MA39822A - Dérivés de pyrimidine bicycle - Google Patents
Dérivés de pyrimidine bicycleInfo
- Publication number
- MA39822A MA39822A MA039822A MA39822A MA39822A MA 39822 A MA39822 A MA 39822A MA 039822 A MA039822 A MA 039822A MA 39822 A MA39822 A MA 39822A MA 39822 A MA39822 A MA 39822A
- Authority
- MA
- Morocco
- Prior art keywords
- bicycle
- pyrimidine derivatives
- pyrimidine
- derivatives
- bicycle pyrimidine
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14163443 | 2014-04-03 | ||
| EP14183747 | 2014-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA39822A true MA39822A (fr) | 2018-02-06 |
Family
ID=52781117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA039822A MA39822A (fr) | 2014-04-03 | 2015-04-01 | Dérivés de pyrimidine bicycle |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10017509B2 (fr) |
| EP (1) | EP3126364B1 (fr) |
| JP (1) | JP6529513B2 (fr) |
| KR (1) | KR102390276B1 (fr) |
| CN (2) | CN114213415A (fr) |
| AU (1) | AU2015239098B2 (fr) |
| BR (1) | BR112016021982B1 (fr) |
| CA (1) | CA2942636C (fr) |
| CL (1) | CL2016002461A1 (fr) |
| EA (1) | EA031246B1 (fr) |
| ES (1) | ES2667723T3 (fr) |
| IL (1) | IL248005B (fr) |
| MA (1) | MA39822A (fr) |
| MX (1) | MX369798B (fr) |
| MY (1) | MY185491A (fr) |
| NZ (1) | NZ725399A (fr) |
| PE (1) | PE20161362A1 (fr) |
| PH (1) | PH12016501963A1 (fr) |
| SG (1) | SG11201608240RA (fr) |
| UA (1) | UA118219C2 (fr) |
| WO (1) | WO2015150555A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017140841A1 (fr) | 2016-02-19 | 2017-08-24 | Sprint Bioscience Ab | Composés 6-aryl-4-morpholin-1-yl-pyridone utilisés pour le traitement du cancer et du diabète |
| SMT202000529T1 (it) | 2016-02-19 | 2020-11-10 | Sprint Bioscience Ab | Composti di 6-eterociclil-4-morfolina-4-ilpiridin-2-one utili per il trattamento di cancro e diabete |
| ES2900199T3 (es) | 2017-03-28 | 2022-03-16 | Bayer Ag | Novedosos compuestos macrocíclicos inhibidores de PTEFB |
| US11242356B2 (en) | 2017-03-28 | 2022-02-08 | Bayer Aktiengesellschaft | PTEFb inhibiting macrocyclic compounds |
| PT3672967T (pt) | 2017-08-23 | 2021-12-28 | Sprint Bioscience Ab | Compostos de azaindolilpiridona e diazaindolilpiridona |
| CN111094244B (zh) | 2017-08-23 | 2023-07-11 | 思普瑞特生物科学公司 | 吡啶基吡啶酮化合物 |
| DK3672948T3 (da) | 2017-08-23 | 2022-12-05 | Sprint Bioscience Ab | Pyridinamin-pyridon- og pyrimidinamin-pyridonforbindelser |
| JP7199736B2 (ja) | 2017-08-23 | 2023-01-06 | スプリント バイオサイエンス アクティエボラーグ | モルホリニルピリドン化合物 |
| MX2022010128A (es) * | 2020-02-18 | 2023-01-04 | Theseus Pharmaceuticals Inc | Compuestos macrocíclicos y usos de estos. |
| CN116535365A (zh) * | 2020-04-07 | 2023-08-04 | Iteos比利时公司 | 作为ent抑制剂用于治疗癌症的大环二胺衍生物以及其与腺苷受体拮抗剂的组合 |
| CN113735879B (zh) * | 2020-05-27 | 2022-05-17 | 百极弘烨(广东)医药科技有限公司 | 一种大环jak抑制剂及其应用 |
| CN113735856A (zh) * | 2020-05-29 | 2021-12-03 | 百极弘烨(南通)医药科技有限公司 | 大环jak抑制剂及其应用 |
| CN116113621A (zh) * | 2020-07-22 | 2023-05-12 | 弗格制药有限公司 | 氨基酸 |
| WO2023046030A1 (fr) * | 2021-09-23 | 2023-03-30 | 河南晟翔医药科技有限公司 | Inhibiteur à petite molécule egfr, composition pharmaceutique le contenant et son utilisation |
| KR102613509B1 (ko) * | 2021-12-15 | 2023-12-13 | 환인제약 주식회사 | 마크로사이클릭 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 신경 퇴행성 질환의 예방 또는 치료용 약학적 조성물 |
| CN117229300A (zh) * | 2023-03-12 | 2023-12-15 | 药雅科技(上海)有限公司 | Egfr抑制剂的制备及其应用 |
| WO2024078263A1 (fr) * | 2022-10-09 | 2024-04-18 | 药雅科技(上海)有限公司 | Préparation et utilisation d'un composé hétérocyclique macrocyclique en tant qu'inhibiteur d'egfr |
| WO2024094171A1 (fr) * | 2022-11-04 | 2024-05-10 | 江苏恒瑞医药股份有限公司 | Composé aminopyrimidine substitué, son procédé de préparation et son utilisation médicale |
| CN116478076A (zh) * | 2023-04-26 | 2023-07-25 | 南京优氟医药科技有限公司 | 一种(2s,4s)-1-叔丁氧羰基-2-(二氟甲基)-4-羟基吡咯烷的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7151096B2 (en) * | 2003-03-05 | 2006-12-19 | Irm Llc | Cyclic compounds and compositions as protein kinase inhibitors |
| RU2380356C2 (ru) | 2003-03-24 | 2010-01-27 | Актимис Фармасьютикалз, Инк. | Производные 2-фенокси и 2-фенилсульфонамида с ссr3 антагонистической активностью для лечения астмы и других воспалительных или иммунологических заболеваний |
| PA8603801A1 (es) | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| DE602004023876D1 (de) | 2003-12-18 | 2009-12-10 | Janssen Pharmaceutica Nv | 3-cyano-chinolin-derivate mit antiproliferativer wirkung |
| CA2549869C (fr) | 2003-12-18 | 2015-05-05 | Janssen Pharmaceutica N.V. | Anti-proliferants a base de derives pyrido- et pyrimidopyrimidine |
| MY169441A (en) | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| JO3088B1 (ar) | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| EA017545B1 (ru) | 2005-06-30 | 2013-01-30 | Янссен Фармацевтика Н.В. | Циклические анилино-пиридинотриазины в качестве ингибиторов gsk-3 |
| PH12012501003B1 (en) | 2005-11-16 | 2018-04-06 | Cti Biopharma Corp | Oxygen linked pyrimidine derivatives |
| EP1961149B1 (fr) | 2005-11-24 | 2018-08-08 | Synchronica plc | Procédé destiné à associer de façon securisée des données au moyen de sessions http et https |
| WO2008155421A2 (fr) | 2007-06-21 | 2008-12-24 | Janssen Pharmaceutica Nv | Indolin-2-ones et aza-indolin-2-ones |
| AU2008281849B2 (en) | 2007-07-27 | 2013-11-28 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| WO2009026197A1 (fr) | 2007-08-20 | 2009-02-26 | Glaxo Group Limited | Nouveaux inhibiteurs de la cathepsine c et leur utilisation |
| US8318929B2 (en) * | 2008-03-10 | 2012-11-27 | Janssen Pharmaceutica Nv | 4-aryl-2-anilino-pyrimidines |
| KR20110031318A (ko) | 2008-06-13 | 2011-03-25 | 노파르티스 아게 | Ia 심부전 및 암 치료에 유용한 단백질 키나제 d 억제제로서의 2,4'-비피리디닐 화합물 |
| BRPI1011612A2 (pt) | 2009-05-28 | 2019-09-24 | Tetralogic Pharm Corp | composto, composição farmacêutica, e, métodos para induzir apoptose em uma célula, para tratar câncer, e para tratar uma doença autoimune. |
| CN102548987B (zh) | 2009-07-14 | 2014-04-16 | 江苏迈度药物研发有限公司 | 作为激酶抑制剂的氟取代化合物及其使用方法 |
| TWI513695B (zh) | 2009-10-27 | 2015-12-21 | Merck Sharp & Dohme | (1,1,1,3,3,3-六氟-2-羥基丙-2-基)苯基衍生物 |
-
2015
- 2015-04-01 MA MA039822A patent/MA39822A/fr unknown
- 2015-04-02 CN CN202111600011.XA patent/CN114213415A/zh active Pending
- 2015-04-02 EP EP15713522.9A patent/EP3126364B1/fr active Active
- 2015-04-02 ES ES15713522.9T patent/ES2667723T3/es active Active
- 2015-04-02 SG SG11201608240RA patent/SG11201608240RA/en unknown
- 2015-04-02 MY MYPI2016001777A patent/MY185491A/en unknown
- 2015-04-02 WO PCT/EP2015/057399 patent/WO2015150555A1/fr not_active Ceased
- 2015-04-02 MX MX2016012992A patent/MX369798B/es active IP Right Grant
- 2015-04-02 BR BR112016021982-1A patent/BR112016021982B1/pt active IP Right Grant
- 2015-04-02 CA CA2942636A patent/CA2942636C/fr active Active
- 2015-04-02 JP JP2016560825A patent/JP6529513B2/ja active Active
- 2015-04-02 AU AU2015239098A patent/AU2015239098B2/en not_active Ceased
- 2015-04-02 PE PE2016001882A patent/PE20161362A1/es unknown
- 2015-04-02 UA UAA201611005A patent/UA118219C2/uk unknown
- 2015-04-02 KR KR1020167028764A patent/KR102390276B1/ko active Active
- 2015-04-02 EA EA201692003A patent/EA031246B1/ru not_active IP Right Cessation
- 2015-04-02 CN CN201580018080.6A patent/CN106164075B/zh active Active
- 2015-04-02 US US15/300,956 patent/US10017509B2/en active Active
- 2015-04-02 NZ NZ725399A patent/NZ725399A/en unknown
-
2016
- 2016-09-25 IL IL248005A patent/IL248005B/en active IP Right Grant
- 2016-09-29 CL CL2016002461A patent/CL2016002461A1/es unknown
- 2016-10-03 PH PH12016501963A patent/PH12016501963A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2016002461A1 (es) | 2017-06-23 |
| MX369798B (es) | 2019-11-21 |
| ES2667723T3 (es) | 2018-05-14 |
| MX2016012992A (es) | 2016-12-07 |
| KR20160142316A (ko) | 2016-12-12 |
| US10017509B2 (en) | 2018-07-10 |
| EA031246B1 (ru) | 2018-12-28 |
| US20170022202A1 (en) | 2017-01-26 |
| JP2017509687A (ja) | 2017-04-06 |
| PH12016501963B1 (en) | 2017-01-09 |
| CA2942636A1 (fr) | 2015-10-08 |
| NZ725399A (en) | 2023-01-27 |
| EP3126364B1 (fr) | 2018-02-07 |
| MY185491A (en) | 2021-05-19 |
| KR102390276B1 (ko) | 2022-04-22 |
| CN106164075A (zh) | 2016-11-23 |
| UA118219C2 (uk) | 2018-12-10 |
| WO2015150555A1 (fr) | 2015-10-08 |
| CA2942636C (fr) | 2023-03-21 |
| EP3126364A1 (fr) | 2017-02-08 |
| BR112016021982B1 (pt) | 2022-07-26 |
| AU2015239098A1 (en) | 2016-09-29 |
| JP6529513B2 (ja) | 2019-06-12 |
| EA201692003A1 (ru) | 2017-06-30 |
| CN106164075B (zh) | 2021-11-26 |
| AU2015239098B2 (en) | 2019-08-01 |
| SG11201608240RA (en) | 2016-10-28 |
| PE20161362A1 (es) | 2016-12-17 |
| IL248005B (en) | 2018-12-31 |
| PH12016501963A1 (en) | 2017-01-09 |
| BR112016021982A2 (fr) | 2017-08-15 |
| CN114213415A (zh) | 2022-03-22 |
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