DK1998748T3 - Forbedret snustobaksammensætning - Google Patents
Forbedret snustobaksammensætning Download PDFInfo
- Publication number
- DK1998748T3 DK1998748T3 DK07723323T DK07723323T DK1998748T3 DK 1998748 T3 DK1998748 T3 DK 1998748T3 DK 07723323 T DK07723323 T DK 07723323T DK 07723323 T DK07723323 T DK 07723323T DK 1998748 T3 DK1998748 T3 DK 1998748T3
- Authority
- DK
- Denmark
- Prior art keywords
- nicotine
- cellulose
- composition
- snuff
- use according
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (30)
1
1. Anvendelse af en nicotin-cellulose-kombination til fremstilling af en snustobaksammensætning til opnåelse af en hurtig indtræden af virkning af nicotin efter anbringelse af snustobaksammensætningen i mundhulen hos et individ, hvor i) nicotin-cellulose-kombinationen er et fast materiale sammensat af mikrokry-stallinsk cellulose, som har absorberet nicotinet i hulrum eller porer i den mikro-krystallinske cellulose, ii) koncentrationen af nicotin-cellulose-kombinationen i sammensætningen er fra 80 til 98% vægt/vægt, iii) koncentrationen af nicotin i sammensætningen er fra 0,1 til 10% vægt/-vægt, og iv) sammensætningen, når den underkastes en in vitro-opløsningstest, 30% eller mere af det samlede indhold af nicotin frigives inden for 30 minutter, og in vitro-opløsningstesten er i overensstemmelse med den fremgangsmåde, som er beskrevet heri under overskriften "In vitro dissolution test" (In vitro-opløsningstest), underoverskrift "Snuff" (Snustobak).
2. Anvendelse ifølge krav 1, hvor sammensætningen har en høj frigivelseshastighed, således at 45% eller mere af det samlede indhold af nicotin frigives inden for 30 minutter, når sammensætningen underkastes in vitro-opløsningstesten.
3. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor nicotin-cellulose-kombinationen er indesluttet i et membranmateriale.
4. Anvendelse ifølge krav 3, hvor membranen er en naturlig, syntetisk, halvsyntetisk hydrofil eller hydrofob membran. 2
5. Anvendelse ifølge krav 3 eller 4, hvor membranen er fremstillet af et eller flere biokompatible og fysiologisk acceptable polymere materialer.
6. Anvendelse ifølge et hvilket som helst af kravene 3-5, hvor membranmaterialet er valgt fra gruppen bestående af celluloseacetat, carboxymethylcellulose, polycelluloseester, ethylcellulose, propylcellulose, polyethylen, polypropylen, polystyren, polyvinylchlorid, polyvinyl acetat, polymerer af methacrylater og acry-later, naturgummi, polycarbonat, polyethylenterephthalat, polyester, polyamid og nylon.
7. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor nicotinet er nicotin (fri base) eller et farmaceutisk acceptabelt salt, solvat eller kompleks.
8. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor 50% eller mere, såsom 60% eller mere, 70% eller mere eller 75% eller mere af det samlede indhold af nicotin frigives inden for 30 minutter, når sammensætningen underkastes in vitro-opløsningstesten.
9. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor sammensætningen - når den underkastes in vitro-opløsningstesten - frigiver 45% eller mere, såsom 50% eller mere, inden for 20 minutter.
10. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor sammensætningen - når den underkastes in vitro-opløsningstesten - frigiver 20% eller mere, såsom 25% eller mere, inden for 10 minutter.
11. Anvendelse ifølge et hvilket som helst af de foregående krav til bukkal administration.
12. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor den mi-krokrystallinske cellulose i nicotin-cellulose-kombinationen omfatter indre hulrum og/eller porer. 3
13. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor den mi-krokrystallinske cellulose er en cellulose, som stammer fra en plante, en alge, en bakterie, en svamp eller kombinationer deraf.
14. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor den mi-krokrystallinske cellulose har et overfladeareal på mindst 0,7 m2/g.
15. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor den mi-krokrystallinske cellulose er syntetiske eller halvsyntetiske celluloser eller er afledt af naturlige celluloser.
16. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor den gennemsnitlige partikelstørrelse i den mikrokrystallinske cellulose ligger i intervallet fra 15 til 250 μιτι.
17. Anvendelse ifølge krav 15, hvor den gennemsnitlige partikelstørrelse i den mikrokrystallinske cellulose er højst 500 pm.
18. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor nicotin forefindes i sammensætningen i en koncentration på fra 0,1 til 8% vægt/vægt, såsom fra 0,1 til 6% vægt/vægt, fra 0,1 til 4% vægt/vægt, fra 0,1 til 2% vægt/-vægt, fra 0,1 til 1,5% vægt/vægt, fra 0,2 til 1,0% vægt/vægt eller fra 0,2 til 0,8% vægt/vægt, beregnet som fri base.
19. Anvendelse ifølge et hvilket som helst af de foregående krav, hvor nicotin-cellulose-kombinationen forefindes i en koncentration på fra 85 til 98% vægt/-vægt, såsom fra 90 til 98% vægt/vægt, fra 92 til 98% vægt/vægt, fra 93 til 97% vægt/vægt eller fra 94 til 96% vægt/vægt.
20. Snustobaksammensætning, som omfatter en nicotin-cellulose-kombination og en eller flere acceptable excipienser, hvor 4 i) nicotin-cellulose-kombinationen er et fast materiale sammensat af mikro-krystallinsk cellulose, som har absorberet nicotinet i hulrum eller porer i den mikrokrystallinske cellulose, ii) koncentrationen af nicotin-cellulose-kombinationen i sammensætningen er fra 80 til 98% vægt/vægt, iii) koncentrationen af nicotin i sammensætningen er fra 0,1 til 10% vægt/vægt, og iv) sammensætningen, når den underkastes en in vitro-opløsningstest, 30% eller mere af det samlede indhold af nicotin frigives inden for 30 minutter, og in vitro-opløsningstesten er i overensstemmelse med den fremgangsmåde, som er beskrevet heri under overskriften "In vitro dissolution test" (In vitro-opløsningstest), underoverskrift "Snuff" (Snustobak).
21. Snustobaksammensætning ifølge krav, hvor nicotinet er nicotin (fri base) eller et farmaceutisk acceptabelt salt, solvat eller kompleks.
22. Snustobaksammensætning ifølge krav 20 eller 21, hvor 50% eller mere af det samlede indhold af nicotin frigives inden for 30 minutter, når sammensætningen underkastes in vitro-opløsningstesten.
23. Snustobaksammensætning ifølge et hvilket som helst af kravene 20-22, hvor sammensætningen - når den underkastes in vitro-opløsningstesten - frigiver 20% eller mere inden for 10 minutter.
24. Snustobaksammensætning ifølge et hvilket som helst af kravene 20-23, hvor den mikrokrystallinske cellulose er en cellulose, som stammer fra en plante, en alge, en bakterie, en svamp eller kombinationer deraf.
25. Snustobaksammensætning ifølge et hvilket som helst af kravene 20-24, hvor den mikrokrystallinske cellulose har et overfladeareal på mindst 0,7 m2/g. 5
26. Snustobaksammensætning ifølge et hvilket som helst af kravene 20-25, hvor den mikrokrystallinske cellulose er syntetiske eller halvsyntetiske celluloser eller er afledt af naturlige celluloser.
27. Snustobaksammensætning ifølge et hvilket som helst af kravene 20-26, hvor den gennemsnitlige partikelstørrelse i den mikrokrystallinske cellulose er højst 500 pm.
28. Snustobaksammensætning ifølge et hvilket som helst af kravene 20-27, hvor nicotin forefindes i sammensætningen i en koncentration på fra 0,1 til 8% vægt/vægt, beregnet som fri base.
29. Snustobaksammensætning ifølge et hvilket som helst af kravene 20-28, hvor nicotin-cellulose-kombinationen forefindes i en koncentration på fra 85 til 98% vægt/vægt.
30. Snustobaksammensætning ifølge et hvilket som helst af kravene 20-29 til anvendelse i mundhulen for at opnå en hurtig indtræden af virkning af nicotin efter anbringelse af snustobaksammensætningen i mundhulen hos et individ.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78290306P | 2006-03-16 | 2006-03-16 | |
| US78297706P | 2006-03-16 | 2006-03-16 | |
| DKPA200600375 | 2006-03-16 | ||
| DKPA200600376 | 2006-03-16 | ||
| PCT/EP2007/002343 WO2007104573A2 (en) | 2006-03-16 | 2007-03-16 | Improved snuff composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1998748T3 true DK1998748T3 (da) | 2015-04-27 |
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ID=52683014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07723323T DK1998748T3 (da) | 2006-03-16 | 2007-03-16 | Forbedret snustobaksammensætning |
Country Status (2)
| Country | Link |
|---|---|
| DK (1) | DK1998748T3 (da) |
| ES (1) | ES2531974T3 (da) |
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2007
- 2007-03-16 DK DK07723323T patent/DK1998748T3/da active
- 2007-03-16 ES ES07723323.7T patent/ES2531974T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2531974T3 (es) | 2015-03-23 |
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