DK1773884T3 - Terapeutiske og diagnostiske fremgangsmåder og sammensætninger til targeting af 4ig-b7-h3 og dets tilsvarende nk-celle-receptor - Google Patents
Terapeutiske og diagnostiske fremgangsmåder og sammensætninger til targeting af 4ig-b7-h3 og dets tilsvarende nk-celle-receptorInfo
- Publication number
- DK1773884T3 DK1773884T3 DK05775603.3T DK05775603T DK1773884T3 DK 1773884 T3 DK1773884 T3 DK 1773884T3 DK 05775603 T DK05775603 T DK 05775603T DK 1773884 T3 DK1773884 T3 DK 1773884T3
- Authority
- DK
- Denmark
- Prior art keywords
- targeting
- therapeutic
- compositions
- similar
- protein
- Prior art date
Links
- 108091008877 NK cell receptors Proteins 0.000 title 1
- 102000010648 Natural Killer Cell Receptors Human genes 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 102100038078 CD276 antigen Human genes 0.000 abstract 5
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 210000000822 natural killer cell Anatomy 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59872704P | 2004-08-03 | 2004-08-03 | |
| PCT/IB2005/002688 WO2006016276A2 (en) | 2004-08-03 | 2005-08-02 | Therapeutic and diagnostic methods and compositions targeting 4ig-b7-h3 and its counterpart nk cell receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1773884T3 true DK1773884T3 (da) | 2012-05-21 |
Family
ID=35241619
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11186925T DK2412728T3 (da) | 2004-08-03 | 2005-08-02 | Terapeutiske præparater mod cancer, der er rettet mod 4Ig-B7-H3 |
| DK05775603.3T DK1773884T3 (da) | 2004-08-03 | 2005-08-02 | Terapeutiske og diagnostiske fremgangsmåder og sammensætninger til targeting af 4ig-b7-h3 og dets tilsvarende nk-celle-receptor |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11186925T DK2412728T3 (da) | 2004-08-03 | 2005-08-02 | Terapeutiske præparater mod cancer, der er rettet mod 4Ig-B7-H3 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7732131B2 (da) |
| EP (2) | EP2412728B1 (da) |
| JP (2) | JP5130044B2 (da) |
| AT (1) | ATE548389T1 (da) |
| AU (1) | AU2005270918B2 (da) |
| CA (1) | CA2575607C (da) |
| DK (2) | DK2412728T3 (da) |
| ES (2) | ES2381557T3 (da) |
| WO (1) | WO2006016276A2 (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002010187A1 (en) | 2000-07-27 | 2002-02-07 | Mayo Foundation For Medical Education And Research | B7-h3 and b7-h4, novel immunoregulatory molecules |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| CA2668800A1 (en) | 2006-11-08 | 2008-06-05 | Macrogenics West, Inc. | Tes7 and antibodies that bind thereto |
| US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
| US20100203035A1 (en) * | 2007-02-14 | 2010-08-12 | Kwon Eugene D | B7-h3 in cancer |
| JP5785490B2 (ja) | 2008-04-02 | 2015-09-30 | マクロジェニクス,インコーポレーテッド | Bcr複合体特異的抗体およびその使用方法 |
| US20110110940A1 (en) * | 2008-04-15 | 2011-05-12 | Oxigene, Inc. | Methods for Enhancing the Efficacy of Vascular Disrupting Agents |
| FR2937470B1 (fr) | 2008-10-16 | 2010-12-10 | Fibercryst | Systeme amplificateur optique pour laser impulsionnel a base d'un milieu a gain guidant et laser impulisionnel le comprenant |
| AU2010215838A1 (en) * | 2009-02-20 | 2010-08-26 | John Wayne Cancer Institute | B7-H3 antibody coupled bead assay for detection of circulating tumor cells |
| US9005616B2 (en) | 2009-08-31 | 2015-04-14 | Amplimmune, Inc. | Methods and compositions for the inhibition of transplant rejection |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| US9150656B2 (en) | 2010-03-04 | 2015-10-06 | Macrogenics, Inc. | Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| WO2012004410A1 (en) * | 2010-07-09 | 2012-01-12 | Oslo Universitetssykehus Hf | B7-h3 antagonists and taxanes |
| LT2703486T (lt) * | 2011-04-25 | 2018-05-25 | Daiichi Sankyo Company, Limited | Anti-b7-h3 antikūnas |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| AU2015217278B2 (en) | 2014-02-14 | 2020-03-19 | Macrogenics, Inc. | Improved methods for the treatment of vascularizing cancers |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| SG10201908685QA (en) | 2015-06-22 | 2019-10-30 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
| US10736963B2 (en) | 2015-07-24 | 2020-08-11 | Innate Pharma | Methods for detecting tissue infiltrating NK cells |
| IL258521B2 (en) | 2015-10-08 | 2024-01-01 | Macrogenics Inc | Combination therapy for the treatment of cancer |
| AU2017236431A1 (en) | 2016-03-24 | 2018-09-27 | Bayer Pharma Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
| MY198114A (en) | 2016-04-15 | 2023-08-04 | Macrogenics Inc | Novel b7-h3-binding molecules, antibody drug conjugates thereof and methods of use thereof |
| CA3027445A1 (en) | 2016-06-15 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies |
| KR20190068602A (ko) | 2016-10-21 | 2019-06-18 | 이나뜨 파르마 | 항-kir3dl2 작용제에 의한 치료 |
| MX2019007641A (es) | 2016-12-21 | 2019-09-09 | Bayer Pharma AG | Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente. |
| WO2018114804A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Spezifische antikörper-wirkstoff-konjugate (adcs) mit ksp-inhibitoren |
| EP3558386A1 (de) | 2016-12-21 | 2019-10-30 | Bayer Aktiengesellschaft | Prodrugs von cytotoxischen wirkstoffen mit enzymatisch spaltbaren gruppen |
| EP3880712A4 (en) | 2018-11-16 | 2022-11-16 | Albert Einstein College of Medicine | MONOCLONAL ANTIBODIES AGAINST IgV DOMAIN OF B7-H3 AND USES THEREOF |
| TW202124717A (zh) * | 2019-12-30 | 2021-07-01 | 白素梅 | 人4IgB7-H3的突變編碼基因及其調節免疫的應用 |
| JP2023529368A (ja) * | 2020-06-03 | 2023-07-10 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | B7h3標的タンパク質及びその使用方法 |
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| ATE159982T1 (de) | 1988-09-15 | 1997-11-15 | Univ Columbia | Antikörper mit modifiziertem kohlenhydratgehalt und verfahren zur herstellung und verwendung |
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| JP2004528824A (ja) | 2000-12-18 | 2004-09-24 | アーンスティテュ ナシオナール ド ラ サント エ ド ラ ルシェルシェ メディカル(イー.エンヌ.エス.ウー.エール.エンム.) | 皮膚t細胞リンパ腫(ctcl)の新規な診断及び治療法 |
| ATE430580T1 (de) | 2001-10-25 | 2009-05-15 | Genentech Inc | Glycoprotein-zusammensetzungen |
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-
2005
- 2005-08-02 DK DK11186925T patent/DK2412728T3/da active
- 2005-08-02 CA CA2575607A patent/CA2575607C/en not_active Expired - Lifetime
- 2005-08-02 DK DK05775603.3T patent/DK1773884T3/da active
- 2005-08-02 US US11/659,175 patent/US7732131B2/en active Active
- 2005-08-02 EP EP11186925.1A patent/EP2412728B1/en not_active Expired - Lifetime
- 2005-08-02 AU AU2005270918A patent/AU2005270918B2/en not_active Ceased
- 2005-08-02 ES ES05775603T patent/ES2381557T3/es not_active Expired - Lifetime
- 2005-08-02 WO PCT/IB2005/002688 patent/WO2006016276A2/en not_active Ceased
- 2005-08-02 AT AT05775603T patent/ATE548389T1/de active
- 2005-08-02 JP JP2007524425A patent/JP5130044B2/ja not_active Expired - Fee Related
- 2005-08-02 ES ES11186925.1T patent/ES2534288T3/es not_active Expired - Lifetime
- 2005-08-02 EP EP05775603A patent/EP1773884B1/en not_active Expired - Lifetime
-
2010
- 2010-05-07 US US12/775,531 patent/US8465931B2/en not_active Expired - Fee Related
-
2012
- 2012-06-20 JP JP2012138816A patent/JP5560301B2/ja not_active Expired - Lifetime
-
2013
- 2013-06-07 US US13/912,333 patent/US20130315892A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK2412728T3 (da) | 2015-04-07 |
| US20130315892A1 (en) | 2013-11-28 |
| EP2412728A3 (en) | 2012-05-02 |
| AU2005270918B2 (en) | 2011-03-03 |
| AU2005270918A1 (en) | 2006-02-16 |
| WO2006016276A2 (en) | 2006-02-16 |
| JP5560301B2 (ja) | 2014-07-23 |
| JP2012197311A (ja) | 2012-10-18 |
| JP2008509130A (ja) | 2008-03-27 |
| ES2534288T3 (es) | 2015-04-21 |
| JP5130044B2 (ja) | 2013-01-30 |
| EP2412728B1 (en) | 2015-01-07 |
| US8465931B2 (en) | 2013-06-18 |
| WO2006016276A3 (en) | 2006-05-04 |
| US20100285531A1 (en) | 2010-11-11 |
| CA2575607C (en) | 2017-07-11 |
| ES2381557T3 (es) | 2012-05-29 |
| EP1773884A2 (en) | 2007-04-18 |
| US7732131B2 (en) | 2010-06-08 |
| CA2575607A1 (en) | 2006-02-16 |
| ATE548389T1 (de) | 2012-03-15 |
| US20080081346A1 (en) | 2008-04-03 |
| EP1773884B1 (en) | 2012-03-07 |
| EP2412728A2 (en) | 2012-02-01 |
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