[go: up one dir, main page]

MA39822A - Dérivés de pyrimidine bicycle - Google Patents

Dérivés de pyrimidine bicycle

Info

Publication number
MA39822A
MA39822A MA039822A MA39822A MA39822A MA 39822 A MA39822 A MA 39822A MA 039822 A MA039822 A MA 039822A MA 39822 A MA39822 A MA 39822A MA 39822 A MA39822 A MA 39822A
Authority
MA
Morocco
Prior art keywords
bicycle
pyrimidine derivatives
pyrimidine
derivatives
bicycle pyrimidine
Prior art date
Application number
MA039822A
Other languages
English (en)
Inventor
Didier Jean-Claude Berthelot
Gaston Stanislas Marcella Diels
Werner Constant Johan Embrechts
Lieven Meerpoel
Bruno Schoentjes
Matthias Luc Aimé Versele
Marcel Viellevoye
Marc Willems
Berthold Wroblowski
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA39822A publication Critical patent/MA39822A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA039822A 2014-04-03 2015-04-01 Dérivés de pyrimidine bicycle MA39822A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14163443 2014-04-03
EP14183747 2014-09-05

Publications (1)

Publication Number Publication Date
MA39822A true MA39822A (fr) 2018-02-06

Family

ID=52781117

Family Applications (1)

Application Number Title Priority Date Filing Date
MA039822A MA39822A (fr) 2014-04-03 2015-04-01 Dérivés de pyrimidine bicycle

Country Status (21)

Country Link
US (1) US10017509B2 (fr)
EP (1) EP3126364B1 (fr)
JP (1) JP6529513B2 (fr)
KR (1) KR102390276B1 (fr)
CN (2) CN114213415A (fr)
AU (1) AU2015239098B2 (fr)
BR (1) BR112016021982B1 (fr)
CA (1) CA2942636C (fr)
CL (1) CL2016002461A1 (fr)
EA (1) EA031246B1 (fr)
ES (1) ES2667723T3 (fr)
IL (1) IL248005B (fr)
MA (1) MA39822A (fr)
MX (1) MX369798B (fr)
MY (1) MY185491A (fr)
NZ (1) NZ725399A (fr)
PE (1) PE20161362A1 (fr)
PH (1) PH12016501963A1 (fr)
SG (1) SG11201608240RA (fr)
UA (1) UA118219C2 (fr)
WO (1) WO2015150555A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017140841A1 (fr) 2016-02-19 2017-08-24 Sprint Bioscience Ab Composés 6-aryl-4-morpholin-1-yl-pyridone utilisés pour le traitement du cancer et du diabète
SMT202000529T1 (it) 2016-02-19 2020-11-10 Sprint Bioscience Ab Composti di 6-eterociclil-4-morfolina-4-ilpiridin-2-one utili per il trattamento di cancro e diabete
ES2900199T3 (es) 2017-03-28 2022-03-16 Bayer Ag Novedosos compuestos macrocíclicos inhibidores de PTEFB
US11242356B2 (en) 2017-03-28 2022-02-08 Bayer Aktiengesellschaft PTEFb inhibiting macrocyclic compounds
PT3672967T (pt) 2017-08-23 2021-12-28 Sprint Bioscience Ab Compostos de azaindolilpiridona e diazaindolilpiridona
CN111094244B (zh) 2017-08-23 2023-07-11 思普瑞特生物科学公司 吡啶基吡啶酮化合物
DK3672948T3 (da) 2017-08-23 2022-12-05 Sprint Bioscience Ab Pyridinamin-pyridon- og pyrimidinamin-pyridonforbindelser
JP7199736B2 (ja) 2017-08-23 2023-01-06 スプリント バイオサイエンス アクティエボラーグ モルホリニルピリドン化合物
MX2022010128A (es) * 2020-02-18 2023-01-04 Theseus Pharmaceuticals Inc Compuestos macrocíclicos y usos de estos.
CN116535365A (zh) * 2020-04-07 2023-08-04 Iteos比利时公司 作为ent抑制剂用于治疗癌症的大环二胺衍生物以及其与腺苷受体拮抗剂的组合
CN113735879B (zh) * 2020-05-27 2022-05-17 百极弘烨(广东)医药科技有限公司 一种大环jak抑制剂及其应用
CN113735856A (zh) * 2020-05-29 2021-12-03 百极弘烨(南通)医药科技有限公司 大环jak抑制剂及其应用
CN116113621A (zh) * 2020-07-22 2023-05-12 弗格制药有限公司 氨基酸
WO2023046030A1 (fr) * 2021-09-23 2023-03-30 河南晟翔医药科技有限公司 Inhibiteur à petite molécule egfr, composition pharmaceutique le contenant et son utilisation
KR102613509B1 (ko) * 2021-12-15 2023-12-13 환인제약 주식회사 마크로사이클릭 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 신경 퇴행성 질환의 예방 또는 치료용 약학적 조성물
CN117229300A (zh) * 2023-03-12 2023-12-15 药雅科技(上海)有限公司 Egfr抑制剂的制备及其应用
WO2024078263A1 (fr) * 2022-10-09 2024-04-18 药雅科技(上海)有限公司 Préparation et utilisation d'un composé hétérocyclique macrocyclique en tant qu'inhibiteur d'egfr
WO2024094171A1 (fr) * 2022-11-04 2024-05-10 江苏恒瑞医药股份有限公司 Composé aminopyrimidine substitué, son procédé de préparation et son utilisation médicale
CN116478076A (zh) * 2023-04-26 2023-07-25 南京优氟医药科技有限公司 一种(2s,4s)-1-叔丁氧羰基-2-(二氟甲基)-4-羟基吡咯烷的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151096B2 (en) * 2003-03-05 2006-12-19 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors
RU2380356C2 (ru) 2003-03-24 2010-01-27 Актимис Фармасьютикалз, Инк. Производные 2-фенокси и 2-фенилсульфонамида с ссr3 антагонистической активностью для лечения астмы и других воспалительных или иммунологических заболеваний
PA8603801A1 (es) 2003-05-27 2004-12-16 Janssen Pharmaceutica Nv Derivados de la quinazolina
DE602004023876D1 (de) 2003-12-18 2009-12-10 Janssen Pharmaceutica Nv 3-cyano-chinolin-derivate mit antiproliferativer wirkung
CA2549869C (fr) 2003-12-18 2015-05-05 Janssen Pharmaceutica N.V. Anti-proliferants a base de derives pyrido- et pyrimidopyrimidine
MY169441A (en) 2004-12-08 2019-04-11 Janssen Pharmaceutica Nv 2,4, (4,6) pyrimidine derivatives
JO3088B1 (ar) 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
EA017545B1 (ru) 2005-06-30 2013-01-30 Янссен Фармацевтика Н.В. Циклические анилино-пиридинотриазины в качестве ингибиторов gsk-3
PH12012501003B1 (en) 2005-11-16 2018-04-06 Cti Biopharma Corp Oxygen linked pyrimidine derivatives
EP1961149B1 (fr) 2005-11-24 2018-08-08 Synchronica plc Procédé destiné à associer de façon securisée des données au moyen de sessions http et https
WO2008155421A2 (fr) 2007-06-21 2008-12-24 Janssen Pharmaceutica Nv Indolin-2-ones et aza-indolin-2-ones
AU2008281849B2 (en) 2007-07-27 2013-11-28 Janssen Pharmaceutica Nv Pyrrolopyrimidines
WO2009026197A1 (fr) 2007-08-20 2009-02-26 Glaxo Group Limited Nouveaux inhibiteurs de la cathepsine c et leur utilisation
US8318929B2 (en) * 2008-03-10 2012-11-27 Janssen Pharmaceutica Nv 4-aryl-2-anilino-pyrimidines
KR20110031318A (ko) 2008-06-13 2011-03-25 노파르티스 아게 Ia 심부전 및 암 치료에 유용한 단백질 키나제 d 억제제로서의 2,4'-비피리디닐 화합물
BRPI1011612A2 (pt) 2009-05-28 2019-09-24 Tetralogic Pharm Corp composto, composição farmacêutica, e, métodos para induzir apoptose em uma célula, para tratar câncer, e para tratar uma doença autoimune.
CN102548987B (zh) 2009-07-14 2014-04-16 江苏迈度药物研发有限公司 作为激酶抑制剂的氟取代化合物及其使用方法
TWI513695B (zh) 2009-10-27 2015-12-21 Merck Sharp & Dohme (1,1,1,3,3,3-六氟-2-羥基丙-2-基)苯基衍生物

Also Published As

Publication number Publication date
CL2016002461A1 (es) 2017-06-23
MX369798B (es) 2019-11-21
ES2667723T3 (es) 2018-05-14
MX2016012992A (es) 2016-12-07
KR20160142316A (ko) 2016-12-12
US10017509B2 (en) 2018-07-10
EA031246B1 (ru) 2018-12-28
US20170022202A1 (en) 2017-01-26
JP2017509687A (ja) 2017-04-06
PH12016501963B1 (en) 2017-01-09
CA2942636A1 (fr) 2015-10-08
NZ725399A (en) 2023-01-27
EP3126364B1 (fr) 2018-02-07
MY185491A (en) 2021-05-19
KR102390276B1 (ko) 2022-04-22
CN106164075A (zh) 2016-11-23
UA118219C2 (uk) 2018-12-10
WO2015150555A1 (fr) 2015-10-08
CA2942636C (fr) 2023-03-21
EP3126364A1 (fr) 2017-02-08
BR112016021982B1 (pt) 2022-07-26
AU2015239098A1 (en) 2016-09-29
JP6529513B2 (ja) 2019-06-12
EA201692003A1 (ru) 2017-06-30
CN106164075B (zh) 2021-11-26
AU2015239098B2 (en) 2019-08-01
SG11201608240RA (en) 2016-10-28
PE20161362A1 (es) 2016-12-17
IL248005B (en) 2018-12-31
PH12016501963A1 (en) 2017-01-09
BR112016021982A2 (fr) 2017-08-15
CN114213415A (zh) 2022-03-22

Similar Documents

Publication Publication Date Title
MA39822A (fr) Dérivés de pyrimidine bicycle
PT3360864T (pt) Composto de pirimidina
LT3236972T (lt) Antivirusiniai n4-hidroksicitidino dariniai
DK3319956T3 (da) Substituerede oxopyridinderivater
IL265166B (en) Anti-influenza virus pyrimidine derivatives
MA41898A (fr) Dérivés de quinazolinone bicyclique
MA54254A (fr) Dérivés de benzodiazépine cytotoxique
LT3204359T (lt) Tetrahidroizochinolino dariniai
EP3457851A4 (fr) Dérivés de sobétirome
ITUA20163536A1 (it) Guarnitura di bicicletta
HUE048321T2 (hu) Karabazol származékok
EP3564216A4 (fr) Dérivé pyrimidine
DK3231803T3 (da) Dihydroindolizinonderivat
LT3371168T (lt) Indolin-2-ono dariniai
CL2016002165A1 (es) Compuestos de aminocarbonilcarbamato
MA41790A (fr) Dérivé de morphinane
PT3131898T (pt) Derivados de fluoroalquilfluoreno
EP3309163A4 (fr) Dérivé de dihydropyrrolopyrazole substitué
IT201600079577A1 (it) Componente di bicicletta
EP3554637A4 (fr) Dérivés de spiropipéridine
EP3371163A4 (fr) Dérivés de pyrrolidine
BR112018001062A2 (pt) compostos inovadores
DK3372589T3 (da) Pyrimidinderivat
MA49708A (fr) Dérivés de dihétérocycle liés à cycloalkyle
BR112017009319A2 (pt) bicicleta