DK2081929T3 - Substituerede 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol-forbindelser og fremgangsmåder angående disse - Google Patents
Substituerede 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol-forbindelser og fremgangsmåder angående disseInfo
- Publication number
- DK2081929T3 DK2081929T3 DK07864160.2T DK07864160T DK2081929T3 DK 2081929 T3 DK2081929 T3 DK 2081929T3 DK 07864160 T DK07864160 T DK 07864160T DK 2081929 T3 DK2081929 T3 DK 2081929T3
- Authority
- DK
- Denmark
- Prior art keywords
- isoquinolin
- pyrido
- hexahydro
- dimethoxy
- isobutyl
- Prior art date
Links
- WEQLWGNDNRARGE-UHFFFAOYSA-N b-Dihydrotetrabenazine Chemical class C1CN2CC(CC(C)C)C(O)CC2C2=C1C=C(OC)C(OC)=C2 WEQLWGNDNRARGE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86494406P | 2006-11-08 | 2006-11-08 | |
| PCT/US2007/084176 WO2008058261A1 (en) | 2006-11-08 | 2007-11-08 | Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2081929T3 true DK2081929T3 (da) | 2013-04-15 |
Family
ID=39110526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07864160.2T DK2081929T3 (da) | 2006-11-08 | 2007-11-08 | Substituerede 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol-forbindelser og fremgangsmåder angående disse |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8039627B2 (da) |
| EP (1) | EP2081929B1 (da) |
| JP (1) | JP5290185B2 (da) |
| KR (1) | KR101500766B1 (da) |
| CN (1) | CN101553487B (da) |
| AU (1) | AU2007317242B2 (da) |
| BR (1) | BRPI0718247B1 (da) |
| CA (1) | CA2668689C (da) |
| DK (1) | DK2081929T3 (da) |
| EA (1) | EA018378B1 (da) |
| ES (1) | ES2402220T3 (da) |
| IL (1) | IL198250A0 (da) |
| MX (1) | MX2009004910A (da) |
| PL (1) | PL2081929T3 (da) |
| PT (1) | PT2081929E (da) |
| WO (1) | WO2008058261A1 (da) |
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| EA018378B1 (ru) | 2006-11-08 | 2013-07-30 | Ньюрокрайн Байосайенсиз, Инк. | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ |
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| FI4168409T3 (fi) | 2021-03-22 | 2025-06-25 | Neurocrine Biosciences Inc | VMAT2:n ESTÄJIÄ JA KÄYTTÖMENETELMIÄ |
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| JP2024525424A (ja) | 2021-06-30 | 2024-07-12 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | 脳性麻痺によるジスキネジアの処置における使用のためのバルベナジン |
| WO2023278987A1 (en) | 2021-06-30 | 2023-01-05 | Neurocrine Biosciences, Inc. | Valbenazine for use in the add-on treatment of schizophrenia |
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| KR20250083502A (ko) | 2022-09-21 | 2025-06-10 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 헥사히드로-2h-피리도[2,1-a]이소퀴놀린 vmat2 억제제 및 사용 방법 |
| WO2025038938A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Valbenazine for use in the treatment of huntington's chorea |
| WO2025038959A1 (en) | 2023-08-17 | 2025-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
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Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| US3209005A (en) * | 1965-09-28 | Hexahydro-llbh-benzo[a] quinolizines and processes therefor | ||
| US2852518A (en) * | 1957-05-23 | 1958-09-16 | Parke Davis & Co | Di-substituted quinoline compounds |
| WO1991016920A1 (en) | 1990-05-07 | 1991-11-14 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
| US6610841B1 (en) | 1997-12-18 | 2003-08-26 | Gilead Sciences, Inc. | Nucleotide-based prodrugs |
| US7045543B2 (en) * | 2001-11-05 | 2006-05-16 | Enzrel Inc. | Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites |
| GB2410947B (en) | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| WO2006053067A2 (en) | 2004-11-09 | 2006-05-18 | Prestwick Pharmaceuticals, Inc. | Combination of amantadine and a tetrabenazine compound for treating hyperkinetic disorders |
| AU2006266229B2 (en) | 2005-06-29 | 2013-02-21 | The Trustees Of Columbia University In The City Of New York | Use of DTBZ for imaging endocrine pancreas and beta cell mass in type 1 diabetes |
| GB0514501D0 (en) | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0516168D0 (en) | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| ATE415968T1 (de) | 2005-08-06 | 2008-12-15 | Cambridge Lab Ireland Ltd | 3,11b-cis-dihydrotetrabanezin zur behandlung von schizophrenie und anderen psychosen |
| EA018378B1 (ru) | 2006-11-08 | 2013-07-30 | Ньюрокрайн Байосайенсиз, Инк. | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ |
-
2007
- 2007-11-08 EA EA200970461A patent/EA018378B1/ru unknown
- 2007-11-08 KR KR1020097011731A patent/KR101500766B1/ko active Active
- 2007-11-08 BR BRPI0718247-3A patent/BRPI0718247B1/pt active IP Right Grant
- 2007-11-08 US US11/937,445 patent/US8039627B2/en active Active
- 2007-11-08 PL PL07864160T patent/PL2081929T3/pl unknown
- 2007-11-08 DK DK07864160.2T patent/DK2081929T3/da active
- 2007-11-08 AU AU2007317242A patent/AU2007317242B2/en active Active
- 2007-11-08 WO PCT/US2007/084176 patent/WO2008058261A1/en not_active Ceased
- 2007-11-08 CA CA2668689A patent/CA2668689C/en active Active
- 2007-11-08 PT PT78641602T patent/PT2081929E/pt unknown
- 2007-11-08 JP JP2009536493A patent/JP5290185B2/ja active Active
- 2007-11-08 EP EP07864160A patent/EP2081929B1/en active Active
- 2007-11-08 CN CN2007800395790A patent/CN101553487B/zh active Active
- 2007-11-08 ES ES07864160T patent/ES2402220T3/es active Active
- 2007-11-08 MX MX2009004910A patent/MX2009004910A/es active IP Right Grant
-
2009
- 2009-04-21 IL IL198250A patent/IL198250A0/en active IP Right Grant
-
2011
- 2011-09-20 US US13/237,709 patent/US8357697B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007317242A1 (en) | 2008-05-15 |
| US20120077839A1 (en) | 2012-03-29 |
| BRPI0718247A2 (pt) | 2014-01-07 |
| CA2668689A1 (en) | 2008-05-15 |
| JP5290185B2 (ja) | 2013-09-18 |
| KR101500766B1 (ko) | 2015-03-16 |
| EP2081929A1 (en) | 2009-07-29 |
| EP2081929B1 (en) | 2013-01-09 |
| WO2008058261A1 (en) | 2008-05-15 |
| ES2402220T8 (es) | 2021-12-23 |
| JP2010509366A (ja) | 2010-03-25 |
| CA2668689C (en) | 2015-12-29 |
| CN101553487A (zh) | 2009-10-07 |
| AU2007317242B2 (en) | 2013-08-01 |
| IL198250A0 (en) | 2009-12-24 |
| KR101500766B9 (ko) | 2024-09-25 |
| PL2081929T3 (pl) | 2013-06-28 |
| BRPI0718247B1 (pt) | 2021-09-21 |
| MX2009004910A (es) | 2009-07-24 |
| US20080167337A1 (en) | 2008-07-10 |
| US8039627B2 (en) | 2011-10-18 |
| US8357697B2 (en) | 2013-01-22 |
| ES2402220T3 (es) | 2013-04-29 |
| KR20090079257A (ko) | 2009-07-21 |
| EA018378B1 (ru) | 2013-07-30 |
| CN101553487B (zh) | 2012-06-13 |
| EA200970461A1 (ru) | 2009-12-30 |
| PT2081929E (pt) | 2013-04-15 |
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