DK1725660T3 - Ekspressionskassetter med multiple promotorer til samtidig afgivelse af RNAi-midler - Google Patents
Ekspressionskassetter med multiple promotorer til samtidig afgivelse af RNAi-midlerInfo
- Publication number
- DK1725660T3 DK1725660T3 DK05727680.0T DK05727680T DK1725660T3 DK 1725660 T3 DK1725660 T3 DK 1725660T3 DK 05727680 T DK05727680 T DK 05727680T DK 1725660 T3 DK1725660 T3 DK 1725660T3
- Authority
- DK
- Denmark
- Prior art keywords
- expression cassettes
- simultaneous delivery
- rnai agents
- multiple promoters
- rnai
- Prior art date
Links
- 108091030071 RNAI Proteins 0.000 title abstract 2
- 230000009368 gene silencing by RNA Effects 0.000 title abstract 2
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55050404P | 2004-03-05 | 2004-03-05 | |
| US55392004P | 2004-03-17 | 2004-03-17 | |
| PCT/US2005/007447 WO2005087926A2 (en) | 2004-03-05 | 2005-03-04 | Multiple promoter expression cassettes for simultaneous delivery of rnai agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1725660T3 true DK1725660T3 (da) | 2011-08-29 |
Family
ID=34963938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05727680.0T DK1725660T3 (da) | 2004-03-05 | 2005-03-04 | Ekspressionskassetter med multiple promotorer til samtidig afgivelse af RNAi-midler |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7727970B2 (da) |
| EP (2) | EP1725660B1 (da) |
| JP (1) | JP4763681B2 (da) |
| KR (2) | KR101337579B1 (da) |
| CN (1) | CN103060324B (da) |
| AT (1) | ATE508190T1 (da) |
| AU (1) | AU2005222084B2 (da) |
| CA (1) | CA2558771C (da) |
| DE (1) | DE602005027820D1 (da) |
| DK (1) | DK1725660T3 (da) |
| IL (1) | IL177862A (da) |
| NZ (1) | NZ550284A (da) |
| WO (1) | WO2005087926A2 (da) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4763681B2 (ja) | 2004-03-05 | 2011-08-31 | ベニテック インコーポレイテッド | ＲＮＡｉ作用媒介物の同時デリバリーのためのマルチプロモーター発現カセット |
| ES2362670T3 (es) | 2004-09-24 | 2011-07-11 | Alnylam Pharmaceuticals, Inc | Orientación a intermedios de replicación de hebra no codificante de virus monocatenarios por arni. |
| AU2005307737C1 (en) * | 2004-11-18 | 2013-08-29 | The Board Of Trustees Of The University Of Illinois | Multicistronic siRNA constructs to inhibit tumors |
| WO2006084209A2 (en) * | 2005-02-03 | 2006-08-10 | Benitec, Inc. | Rnai expression constructs |
| WO2006116756A1 (en) * | 2005-04-28 | 2006-11-02 | Benitec, Limited. | Multiple-rnai expression cassettes for simultaneous delivery of rnai agents related to heterozygotic expression patterns |
| US7452696B2 (en) * | 2006-10-27 | 2008-11-18 | National Taiwan University | Recombinant plasmid and method for expressing hepatitis B viral antigens and virions in vivo |
| WO2008069940A2 (en) * | 2006-12-06 | 2008-06-12 | Albert Einstein College Of Medicine Of Yeshiva University | Multi-microrna methods and compositions |
| WO2008134720A2 (en) * | 2007-04-30 | 2008-11-06 | Medtronic, Inc. | Inert dna sequences for efficient viral packaging and methods of use |
| US8614198B2 (en) * | 2007-06-22 | 2013-12-24 | Alnylam Pharmaceuticals, Inc. | Hepatitis C dsRNA effector molecules, expression constructs, compositions, and methods of use |
| US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| US20100041133A1 (en) * | 2008-08-13 | 2010-02-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Biological targeting compositions and methods of using the same |
| US20120034155A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
| US20100042072A1 (en) * | 2008-08-13 | 2010-02-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Biological targeting compositions and methods of using the same |
| US20100040546A1 (en) * | 2008-08-13 | 2010-02-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Biological targeting compositions and methods of using the same |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| JP2013533847A (ja) | 2010-04-23 | 2013-08-29 | ユニバーシティ オブ マサチューセッツ | コレステロール関連障害のａａｖベースの治療 |
| EP3514232A1 (en) | 2010-04-23 | 2019-07-24 | University of Massachusetts | Cns targeting aav vectors and methods of use thereof |
| WO2011133874A1 (en) * | 2010-04-23 | 2011-10-27 | University Of Massachusetts | Multicistronic expression constructs |
| RS58982B1 (sr) | 2010-10-28 | 2019-08-30 | Benitec Biopharma Ltd | Lečenje hbv |
| KR101554678B1 (ko) * | 2012-10-19 | 2015-09-21 | 영남대학교 산학협력단 | 식물 바이러스를 이용한 식물체 형질전환을 위한 유전자 전달 시스템 및 이의 용도 |
| AU2014205036A1 (en) | 2013-01-08 | 2015-07-30 | Benitec Biopharma Limited | Age-related macular degeneration treatment |
| DK3119797T3 (da) | 2014-03-18 | 2021-03-15 | Univ Massachusetts | Raav-baserede sammensætninger og fremgangsmåder til behandling af amyotrofisk lateralsklerose |
| GB201405834D0 (en) * | 2014-04-01 | 2014-05-14 | Univ London Queen Mary | Oncolytic virus |
| US10689653B2 (en) | 2014-06-03 | 2020-06-23 | University Of Massachusetts | Compositions and methods for modulating dysferlin expression |
| US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
| US10711270B2 (en) | 2014-10-03 | 2020-07-14 | University Of Massachusetts | High efficiency library-identified AAV vectors |
| RU2020140209A (ru) | 2014-10-21 | 2021-01-25 | Юниверсити Оф Массачусетс | Варианты рекомбинантных aav и их применения |
| MX2017006216A (es) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela). |
| KR102584655B1 (ko) | 2014-11-14 | 2023-10-06 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US10517898B2 (en) | 2014-11-20 | 2019-12-31 | The Regents Of The University Of California | Compositions and methods related to hematologic recovery |
| EP3256170B1 (en) | 2015-02-13 | 2020-09-23 | University of Massachusetts | Compositions and methods for transient delivery of nucleases |
| WO2016172008A1 (en) | 2015-04-24 | 2016-10-27 | University Of Massachusetts | Modified aav constructions and uses thereof |
| US11426469B2 (en) | 2015-10-22 | 2022-08-30 | University Of Massachusetts | Prostate-targeting adeno-associated virus serotype vectors |
| CA3002982A1 (en) | 2015-10-22 | 2017-04-27 | University Of Massachusetts | Methods and compositions for treating metabolic imbalance in neurodegenerative disease |
| EP3377630A4 (en) | 2015-11-16 | 2020-01-01 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| CN108779463B (zh) | 2016-02-02 | 2022-05-24 | 奥利克斯医药有限公司 | 使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘 |
| US11826433B2 (en) | 2016-02-02 | 2023-11-28 | University Of Massachusetts | Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system |
| CA3012344A1 (en) | 2016-02-12 | 2017-08-17 | University Of Massachusetts | Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization |
| WO2017176929A1 (en) | 2016-04-05 | 2017-10-12 | University Of Massachusetts | Compositions and methods for selective inhibition of grainyhead-like protein expression |
| US11413356B2 (en) | 2016-04-15 | 2022-08-16 | University Of Massachusetts | Methods and compositions for treating metabolic imbalance |
| RU2758488C2 (ru) | 2016-05-18 | 2021-10-28 | Вояджер Терапьютикс, Инк. | Модулирующие полинуклеотиды |
| US11882815B2 (en) | 2016-06-15 | 2024-01-30 | University Of Massachusetts | Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells |
| WO2018017814A1 (en) | 2016-07-20 | 2018-01-25 | President And Fellows Of Harvard College | Peptidoglycan glycosyltransferase inhibitors of sed proteins for treating bacterial infections |
| US11202818B2 (en) | 2016-09-14 | 2021-12-21 | President And Fellows Of Harvard College | Methods and compositions for modulating erythropoiesis |
| US10457940B2 (en) | 2016-09-22 | 2019-10-29 | University Of Massachusetts | AAV treatment of Huntington's disease |
| AU2017341849B2 (en) | 2016-10-13 | 2024-03-21 | University Of Massachusetts | AAV capsid designs |
| WO2018112032A1 (en) | 2016-12-13 | 2018-06-21 | President And Fellows Of Harvard College | Methods and compositions for targeting tumor-infiltrating tregs using inhibitors of ccr8 and tnfrsf8 |
| US20190314427A1 (en) | 2016-12-16 | 2019-10-17 | Evelo Biosciences, Inc. | Methods of treating cancer using parabacteroides |
| WO2018112360A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating cancer |
| WO2018112364A1 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Combination therapies for treating melanoma |
| WO2018112365A2 (en) | 2016-12-16 | 2018-06-21 | Evelo Biosciences, Inc. | Methods of treating colorectal cancer and melanoma using parabacteroides goldsteinii |
| WO2018136598A1 (en) | 2017-01-18 | 2018-07-26 | Evelo Biosciences, Inc. | Methods of treating cancer |
| EP3570856A2 (en) | 2017-01-18 | 2019-11-27 | Evelo Biosciences, Inc. | Methods of treating cancer |
| AU2018261790B2 (en) * | 2017-05-05 | 2024-10-03 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| JP7327803B2 (ja) | 2017-05-09 | 2023-08-16 | ユニバーシティ オブ マサチューセッツ | 筋萎縮性側索硬化症（ａｌｓ）を処置する方法 |
| WO2019046401A1 (en) | 2017-08-29 | 2019-03-07 | Evelo Biosciences, Inc. | TREATMENT OF CANCER USING BLAUTIA STRAIN |
| CN111448321A (zh) | 2017-09-22 | 2020-07-24 | 马萨诸塞大学 | Sod1双表达载体及其用途 |
| EP4454654A3 (en) | 2017-10-16 | 2025-02-19 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
| WO2019169143A1 (en) | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using turicibacter sanguinis |
| WO2019169168A1 (en) | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using agathobaculum |
| WO2019169138A1 (en) | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using paraclostridium benzoelyticum |
| WO2019169160A1 (en) | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using ruminococcus gnavus |
| WO2019178057A1 (en) | 2018-03-12 | 2019-09-19 | Evelo Biosciences, Inc. | Methods of treating cancer using burkholderia |
| US20210047645A1 (en) * | 2018-05-08 | 2021-02-18 | Mayo Foundation For Medical Education And Research | Methods for treating ovarian cancer |
| EP3802829A4 (en) | 2018-06-08 | 2022-10-19 | University of Massachusetts | ANTISENSE OLIGONUCLEOTIDES TO RESTORE DYSFERLIN PROTEIN EXPRESSION IN CELLS FROM PATIENTS WITH DYSFERLINOPATHY |
| WO2020172229A1 (en) * | 2019-02-19 | 2020-08-27 | Board Of Regents, The University Of Texas System | Genetic targeting of cellular or neuronal sub-populations |
| AU2020237225A1 (en) | 2019-03-12 | 2021-10-14 | President And Fellows Of Harvard College | Methods and compositions for treating cancer |
| EP3946470A4 (en) * | 2019-04-05 | 2023-05-31 | Earli Inc. | IMPROVED METHODS AND COMPOSITIONS FOR SYNTHETIC BIOMARKERS |
| US20220226269A1 (en) | 2019-06-12 | 2022-07-21 | President And Fellows Of Harvard College | Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism |
| WO2021022110A1 (en) | 2019-08-01 | 2021-02-04 | Evelo Biosciences, Inc. | Inducing immune effects using bacteria of the genus bifidobacterium |
| CN115484986A (zh) | 2020-01-06 | 2022-12-16 | 海阳制药 | 用于预防或治疗黄斑变性的含有细胞可渗透的核酸复合物作为活性成分的组合物 |
| WO2021178556A1 (en) | 2020-03-04 | 2021-09-10 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for sensitization of tumor cells to immune therapy |
| US20230140435A1 (en) * | 2020-03-16 | 2023-05-04 | The Trustees Of The University Of Pennsylvania | Composition and methods for improving heart function and treating heart failure |
| EP4157264A4 (en) | 2020-05-27 | 2024-06-19 | The Regents of the University of California | Compositions and methods for transdifferentiating cells |
| WO2022056454A2 (en) | 2020-09-14 | 2022-03-17 | President And Fellows Of Harvard College | Methods and compositions for treating hpv-positive cancers |
| US20230340124A1 (en) | 2020-09-16 | 2023-10-26 | President And Fellows Of Harvard College | Methods of treating an individual that has failed an anti-pd-1/anti-pd-l1 therapy |
| US20250230412A1 (en) | 2022-02-01 | 2025-07-17 | President And Fellows Of Harvard College | Methods and compositions for treating cancer |
| CN119137278A (zh) * | 2022-03-24 | 2024-12-13 | 细胞和大脑有限公司 | 新型重组载体及其用途 |
| WO2023182870A1 (ko) * | 2022-03-24 | 2023-09-28 | (주)셀레브레인 | 신규 재조합 벡터 및 이의 용도 |
| WO2025038750A2 (en) | 2023-08-14 | 2025-02-20 | President And Fellows Of Harvard College | Methods and compositions for treating cancer |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194140B1 (en) | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
| PL169273B1 (pl) * | 1990-04-04 | 1996-06-28 | Chiron Corp | skierowanej przeciw wirusowi zapalenia watroby C PL |
| WO2002081494A1 (en) * | 2001-03-26 | 2002-10-17 | Sirna Therapeutics, Inc. | Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication |
| US6127116A (en) * | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| US6218181B1 (en) | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
| ES2374290T3 (es) | 1998-03-20 | 2012-02-15 | Commonwealth Scientific And Industrial Research Organisation | Genes sintéticos y constructos genéticos que comprenden los mismos. |
| US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| AU2001245793A1 (en) | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
| US20010055756A1 (en) | 2000-04-21 | 2001-12-27 | Charles Pellerin | Internal de novo initiation sites of the HCV NS5B polymerase and use thereof |
| US6693701B2 (en) * | 2001-05-29 | 2004-02-17 | Ibsen Photonics A/S | Method and apparatus for diffractive transfer of a mask grating |
| AUPR644301A0 (en) * | 2001-07-17 | 2001-08-09 | Unisearch Limited | Method and composition for treatment of cancer |
| WO2003016572A1 (en) | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | Oligonucleotide therapeutics for treating hepatitis c virus infections |
| AU2002326906C1 (en) | 2001-09-13 | 2009-01-29 | California Institute Of Technology | Method for expression of small antiviral RNA molecules within a cell |
| EP1462525B1 (en) * | 2001-11-28 | 2010-10-06 | Toudai Tlo, Ltd. | siRNA EXPRESSION SYSTEM AND PROCESS FOR PRODUCING FUNCTIONAL GENE KNOCKDOWN CELL OR THE LIKE USING THE SAME |
| EP1430157B1 (en) * | 2002-02-20 | 2011-08-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20030175783A1 (en) * | 2002-03-14 | 2003-09-18 | Peter Waterhouse | Methods and means for monitoring and modulating gene silencing |
| DE10212892A1 (de) | 2002-03-20 | 2003-10-09 | Basf Plant Science Gmbh | Konstrukte und Verfahren zur Regulation der Genexpression |
| EP1495141A4 (en) * | 2002-03-20 | 2006-03-22 | Massachusetts Inst Technology | THERAPY OF HIV |
| US20040053876A1 (en) * | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
| US8211455B2 (en) * | 2002-06-19 | 2012-07-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
| CA2884658A1 (en) | 2002-07-26 | 2004-02-05 | Novartis Vaccines And Diagnostics, Inc. | Modified small interfering rna molecules and methods of use |
| WO2004020605A2 (en) | 2002-08-29 | 2004-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Circular nucleic acid vectors, and methods for making and using the same |
| EP2071030A3 (en) * | 2003-01-24 | 2009-07-22 | Tokyo Metropolitan Organization for Medical Research | Oligoribonucleotide or peptide nucleic acid which inhibits action of hepatitis C virus |
| CN1276976C (zh) | 2003-10-30 | 2006-09-27 | 封江南 | 单一载体编码多个发夹结构小干扰性rna表达系统及其构建方法 |
| CN101068926B (zh) * | 2004-03-05 | 2013-01-02 | 贝尼泰克生物制药有限公司 | 用于RNAi试剂同时递送的多启动子表达盒及用途 |
| JP4763681B2 (ja) * | 2004-03-05 | 2011-08-31 | ベニテック インコーポレイテッド | ＲＮＡｉ作用媒介物の同時デリバリーのためのマルチプロモーター発現カセット |
-
2005
- 2005-03-04 JP JP2007502094A patent/JP4763681B2/ja not_active Expired - Fee Related
- 2005-03-04 KR KR1020127000533A patent/KR101337579B1/ko not_active Expired - Fee Related
- 2005-03-04 AU AU2005222084A patent/AU2005222084B2/en not_active Ceased
- 2005-03-04 WO PCT/US2005/007447 patent/WO2005087926A2/en not_active Ceased
- 2005-03-04 KR KR1020067020986A patent/KR101246862B1/ko not_active Expired - Fee Related
- 2005-03-04 DE DE602005027820T patent/DE602005027820D1/de not_active Expired - Lifetime
- 2005-03-04 NZ NZ550284A patent/NZ550284A/en not_active IP Right Cessation
- 2005-03-04 AT AT05727680T patent/ATE508190T1/de not_active IP Right Cessation
- 2005-03-04 CN CN201210556628.0A patent/CN103060324B/zh not_active Expired - Fee Related
- 2005-03-04 EP EP05727680A patent/EP1725660B1/en not_active Expired - Lifetime
- 2005-03-04 US US11/072,592 patent/US7727970B2/en not_active Expired - Fee Related
- 2005-03-04 EP EP11161216.4A patent/EP2363483A3/en not_active Withdrawn
- 2005-03-04 DK DK05727680.0T patent/DK1725660T3/da active
- 2005-03-04 CA CA2558771A patent/CA2558771C/en not_active Expired - Fee Related
-
2006
- 2006-09-03 IL IL177862A patent/IL177862A/en not_active IP Right Cessation
-
2010
- 2010-03-12 US US12/723,466 patent/US8283461B2/en not_active Expired - Fee Related
-
2012
- 2012-09-26 US US13/627,644 patent/US8691967B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1725660B1 (en) | 2011-05-04 |
| IL177862A0 (en) | 2006-12-31 |
| KR101246862B1 (ko) | 2013-03-27 |
| US8283461B2 (en) | 2012-10-09 |
| DE602005027820D1 (de) | 2011-06-16 |
| WO2005087926A2 (en) | 2005-09-22 |
| ATE508190T1 (de) | 2011-05-15 |
| JP4763681B2 (ja) | 2011-08-31 |
| CA2558771A1 (en) | 2005-09-22 |
| JP2007527244A (ja) | 2007-09-27 |
| AU2005222084B2 (en) | 2010-04-22 |
| US20130171726A1 (en) | 2013-07-04 |
| WO2005087926A3 (en) | 2006-03-16 |
| CN103060324A (zh) | 2013-04-24 |
| EP2363483A3 (en) | 2014-07-16 |
| EP1725660A2 (en) | 2006-11-29 |
| KR20070063470A (ko) | 2007-06-19 |
| US7727970B2 (en) | 2010-06-01 |
| KR101337579B1 (ko) | 2013-12-06 |
| KR20120008094A (ko) | 2012-01-25 |
| US20110003378A1 (en) | 2011-01-06 |
| US8691967B2 (en) | 2014-04-08 |
| EP2363483A2 (en) | 2011-09-07 |
| IL177862A (en) | 2014-05-28 |
| US20050197313A1 (en) | 2005-09-08 |
| NZ550284A (en) | 2009-04-30 |
| CA2558771C (en) | 2013-01-08 |
| CN103060324B (zh) | 2015-04-01 |
| AU2005222084A1 (en) | 2005-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1725660T3 (da) | Ekspressionskassetter med multiple promotorer til samtidig afgivelse af RNAi-midler | |
| CY1118007T1 (el) | Μεθοδοι για την χορηγηση υπογλυκαιμικων μεσων | |
| LTPA2017019I1 (lt) | Žmogaus antikūnai, pasižymintys dideliu giminingumu PCSK9 | |
| ATE546119T1 (de) | Saugfähiger kern mit verbesserter struktur | |
| HRP20150828T8 (hr) | Kompozicije i postupci in vitro i in vivo ciljanog oslobađanja lijeka u stanicama sisavaca, preko intaktnih mini-stanica izvedenih iz bakterija | |
| CU20080006A7 (es) | Formas cristalinas de la 4-metil-n-[3-(4-metil-imidazol-1-il)-5-trifluoro-metil-fenil]-3-(4-piridin-3-il-pirimidin-2-il-amino)-benzamida | |
| WO2005086860A3 (en) | Methods for generating insulin-producing cells | |
| CR20110477A (es) | Inhibidores de enzimas de proteina cinasa activadas por mitogeno p38 | |
| DK2203439T3 (da) | 1',3'-disubstituerede 4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']-bipyridinyl-2'-oner | |
| ATE375518T1 (de) | Diagnoseverfahren für erkrankungen unter verwendung von copeptin | |
| DE602004011334D1 (de) | Rüttler für Zellkulturklimaschrank | |
| EP2507267A4 (en) | COMPOSITIONS AND METHODS FOR INCREASING THE SERUM DURABILITY OF FC FUSION PROTEINS | |
| PL1824887T3 (pl) | Przeciwciało cytotoksyczne skierowane przeciwko proliferacjom krwiotwórczych komórek limfatycznych typu B | |
| CY1115786T1 (el) | Μεσο φυλαξης για κυτταρα | |
| CO6241120A2 (es) | (DIHIDRO)PIRROLO[2,1-á]ISOQUINOLINAS. | |
| DE602005026548D1 (de) | Serumfreies kulturmedium für säugerzellen | |
| DE602005011780D1 (de) | Triazinderivate mit carbamatfunktion | |
| CL2009000257A1 (es) | Uso de imidazolinas 1,3 sustituidas y de sus sales fisiologicamente compatibles para el tratamiento del sindrome metabolico. | |
| EA200801297A1 (ru) | Способ снижения уровня постпрандиальной глюкозы | |
| TW200738752A (en) | Modulation of MDL-1 activity for treatment of inflammatory disease | |
| ATE553123T1 (de) | Wachstumsfaktormutanten mit hoher aktivität | |
| EA200801385A1 (ru) | Способ образования дендритных клеток с применением пониженной температуры | |
| RU2008125409A (ru) | Ген hgfopt фактора роста гепатоцитов | |
| FR2866532B3 (fr) | Plate-forme a plateau relevable a destination notamment de lit | |
| WO2006078337A3 (en) | Methods to create fluorescent biosensors using aptamers with fluorescent base analogs |