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WO2009044777A1 - ７員ヘテロ環を有するオキサゾリジノン誘導体 - Google Patents

７員ヘテロ環を有するオキサゾリジノン誘導体 Download PDF

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Publication number
WO2009044777A1
WO2009044777A1 PCT/JP2008/067843 JP2008067843W WO2009044777A1 WO 2009044777 A1 WO2009044777 A1 WO 2009044777A1 JP 2008067843 W JP2008067843 W JP 2008067843W WO 2009044777 A1 WO2009044777 A1 WO 2009044777A1
Authority
WO
WIPO (PCT)
Prior art keywords
ring
hetero ring
atom
oxazolidinone
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/067843
Other languages
English (en)
French (fr)
Inventor
Hideyuki Suzuki
Iwao Utsunomiya
Koichi Shudo
Tsutomu Iwaki
Tatsuro Yasukata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RESEARCH FOUNDATION ITSUU LABORATORY
Shionogi and Co Ltd
Original Assignee
RESEARCH FOUNDATION ITSUU LABORATORY
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RESEARCH FOUNDATION ITSUU LABORATORY, Shionogi and Co Ltd filed Critical RESEARCH FOUNDATION ITSUU LABORATORY
Priority to JP2009536071A priority Critical patent/JPWO2009044777A1/ja
Priority to CN2008801187323A priority patent/CN101883768A/zh
Priority to EP08836063A priority patent/EP2208729A4/en
Priority to US12/733,954 priority patent/US8530646B2/en
Publication of WO2009044777A1 publication Critical patent/WO2009044777A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

　本発明は、抗菌剤として有用な、式（Ｉ） ［Ａ環は、（Ａ－１）３個のＮ原子を含有する７員の単環性複素環、（Ａ－２）２個のＮ原子と１個のＯ原子を含有する７員の単環性複素環、または（Ａ－３）２個のＮ原子と１個のＳ原子、ＳＯまたはＳＯ2を含有する７員の単環性複素環であって、該単環性複素環は置換されていてもよく、不飽和結合を有していてもよく、かつ該単環性複素環にはさらに環が縮合していてもよく；Ｘ1は、単結合、または－Ｏ－、－Ｓ－、－ＮＲ2－、－ＣＯ－、－ＣＳ－、－ＣＯＮＲ3－、－ＮＲ4ＣＯ－、－ＳＯ2ＮＲ5－、および－ＮＲ6ＳＯ2－（ここにＲ2～Ｒ6はそれぞれ独立して水素または低級アルキルである）からなる群から選択されるヘテロ原子含有基、または該ヘテロ原子含有基が介在していてもよい低級アルキレンもしくは低級アルケニレンであり；Ｂ環は置換されていてもよい炭素環または置換されていてもよい複素環であり；Ｒ1は水素またはオキサゾリジノン系抗菌剤のオキサゾリジノン環の５位に結合可能な有機残基である］で示される新規オキサゾリジノン誘導体、その製薬上許容される塩、およびそれらの溶媒和物を提供する。
PCT/JP2008/067843 2007-10-02 2008-10-01 ７員ヘテロ環を有するオキサゾリジノン誘導体 Ceased WO2009044777A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009536071A JPWO2009044777A1 (ja) 2007-10-02 2008-10-01 ７員ヘテロ環を有するオキサゾリジノン誘導体
CN2008801187323A CN101883768A (zh) 2007-10-02 2008-10-01 具有7元杂环的噁唑烷酮衍生物
EP08836063A EP2208729A4 (en) 2007-10-02 2008-10-01 OXAZOLIDINONE DERIVATIVE WITH 7-CHAIN HETEROCYCLE
US12/733,954 US8530646B2 (en) 2007-10-02 2008-10-01 Oxazolidinone derivative having 7-membered hetero ring

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007258898 2007-10-02
JP2007-258898 2007-10-02

Publications (1)

Publication Number Publication Date
WO2009044777A1 true WO2009044777A1 (ja) 2009-04-09

Family

ID=40526202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/067843 Ceased WO2009044777A1 (ja) 2007-10-02 2008-10-01 ７員ヘテロ環を有するオキサゾリジノン誘導体

Country Status (5)

Country Link
US (1) US8530646B2 (ja)
EP (3) EP2233484A3 (ja)
JP (2) JPWO2009044777A1 (ja)
CN (1) CN101883768A (ja)
WO (1) WO2009044777A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014500247A (ja) * 2010-11-03 2014-01-09 ウォックハート リミテッド リン酸モノ−（１−｛４−［（ｓ）―５−（アセチルアミノメチル）−２−オキソ−オキサゾリジン−３−イル］−２，６−ジフルオロフェニル｝−４−メトキシメチルピペリジン−４−イル）エステルの調製方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103420995B (zh) * 2013-09-07 2015-07-01 吉首大学 噁唑烷酮-烷胺基-呋喃酮型化合物及其制法和用途
CN107311869B (zh) * 2017-06-14 2019-11-08 浙江解氏新材料股份有限公司 3,4,5-三氟硝基苯的制备方法
CN107445915A (zh) * 2017-09-18 2017-12-08 张家港九力新材料科技有限公司 一种4,5‑二叔丁氧羰基‑[1,4,5]氧二氮杂庚烷制备方法
CN111718311A (zh) * 2019-03-21 2020-09-29 利尔化学股份有限公司 氧二氮杂环化合物的制备工艺

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EP2208729A4 (en) 2011-04-27
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EP2233484A3 (en) 2012-04-04
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