DK1922073T3 - Nye beskyttede pyrazinoylguanidin-natrium-kanalblokkere - Google Patents
Nye beskyttede pyrazinoylguanidin-natrium-kanalblokkereInfo
- Publication number
- DK1922073T3 DK1922073T3 DK06751598.1T DK06751598T DK1922073T3 DK 1922073 T3 DK1922073 T3 DK 1922073T3 DK 06751598 T DK06751598 T DK 06751598T DK 1922073 T3 DK1922073 T3 DK 1922073T3
- Authority
- DK
- Denmark
- Prior art keywords
- sodium channel
- channel blockers
- new protected
- pyrazinoylguanidine sodium
- pyrazinoylguanidine
- Prior art date
Links
- BGGCAGOTBOAZPU-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide;sodium Chemical compound [Na].NC(N)=NC(=O)C1=CN=CC=N1 BGGCAGOTBOAZPU-UHFFFAOYSA-N 0.000 title 1
- 239000003195 sodium channel blocking agent Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/04—Artificial tears; Irrigation solutions
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- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/195,758 US7807834B2 (en) | 2005-08-03 | 2005-08-03 | Capped pyrazinoylguanidine sodium channel blockers |
| PCT/US2006/015957 WO2007018640A1 (en) | 2005-08-03 | 2006-04-27 | New capped pyrazinoylguanidine sodium channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1922073T3 true DK1922073T3 (da) | 2013-10-14 |
Family
ID=37718396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06751598.1T DK1922073T3 (da) | 2005-08-03 | 2006-04-27 | Nye beskyttede pyrazinoylguanidin-natrium-kanalblokkere |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7807834B2 (da) |
| EP (1) | EP1922073B1 (da) |
| JP (2) | JP5225085B2 (da) |
| KR (1) | KR20080043773A (da) |
| AU (1) | AU2006276978B2 (da) |
| BR (1) | BRPI0614389A2 (da) |
| CA (1) | CA2617269A1 (da) |
| CY (1) | CY1114638T1 (da) |
| DK (1) | DK1922073T3 (da) |
| ES (1) | ES2430288T3 (da) |
| IL (1) | IL188941A0 (da) |
| NO (1) | NO20081111L (da) |
| PL (1) | PL1922073T3 (da) |
| PT (1) | PT1922073E (da) |
| RS (1) | RS52998B (da) |
| SI (1) | SI1922073T1 (da) |
| WO (1) | WO2007018640A1 (da) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| CA2534682C (en) * | 2003-08-18 | 2013-02-26 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| EP1670474A4 (en) * | 2003-08-18 | 2008-08-06 | Parion Sciences Inc | BLOCKERS OF THE PYRAZINOYL-GUANIDINE SODIUM CHANNEL |
| US7745442B2 (en) * | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| JP2008510708A (ja) | 2004-08-18 | 2008-04-10 | マイケル・アール・ジョンソン | 環式アミド及びエステルピラジノイルグアニジンナトリウムチャネル遮断薬 |
| EP1786427A4 (en) * | 2004-08-18 | 2009-11-11 | Michael R Johnson | BLOCKERS OF SODIUM CHANNELS OF PYRAZINOYLGUANIDINE WITH AMIDE AND ALIPHATIC ESTER |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US7807834B2 (en) * | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| WO2007146867A2 (en) * | 2006-06-09 | 2007-12-21 | Parion Sciences Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity |
| DK2035004T3 (en) * | 2006-06-09 | 2013-01-02 | Parion Sciences Inc | Phenylsubstituerede pyrazinoylguanidin-natriumkanalblokkere med beta-agonistaktivitet |
| MX2009002602A (es) * | 2006-09-07 | 2009-05-28 | Parion Sciences Inc | Metodos para aumentar la hidratacion mucosa y el despeje mucoso mediante tratamiento con bloqueadores de canal de sodio y osmolitos. |
| AR062742A1 (es) * | 2006-09-07 | 2008-12-03 | Johnson Michael R | Hidratacion de la mucosa y depuracion de la mucosa aumentadas por tratamiento con bloquadores de canales de sodio y osmolitos |
| WO2008124491A1 (en) * | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use taste modulators |
| WO2008124496A1 (en) * | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders |
| WO2009049159A1 (en) | 2007-10-10 | 2009-04-16 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| TWI432198B (zh) * | 2008-02-26 | 2014-04-01 | Parion Sciences Inc | 多芳香族鈉通道阻斷劑 |
| US20100074881A1 (en) * | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
| AR081377A1 (es) | 2010-05-10 | 2012-08-29 | Gilead Sciences Inc | Compuestos de pirazolopiridina bifuncionales |
| NZ603136A (en) | 2010-05-10 | 2014-11-28 | Gilead Sciences Inc | Bifunctional quinoline derivatives |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| EP2717855A4 (en) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | PROCESSING METHODS |
| SI2723176T1 (sl) | 2011-06-27 | 2017-09-29 | Parion Sciences, Inc. | Kemijsko in metabolno stabilni dipeptid, ki ima močno aktivnost blokiranja natrijevega kanala |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| EP2830338A4 (en) * | 2012-03-23 | 2015-12-30 | Nec Corp | SUBSCRIBER SERVER, MONITOR SERVER, MOBILE TERMINAL, ASSOCIATED METHOD AND COMPUTER READABLE MEDIUM |
| LT2855435T (lt) | 2012-05-29 | 2018-09-10 | Parion Sciences, Inc. | Amino amidai, panašūs į dendrimerus, su natrio kanalų blokavimo aktyvumu, skirti gydyti sausų akių sindromą ir kitas gleivinių ligas |
| WO2014099673A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| US9593084B2 (en) | 2012-12-17 | 2017-03-14 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity |
| EP3022196B1 (en) | 2013-07-15 | 2017-09-06 | Boehringer Ingelheim International GmbH | Novel benzimidazolium compounds |
| JP6461133B2 (ja) * | 2013-07-15 | 2019-01-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規4置換及び5置換ベンゾイミダゾリウム化合物 |
| KR20160045863A (ko) | 2013-08-23 | 2016-04-27 | 패리온 사이언스 인코퍼레이티드 | 디티올 점액 용해제 |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
| CN112321472A (zh) | 2015-01-30 | 2021-02-05 | 帕里昂科学公司 | 新型单硫醇粘液溶解剂 |
| JP2018520986A (ja) | 2015-04-30 | 2018-08-02 | パリオン・サイエンシィズ・インコーポレーテッド | ジチオール粘液溶解剤の新規なプロドラッグ |
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
| KR102788081B1 (ko) | 2022-10-31 | 2025-03-31 | 한국과학기술연구원 | 가변 구조형 로봇 손바닥을 갖는 로봇 핸드 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894376A (en) * | 1988-02-26 | 1990-01-16 | Trustees Of The University Of Pennsylvania | Methods of treating diseases characterized by hyperexcitability of neurons |
| US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6858614B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| CA2534682C (en) | 2003-08-18 | 2013-02-26 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| EP1670474A4 (en) | 2003-08-18 | 2008-08-06 | Parion Sciences Inc | BLOCKERS OF THE PYRAZINOYL-GUANIDINE SODIUM CHANNEL |
| CA2534568A1 (en) * | 2003-08-18 | 2005-03-24 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| US20090253714A1 (en) | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
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-
2005
- 2005-08-03 US US11/195,758 patent/US7807834B2/en not_active Expired - Fee Related
-
2006
- 2006-04-27 EP EP06751598.1A patent/EP1922073B1/en active Active
- 2006-04-27 JP JP2008524957A patent/JP5225085B2/ja not_active Expired - Fee Related
- 2006-04-27 BR BRPI0614389-0A patent/BRPI0614389A2/pt not_active IP Right Cessation
- 2006-04-27 RS RS20130441A patent/RS52998B/sr unknown
- 2006-04-27 SI SI200631660T patent/SI1922073T1/sl unknown
- 2006-04-27 PT PT67515981T patent/PT1922073E/pt unknown
- 2006-04-27 WO PCT/US2006/015957 patent/WO2007018640A1/en not_active Ceased
- 2006-04-27 KR KR1020087002867A patent/KR20080043773A/ko not_active Withdrawn
- 2006-04-27 PL PL06751598T patent/PL1922073T3/pl unknown
- 2006-04-27 DK DK06751598.1T patent/DK1922073T3/da active
- 2006-04-27 ES ES06751598T patent/ES2430288T3/es active Active
- 2006-04-27 AU AU2006276978A patent/AU2006276978B2/en not_active Ceased
- 2006-04-27 CA CA002617269A patent/CA2617269A1/en not_active Abandoned
-
2008
- 2008-01-22 IL IL188941A patent/IL188941A0/en unknown
- 2008-03-03 NO NO20081111A patent/NO20081111L/no not_active Application Discontinuation
-
2010
- 2010-09-07 US US12/876,615 patent/US8211895B2/en not_active Expired - Fee Related
-
2012
- 2012-05-09 US US13/467,618 patent/US8507497B2/en not_active Expired - Fee Related
- 2012-07-30 JP JP2012168186A patent/JP2012211188A/ja active Pending
-
2013
- 2013-10-08 CY CY20131100870T patent/CY1114638T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1114638T1 (el) | 2016-10-05 |
| CA2617269A1 (en) | 2007-02-15 |
| US20120220606A1 (en) | 2012-08-30 |
| PL1922073T3 (pl) | 2013-12-31 |
| JP5225085B2 (ja) | 2013-07-03 |
| RS52998B (sr) | 2014-02-28 |
| NO20081111L (no) | 2008-04-01 |
| AU2006276978A1 (en) | 2007-02-15 |
| JP2009503067A (ja) | 2009-01-29 |
| WO2007018640A1 (en) | 2007-02-15 |
| JP2012211188A (ja) | 2012-11-01 |
| IL188941A0 (en) | 2008-04-13 |
| KR20080043773A (ko) | 2008-05-19 |
| PT1922073E (pt) | 2013-10-16 |
| AU2006276978B2 (en) | 2011-12-01 |
| US7807834B2 (en) | 2010-10-05 |
| BRPI0614389A2 (pt) | 2011-03-22 |
| EP1922073A1 (en) | 2008-05-21 |
| ES2430288T3 (es) | 2013-11-19 |
| SI1922073T1 (sl) | 2013-11-29 |
| US8211895B2 (en) | 2012-07-03 |
| HK1112853A1 (en) | 2008-09-19 |
| EP1922073B1 (en) | 2013-07-10 |
| US8507497B2 (en) | 2013-08-13 |
| EP1922073A4 (en) | 2010-07-07 |
| US20110003832A1 (en) | 2011-01-06 |
| US20070032509A1 (en) | 2007-02-08 |
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