DK1773870T3 - Fremgangsmåder til fremstilling af peptid, der har et C-terminalt amid - Google Patents

Fremgangsmåder til fremstilling af peptid, der har et C-terminalt amid

Info

Publication number: DK1773870T3
Authority: DK; Denmark
Prior art keywords: methods; terminal amide; preparing peptide; relates; phase synthesis
Prior art date: 2005-05-03

Application number

DK06759010.9T

Other languages

English (en)

Inventor

Gil Zaovi

Hagi Alon

Shai Elster

Shimon Shushan

Avi Tovi

Tehila Gadi

Gabriel-Marcus Butilca

Leah Bar-Oz

Eleonora Alterman

Alexander Ivchenko

Chaim Eidelman

Original Assignee

Novetide Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-03

Filing date

2006-05-02

Publication date

2010-04-12

2006-05-02 Application filed by Novetide Ltd filed Critical Novetide Ltd

2010-04-12 Application granted granted Critical

2010-04-12 Publication of DK1773870T3 publication Critical patent/DK1773870T3/da

Links

238000000034 method Methods 0.000 title abstract 2
125000003368 amide group Chemical group 0.000 title 1
210000004899 c-terminal region Anatomy 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
108010000817 Leuprolide Proteins 0.000 abstract 2
GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 abstract 2
229960004338 leuprorelin Drugs 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
239000012071 phase Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Analytical Chemistry (AREA)
Virology (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Urology & Nephrology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK06759010.9T 2005-05-03 2006-05-02 Fremgangsmåder til fremstilling af peptid, der har et C-terminalt amid DK1773870T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67758205P	2005-05-03	2005-05-03
PCT/US2006/017044 WO2006119388A2 (en)	2005-05-03	2006-05-02	Methods for the production of peptide having a c-terminal amide

Publications (1)

Publication Number	Publication Date
DK1773870T3 true DK1773870T3 (da)	2010-04-12

Family

ID=37199222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06759010.9T DK1773870T3 (da)	2005-05-03	2006-05-02	Fremgangsmåder til fremstilling af peptid, der har et C-terminalt amid

Country Status (9)

Country	Link
US (1)	US20060276626A1 (da)
EP (3)	EP2119725A1 (da)
JP (1)	JP2008534628A (da)
AT (1)	ATE452145T1 (da)
DE (1)	DE602006011099D1 (da)
DK (1)	DK1773870T3 (da)
ES (1)	ES2336826T3 (da)
IL (1)	IL185493A0 (da)
WO (1)	WO2006119388A2 (da)

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KR101046846B1 (ko)	2006-10-12	2011-07-06	동국제약 주식회사	고체상 합성법을 이용한 펩타이드의 제조방법
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CN102702325B (zh) *	2012-06-19	2015-09-23	深圳翰宇药业股份有限公司	一种抗凝血多肽的制备方法
WO2014067084A1 (zh) *	2012-10-31	2014-05-08	深圳翰宇药业股份有限公司	一种艾塞那肽的制备方法
KR101454892B1 (ko)	2012-10-31	2014-11-04	애니젠 주식회사	엑세나타이드의 제조방법
US9150615B2 (en)	2013-12-18	2015-10-06	Scinopharm Taiwan, Ltd.	Process for the preparation of leuprolide and its pharmaceutically acceptable salts
CN104910257B (zh) *	2015-01-07	2018-04-03	苏州天马医药集团天吉生物制药有限公司	戈舍瑞林的固相合成方法
CN106146360B (zh) *	2015-03-31	2020-05-15	深圳翰宇药业股份有限公司	一种制备酪氨酸-o-磺酸盐的方法
WO2017178950A1 (en) *	2016-04-11	2017-10-19	Emcure Pharmaceuticals Limited	Process for preparation of lanreotide acetate
CN107540727B (zh) *	2016-06-28	2021-03-16	深圳翰宇药业股份有限公司	布舍瑞林或戈舍瑞林的制备方法
CN106967155B (zh) *	2017-03-17	2018-05-15	兰州凯博药业股份有限公司	一种多肽液相合成缩宫素的方法
CN107602668A (zh) *	2017-10-10	2018-01-19	合肥师范学院	一种液相全合成制备布舍瑞林的方法
CN108892711A (zh) *	2018-06-29	2018-11-27	江苏吉泰肽业科技有限公司	一种纯化布舍瑞林的方法
EP3590526A1 (en) *	2018-07-05	2020-01-08	Antev Limited	A lyophilization process and a teverelix-tfa lyophilizate obtained thereby
EP3628683A1 (en) *	2018-09-28	2020-04-01	Zealand Pharma A/S	Formulations of glucagon-like-peptide-2 (glp-2) analogues
WO2020170185A1 (en) *	2019-02-21	2020-08-27	Dr. Reddy’S Laboratories Limited	Substantially pure lanreotide or its salt & process thereof
CN111825742B (zh) *	2019-04-18	2024-01-30	陈铭	Ctpa作为特种偶合剂用于氨基酸离子液体的多肽固相合成
CN110128505A (zh) *	2019-05-21	2019-08-16	梯尔希（南京）药物研发有限公司	一种戈舍瑞林杂质的合成方法
WO2021127234A2 (en) *	2019-12-20	2021-06-24	Northwestern University	Terlipressin-octadecanedioic acid conjugate for vasoconstrictive therapy
CN114685616B (zh) *	2020-12-31	2024-03-29	哈尔滨三联药业股份有限公司	醋酸曲普瑞林的合成方法
CN114716515A (zh) *	2022-03-31	2022-07-08	深圳深创生物药业有限公司	一种多肽类似物及其制备方法和应用
CN115417923B (zh) *	2022-07-29	2025-10-28	海南双成药业股份有限公司	一种无菌兰瑞肽原料药的制备方法
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2006
- 2006-05-02 EP EP09010809A patent/EP2119725A1/en not_active Withdrawn
- 2006-05-02 DK DK06759010.9T patent/DK1773870T3/da active
- 2006-05-02 AT AT06759010T patent/ATE452145T1/de not_active IP Right Cessation
- 2006-05-02 ES ES06759010T patent/ES2336826T3/es active Active
- 2006-05-02 US US11/416,856 patent/US20060276626A1/en not_active Abandoned
- 2006-05-02 EP EP09010808A patent/EP2119724A1/en not_active Withdrawn
- 2006-05-02 WO PCT/US2006/017044 patent/WO2006119388A2/en not_active Ceased
- 2006-05-02 JP JP2008504545A patent/JP2008534628A/ja active Pending
- 2006-05-02 DE DE602006011099T patent/DE602006011099D1/de not_active Expired - Fee Related
- 2006-05-02 EP EP06759010A patent/EP1773870B1/en not_active Not-in-force
2007
- 2007-08-23 IL IL185493A patent/IL185493A0/en unknown

Also Published As

Publication number	Publication date
IL185493A0 (en)	2008-01-06
JP2008534628A (ja)	2008-08-28
EP2119724A1 (en)	2009-11-18
WO2006119388A8 (en)	2008-04-17
EP1773870A2 (en)	2007-04-18
DE602006011099D1 (de)	2010-01-28
ES2336826T3 (es)	2010-04-16
EP2119725A1 (en)	2009-11-18
EP1773870B1 (en)	2009-12-16
WO2006119388A3 (en)	2007-06-28
ATE452145T1 (de)	2010-01-15
US20060276626A1 (en)	2006-12-07
WO2006119388A2 (en)	2006-11-09

Publication	Publication Date	Title
DK1773870T3 (da)	2010-04-12	Fremgangsmåder til fremstilling af peptid, der har et C-terminalt amid
CY1125885T1 (el)	2024-02-16	Τροποποιημενο πολυπεπτιδιο παραγοντα ix, οι χρησεις του και μια μεθοδος για την παραγωγη του
DK1511761T3 (da)	2006-11-27	Fremgangsmåde til fremstilling af cykliske peptider
ECSP13013115A (es)	2014-06-30	Composiciones que contienen, métodos que involucran, y usos de derivados de dolastatina unidos a aminoácidos no naturales
DE602005008996D1 (de)	2008-09-25	Radiofluorierte peptide
MX382833B (es)	2025-03-13	Compuestos derivados de prostaciclinas, y el uso de los mismo para el tratamiento de la hipertension pulmonar
UA108607C2 (uk)	2015-05-25	Пряна основа, яка підсилює смакові властивості, та спосіб її приготування
MX2009006617A (es)	2009-07-24	Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales.
BRPI0516385A (pt)	2007-11-27	composições contendo aminoácidos não naturais e polipeptìdeos, métodos envolvendo os mesmos e usos dos mesmos
DK1144607T5 (da)	2009-10-05	Fremgangsmåde til præsentation af (poly)peptider/proteiner på bakteriofage partikler via disulfidbindinger
WO2012170969A3 (en)	2013-08-15	Pro-coagulant compounds and methods of use thereof
ATE417595T1 (de)	2009-01-15	Keratin-bindende polypeptide
DK2007885T3 (da)	2010-11-08	Fremgangsmåde til forøgelse af in vivo-genvindingen af terapeutiske polypeptider
AR076977A1 (es)	2011-07-20	Proteinas precursoras repetitivas autoensambladas
DK1951747T3 (da)	2009-10-12	Fremgangsmåde og mellemprodukter til syntese af caspofungin
WO2010089757A3 (en)	2011-01-20	An improved process for synthesis of cyclic octapeptide
EA201170477A1 (ru)	2011-10-31	СПОСОБ СИНТЕЗА (Aib)hGLP-1(7-36)-NH
DK1879612T3 (da)	2009-07-20	Anvendelse af native peptider og deres optimerede derivater til vaccination
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