system for otolaryngologic pathogens and use thereof
US20050069898A1 (en) 2003-09-25 2005-03-31 Cepheid Lyophilized beads containing mannitol
DE10344700A1 (de) 2003-09-26 2005-04-14 Hirschmann Laborgeräte GmbH & Co. KG Mehrkanal-Pipettiervorrichtung
EP1673608A4 (en) 2003-09-29 2008-05-07 Vision Biosystems Ltd SYSTEM AND METHOD FOR PROCESSING HISTOLOGICAL TISSUE SPECIMENS
USD528215S1 (en) 2003-09-30 2006-09-12 Biacore Ab Chip carrier for biosensor
WO2005033672A1 (en) 2003-10-01 2005-04-14 Caliper Life Sciences, Inc. Method for measuring diffusivities of compounds using microfluidic devices
NL1024578C2 (nl) 2003-10-21 2005-04-22 Univ Delft Tech Inrichting voor het uitvoeren van een reactie.
WO2005048814A2 (en) 2003-11-12 2005-06-02 Van Lue Stephen J Magnetic devices and apparatus for medical/surgical procedures and methods for using same
EP2264191A1 (en) 2003-11-21 2010-12-22 ANP Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
EP1541237A3 (en) * 2003-12-10 2006-02-01 Samsung Electronics Co., Ltd. Polymerase chain reaction (pcr) module and multiple pcr system using the same
JP4595446B2 (ja) 2003-12-12 2010-12-08 Ｄｉｃ株式会社 核酸増幅方法
JP2005176613A (ja) 2003-12-16 2005-07-07 Yokogawa Electric Corp デンドリマー利用のｄｎａ抽出方法およびバイオチップ
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
RU2006126664A (ru) 2003-12-23 2008-01-27 Кайлипер Лайф Сайенсиз, Инк. (Us) Система ввода аналита
JP4750412B2 (ja) 2003-12-25 2011-08-17 モレックス インコーポレイテド 生体由来分子、ダイオキシン類及び内分泌撹乱物質検出装置及び当該装置を使用した検出方法
KR100750586B1 (ko) 2003-12-26 2007-08-20 한국전자통신연구원 미소유체 가열 시스템
JP4732683B2 (ja) 2003-12-29 2011-07-27 ユニバーサル・バイオ・リサーチ株式会社 標的物質の検出方法
US7099778B2 (en) 2003-12-30 2006-08-29 Caliper Life Sciences, Inc. Method for determining diffusivity and molecular weight in a microfluidic device
MXPA06008399A (es) 2004-01-25 2008-03-07 Fluidigm Corp Dispositivos formadores de cristal y sistemas y metodos para hacer y utilizar los mismos.
JP2005224110A (ja) * 2004-02-10 2005-08-25 Kawamura Inst Of Chem Res ポリヌクレオチドまたはオリゴヌクレオチドの検出方法、およびマイクロ流体デバイス
WO2005080606A1 (en) 2004-02-18 2005-09-01 Xiaochuan Zhou Fluidic devices and methods for multiplex chemical and biochemical reactions
JP5297651B2 (ja) 2004-02-24 2013-09-25 サーマル グラディエント 熱サイクル装置
US20050196321A1 (en) 2004-03-03 2005-09-08 Zhili Huang Fluidic programmable array devices and methods
TWD106277S1 (zh) 2004-03-05 2005-09-01 精工愛普生股份有限公司 照相軟片掃描機
KR100552706B1 (ko) * 2004-03-12 2006-02-20 삼성전자주식회사 핵산 증폭 방법 및 장치
WO2005091993A2 (en) 2004-03-19 2005-10-06 Espir Kahatt Device for aspirating, manipulating, mixing and dispensing nano-volumes of liquids
JP3858029B2 (ja) 2004-03-22 2006-12-13 株式会社アイディエス 試験管の検知装置
US8298832B2 (en) 2004-03-23 2012-10-30 Toray Industries, Inc. Method of agitating solution
WO2005094981A1 (en) 2004-03-29 2005-10-13 Agilent Technologies, Inc. Cyclic pcr system
JP2005291954A (ja) 2004-03-31 2005-10-20 Olympus Corp 使い捨て試薬パックとその試薬パックを用いる分析装置
RU2418633C2 (ru) 2004-04-08 2011-05-20 Байоматрика, Инк. Объединение процессов хранения образцов и управление образцами в медико-биологических науках
CA2604075C (en) 2004-04-09 2011-03-29 Research Think Tank, Inc. Devices and methods for collection, storage and transportation of biological specimens
CA2562517A1 (en) 2004-04-16 2005-10-27 Spartan Bioscience Inc. System for rapid nucleic acid amplification and detection
US20230041595A1 (en) 2004-05-03 2023-02-09 Handylab, Inc. Method for processing polynucleotide-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP5344817B2 (ja) 2004-05-03 2013-11-20 ハンディーラブ インコーポレイテッド ポリヌクレオチド含有サンプルの処理
WO2005108571A1 (ja) 2004-05-07 2005-11-17 Konica Minolta Medical & Graphic, Inc. 検査用マイクロリアクタおよび遺伝子検査装置ならびに遺伝子検査方法
GB2414059B (en) 2004-05-10 2008-06-11 E2V Tech Uk Ltd Microfluidic device
JP3952036B2 (ja) 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 マイクロ流体デバイス並びに試液の試験方法および試験システム
WO2005114223A2 (en) 2004-05-21 2005-12-01 Caliper Life Sciences, Inc. Automat system for handling microfluidic devices
US7553671B2 (en) 2004-05-25 2009-06-30 Vertex Pharmaceuticals, Inc. Modular test tube rack
WO2005116202A1 (ja) 2004-05-27 2005-12-08 Universal Bio Research Co., Ltd. 反応容器、反応測定装置、および液回転処理装置
US7622296B2 (en) 2004-05-28 2009-11-24 Wafergen, Inc. Apparatus and method for multiplex analysis
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
JP2008505345A (ja) 2004-06-07 2008-02-21 アイアールエム エルエルシー 分注システム、ソフトウェア、および関連する方法
JP2008504446A (ja) 2004-06-28 2008-02-14 ボイス ステート ユニバーシティ 溶液の微小滴を使用した電気化学的方法
US7480042B1 (en) 2004-06-30 2009-01-20 Applied Biosystems Inc. Luminescence reference standards
US20060002817A1 (en) 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
US8965710B2 (en) 2004-07-02 2015-02-24 The United States Of America, As Represented By The Secretary Of The Navy Automated sample-to-microarray apparatus and method
JP4440020B2 (ja) 2004-07-09 2010-03-24 株式会社神戸製鋼所 マイクロ反応器及びその製造方法
USD523153S1 (en) 2004-07-23 2006-06-13 Hitachi High-Technologies Corporation Main part for immunity analysis machine
EP1621890A1 (en) 2004-07-26 2006-02-01 bioMerieux B.V. Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods
US7585663B2 (en) 2004-08-26 2009-09-08 Applied Biosystems, Llc Thermal device, system, and method, for fluid processing device
US8053214B2 (en) 2004-09-09 2011-11-08 Microfluidic Systems, Inc. Apparatus and method of extracting and optically analyzing an analyte from a fluid-based sample
EP2261650A3 (en) 2004-09-15 2011-07-06 IntegenX Inc. Microfluidic devices
KR100668304B1 (ko) 2004-09-16 2007-01-12 삼성전자주식회사 Ｐｃｒ 혼합액을 ｐｃｒ 칩의 각 ｐｃｒ 채널에 주입하기위한 장치 및 상기 장치를 포함하는 ｐｃｒ 칩 유니트
EP1795899B1 (en) 2004-09-30 2012-06-06 ARKRAY, Inc. Analytical instrument with film heater
USD548841S1 (en) 2004-10-15 2007-08-14 Microsulis, Ltd Electrical equipment for ablative treatment
WO2006043642A1 (ja) 2004-10-20 2006-04-27 Ebara Corporation 流体反応装置
US20060094004A1 (en) 2004-10-28 2006-05-04 Akihisa Nakajima Micro-reactor, biological material inspection device, and microanalysis system
JP2006145458A (ja) 2004-11-24 2006-06-08 Yaskawa Electric Corp 分注装置
US7785868B2 (en) 2004-12-02 2010-08-31 Microfluidic Systems, Inc. Apparatus to automatically lyse a sample
US7727477B2 (en) 2004-12-10 2010-06-01 Bio-Rad Laboratories, Inc. Apparatus for priming microfluidics devices with feedback control
JP4573243B2 (ja) 2004-12-15 2010-11-04 小林クリエイト株式会社 試験管用トレイ
JP4739352B2 (ja) 2004-12-17 2011-08-03 日東電工株式会社 真核細胞をトランスフェクトするための固定化分解性カチオンポリマーを持つ固体表面
US20060165558A1 (en) 2004-12-21 2006-07-27 Thomas Witty Cartridge for diagnostic assays
US7315376B2 (en) 2005-01-07 2008-01-01 Advanced Molecular Systems, Llc Fluorescence detection system
US7964380B2 (en) 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
US20060183216A1 (en) 2005-01-21 2006-08-17 Kalyan Handique Containers for liquid storage and delivery with application to microfluidic devices
DE102005004664B4 (de) 2005-02-02 2007-06-21 Chemagen Biopolymer-Technologie Aktiengesellschaft Vorrichtung und Verfahren und Verwendung zum Abtrennen von magnetischen oder magnetisierbaren Partikeln aus einer Flüssigkeit sowie deren Verwendungen
US20080069729A1 (en) 2005-02-16 2008-03-20 Mcneely Michael R Liquid Valving Using Reactive or Responsive Materials
WO2006089192A2 (en) 2005-02-18 2006-08-24 Canon U.S. Life Sciences, Inc. Devices and methods for identifying genomic dna of organisms
USD535403S1 (en) 2005-02-25 2007-01-16 Fuji Photo Film Co., Ltd. Component extractor for biochemistry
JP2008532048A (ja) 2005-03-07 2008-08-14 ノブックス システムズ インコーポレーテッド 自動分析器
CA2599569A1 (en) 2005-03-08 2006-09-14 Authentix, Inc. Microfluidic device for identification, quantification, and authentication of latent markers
US7897337B2 (en) 2005-03-10 2011-03-01 Gen-Probe Incorporated Method for performing multi-formatted assays
US20060228734A1 (en) 2005-03-18 2006-10-12 Applera Corporation Fluid processing device with captured reagent beads
US9097723B2 (en) 2005-04-01 2015-08-04 Caliper Life Sciences, Inc. Method and apparatus for performing peptide digestion on a microfluidic device
JP4525427B2 (ja) 2005-04-01 2010-08-18 パナソニック株式会社 分析ディスク、並びに分析ディスクおよび分析装置の検査方法
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
CA112854S (en) 2005-04-10 2007-03-27 Akubio Ltd Microbalance analyser cartridge
EP2453223B1 (en) 2005-04-12 2019-07-03 Caliper Life Sciences Inc. Optical detection system for a microfluidic device and method for aligning and focusing an optical detection system
US20060234251A1 (en) 2005-04-19 2006-10-19 Lumigen, Inc. Methods of enhancing isolation of RNA from biological samples
WO2006116616A2 (en) 2005-04-26 2006-11-02 Applera Corporation Systems and methods for multiple analyte detection
WO2006118420A1 (en) 2005-04-30 2006-11-09 Jae Chern Yoo Bio-disc, bio-driver apparatus, and assay method using the same
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
EP1896610A2 (en) 2005-05-03 2008-03-12 Handylab, Inc. Lyophilized pellets
USD566291S1 (en) 2005-05-03 2008-04-08 Handylab, Inc. Microfluidic cartridge
USD534280S1 (en) 2005-05-04 2006-12-26 Abbott Laboratories Reagent carrier for use in an automated analyzer
JP4875066B2 (ja) 2005-05-06 2012-02-15 カリパー・ライフ・サイエンシズ・インク． 除去された周囲を有するマイクロタイタープレート
WO2006122310A2 (en) 2005-05-11 2006-11-16 The Trustess Of The University Of Pennsylvania System for testing
WO2007005907A1 (en) 2005-07-01 2007-01-11 Honeywell International, Inc. A molded cartridge with 3-d hydrodynamic focusing
US7527763B2 (en) 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
WO2007006315A2 (en) 2005-07-07 2007-01-18 Inverness Medical Switzerland Gmbh A method of performing a test, a support instrument and a microliquid system comprising such support instrument
US20070020699A1 (en) 2005-07-19 2007-01-25 Idexx Laboratories, Inc. Lateral flow assay and device using magnetic particles
JP4581128B2 (ja) 2005-07-20 2010-11-17 独立行政法人産業技術総合研究所 酵素免疫測定方法及びそのための酵素免疫センサ
US20070020764A1 (en) 2005-07-20 2007-01-25 Miller Kerry L Method for processing chemistry and coagulation test samples in a laboratory workcell
US20070141593A1 (en) 2005-08-22 2007-06-21 Lee Linda G Apparatus, system, and method using immiscible-fluid-discrete-volumes
JP2007074960A (ja) 2005-09-13 2007-03-29 Shimadzu Corp 遺伝子増幅法
USD549827S1 (en) 2005-09-16 2007-08-28 Horiba, Ltd. Blood analyzer
US20070184463A1 (en) 2005-09-30 2007-08-09 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
JP4827483B2 (ja) 2005-10-04 2011-11-30 キヤノン株式会社 核酸試料処理装置
JP4630786B2 (ja) 2005-10-04 2011-02-09 キヤノン株式会社 生化学処理装置、ｄｎａ増幅精製装置、該装置を含むｄｎａ検査装置
JP4656646B2 (ja) 2005-10-04 2011-03-23 キヤノン株式会社 表示方法と表示装置、該表示装置を備えた全自動検査装置
US20070199821A1 (en) 2005-10-05 2007-08-30 Chow Andrea W Automated two-dimensional gel electrophoresis
US7727371B2 (en) 2005-10-07 2010-06-01 Caliper Life Sciences, Inc. Electrode apparatus for use with a microfluidic device
WO2007044917A2 (en) 2005-10-11 2007-04-19 Handylab, Inc. Polynucleotide sample preparation device
DE102005049920A1 (de) 2005-10-17 2007-04-19 Manz Automation Ag Roboteranordnung
USD556914S1 (en) 2005-10-21 2007-12-04 Sanyo Electric Co., Ltd. Gene amplification apparatus
USD537951S1 (en) 2005-10-21 2007-03-06 Sanyo Electric Co., Ltd. Gene amplification apparatus
US20070092403A1 (en) 2005-10-21 2007-04-26 Alan Wirbisky Compact apparatus, compositions and methods for purifying nucleic acids
DE102005051850A1 (de) 2005-10-28 2007-05-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Vervielfältigung und Detektion von Nukleinsäuren
US20070104617A1 (en) 2005-11-04 2007-05-10 Advanced Biotechnologies Limited Capped tubes
US20070116613A1 (en) 2005-11-23 2007-05-24 Donat Elsener Sample tube and system for storing and providing nucleic acid samples
WO2007064117A1 (en) 2005-11-30 2007-06-07 Electronics And Telecommunications Research Institute Affinity chromatography microdevice and method for manufacturing the same
EP1792656B1 (en) 2005-11-30 2011-11-02 F. Hoffmann-La Roche AG Integrally built, linear array of cuvettes, two dimensional array of cuvettes and system comprising two or more two-dimensional arrays of cuvettes
JP3899360B2 (ja) 2005-12-19 2007-03-28 オリンパス株式会社 Ｄｎａ増幅装置
WO2007075919A2 (en) 2005-12-22 2007-07-05 Honeywell International Inc. Portable sample analyzer system
JP2007178328A (ja) 2005-12-28 2007-07-12 Shimadzu Corp 反応容器キット及び反応容器処理装置
WO2007079257A2 (en) 2005-12-30 2007-07-12 Caliper Life Sciences, Inc. Integrated dissolution processing and sample transfer system
US20070154895A1 (en) 2005-12-30 2007-07-05 Caliper Life Sciences, Inc. Multi-assay microfluidic chips
SG134186A1 (en) 2006-01-12 2007-08-29 Nanyang Polytechnic Smart nano-integrated system assembly
JP5006215B2 (ja) 2006-02-07 2012-08-22 古河電気工業株式会社 光検出装置及び測定対象読取装置
US8124033B2 (en) * 2006-02-17 2012-02-28 Agency, Science, Technology and Research Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same
USD538436S1 (en) 2006-03-06 2007-03-13 Steris Inc. Reprocessor for decontaminating medical, dental and veterinary instruments and articles
JP5254949B2 (ja) 2006-03-15 2013-08-07 マイクロニクス， インコーポレイテッド 一体型の核酸アッセイ
DK3088083T3 (da) 2006-03-24 2018-11-26 Handylab Inc Fremgangsmåde til udøvelse af PCR ned eb flersporet patron
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
USD569526S1 (en) 2006-03-27 2008-05-20 Handylab, Inc. Molecular diagnostic instrument
USD559995S1 (en) 2006-03-27 2008-01-15 Handylab, Inc. Controller cartridge for a diagnostic instrument
EP1839756A1 (en) 2006-03-31 2007-10-03 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
US8021531B2 (en) 2006-04-14 2011-09-20 Caliper Life Sciences, Inc. Method for modifying the concentration of reactants in a microfluidic device
CA2680061C (en) 2006-04-18 2015-10-13 Duke University Droplet-based biochemistry
USD554070S1 (en) 2006-05-03 2007-10-30 Data I/O Corporation Processing apparatus
USD554069S1 (en) 2006-05-03 2007-10-30 Data I/O Corporation Processing apparatus
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
CN101522909A (zh) 2006-05-17 2009-09-02 加利福尼亚技术学院 热循环系统
RU2008148143A (ru) 2006-06-08 2010-06-10 Конинклейке Филипс Электроникс Н.В. (Nl) Микроэлектронное сенсорное устройство для детектирования днк
US7629124B2 (en) 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
US7633606B2 (en) 2006-08-24 2009-12-15 Microfluidic Systems, Inc. Integrated airborne substance collection and detection system
US7858366B2 (en) 2006-08-24 2010-12-28 Microfluidic Systems, Inc Integrated airborne substance collection and detection system
US7705739B2 (en) 2006-08-24 2010-04-27 Microfluidic Systems, Inc. Integrated airborne substance collection and detection system
JP5553602B2 (ja) 2006-09-06 2014-07-16 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッド マイクロ流体アッセイを実施するためのチップ及びカートリッジ設計構成
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8246919B2 (en) 2006-09-21 2012-08-21 Abbott Laboratories Specimen sample rack
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
JPWO2008044387A1 (ja) 2006-10-06 2010-02-04 コニカミノルタエムジー株式会社 マイクロ総合分析チップおよびマイクロ総合分析システム
US20080095673A1 (en) 2006-10-20 2008-04-24 Lin Xu Microplate with fewer peripheral artifacts
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US8338166B2 (en) 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
KR101422467B1 (ko) 2007-02-08 2014-07-24 삼성전자주식회사 미세유체 칩 내의 형광을 검출하기 위한 시스템 및 형광검출 방법
US7985375B2 (en) 2007-04-06 2011-07-26 Qiagen Gaithersburg, Inc. Sample preparation system and method for processing clinical specimens
JP2008267950A (ja) 2007-04-19 2008-11-06 Enplas Corp 流体取扱装置
US20080257882A1 (en) 2007-04-20 2008-10-23 Bioinnovations Oy Vessel for accurate analysis
EP2140001A2 (en) 2007-04-25 2010-01-06 3M Innovative Properties Company Methods for nucleic acid amplification
WO2008149282A2 (en) 2007-06-06 2008-12-11 Koninklijke Philips Electronics N. V. Microfluidic device and method of operating a microfluidic device
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
EP2171460B1 (en) 2007-07-13 2017-08-30 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
GB0719193D0 (en) 2007-10-02 2007-11-07 Advanced Biotech Ltd A Vessel
CN104777291B (zh) 2007-10-10 2017-09-12 普凯尔德诊断技术有限公司 用于鉴定尿中细菌的系统
JP5035842B2 (ja) 2007-11-02 2012-09-26 アルパイン株式会社 ナビゲーション装置
USD632799S1 (en) 2008-05-15 2011-02-15 The Automation Partnership Cell dispenser
CN102083535B (zh) 2008-06-09 2015-04-15 奇亚根盖瑟斯堡股份有限公司 磁性微板组件
USD596312S1 (en) 2008-06-13 2009-07-14 Csp Technologies, Inc. Vial rack
USD595423S1 (en) 2008-06-30 2009-06-30 Ge Healthcare Bio-Sciences Ab Magnetic rack
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US20100009351A1 (en) 2008-07-11 2010-01-14 Handylab, Inc. Polynucleotide Capture Materials, and Method of Using Same
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
USD598566S1 (en) 2008-08-12 2009-08-18 Diagenode Societe Anonyme Medical instrument for laboratory use
JP5492207B2 (ja) 2008-08-27 2014-05-14 ライフ テクノロジーズ コーポレーション 生物学的サンプルの処理装置および処理方法
CA2752760C (en) 2009-04-15 2019-12-24 Biocartis Sa Optical detection system for monitoring rtpcr reaction
USD599234S1 (en) 2009-04-28 2009-09-01 Shiseido Co., Ltd. Auto-sampler for chromatograph
USD638953S1 (en) 2009-05-12 2011-05-31 Invitrogen Dynal As Laboratory apparatus
GB2473868A (en) 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
US8329117B2 (en) 2009-05-14 2012-12-11 Canon U.S. Life Sciences, Inc. Microfluidic chip features for optical and thermal isolation
WO2010130310A1 (en) 2009-05-15 2010-11-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Pipette head with filter and flushing means
EP2263802A1 (en) 2009-05-25 2010-12-22 F. Hoffmann-La Roche AG System and method for dispensing fluids
JP5690724B2 (ja) 2009-06-04 2015-03-25 ユニバーサル・バイオ・リサーチ株式会社 検体検査装置およびその方法
USD628305S1 (en) 2009-07-14 2010-11-30 Medical Research Council Sitting-drop microwell plate for crystalization
EP2454381A1 (en) 2009-07-16 2012-05-23 Abbott Laboratories A method for amplification of nucleic acids
JP4857373B2 (ja) 2009-09-09 2012-01-18 国立大学法人東京農工大学 デンドリマー被覆磁気微粒子並びにその製造方法及び用途
US8282895B2 (en) 2009-09-15 2012-10-09 Qiagen Gaithersburg, Inc. Reagent cabinet system
US20110097493A1 (en) 2009-10-27 2011-04-28 Kerr Roger S Fluid distribution manifold including non-parallel non-perpendicular slots
US20130029343A1 (en) 2010-02-22 2013-01-31 4Titude Ltd. Multiwell strips
ES2583643T3 (es) 2010-04-01 2016-09-21 F. Hoffmann-La Roche Ag Método implementado por ordenador para operar una celda de trabajo para muestras automatizada
US20110300033A1 (en) 2010-06-07 2011-12-08 Chemence Medical, Inc. Pipette Holder and Applicator Apparatus
CN103540517B (zh) 2010-07-23 2017-05-24 贝克曼考尔特公司 处理样本的系统及方法
WO2012036296A1 (ja) 2010-09-17 2012-03-22 ユニバーサル・バイオ・リサーチ株式会社 カートリッジおよび自動分析装置
ES2617599T3 (es) 2011-04-15 2017-06-19 Becton, Dickinson And Company Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
EP2761305B1 (en) 2011-09-30 2017-08-16 Becton, Dickinson and Company Unitized reagent strip
CN103998921B (zh) 2011-10-14 2016-04-20 贝克顿·迪金森公司 方波热循环
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
CN114134029A (zh) 2012-02-13 2022-03-04 纽莫德克斯莫勒库拉尔公司 用于处理和检测核酸的微流体盒
WO2013154734A1 (en) 2012-04-13 2013-10-17 Becton, Dickinson And Company, Inc. Reflex testing of samples using residual materials from a prior test
USD686749S1 (en) 2012-04-20 2013-07-23 Stratec Biomedical Ag Rack for holding sheaths
USD702854S1 (en) 2012-05-18 2014-04-15 Yoko Nakahana Micro tube array container
USD687567S1 (en) 2012-10-22 2013-08-06 Qiagen Gaithersburg, Inc. Tube strip for automated processing systems
WO2014066376A1 (en) 2012-10-25 2014-05-01 Neumodx Molecular, Inc. Method and materials for isolation of nucleic acid materials
USD710024S1 (en) 2013-03-14 2014-07-29 Bio-Rad Laboratories, Inc. Microplate
CA2905204C (en) 2013-03-15 2021-08-10 Becton, Dickinson And Company Process tube and carrier tray
EP2969213B1 (en) 2013-03-16 2022-11-02 Leslie Don ROBERTS Self-contained modular analytical cartridge and programmable reagent delivery system
CA3009218C (en) 2013-08-08 2020-10-27 Illumina, Inc. Fluidic system for reagent delivery to a flow cell
CH709054A1 (de) 2013-12-20 2015-06-30 Tecan Trading Ag Abstandhalter für übereinandergestapelte Pipettenspitzen-Träger.
USD729404S1 (en) 2014-06-02 2015-05-12 Seahorse Bioscience Carrier
WO2016037000A1 (en) 2014-09-04 2016-03-10 Miodx Method of multivariate molecule analysis
WO2017204868A1 (en) 2016-05-23 2017-11-30 Becton, Dickinson And Company Liquid dispenser with manifold mount for modular independently-actuated pipette channels

Also Published As

Publication number Publication date
US20200156059A1 (en) 2020-05-21
US20200156060A1 (en) 2020-05-21
US20210276008A1 (en) 2021-09-09
JP2014097080A (ja) 2014-05-29
US10857535B2 (en) 2020-12-08
EP2001990A4 (en) 2011-07-20
US20250325977A1 (en) 2025-10-23
ES2692380T3 (es) 2018-12-03
WO2007112114A2 (en) 2007-10-04
DK3088083T3 (da) 2018-11-26
EP3088083B1 (en) 2018-08-01
US10799862B2 (en) 2020-10-13
US10913061B2 (en) 2021-02-09
US12162007B2 (en) 2024-12-10
US20200139363A1 (en) 2020-05-07
JP2009531064A (ja) 2009-09-03
US20150328638A1 (en) 2015-11-19
US20240139731A1 (en) 2024-05-02
US10821436B2 (en) 2020-11-03
JP5415253B2 (ja) 2014-02-12
US20200215536A1 (en) 2020-07-09
US20070292941A1 (en) 2007-12-20
JP2016154559A (ja) 2016-09-01
JP2012055321A (ja) 2012-03-22
EP2001990A2 (en) 2008-12-17
US10843188B2 (en) 2020-11-24
JP6265581B2 (ja) 2018-01-24
EP3088083A1 (en) 2016-11-02
EP2001990B1 (en) 2016-06-29
JP6385387B2 (ja) 2018-09-05
US11666903B2 (en) 2023-06-06
WO2007112114A3 (en) 2008-07-03
US20200164363A1 (en) 2020-05-28
ES2587007T3 (es) 2016-10-20
JP5981473B2 (ja) 2016-08-31
US9040288B2 (en) 2015-05-26

Similar Documents

Publication Publication Date Title
US12162007B2 (en) Integrated system for processing microfluidic samples, and method of using same
US11441171B2 (en) Method for processing polynucleotide-containing samples
CN103725592B (zh) 用于在多个生物样品上进行核酸提取和诊断测试的集成装置
EP1745153B1 (en) Processing polynucleotide-containing samples
US20230041595A1 (en) Method for processing polynucleotide-containing samples
AU2015200157B2 (en) Processing polynucleotide-containing samples