DK1824856T3 - 2,4 (4,6)-pyrimidinderivater - Google Patents

2,4 (4,6)-pyrimidinderivater

Info

Publication number: DK1824856T3
Authority: DK; Denmark
Prior art keywords: pyrimidine derivatives; pyrimidine; derivatives
Prior art date: 2004-12-08

Application number

DK05819148.7T

Other languages

English (en)

Inventor

Eddy Jean E Freyne

Marc Willems

Werner C J Embrechts

Emelen Kristof Van

Brandt Sven F A Van

Frederik J R Rombouts

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-08

Filing date

2005-12-08

Publication date

2014-01-27

2005-12-08 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2014-01-27 Application granted granted Critical

2014-01-27 Publication of DK1824856T3 publication Critical patent/DK1824856T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

DK05819148.7T 2004-12-08 2005-12-08 2,4 (4,6)-pyrimidinderivater DK1824856T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US63429104P	2004-12-08	2004-12-08
EP04106384		2004-12-08
PCT/EP2005/056606 WO2006061415A1 (en)	2004-12-08	2005-12-08	2,4 (4,6) pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
DK1824856T3 true DK1824856T3 (da)	2014-01-27

Family

ID=34930016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05819148.7T DK1824856T3 (da)	2004-12-08	2005-12-08	2,4 (4,6)-pyrimidinderivater

Country Status (22)

Country	Link
US (2)	US8148388B2 (da)
EP (1)	EP1824856B1 (da)
JP (1)	JP5022909B2 (da)
KR (1)	KR101428506B1 (da)
CN (1)	CN101072779B (da)
AR (1)	AR051788A1 (da)
AU (1)	AU2005313348B2 (da)
BR (1)	BRPI0518424B8 (da)
CA (1)	CA2588761C (da)
CR (1)	CR9234A (da)
DK (1)	DK1824856T3 (da)
EA (1)	EA013368B1 (da)
ES (1)	ES2442458T3 (da)
IL (1)	IL183706A0 (da)
MX (1)	MX2007006821A (da)
MY (1)	MY169441A (da)
NO (1)	NO340130B1 (da)
NZ (1)	NZ554820A (da)
TW (1)	TWI374140B (da)
UA (1)	UA90693C2 (da)
WO (1)	WO2006061415A1 (da)
ZA (1)	ZA200705040B (da)

Families Citing this family (38)

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NZ547794A (en)	2003-12-18	2009-11-27	Janssen Pharmaceutica Nv	Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents
ES2442857T3 (es) *	2004-08-10	2014-02-13	Janssen Pharmaceutica Nv	Derivados de 1,2,4-triazin-6-ona inhibidores de VIH
JO3088B1 (ar) *	2004-12-08	2017-03-15	Janssen Pharmaceutica Nv	مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
NI200700147A (es)	2004-12-08	2019-05-10	Janssen Pharmaceutica Nv	Derivados de quinazolina inhibidores de cinasas dirigidos a multip
US8143255B2 (en) *	2005-11-16	2012-03-27	S*Bio Pte Ltd.	Heteroalkyl linked pyrimidine derivatives
EP2044084B1 (en)	2006-07-13	2016-02-17	Janssen Pharmaceutica NV	Mtki quinazoline derivatives
WO2008060248A1 (en) *	2006-11-15	2008-05-22	S*Bio Pte Ltd.	Indole sustituted pyrimidines and use thereof in the treatment of cancer
EP2185562B1 (en)	2007-07-27	2015-12-02	Janssen Pharmaceutica, N.V.	Pyrrolopyrimidines useful for the treatment of proliferative diseases
US7989465B2 (en)	2007-10-19	2011-08-02	Avila Therapeutics, Inc.	4,6-disubstituted pyrimidines useful as kinase inhibitors
EP2214486A4 (en)	2007-10-19	2011-03-09	Avila Therapeutics Inc	HETEROARYL COMPOUNDS AND ITS USES
CA2716079C (en) *	2008-03-10	2018-01-16	Janssen Pharmaceutica Nv	4-aryl-2-anilino-pyrimidines as plk kinase inhibitors
US8871753B2 (en)	2008-04-24	2014-10-28	Incyte Corporation	Macrocyclic compounds and their use as kinase inhibitors
US11351168B1 (en)	2008-06-27	2022-06-07	Celgene Car Llc	2,4-disubstituted pyrimidines useful as kinase inhibitors
US8338439B2 (en)	2008-06-27	2012-12-25	Celgene Avilomics Research, Inc.	2,4-disubstituted pyrimidines useful as kinase inhibitors
MX2011002470A (es) *	2008-09-08	2011-04-05	Merck Patent Gmbh	Pirimidinas macrociclicas como inhibidores de aurora cinasa.
US8765727B2 (en)	2009-01-23	2014-07-01	Incyte Corporation	Macrocyclic compounds and their use as kinase inhibitors
JP2012197231A (ja) *	2009-08-06	2012-10-18	Oncotherapy Science Ltd	Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体
RU2528386C2 (ru)	2010-05-21	2014-09-20	Кемилиа Аб	Новые производные пиримидина
TWI545115B (zh)	2010-11-01	2016-08-11	阿維拉製藥公司	雜環化合物及其用途
JP6000273B2 (ja) *	2010-11-29	2016-09-28	オーエスアイ・ファーマシューティカルズ，エルエルシー	大環状キナーゼ阻害剤
DK2688883T3 (da)	2011-03-24	2016-09-05	Noviga Res Ab	Pyrimidinderivater
US9108927B2 (en)	2012-03-15	2015-08-18	Celgene Avilomics Research, Inc.	Salts of an epidermal growth factor receptor kinase inhibitor
US9056839B2 (en)	2012-03-15	2015-06-16	Celgene Avilomics Research, Inc.	Solid forms of an epidermal growth factor receptor kinase inhibitor
CA2911259A1 (en) *	2013-05-06	2014-11-13	Merck Patent Gmbh	Macrocycles as kinase inhibitors
MA39823A (fr)	2014-04-03	2018-01-09	Janssen Pharmaceutica Nv	Dérivés de pyridine macrocyclique
MA39822A (fr)	2014-04-03	2018-02-06	Janssen Pharmaceutica Nv	Dérivés de pyrimidine bicycle
EP3253764B1 (en) *	2015-02-05	2021-06-09	Merck Patent GmbH	Macrocyclic compounds as irak1/4 inhibitors and uses thereof
CA3057891A1 (en) *	2017-03-28	2018-10-04	Bayer Aktiengesellschaft	Novel ptefb inhibiting macrocyclic compounds
US11254690B2 (en)	2017-03-28	2022-02-22	Bayer Pharma Aktiengesellschaft	PTEFb inhibiting macrocyclic compounds
EP3983340B1 (en) *	2019-06-12	2023-08-02	Nouryon Chemicals International B.V.	Method for isolating carboxylic acid from an aqueous side stream
HUE063678T2 (hu)	2019-06-12	2024-01-28	Nouryon Chemicals Int Bv	Eljárás peroxiészterek elõállítására
EP3983370B1 (en)	2019-06-12	2023-08-02	Nouryon Chemicals International B.V.	Process for the production of diacyl peroxides
WO2020249688A1 (en)	2019-06-12	2020-12-17	Nouryon Chemicals International B.V.	Process for the production of diacyl peroxides
US12209065B2 (en)	2019-06-12	2025-01-28	Nouryon Chemicals International B.V.	Process for the production of diacyl peroxides
EP4103183A4 (en) *	2020-02-14	2024-02-28	Salk Institute for Biological Studies	Macrocyclic ulk1/2 inhibitors
CN113549113A (zh) *	2020-06-17	2021-10-26	广州百霆医药科技有限公司	一种含膦大环化合物及其制备方法与应用
CA3250447A1 (en) *	2021-12-15	2025-07-09	Whan In Pharmaceutical Co., Ltd.	MACROCYCLIC PYRIMIDINE DERIVATIVE, ITS PREPARATION PROCESS, AND PHARMACEUTICAL COMPOSITION INTENDED FOR THE PREVENTION OR TREATMENT OF A NEURODEGENERATIVE DISEASE AND CONTAINING THIS DERIVATIVE AS AN ACTIVE INGREDIENT
KR102613509B1 (ko) *	2021-12-15	2023-12-13	환인제약 주식회사	마크로사이클릭 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 신경 퇴행성 질환의 예방 또는 치료용 약학적 조성물

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Publication number	Priority date	Publication date	Assignee	Title
JP2002523497A (ja) *	1998-08-29	2002-07-30	アストラゼネカ・アクチエボラーグ	ピリミジン化合物
GB9828511D0 (en) *	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
GB0004890D0 (en) *	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
GB0206215D0 (en) *	2002-03-15	2002-05-01	Novartis Ag	Organic compounds
BR0313059B8 (pt) *	2002-07-29	2021-07-27	Rigel Pharmaceuticals	composto, e, composição farmacêutica
DE10239042A1 (de)	2002-08-21	2004-03-04	Schering Ag	Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
PA8603801A1 (es)	2003-05-27	2004-12-16	Janssen Pharmaceutica Nv	Derivados de la quinazolina
KR101158440B1 (ko)	2003-12-18	2012-07-06	얀센 파마슈티카 엔.브이.	항증식활성을 지닌 3-시아노-퀴놀린 유도체
NZ547794A (en)	2003-12-18	2009-11-27	Janssen Pharmaceutica Nv	Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents

2005
- 2005-12-06 MY MYPI20055703A patent/MY169441A/en unknown
- 2005-12-07 TW TW094143059A patent/TWI374140B/zh active
- 2005-12-07 AR ARP050105123A patent/AR051788A1/es unknown
- 2005-12-08 WO PCT/EP2005/056606 patent/WO2006061415A1/en not_active Ceased
- 2005-12-08 JP JP2007544917A patent/JP5022909B2/ja not_active Expired - Lifetime
- 2005-12-08 CN CN2005800420717A patent/CN101072779B/zh not_active Expired - Lifetime
- 2005-12-08 UA UAA200705051A patent/UA90693C2/ru unknown
- 2005-12-08 NZ NZ554820A patent/NZ554820A/en unknown
- 2005-12-08 US US11/720,681 patent/US8148388B2/en active Active
- 2005-12-08 KR KR1020077011771A patent/KR101428506B1/ko not_active Expired - Lifetime
- 2005-12-08 EP EP05819148.7A patent/EP1824856B1/en not_active Expired - Lifetime
- 2005-12-08 EA EA200701245A patent/EA013368B1/ru not_active IP Right Cessation
- 2005-12-08 MX MX2007006821A patent/MX2007006821A/es active IP Right Grant
- 2005-12-08 CA CA2588761A patent/CA2588761C/en not_active Expired - Lifetime
- 2005-12-08 AU AU2005313348A patent/AU2005313348B2/en not_active Expired
- 2005-12-08 DK DK05819148.7T patent/DK1824856T3/da active
- 2005-12-08 BR BRPI0518424A patent/BRPI0518424B8/pt active IP Right Grant
- 2005-12-08 ES ES05819148.7T patent/ES2442458T3/es not_active Expired - Lifetime
2007
- 2007-06-06 IL IL183706A patent/IL183706A0/en active IP Right Grant
- 2007-06-07 ZA ZA200705040A patent/ZA200705040B/xx unknown
- 2007-07-06 CR CR9234A patent/CR9234A/es not_active Application Discontinuation
- 2007-07-09 NO NO20073492A patent/NO340130B1/no unknown
2011
- 2011-10-20 US US13/277,651 patent/US8394955B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
BRPI0518424B8 (pt)	2021-05-25
AU2005313348B2 (en)	2011-10-06
AU2005313348A1 (en)	2006-06-15
US20100160310A1 (en)	2010-06-24
CA2588761A1 (en)	2006-06-15
WO2006061415A1 (en)	2006-06-15
IL183706A0 (en)	2007-09-20
EA200701245A1 (ru)	2007-12-28
BRPI0518424A2 (pt)	2008-11-25
AR051788A1 (es)	2007-02-07
NO20073492L (no)	2007-07-09
US8394955B2 (en)	2013-03-12
CR9234A (es)	2008-09-09
BRPI0518424B1 (pt)	2020-10-13
EP1824856A1 (en)	2007-08-29
ZA200705040B (en)	2008-09-25
US20120065395A1 (en)	2012-03-15
MX2007006821A (es)	2007-07-24
CN101072779A (zh)	2007-11-14
CN101072779B (zh)	2010-12-22
EP1824856B1 (en)	2013-10-23
ES2442458T3 (es)	2014-02-11
KR101428506B1 (ko)	2014-08-12
NO340130B1 (no)	2017-03-13
HK1112455A1 (en)	2008-09-05
NZ554820A (en)	2010-10-29
EA013368B1 (ru)	2010-04-30
TWI374140B (en)	2012-10-11
JP5022909B2 (ja)	2012-09-12
CA2588761C (en)	2015-04-21
MY169441A (en)	2019-04-11
KR20070085438A (ko)	2007-08-27
JP2008523033A (ja)	2008-07-03
US8148388B2 (en)	2012-04-03
TW200635931A (en)	2006-10-16
UA90693C2 (en)	2010-05-25

Publication	Publication Date	Title
DK1824856T3 (da)	2014-01-27	2,4 (4,6)-pyrimidinderivater
NL2000323A1 (nl)	2007-06-21	Pyrimidine-derivaten.
ZA200606974B (en)	2008-04-30	Substituted 1,2,3,4-tetrahydrolsoquinoline derivatives
MA28824B1 (fr)	2007-08-01	Derives de pyrimidine
DE602005022897D1 (de)	2010-09-23	Piperidinylamino-thienoä2,3-dü-pyrimidinverbindungen
IS8578A (is)	2006-12-08	3- karbamoýl - 2- pýridón afleiður
MA28813B1 (fr)	2007-08-01	Derives de pyrimidine
EP1724267A4 (en)	2009-04-22	pyrimidine derivative
ATE394399T1 (de)	2008-05-15	Tetrahydropyridoindolderivate
ATE540935T1 (de)	2012-01-15	Chinazolinderivate
ATE383361T1 (de)	2008-01-15	Pyrrazolopyrimidinderivate
ATE506362T1 (de)	2011-05-15	1-aza-bicycloä3.3.1ünonane
ATE417830T1 (de)	2009-01-15	Sulfonylbenzimidazolderivate
ATE487718T1 (de)	2010-11-15	Substituierte bizyklische pyrimidonderivate
DE602004007387D1 (de)	2007-08-16	5-substituierte chinazolinonderivate
ATE430142T1 (de)	2009-05-15	Phenylpiperazin-methanon-derivate
ATE404542T1 (de)	2008-08-15	4-phenylpyrimidin-2-carbonitrilderivate
IS8015A (is)	2005-09-08	6-útskipt imídasópýrasín
DK1740574T3 (da)	2007-10-15	4-amino-5-cyanopyrimidinderivater
NL1030010A1 (nl)	2006-03-27	4-Amino-gesubstitueerde-2-gesubstitueerde-1,2,3,4- tetrahydrochinolineverbindingen.
ATE445604T1 (de)	2009-10-15	Neue 2,6-diaminopyridin-3-on-derivate
EP1799223A4 (en)	2008-01-23	ARYLTHIOBENZYLPIPERIDINE DERIVATIVES
EP1804796A4 (en)	2009-10-21	AMINO-SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES
ES1058958Y (es)	2005-06-16	Mastil perfeccionado.
EP1711189A4 (en)	2009-12-23	6,11-3C-BICYCLIC 8A-AZALID DERIVATIVES