DK1791537T3 - 3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase - Google Patents

3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase

Info

Publication number: DK1791537T3
Authority: DK; Denmark
Prior art keywords: casein kinase; arylthioindole; analogues; inhibitors; carboxamide derivatives
Prior art date: 2004-08-19

Application number

DK05785433.3T

Other languages

English (en)

Inventor

William Arthur Metz Jr

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-08-19

Filing date

2005-08-19

Publication date

2010-03-01

2005-08-19 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2010-03-01 Application granted granted Critical

2010-03-01 Publication of DK1791537T3 publication Critical patent/DK1791537T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DK05785433.3T 2004-08-19 2005-08-19 3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase DK1791537T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60334804P	2004-08-19	2004-08-19
PCT/US2005/029306 WO2006023590A1 (en)	2004-08-19	2005-08-19	3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE Iϵ

Publications (1)

Publication Number	Publication Date
DK1791537T3 true DK1791537T3 (da)	2010-03-01

Family

ID=35311784

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05785433.3T DK1791537T3 (da)	2004-08-19	2005-08-19	3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase

Country Status (19)

Country	Link
US (1)	US8008340B2 (da)
EP (1)	EP1791537B1 (da)
JP (1)	JP4931814B2 (da)
KR (1)	KR20070045264A (da)
CN (1)	CN101039666A (da)
AT (1)	ATE445396T1 (da)
AU (1)	AU2005277460A1 (da)
BR (1)	BRPI0514397A (da)
CA (1)	CA2577511A1 (da)
DE (1)	DE602005017162D1 (da)
DK (1)	DK1791537T3 (da)
ES (1)	ES2334927T3 (da)
IL (1)	IL181155A0 (da)
MX (1)	MX2007001077A (da)
PL (1)	PL1791537T3 (da)
PT (1)	PT1791537E (da)
RU (1)	RU2391098C2 (da)
SI (1)	SI1791537T1 (da)
WO (1)	WO2006023590A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2716332A1 (en) *	2008-02-22	2009-08-27	Irm Llc	Compounds and compositions as modulators of gpr119 activity
US9018238B2 (en)	2009-02-12	2015-04-28	Pharmadesign, Inc.	Inhibitor of casein kinase 1δ and casein kinase 1ε
EP2493876B1 (en) *	2009-10-28	2014-02-12	Pfizer Inc	Imidazole derivatives as casein kinase inhibitors
AU2011248175A1 (en) *	2010-05-06	2012-10-25	Merck Sharp & Dohme Corp.	Aza-Indole derivatives useful as modulators of FAAH
WO2012020726A1 (ja)	2010-08-09	2012-02-16	株式会社ファルマデザイン	カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
KR101350077B1 (ko) *	2010-12-13	2014-01-14	한국화학연구원	신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
WO2012080729A2 (en) *	2010-12-14	2012-06-21	Electrophoretics Limited	CASEIN KINASE 1δ (CK1δ) INHIBITORS
NZ728724A (en) *	2012-05-11	2018-03-23	Reset Therapeutics Inc	Carbazole-containing sulfonamides as cryptochrome modulators
TWI690521B (zh)	2014-04-07	2020-04-11	美商同步製藥公司	作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
WO2018133835A1 (en) *	2017-01-20	2018-07-26	National Institute Of Biological Sciences, Beijing	Nucleoside analogue regulating mammalian circadian rhythm

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3705934A1 (de) *	1987-02-25	1988-09-08	Nattermann A & Cie	Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO1994019321A1 (en) *	1993-02-24	1994-09-01	Merck & Co., Inc.	Inhibitors of hiv reverse transcriptase
US5807693A (en) *	1994-11-23	1998-09-15	Icos Corporation	Calcineurin inhibitory compounds and anchoring protein
AU767800B2 (en) *	1999-06-08	2003-11-27	Aventisub Ii Inc.	Screening methods for altering circadian rhythm proteins
BR0308391A (pt) *	2002-03-13	2005-01-11	Pharmacia & Upjohn Co Llc	Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores
WO2004005501A1 (en) *	2002-07-08	2004-01-15	Bayer Healthcare Ag	Regulation of human casein kinase i epsilon
AU2003257170B2 (en) *	2002-08-09	2008-12-11	Merck Sharp & Dohme Corp.	Tyrosine kinase inhibitors
CA2549183A1 (en) *	2003-12-11	2005-07-07	Aventis Pharmaceuticals Inc.	Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon

2005
- 2005-08-19 DE DE602005017162T patent/DE602005017162D1/de not_active Expired - Lifetime
- 2005-08-19 SI SI200530889T patent/SI1791537T1/sl unknown
- 2005-08-19 PT PT05785433T patent/PT1791537E/pt unknown
- 2005-08-19 CA CA002577511A patent/CA2577511A1/en not_active Abandoned
- 2005-08-19 JP JP2007527987A patent/JP4931814B2/ja not_active Expired - Fee Related
- 2005-08-19 RU RU2007109813/14A patent/RU2391098C2/ru not_active IP Right Cessation
- 2005-08-19 WO PCT/US2005/029306 patent/WO2006023590A1/en not_active Ceased
- 2005-08-19 EP EP05785433A patent/EP1791537B1/en not_active Expired - Lifetime
- 2005-08-19 MX MX2007001077A patent/MX2007001077A/es not_active Application Discontinuation
- 2005-08-19 PL PL05785433T patent/PL1791537T3/pl unknown
- 2005-08-19 ES ES05785433T patent/ES2334927T3/es not_active Expired - Lifetime
- 2005-08-19 DK DK05785433.3T patent/DK1791537T3/da active
- 2005-08-19 BR BRPI0514397-7A patent/BRPI0514397A/pt not_active IP Right Cessation
- 2005-08-19 KR KR1020077003924A patent/KR20070045264A/ko not_active Withdrawn
- 2005-08-19 CN CNA2005800346526A patent/CN101039666A/zh active Pending
- 2005-08-19 AU AU2005277460A patent/AU2005277460A1/en not_active Abandoned
- 2005-08-19 AT AT05785433T patent/ATE445396T1/de not_active IP Right Cessation
2007
- 2007-02-04 IL IL181155A patent/IL181155A0/en unknown
- 2007-02-15 US US11/675,230 patent/US8008340B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2577511A1 (en)	2006-03-02
IL181155A0 (en)	2007-07-04
DE602005017162D1 (de)	2009-11-26
EP1791537B1 (en)	2009-10-14
SI1791537T1 (sl)	2010-02-26
PT1791537E (pt)	2010-01-19
MX2007001077A (es)	2007-04-17
EP1791537A1 (en)	2007-06-06
RU2007109813A (ru)	2008-09-27
RU2391098C2 (ru)	2010-06-10
US8008340B2 (en)	2011-08-30
AU2005277460A1 (en)	2006-03-02
CN101039666A (zh)	2007-09-19
KR20070045264A (ko)	2007-05-02
JP4931814B2 (ja)	2012-05-16
WO2006023590A1 (en)	2006-03-02
BRPI0514397A (pt)	2008-06-10
US20070142454A1 (en)	2007-06-21
PL1791537T3 (pl)	2010-04-30
ATE445396T1 (de)	2009-10-15
JP2008510704A (ja)	2008-04-10
ES2334927T3 (es)	2010-03-17

Publication	Publication Date	Title
IL181155A0 (en)	2007-07-04	3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase i?á
WO2005110410A3 (en)	2007-03-29	Kinase inhibitors as therapeutic agents
TN2010000019A1 (en)	2011-09-26	Solid preparation comprising alogliptin and metformin hydrochloride
WO2005075425A3 (en)	2006-12-14	Substituted bisarylurea derivatives as kinase inhibitors
CO6361856A2 (es)	2012-01-20	Compuestos de pirazolopirimidina inhibidores de jak y metodos
EA201000805A1 (ru)	2010-12-30	Бис-(сульфониламино)производные в терапии 066
EA201070167A1 (ru)	2013-07-30	Замещенные производные индазола, активные как ингибиторы киназы
EA201101672A1 (ru)	2012-06-29	Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
EA200501849A1 (ru)	2006-06-30	Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ
SE0400284D0 (sv)	2004-02-10	Novel compounds
TW200728307A (en)	2007-08-01	Novel spirochromanone derivatives
EA201001013A1 (ru)	2010-12-30	Бис(сульфониламино)производные для применения в терапии
MX2011012628A (es)	2011-12-14	Derivados amino-propionicos sustituidos como inhibidores de neprilisina.
NO20073959L (no)	2007-09-27	Kinazolinderivat, fremgangsmate for fremstilling og anvendelse derav for inhibering av vekst av kreftceller
EA200970585A1 (ru)	2009-10-30	Бензамидные производные как агонисты ер-рецепторов
MX2009011579A (es)	2009-11-11	Pirimidinonas como moduladores de caseina cinasa ii (ck2).
NO20091590L (no)	2009-05-08	Heterocykliske amidforbindelser anvendbare som kinaseinhibitorer
MX346186B (es)	2017-03-10	Inhibidores de proteina cinasas.
NO20083708L (no)	2008-09-23	4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
TW200637810A (en)	2006-11-01	Substituted N-aminomethylenesulfonamides, their preparation and use as medicaments
EA200970041A1 (ru)	2009-06-30	Ингибиторы акт (протеинкиназы в)
DK1753723T3 (da)	2008-10-20	Substituerede quinolinderivater som mitotiske kinesininhibitorer
PH12022550531A1 (en)	2023-03-20	Irak inhibitor and preparation method therefor and use thereof
MX2007004248A (es)	2007-06-12	Derivados heterociclicos de bisarilurea sustituidos como inhibidores de cinasa.
NO20065719L (no)	2006-12-12	I det vesentlige rene 2-{[2-(2-metylamino-pyrimidin-4-yl)-1H-indol-5-karbonyl]-amlno}-3-(fenylpyridin-2-yl-amino)-propionsyre som en IkB kinaseinhibitor.