DK1709044T3 - Oxazolidinon-quinolon-hybridantibiotika - Google Patents
Oxazolidinon-quinolon-hybridantibiotikaInfo
- Publication number
- DK1709044T3 DK1709044T3 DK04804099T DK04804099T DK1709044T3 DK 1709044 T3 DK1709044 T3 DK 1709044T3 DK 04804099 T DK04804099 T DK 04804099T DK 04804099 T DK04804099 T DK 04804099T DK 1709044 T3 DK1709044 T3 DK 1709044T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxazolidinone
- quinolone hybrid
- hybrid antibiotics
- antibiotics
- quinolone
- Prior art date
Links
- HGKANZZLRDQFIM-UHFFFAOYSA-N 1,3-oxazolidin-2-one;1h-quinolin-2-one Chemical compound O=C1NCCO1.C1=CC=C2NC(=O)C=CC2=C1 HGKANZZLRDQFIM-UHFFFAOYSA-N 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4087—Esters with arylalkanols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53082203P | 2003-12-18 | 2003-12-18 | |
| EP04001506A EP1557416A1 (en) | 2004-01-23 | 2004-01-23 | Oxazolidinone-quinolone hybrid antibiotics |
| PCT/EP2004/014500 WO2005058888A2 (en) | 2003-12-18 | 2004-12-20 | Oxazolidinone-quinolone hybrid antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK1709044T3 true DK1709044T3 (da) | 2008-11-03 |
| DK1709044T4 DK1709044T4 (da) | 2014-01-20 |
Family
ID=39109376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04804099T DK1709044T4 (da) | 2003-12-18 | 2004-12-20 | Oxazolidinon-quinolon-hybridantibiotika |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US8501774B2 (da) |
| EP (1) | EP1709044B2 (da) |
| JP (2) | JP2007516263A (da) |
| KR (1) | KR101176450B1 (da) |
| CN (2) | CN1898238A (da) |
| AT (1) | ATE401326T1 (da) |
| AU (1) | AU2004299278C9 (da) |
| BR (1) | BRPI0417193B8 (da) |
| CA (1) | CA2549675C (da) |
| CY (1) | CY1108409T1 (da) |
| DE (1) | DE602004015158D1 (da) |
| DK (1) | DK1709044T4 (da) |
| ES (1) | ES2310299T5 (da) |
| IL (1) | IL175409A (da) |
| MX (1) | MXPA06006769A (da) |
| NZ (1) | NZ547382A (da) |
| PL (1) | PL1709044T5 (da) |
| PT (1) | PT1709044E (da) |
| RU (1) | RU2371443C2 (da) |
| SI (1) | SI1709044T2 (da) |
| WO (1) | WO2005058888A2 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| EP1620098B1 (en) | 2003-04-30 | 2008-06-11 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| AR054608A1 (es) * | 2005-08-08 | 2007-06-27 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidinona enlazados a quinolonas como antibacterianos |
| US8148362B2 (en) | 2006-03-31 | 2012-04-03 | Research Foundation Itsuu Laboratory | Compound having heterocyclic ring |
| US8124623B2 (en) | 2006-11-10 | 2012-02-28 | Actelion Pharmaceuticals Ltd. | 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials |
| EP2086968B1 (en) * | 2006-11-10 | 2012-02-08 | Actelion Pharmaceuticals Ltd. | 5-hydroxymethyl-oxazolidin-2-one derivatives |
| CL2007003332A1 (es) * | 2006-11-24 | 2008-06-20 | Actelion Pharmaceuticals Ltd | Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas. |
| WO2009044777A1 (ja) | 2007-10-02 | 2009-04-09 | Research Foundation Itsuu Laboratory | ７員ヘテロ環を有するオキサゾリジノン誘導体 |
| JP5404652B2 (ja) * | 2008-02-22 | 2014-02-05 | アクテリオン ファーマシューティカルズ リミテッド | オキサゾリジノン誘導体 |
| CN101965353B (zh) * | 2008-03-26 | 2014-12-17 | 丹诺医药(苏州）有限公司 | 共价连接到取代苯基噁唑烷酮的双环硝基咪唑类 |
| CN102239152B (zh) | 2008-10-27 | 2014-10-29 | 田边三菱制药株式会社 | 新型酰胺衍生物及其作为药物的用途 |
| EP2776431B1 (en) * | 2011-11-08 | 2016-05-04 | Actelion Pharmaceuticals Ltd. | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
| PT3003289T (pt) * | 2013-05-28 | 2019-06-04 | Morphochem Gmbh | Administração de antibacterianos híbridos de oxazolidinona-quinolona |
| AU2014273471B2 (en) * | 2013-05-28 | 2019-10-03 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections |
| CN103435611B (zh) * | 2013-09-07 | 2015-05-27 | 吉首大学 | 一类多靶点吡咯酮-喹啉酮型化合物及其制法和用途 |
| CN103483321B (zh) * | 2013-09-07 | 2014-08-13 | 吉首大学 | 烷基连接吡咯酮-喹啉酮型化合物及其制法和用途 |
| CN104725330B (zh) * | 2013-12-18 | 2017-06-13 | 四川好医生药业集团有限公司 | 噁唑烷酮类化合物及其制备方法和用途 |
| CN107286182A (zh) * | 2016-04-12 | 2017-10-24 | 李靖 | 新型噁唑烷酮‑氟喹诺酮衍生物及用途 |
| CN108059624A (zh) * | 2016-11-08 | 2018-05-22 | 上海医药工业研究院 | 用于制备咔哒唑胺关键中间体的制备方法 |
| US10087171B2 (en) | 2016-12-19 | 2018-10-02 | Actelion Pharmaceuticals Ltd | Crystalline forms of cadazolid |
| CN112898317B (zh) * | 2021-01-21 | 2021-12-07 | 河南科技大学第一附属医院 | 一种用于医院护理杀菌消毒的噁唑类化合物及其制备方法和应用 |
| CN114478486B (zh) * | 2022-01-28 | 2023-07-25 | 西南大学 | 以对氨基水杨酸为母核的三分子缀合物、中间体、制备方法及用途 |
| TW202415651A (zh) | 2022-07-29 | 2024-04-16 | 日商住友製藥股份有限公司 | 含氮飽和雜環衍生物 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4840956A (en) | 1986-02-18 | 1989-06-20 | Warner-Lambert Company | Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents |
| NZ222047A (en) | 1986-10-08 | 1991-01-29 | Bristol Myers Co | Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents |
| JPH0269478A (ja) | 1988-09-05 | 1990-03-08 | Sagami Chem Res Center | キノロンカルボン酸誘導体 |
| US5491139A (en) | 1988-10-24 | 1996-02-13 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
| EP0390215B1 (en) | 1989-03-30 | 1995-06-07 | Wakunaga Seiyaku Kabushiki Kaisha | Quinolone derivatives and salts thereof, preparation process es thereof, and antibacterial agents containing the same |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| CA2119556C (en) | 1991-11-01 | 2004-07-06 | Michael Robert Barbachyn | Substituted aryl- and heteroaryl-phenyloxazolidinones |
| US5221676A (en) | 1992-02-06 | 1993-06-22 | Warner-Lambert Company | 7-substituted quinolones and naphthyridones as antibacterial agents |
| JP3103380B2 (ja) | 1995-09-22 | 2000-10-30 | 湧永製薬株式会社 | 新規ピリドンカルボン酸誘導体又はその塩並びに該物質を有効成分とする抗菌剤 |
| DE19601265A1 (de) | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| DE19633480A1 (de) | 1996-08-20 | 1998-02-26 | Bayer Ag | Oral applizierbare Formulierungen von Chinolon- und Naphthyridoncarbonsäuren |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| EP1049682A1 (en) | 1998-01-23 | 2000-11-08 | Versicor, Inc. | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| TW572757B (en) | 1998-08-24 | 2004-01-21 | Bristol Myers Squibb Co | Novel isoxazolinone antibacterial agents |
| KR100324621B1 (ko) * | 1999-04-27 | 2002-02-27 | 박호군 | 퀴놀론이 치환된 옥사졸리디논 유도체 및 그의 제조 방법과 항균제로서의 용도 |
| EP1200416A1 (en) | 1999-07-28 | 2002-05-02 | Pharmacia & Upjohn Company | Oxazolidinones and their use as antiinfectives |
| US6518285B2 (en) | 1999-12-21 | 2003-02-11 | Ortho Mcneil Pharmaceutical, Inc. | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials |
| EP1349853B1 (en) * | 2000-12-21 | 2006-03-08 | Pharmacia & Upjohn Company LLC | Antimicrobial quinolone derivatives and use of the same to treat bacterial infections |
| ES2186550B2 (es) * | 2001-06-27 | 2003-11-16 | Vita Lab | Nuevos derivados de oxazolidinonas como antibacterianos. |
| WO2003031443A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| WO2003031441A1 (en) * | 2001-10-04 | 2003-04-17 | Morphochen Aktiengesellschaft Für Kombinatorische Chemie | Multiple action compounds |
| US6624593B2 (en) | 2001-10-08 | 2003-09-23 | Randall D. Blanchard | Dimmable ballast for electrodeless fluorescent lamps |
| US20040132764A1 (en) | 2002-10-23 | 2004-07-08 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Antibiotics for the treatment of infections in acidic environments |
| AU2003202753A1 (en) | 2003-02-07 | 2004-08-30 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| EP1620098B1 (en) * | 2003-04-30 | 2008-06-11 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
| DE10340485B4 (de) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| AR054608A1 (es) | 2005-08-08 | 2007-06-27 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidinona enlazados a quinolonas como antibacterianos |
| KR200430712Y1 (ko) | 2006-08-30 | 2006-11-13 | 명 식 신 | 천장등 |
| EP2086968B1 (en) † | 2006-11-10 | 2012-02-08 | Actelion Pharmaceuticals Ltd. | 5-hydroxymethyl-oxazolidin-2-one derivatives |
| CL2007003332A1 (es) | 2006-11-24 | 2008-06-20 | Actelion Pharmaceuticals Ltd | Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas. |
| JP4819980B2 (ja) † | 2008-05-09 | 2011-11-24 | アクテリオン ファーマシューティカルズ リミテッド | 細菌性腸管疾患の治療のための５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体 |
-
2004
- 2004-12-20 AU AU2004299278A patent/AU2004299278C9/en not_active Expired
- 2004-12-20 SI SI200430867T patent/SI1709044T2/sl unknown
- 2004-12-20 PT PT04804099T patent/PT1709044E/pt unknown
- 2004-12-20 RU RU2006125510A patent/RU2371443C2/ru active
- 2004-12-20 ES ES04804099T patent/ES2310299T5/es not_active Expired - Lifetime
- 2004-12-20 DK DK04804099T patent/DK1709044T4/da active
- 2004-12-20 CN CNA200480038072XA patent/CN1898238A/zh active Pending
- 2004-12-20 JP JP2006544382A patent/JP2007516263A/ja active Pending
- 2004-12-20 KR KR20067014403A patent/KR101176450B1/ko not_active Expired - Lifetime
- 2004-12-20 MX MXPA06006769A patent/MXPA06006769A/es active IP Right Grant
- 2004-12-20 DE DE200460015158 patent/DE602004015158D1/de not_active Expired - Lifetime
- 2004-12-20 CA CA 2549675 patent/CA2549675C/en not_active Expired - Lifetime
- 2004-12-20 WO PCT/EP2004/014500 patent/WO2005058888A2/en not_active Ceased
- 2004-12-20 NZ NZ547382A patent/NZ547382A/en not_active IP Right Cessation
- 2004-12-20 BR BRPI0417193A patent/BRPI0417193B8/pt not_active IP Right Cessation
- 2004-12-20 EP EP04804099.2A patent/EP1709044B2/en not_active Expired - Lifetime
- 2004-12-20 CN CN201611120339.0A patent/CN106957316A/zh active Pending
- 2004-12-20 PL PL04804099T patent/PL1709044T5/pl unknown
- 2004-12-20 AT AT04804099T patent/ATE401326T1/de active
-
2006
- 2006-05-04 IL IL175409A patent/IL175409A/en active IP Right Grant
-
2008
- 2008-10-13 CY CY081101128T patent/CY1108409T1/el unknown
-
2011
- 2011-07-20 JP JP2011158523A patent/JP5722149B2/ja not_active Expired - Lifetime
-
2012
- 2012-02-08 US US13/368,667 patent/US8501774B2/en not_active Expired - Fee Related
-
2013
- 2013-07-02 US US13/933,811 patent/US9133213B2/en not_active Expired - Lifetime
-
2015
- 2015-08-03 US US14/816,789 patent/US20150336992A1/en not_active Abandoned
Also Published As
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