[go: up one dir, main page]

DK1809238T3 - Ophthalmiske emulsioner indeholdende et immunosuppressivt middel - Google Patents

Ophthalmiske emulsioner indeholdende et immunosuppressivt middel

Info

Publication number
DK1809238T3
DK1809238T3 DK05802097.5T DK05802097T DK1809238T3 DK 1809238 T3 DK1809238 T3 DK 1809238T3 DK 05802097 T DK05802097 T DK 05802097T DK 1809238 T3 DK1809238 T3 DK 1809238T3
Authority
DK
Denmark
Prior art keywords
immunosuppressant
emulsions containing
ophthalmic emulsions
ophthalmic
emulsions
Prior art date
Application number
DK05802097.5T
Other languages
English (en)
Inventor
Betty Philips
Severine Bague
Laura Rabinovich-Guilatt
Gregory Lambert
Original Assignee
Novagali Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04292645A external-priority patent/EP1655021B1/en
Application filed by Novagali Pharma Sa filed Critical Novagali Pharma Sa
Application granted granted Critical
Publication of DK1809238T3 publication Critical patent/DK1809238T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
DK05802097.5T 2004-11-09 2005-10-10 Ophthalmiske emulsioner indeholdende et immunosuppressivt middel DK1809238T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP04292645A EP1655021B1 (en) 2004-11-09 2004-11-09 Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
US10/991,346 US8298568B2 (en) 2004-11-09 2004-11-18 Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
PCT/EP2005/011649 WO2006050837A2 (en) 2004-11-09 2005-10-10 Ophthalmic emulsions containing an immunosuppressive agent
EP05802097A EP1809238B1 (en) 2004-11-09 2005-10-10 Ophthalmic emulsions containing an immunosuppressive agent

Publications (1)

Publication Number Publication Date
DK1809238T3 true DK1809238T3 (da) 2010-01-25

Family

ID=35466464

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05802097.5T DK1809238T3 (da) 2004-11-09 2005-10-10 Ophthalmiske emulsioner indeholdende et immunosuppressivt middel

Country Status (7)

Country Link
EP (4) EP1827373B1 (da)
JP (2) JP5008571B2 (da)
KR (2) KR101319772B1 (da)
AU (2) AU2005304034B2 (da)
CA (2) CA2586074C (da)
DK (1) DK1809238T3 (da)
WO (3) WO2006050837A2 (da)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1655021B1 (en) * 2004-11-09 2008-10-29 Novagali Pharma SA Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
PT1864667E (pt) 2006-06-01 2013-11-18 Novagali Pharma Sa Uso de pró-fármacos para administração intravítrea ocular
JP4411440B2 (ja) * 2006-06-02 2010-02-10 国立大学法人 筑波大学 粒子特性計測装置および粒子特性計測方法
US9561178B2 (en) 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
AU2016203191B2 (en) * 2006-07-25 2018-03-01 Allergan, Inc. Cyclosporin compositions
AU2014201978B2 (en) * 2006-07-28 2016-03-10 Santen Sas Compositions containing quaternary ammonium compounds
WO2008035246A2 (en) * 2006-07-28 2008-03-27 Novagali Pharma Sa Compositions containing quaternary ammonium compounds
EP1891939B1 (en) * 2006-07-28 2013-09-11 Novagali Pharma S.A. Compositions containing quaternary ammonium compounds
CA2672973C (en) 2006-12-21 2016-03-08 Novagali Pharma Sa Process for manufacturing ophthalmic oil-in-water emulsions
KR20090108723A (ko) * 2007-01-31 2009-10-16 알러간, 인코포레이티드 안 약물 송달을 위한 신규한 생체적합물질 및 이의 제조방법 및 용도
US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
EP1985298A1 (en) * 2007-04-24 2008-10-29 Azad Pharma AG Ophtalmic oil-in-water emulsions containing prostaglandins
EP2008651A1 (en) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited A bioerodible patch
CA2694929C (en) * 2007-07-26 2016-10-18 Azad Pharma Ag Pharmaceutical preparations comprising electrochemically activated hypochlorite solutions
MX340897B (es) * 2007-10-02 2016-07-29 Theranos Inc Dispositivos modulares de punto de cuidado y usos de los mismos.
CN101835473B (zh) * 2007-10-16 2012-12-05 太阳医药高级研发有限公司 一种含有拉坦前列腺素的眼药组合物
KR101805852B1 (ko) * 2007-12-04 2018-01-10 산텐 에스에이에스 덱사메타손 팔미테이트와 같은 코르티코스테로이드 전구약물을 포함하는 안과질환 치료용 조성물
EP2228057A1 (en) * 2009-03-04 2010-09-15 Novagali Pharma S.A. Cationic oil-in-water emulsions containing prostaglandins and uses thereof
EP2228058A1 (en) 2009-03-04 2010-09-15 Novagali Pharma S.A. Anionic oil-in-water emulsion containing prostaglandins and uses thereof
US20100305046A1 (en) 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Stable cyclosporine containing ophthalmic emulsion for treating dry eyes
US20100303915A1 (en) * 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Therapeutic opthalmic emulsions
US9480645B2 (en) 2009-06-02 2016-11-01 Abbott Medical Optics Inc. Omega-3 oil containing ophthalmic emulsions
EP2308468A1 (en) 2009-10-08 2011-04-13 Novaliq GmbH Novel pharmaceutical composition comprising a macrolide immunosuppressant drug
US20110112198A1 (en) * 2009-11-09 2011-05-12 Allergan, Inc. Compositions for enhancing hair growth
EP2389939A1 (en) 2010-05-28 2011-11-30 Novagali Pharma S.A. Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions
RS52565B (sr) † 2009-12-03 2013-04-30 Novartis Ag Metod interakcije i komore sa povratnim pritiskom za mikrofluidizaciju
JP5820390B2 (ja) 2009-12-03 2015-11-24 ノバルティス アーゲー エマルジョンの微小流動化中および／または均質化中における成分の循環
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CL2012001399A1 (es) 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
KR101616735B1 (ko) 2009-12-03 2016-04-29 노파르티스 아게 백신 보조제 제조 중의 친수성 여과
IT1404931B1 (it) 2010-06-11 2013-12-09 Medivis S R L Composizioni oftalmiche per la somministrazione di principi attivi liposolubili .
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
WO2012123515A1 (en) 2011-03-14 2012-09-20 Drug Delivery Solutions Limited An ophthalmic composition
KR101318151B1 (ko) 2011-09-26 2013-10-15 (주) 제노텍 타크롤리무스 당화 유도체를 포함하는 면역억제용 약제학적 조성물
WO2013022238A2 (ko) * 2011-08-05 2013-02-14 (주)제노텍 트리사이클로 당화 유도체 화합물, 그 제조방법 및 타크롤리무스 당화 유도체를 포함하는 면역억제용 약제학적 조성물
SG10201604104PA (en) 2011-10-25 2016-07-28 Prothena Therapeutics Ltd Antibody formulations and methods
CN105142686B (zh) * 2013-03-14 2020-04-10 帕恩欧普佳有限公司 给药于眼后段的眼用制剂
US9630909B2 (en) 2013-06-27 2017-04-25 Mylan Laboratories Ltd Process for the preparation of nepafenac
JP2014028865A (ja) * 2013-11-11 2014-02-13 Santen Sas 眼科用水中油型乳剤を製造する方法
BR112016018673B1 (pt) * 2014-02-14 2023-10-17 Jingjun Huang Composição em nanoemulsão de óleo em água estável opticamente clara, método de produção da mesma, e, formulação de carreador
EP2937076B1 (en) * 2014-04-25 2019-09-11 Alfred E. Tiefenbacher (GmbH & Co. KG) Eye drops containing prostaglandin and tyloxapol
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
PT3848028T (pt) * 2014-10-20 2024-09-20 Oyster Point Pharma Inc Métodos de tratamento de estados oculares
JPWO2016093299A1 (ja) * 2014-12-10 2017-09-21 千寿製薬株式会社 水性液剤
US11324800B2 (en) 2015-01-15 2022-05-10 Wellspring Ophthalmics, Inc. Aqueous suspensions of cyclosporin
US20200237859A1 (en) 2019-01-25 2020-07-30 Newport Research, Inc. Aqueous suspensions of cyclosporin
WO2016127022A1 (en) 2015-02-06 2016-08-11 Foreman James Michael Preparation of an oil-in-water emulsion for polymer stabilized pharmaceutical formulations
WO2018227190A1 (en) 2017-06-10 2018-12-13 Eyenovia, Inc. Methods and devices for handling a fluid and delivering the fluid to the eye
KR20250065422A (ko) 2017-12-15 2025-05-12 타르서스 파마수티칼스, 아이엔씨. 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법
EP3758677A1 (en) * 2018-02-26 2021-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Drug delivery systems
EP3542788A1 (en) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topical composition comprising calcipotriol and betamethasone dipropionate
CA3115664A1 (en) * 2018-08-29 2020-03-05 Ocugen, Inc. Ophthalmic compositions and methods of use
WO2020044308A1 (en) * 2018-08-30 2020-03-05 Sabic Global Technologies B.V. High yield stabilized colloidal particle assemblies
CN115038414A (zh) 2019-12-11 2022-09-09 艾诺维亚股份有限公司 用于向眼睛输送流体的系统和装置及使用方法
HUE071285T2 (hu) 2020-09-18 2025-08-28 Omnivision Gmbh Lipid alapú szemészeti készítmény száraz szem kezelésére
WO2025010040A1 (en) * 2023-07-06 2025-01-09 Ardi Farma Ilac Pazarlama Ticaret Limited Sirketi Stable multiple dose cyclosporin water-in-oil emulsion compositions
WO2025078561A1 (en) 2023-10-11 2025-04-17 Santen Sas Kit for stabilising prostaglandin emulsions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0818989B2 (ja) * 1984-01-12 1996-02-28 株式会社ミドリ十字 脂肪乳剤中のプロスタグランジンの安定化方法
US4839342A (en) 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
JP2602964B2 (ja) * 1989-10-16 1997-04-23 裕 水島 プロスタグランジン類縁体およびその脂肪乳剤
IL101241A (en) 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
IL103907A0 (en) * 1992-11-27 1993-04-04 Pharmos Corp Ophthalmic compositions
CA2142103C (en) * 1992-08-28 2003-07-08 Haim Aviv Submicron emulsions as ocular drug delivery vehicles
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
US6011062A (en) * 1994-12-22 2000-01-04 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
JP3410364B2 (ja) * 1997-05-14 2003-05-26 千寿製薬株式会社 ジフルプレドナート含有組成物
US6114319A (en) 1997-05-14 2000-09-05 Senju Pharmaceutical Co., Ltd. Compositions containing difluprednate
EP1441696B1 (en) * 2001-11-01 2010-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method and composition for dry eye treatment
US6656460B2 (en) * 2001-11-01 2003-12-02 Yissum Research Development Method and composition for dry eye treatment
KR100446960B1 (ko) * 2001-12-04 2004-09-01 김종국 프로스타글란딘 ｅ1을 포함하는 온도감응성 에멀젼 외용제조성물
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
KR101091461B1 (ko) 2003-11-07 2011-12-07 센주 세이야꾸 가부시키가이샤 프로스타글란딘 함유 의약 조성물
EP1611879B1 (en) 2004-07-02 2009-08-12 Novagali Pharma SA Use of emulsions for intra- and periocular injection

Also Published As

Publication number Publication date
JP5008571B2 (ja) 2012-08-22
KR20070084107A (ko) 2007-08-24
JP2008518993A (ja) 2008-06-05
WO2006050838A2 (en) 2006-05-18
EP1809238A2 (en) 2007-07-25
AU2005304035A1 (en) 2006-05-18
KR101333923B1 (ko) 2013-11-27
EP1827373A2 (en) 2007-09-05
KR20070083573A (ko) 2007-08-24
WO2006050837A2 (en) 2006-05-18
WO2006050837A3 (en) 2006-11-16
EP1809237A2 (en) 2007-07-25
WO2006050836A3 (en) 2007-07-12
AU2005304034B2 (en) 2012-02-16
AU2005304034A1 (en) 2006-05-18
CA2586074A1 (en) 2006-05-18
EP1809238B1 (en) 2008-10-29
AU2005304035B2 (en) 2010-07-22
EP1827373B1 (en) 2008-12-03
CA2586074C (en) 2013-07-23
EP1929996B1 (en) 2011-02-16
EP1809237B1 (en) 2008-12-31
JP2008518992A (ja) 2008-06-05
JP5122969B2 (ja) 2013-01-16
EP1929996A2 (en) 2008-06-11
WO2006050838A3 (en) 2006-11-16
EP1929996A3 (en) 2009-05-20
WO2006050836A2 (en) 2006-05-18
CA2578176A1 (en) 2006-05-18
KR101319772B1 (ko) 2013-10-23
CA2578176C (en) 2013-09-24

Similar Documents

Publication Publication Date Title
DK1809238T3 (da) Ophthalmiske emulsioner indeholdende et immunosuppressivt middel
EP1888123A4 (en) CELL THERAPY FOR EYE GENERATION
DE602005027428D1 (de) Toner
DE602004018414D1 (de) Ophthalmologisches Gerät
DE602004019389D1 (de) Toner
DE602005026205D1 (de) Rasiersystem
FR2865631B1 (fr) Lunettes-masque
EP1694250A4 (en) REMOVABLE STENTIMPLANTAT
DE502005005785D1 (de) Laserfilm
DE602005018315D1 (de) Rollstuhl
NO20051873D0 (no) Antirotasjons-las
DE602004001140D1 (de) Ophthalmologisches Gerät
DE602004011962D1 (de) Armstütze für Operateur
FR2871247B1 (fr) Lentille ophtalmique
DE502004009754D1 (de) Tourbillon
DE602005018577D1 (de) Armstütze
DE602005001326D1 (de) Brille
FR2871248B1 (fr) Lentille ophtalmique
DE502005005229D1 (de) Elastomerlager
ITMI20040586A1 (it) Emulsioni complesse di perfluoropolieteri
FR2884325B1 (fr) Lentille ophtalmique
ATA3402004A (de) Kunstleder
DE602005003586D1 (de) Verbesserte brillen
DE502005011057D1 (de) Laseranordnung
ES1054274Y (es) Anteojos desmontables