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MX2009006617A - Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales. - Google Patents

Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales.

Info

Publication number
MX2009006617A
MX2009006617A MX2009006617A MX2009006617A MX2009006617A MX 2009006617 A MX2009006617 A MX 2009006617A MX 2009006617 A MX2009006617 A MX 2009006617A MX 2009006617 A MX2009006617 A MX 2009006617A MX 2009006617 A MX2009006617 A MX 2009006617A
Authority
MX
Mexico
Prior art keywords
natural amino
polypeptides
amino acids
amino acid
methods
Prior art date
Application number
MX2009006617A
Other languages
English (en)
Inventor
Zhenwei Miao
Junjie Liu
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of MX2009006617A publication Critical patent/MX2009006617A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Se revelan en la presente aminoácidos no naturales y polipéptidos que incluyen por lo menos un aminoácido no natural y métodos para la fabricación de tales aminoácidos no naturales y polipéptidos. Los aminoácidos no naturales, por sí mismos o como parte de un polipéptido, pueden incluir un amplio intervalo de funcionalidades, pero tienen por lo menos comúnmente por lo menos un grupo indol, carbonilo y/o hidracina. También se revelan en la presente polipéptidos de aminoácidos no naturales que son modificados además post-traduccionalmente, métodos para efectuar tales modificaciones y métodos para purificar tales polipéptidos. Comúnmente, los polipéptidos de aminoácidos no naturales modificados incluyen por lo menos un grupo indol, carbonilo y/o hidracina. Se revelan además métodos para usar tales polipéptidos de aminoácidos no naturales y polipéptidos de aminoácidos no naturales modificados, en los que se incluyen usos terapéuticos, de diagnósticos y otros usos de biotecnología.
MX2009006617A 2006-12-18 2007-12-18 Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales. MX2009006617A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87059406P 2006-12-18 2006-12-18
PCT/US2007/088011 WO2008077079A1 (en) 2006-12-18 2007-12-18 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides

Publications (1)

Publication Number Publication Date
MX2009006617A true MX2009006617A (es) 2009-07-24

Family

ID=39536734

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006617A MX2009006617A (es) 2006-12-18 2007-12-18 Composiciones que contienen, metodos que involucran y usos de aminoacidos y polipeptidos no naturales.

Country Status (8)

Country Link
EP (1) EP2079687A1 (es)
JP (1) JP2010512800A (es)
KR (1) KR20090100407A (es)
CN (1) CN101578264A (es)
AU (1) AU2007333737A1 (es)
CA (1) CA2672205A1 (es)
MX (1) MX2009006617A (es)
WO (2) WO2008077079A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010068278A2 (en) * 2008-12-10 2010-06-17 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
WO2010096394A2 (en) 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
EP2605789B1 (en) * 2010-08-17 2019-06-05 Ambrx, Inc. Modified relaxin polypeptides and their uses
WO2012097333A2 (en) 2011-01-14 2012-07-19 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
WO2013130917A1 (en) * 2012-02-29 2013-09-06 Ambrx, Inc. Interleukin-3 polypeptide conjugates their uses
WO2013130814A1 (en) * 2012-02-29 2013-09-06 Ambrx, Inc. Novel prodrug containing molecule compostions and their uses
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP3536700A1 (en) * 2012-06-07 2019-09-11 Ambrx, Inc. Prostate-specific membrane antigen antibody drug conjugates
IL278638B1 (en) 2012-06-19 2025-09-01 Ambrx Inc Anti-CD70 antibody drug conjugates
US20160017058A1 (en) 2013-03-14 2016-01-21 The California Institute For Biomedical Research Bispecific antibodies and uses thereof
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
CN105829349B (zh) 2013-10-15 2023-02-03 斯克利普斯研究所 肽嵌合抗原受体t细胞开关和其用途
WO2016154621A1 (en) 2015-03-26 2016-09-29 The California Institute For Biomedical Research SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF
EP3283113A4 (en) 2015-04-15 2018-12-05 The California Institute for Biomedical Research Optimized pne-based chimeric receptor t cell switches and uses thereof
ES2992761T3 (en) 2016-02-04 2024-12-17 Scripps Research Inst Humanized anti-cd3 antibodies, conjugates and uses thereof
JP2019515677A (ja) 2016-04-26 2019-06-13 アール．ピー．シェーラー テクノロジーズ エルエルシー 抗体複合体ならびにそれを作製および使用する方法
US11174306B2 (en) 2016-10-19 2021-11-16 The Scripps Research Institute Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof
BR112019016139A2 (pt) 2017-02-08 2020-04-07 Bristol-Myers Squibb Company polipeptídio de relaxina modificada compreendendo um melhorador farmacocinético e usos do mesmo
WO2019241430A2 (en) 2018-06-12 2019-12-19 Angiex, Inc. Antibody-oligonucleotide conjugates
WO2020056066A1 (en) 2018-09-11 2020-03-19 Ambrx, Inc. Interleukin-2 polypeptide conjugates and their uses
JP2022522007A (ja) 2019-02-27 2022-04-13 アンジーエックス・インコーポレーテッド 抗ｔｍ４ｓｆ１抗体を含む抗体薬物コンジュゲートおよびそれを使用する方法
CN114127974B (zh) * 2019-05-13 2023-04-18 上海宸安生物科技有限公司 用于标记生物分子的标志
CN114524934B (zh) * 2020-11-23 2024-01-30 华东理工大学 多肽聚合物或多肽模拟物在骨修复中的应用
JPWO2023282315A1 (es) * 2021-07-07 2023-01-12
WO2024077277A1 (en) 2022-10-07 2024-04-11 Ambrx, Inc. Drug linkers and antibody conjugates thereof
KR20250134670A (ko) 2023-01-16 2025-09-11 암브룩스, 인코포레이티드 항-cd70 항체-약물 접합체
WO2024178310A1 (en) 2023-02-23 2024-08-29 Ambrx, Inc. Trop2-directed antibody-drug conjugates and uses thereof
WO2024241086A1 (en) 2023-05-24 2024-11-28 Ambrx, Inc. Pegylated bovine interferon lambda and methods of use thereof
WO2025041055A1 (en) 2023-08-22 2025-02-27 Ambrx, Inc. Anti-psma adc conjugate compositions and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0832065B1 (en) * 1995-06-06 2001-10-10 Pfizer Inc. Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors
EP1067950B1 (en) * 1998-04-10 2008-05-14 Mayo Foundation For Medical Education And Research Neo-tryptophan
US6858577B1 (en) * 1999-06-29 2005-02-22 Ortho-Mcneil Pharmaceutical, Inc. Indole peptidomimetics as thrombin receptor antagonists
JP3966816B2 (ja) * 2000-05-30 2007-08-29 中外製薬株式会社 トロンボポエチン様活性を有する化合物
US7129225B2 (en) * 2001-10-22 2006-10-31 The Research Foundation Of State University Of New York Protection against and treatment of hearing loss

Also Published As

Publication number Publication date
JP2010512800A (ja) 2010-04-30
AU2007333737A1 (en) 2008-06-26
EP2079687A1 (en) 2009-07-22
WO2011028195A2 (en) 2011-03-10
KR20090100407A (ko) 2009-09-23
CA2672205A1 (en) 2008-06-26
CN101578264A (zh) 2009-11-11
WO2011028195A3 (en) 2011-06-16
WO2008077079A1 (en) 2008-06-26

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