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DK1940366T3 - Blöde kapsler, der omfatter palonosetron-hydrochlorid, som har forbedret stabilitet og biotilgængelighed - Google Patents

Blöde kapsler, der omfatter palonosetron-hydrochlorid, som har forbedret stabilitet og biotilgængelighed

Info

Publication number
DK1940366T3
DK1940366T3 DK07819163T DK07819163T DK1940366T3 DK 1940366 T3 DK1940366 T3 DK 1940366T3 DK 07819163 T DK07819163 T DK 07819163T DK 07819163 T DK07819163 T DK 07819163T DK 1940366 T3 DK1940366 T3 DK 1940366T3
Authority
DK
Denmark
Prior art keywords
bioavailability
improved stability
soft capsules
palonosetron hydrochloride
palonosetron
Prior art date
Application number
DK07819163T
Other languages
English (en)
Inventor
Daniele Bonadeo
Giorgio Calderari
Enrico Braglia
Riccardo Braglia
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38921772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1940366(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Application granted granted Critical
Publication of DK1940366T3 publication Critical patent/DK1940366T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK07819163T 2006-10-24 2007-10-19 Blöde kapsler, der omfatter palonosetron-hydrochlorid, som har forbedret stabilitet og biotilgængelighed DK1940366T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85434206P 2006-10-24 2006-10-24
PCT/EP2007/009098 WO2008049552A1 (en) 2006-10-24 2007-10-19 Soft capsules comprising palonosetron hydrochloride having improved stability and bioavailability

Publications (1)

Publication Number Publication Date
DK1940366T3 true DK1940366T3 (da) 2009-06-29

Family

ID=38921772

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07819163T DK1940366T3 (da) 2006-10-24 2007-10-19 Blöde kapsler, der omfatter palonosetron-hydrochlorid, som har forbedret stabilitet og biotilgængelighed

Country Status (35)

Country Link
US (2) US20080152704A1 (da)
EP (1) EP1940366B9 (da)
JP (1) JP5144527B2 (da)
KR (1) KR101441459B1 (da)
CN (1) CN101573106B (da)
AR (1) AR063362A1 (da)
AT (1) ATE427742T1 (da)
AU (1) AU2007308378B2 (da)
BR (1) BRPI0718497B1 (da)
CA (1) CA2666512C (da)
CL (1) CL2007003055A1 (da)
CO (1) CO6160289A2 (da)
CR (1) CR10728A (da)
CY (1) CY1109914T1 (da)
DE (1) DE602007000856D1 (da)
DK (1) DK1940366T3 (da)
EA (1) EA016455B1 (da)
ES (1) ES2325339T3 (da)
GT (1) GT200900096A (da)
HN (1) HN2009000785A (da)
HR (1) HRP20090341T1 (da)
IL (1) IL198225A (da)
ME (1) ME01949B (da)
MX (1) MX2009004461A (da)
NO (1) NO342353B1 (da)
NZ (1) NZ576237A (da)
PL (1) PL1940366T3 (da)
PT (1) PT1940366E (da)
RS (1) RS50842B (da)
SI (1) SI1940366T1 (da)
SV (1) SV2009003238A (da)
TW (1) TWI367212B (da)
UA (1) UA97653C2 (da)
WO (1) WO2008049552A1 (da)
ZA (1) ZA200902773B (da)

Families Citing this family (24)

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NZ569984A (en) * 2006-01-27 2011-06-30 Eurand Inc Drug delivery systems comprising weakly basic drugs and organic acids
CA2640460C (en) * 2006-01-27 2015-05-26 Eurand, Inc Drug delivery systems comprising weakly basic selective serotonin 5-ht3 blocking agent and organic acids
WO2010077669A2 (en) 2008-12-08 2010-07-08 Teva Pharmaceutical Industries Ltd. Palonosetron formulation
US20110003005A1 (en) * 2009-07-06 2011-01-06 Gopi Venkatesh Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions
CN102048705B (zh) * 2009-11-10 2012-07-18 齐鲁制药有限公司 盐酸帕洛诺司琼口腔崩解片制剂及其制备方法
US20120253046A1 (en) * 2009-11-13 2012-10-04 Helsinn Healthcare S.A. Palonosetron metabolites
EP2722045B1 (en) 2009-11-18 2016-07-06 Helsinn Healthcare SA Compositions for treating centrally mediated nausea and vomiting
CN107050455B (zh) 2009-11-18 2020-09-29 赫尔森保健股份公司 用于治疗中枢介导的恶心及呕吐的组合物及方法
HUE030811T2 (hu) 2011-10-18 2017-05-29 Helsinn Healthcare Sa Netupitant és palonosetron terápiás kombinációi
CN103446072A (zh) * 2012-06-02 2013-12-18 正大天晴药业集团股份有限公司 帕洛诺司琼的固体药物组合物
US20160287524A1 (en) * 2013-03-19 2016-10-06 Galenicum Health S.L. Pharmaceutical compositions comprising an active agent
WO2015023675A2 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9877959B2 (en) 2013-12-23 2018-01-30 Samyang Biopharmaceuticals Corporation Pharmaceutical composition containing palonosetron
EP3169315B1 (en) 2014-07-17 2020-06-24 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
EP3209282A4 (en) 2014-10-20 2018-05-23 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
KR20160128573A (ko) * 2015-04-29 2016-11-08 주식회사 삼양바이오팜 약제학적 패키지
JP2019019067A (ja) * 2017-07-13 2019-02-07 ニプロ株式会社 液体製剤
CN111205283A (zh) * 2020-01-20 2020-05-29 广州九植医药科技有限公司 一种盐酸帕洛诺司琼有关物质b的合成方法
EP4385500A1 (en) 2022-12-12 2024-06-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Fixed dose combination comprising netupitant and palonosetron
EP4633608A1 (en) 2022-12-12 2025-10-22 Alfred E. Tiefenbacher (GmbH & Co. KG) Antioxidant-free fixed dose combination of netupitant and palonosetron
EP4385497A1 (en) 2022-12-12 2024-06-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Antioxidant-free fixed dose combination of netupitant and palonosetron
CN120693151A (zh) 2022-12-12 2025-09-23 阿尔弗雷德.E.蒂芬巴赫尔有限责任两合公司 包括奈妥匹坦和帕洛诺司琼的固定剂量组合

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GB1015251A (en) * 1963-03-12 1965-12-31 Glaxo Lab Ltd Aqueous pharmaceutical compositions in capsule form
US4182914A (en) * 1974-01-22 1980-01-08 Nippon Oil Company Limited Process for continuously producing diisopropyl ether
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
US4937247A (en) * 1985-04-27 1990-06-26 Beecham Group P.L.C. 1-acyl indazoles
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US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
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US5011846A (en) * 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
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US5344658A (en) * 1989-06-28 1994-09-06 Glaxo Group Limited Process and composition using ondansetron
ZA909529B (en) * 1989-11-28 1992-08-26 Syntex Inc New tricyclic compounds
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US20030095926A1 (en) * 1997-10-01 2003-05-22 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract
US20040136914A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US6294548B1 (en) * 1998-05-04 2001-09-25 Hoffmann-La Roche Inc. Multidose vial formulations for administering endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride
FR2818905A1 (fr) * 2000-12-28 2002-07-05 Cll Pharma Compositions pharmaceutiques colloidales micellaires renfermant un principe actif lipophile
FR2823118B1 (fr) * 2001-04-04 2004-03-19 Lavipharm Lab Inc Nouvelle composition filmogene a usage topique et son utilisation pour la delivrance d'agents actifs
FR2827770B1 (fr) * 2001-07-27 2005-08-19 Gattefosse Ets Sa Composition pharmaceutique a usage oral comprenant un principe actif susceptible de subir un important effet de premier passage intestinal
CA2505990C (en) 2002-11-15 2009-05-19 Helsinn Healthcare S.A. Palonosetron for the treatment of chemotherapy-induced emesis
MY143789A (en) * 2003-02-18 2011-07-15 Helsinn Healthcare Sa Use of palonosetron treating post- operative nausea and vomiting
IL159729A0 (en) * 2004-01-06 2004-06-20 Doron I Friedman Non-aqueous composition for oral delivery of insoluble bioactive agents

Also Published As

Publication number Publication date
MX2009004461A (es) 2009-09-16
RS50842B (sr) 2010-08-31
IL198225A0 (en) 2009-12-24
EP1940366B1 (en) 2009-04-08
SI1940366T1 (sl) 2009-08-31
NO20091945L (no) 2009-05-25
KR20090073234A (ko) 2009-07-02
HK1117769A1 (en) 2009-01-23
HN2009000785A (es) 2011-10-14
ES2325339T3 (es) 2009-09-01
WO2008049552A1 (en) 2008-05-02
EP1940366A1 (en) 2008-07-09
NO342353B1 (no) 2018-05-07
HRP20090341T1 (hr) 2009-07-31
CA2666512A1 (en) 2008-05-02
PL1940366T3 (pl) 2009-09-30
EA016455B1 (ru) 2012-05-30
CY1109914T1 (el) 2014-09-10
CA2666512C (en) 2014-05-27
US20170035748A1 (en) 2017-02-09
PT1940366E (pt) 2009-06-17
AU2007308378B2 (en) 2013-02-21
US20080152704A1 (en) 2008-06-26
TW200827355A (en) 2008-07-01
BRPI0718497B1 (pt) 2024-02-06
JP5144527B2 (ja) 2013-02-13
EA200970396A1 (ru) 2009-10-30
NZ576237A (en) 2011-12-22
GT200900096A (es) 2011-08-29
UA97653C2 (ru) 2012-03-12
IL198225A (en) 2013-03-24
EP1940366B9 (en) 2009-12-02
TWI367212B (en) 2012-07-01
CN101573106B (zh) 2013-07-24
AU2007308378A1 (en) 2008-05-02
AR063362A1 (es) 2009-01-21
ZA200902773B (en) 2010-03-31
KR101441459B1 (ko) 2014-09-18
ME01949B (me) 2010-08-31
CL2007003055A1 (es) 2008-03-24
SV2009003238A (es) 2009-11-09
CR10728A (es) 2009-07-23
BRPI0718497A2 (pt) 2014-07-08
ATE427742T1 (de) 2009-04-15
CN101573106A (zh) 2009-11-04
CO6160289A2 (es) 2010-05-20
JP2009507933A (ja) 2009-02-26
DE602007000856D1 (de) 2009-05-20

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