DK1638551T3 - Immunosuppressive forbindelser og sammensætninger - Google Patents
Immunosuppressive forbindelser og sammensætningerInfo
- Publication number
- DK1638551T3 DK1638551T3 DK04752678.5T DK04752678T DK1638551T3 DK 1638551 T3 DK1638551 T3 DK 1638551T3 DK 04752678 T DK04752678 T DK 04752678T DK 1638551 T3 DK1638551 T3 DK 1638551T3
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- immunosuppressive compounds
- diseases
- immunosuppressant
- prevention
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102000036530 EDG receptors Human genes 0.000 abstract 1
- 108091007263 EDG receptors Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47193103P | 2003-05-19 | 2003-05-19 | |
| PCT/US2004/015701 WO2004103309A2 (en) | 2003-05-19 | 2004-05-19 | Immunosuppressant compounds and compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1638551T3 true DK1638551T3 (da) | 2012-04-02 |
Family
ID=33476902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04752678.5T DK1638551T3 (da) | 2003-05-19 | 2004-05-19 | Immunosuppressive forbindelser og sammensætninger |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7060697B2 (da) |
| EP (1) | EP1638551B1 (da) |
| JP (1) | JP4575920B2 (da) |
| CN (4) | CN1791592B (da) |
| AT (1) | ATE537825T1 (da) |
| AU (2) | AU2004240649A1 (da) |
| BR (1) | BRPI0410454A (da) |
| CA (1) | CA2524054C (da) |
| CY (1) | CY1112505T1 (da) |
| DK (1) | DK1638551T3 (da) |
| ES (1) | ES2379169T3 (da) |
| MX (1) | MXPA05012459A (da) |
| PL (1) | PL1638551T3 (da) |
| PT (1) | PT1638551E (da) |
| SI (1) | SI1638551T1 (da) |
| WO (1) | WO2004103309A2 (da) |
| ZA (1) | ZA200508203B (da) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1546110A4 (en) * | 2002-07-30 | 2008-03-26 | Univ Virginia | COMPOUNDS WITH EFFECT ON SIGNAL TRANSMISSION BY SPHINGOSINE-1-PHOSPHATE |
| ES2754221T3 (es) * | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
| US7638637B2 (en) * | 2003-11-03 | 2009-12-29 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| WO2005082841A1 (en) * | 2004-02-24 | 2005-09-09 | Irm Llc | Immunosuppressant compounds and compositions |
| TW200538433A (en) * | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
| AU2005264431B2 (en) * | 2004-07-16 | 2010-08-19 | Kyorin Pharmaceutical Co., Ltd. | Method of effectively using medicine and method concerning prevention of side effect |
| PT2511262T (pt) | 2004-10-12 | 2017-03-30 | Kyorin Seiyaku Kk | Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol |
| US7888527B2 (en) * | 2004-12-06 | 2011-02-15 | University Of Virginia Patent Foundation | Aryl amide sphingosine 1-phosphate analogs |
| EP2371811B1 (en) * | 2004-12-13 | 2014-10-08 | Ono Pharmaceutical Co., Ltd. | Azetidinecarboxylic acid derivative and medicinal use thereof |
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| BRPI0617077A2 (pt) * | 2005-10-07 | 2015-01-06 | Kyorin Seiyaku Kk | Agente terapêutico para tratamento de doenças do fígado contendo 2-amina-1, 3-propanediol derivativo como ingrediente ativo, e método para tratamento de doenças do fígado |
| EP1986623A2 (en) * | 2006-01-27 | 2008-11-05 | University Of Virginia Patent Foundation | Method for treatment of neuropathic pain |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| JP2009526073A (ja) * | 2006-02-09 | 2009-07-16 | ユニバーシティ オブ バージニア パテント ファンデーション | 二環式スフィンゴシン−１−リン酸受容体アナログ |
| NZ574011A (en) * | 2006-08-08 | 2011-10-28 | Kyorin Seiyaku Kk | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient |
| CA2659599C (en) | 2006-08-08 | 2014-06-17 | Kyorin Pharmaceutical Co., Ltd. | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
| WO2008064320A2 (en) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
| EP2097371A2 (en) * | 2006-11-21 | 2009-09-09 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
| NZ576893A (en) * | 2006-11-21 | 2012-01-12 | Univ Virginia Patent Found | Tetralin analogs having sphingosine 1-phosphate agonist activity |
| CA2699157A1 (en) | 2007-09-10 | 2009-03-19 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
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| GB0725104D0 (en) * | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
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| TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
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| PT2307007E (pt) * | 2008-07-23 | 2014-11-13 | Novartis Ag | Moduladores do receptor esfingosina 1 fosfato e sua utilização para tratamento de inflamação muscular |
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| CN105816453B (zh) | 2008-08-27 | 2021-03-05 | 艾尼纳制药公司 | 用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物 |
| KR101724161B1 (ko) | 2008-08-27 | 2017-04-06 | 칼시메디카, 인크 | 세포내 칼슘을 조절하는 화합물 |
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| US12195457B2 (en) * | 2018-12-06 | 2025-01-14 | Shanghai Jemincare Pharmaceuticals Co., Ltd; | Aromatic ring derivative as immunoregulation and preparation method and application of aromatic ring derivative |
| WO2020114477A1 (zh) * | 2018-12-06 | 2020-06-11 | 上海济煜医药科技有限公司 | 作为免疫调节剂的化合物及其制备方法和应用 |
| CN111484434A (zh) * | 2019-01-29 | 2020-08-04 | 东莞市东阳光仿制药研发有限公司 | 一种辛波莫德晶型及其制备方法 |
| CN113382982B (zh) * | 2019-02-25 | 2023-01-31 | 广东东阳光药业有限公司 | 一种辛波莫德的制备方法 |
| KR20220100921A (ko) | 2019-11-13 | 2022-07-18 | 아프리노이아 테라퓨틱스 리미티드 | 타우 단백질 응집체를 분해하기 위한 화합물 및 이의 용도 |
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| CN119776509A (zh) * | 2023-10-08 | 2025-04-08 | 华东师范大学 | Ndufa10基因和S1pr4基因突变在肌病诊断、预测和治疗中的用途 |
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| CH540247A (de) | 1967-04-21 | 1973-09-28 | Ciba Geigy Ag | Verfahren zur Herstellung von heterocyclischen, Asthylendoppelbindungen enthaltenden Verbindungen |
| IL109161A0 (en) * | 1993-03-31 | 1994-06-24 | Cell Therapeutics Inc | Amino alcohol derivatives, methods for the preparation thereof, and pharmaceutical compositions containing the same |
| WO1996005828A1 (en) * | 1994-08-24 | 1996-02-29 | Eli Lilly And Company | Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor antagonists |
| US6110922A (en) * | 1998-12-29 | 2000-08-29 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| WO2001003739A1 (fr) * | 1999-07-12 | 2001-01-18 | Ono Pharmaceutical Co., Ltd. | Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate |
| WO2003020313A1 (en) * | 2001-09-04 | 2003-03-13 | Ono Pharmaceutical Co., Ltd. | Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller |
| US20050143372A1 (en) * | 2001-10-30 | 2005-06-30 | Shomir Ghosh | Compounds, pharmaceutical compositions and methods of use therefor |
| IL161626A0 (en) * | 2001-12-14 | 2004-09-27 | Zentaris Gmbh | Tetrahydrocarbozole derivatives as ligands for g-protein coupled receptors (gpcr) |
| AU2003216054B2 (en) | 2002-01-18 | 2007-01-04 | Merck & Co., Inc. | Selective S1P1/Edg1 receptor agonists |
| AU2003207567B2 (en) * | 2002-01-18 | 2008-01-24 | Merck Sharp & Dohme Corp. | Edg receptor agonists |
| DE10207844A1 (de) * | 2002-02-15 | 2003-09-04 | Schering Ag | 1-Phenyl-2-heteroaryl-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
| US20030207924A1 (en) * | 2002-03-07 | 2003-11-06 | Xue-Min Cheng | Compounds that modulate PPAR activity and methods of preparation |
| KR100681585B1 (ko) * | 2002-04-26 | 2007-02-09 | 에프. 호프만-라 로슈 아게 | 아이소퀴놀린 유도체 |
| JP2007186422A (ja) * | 2004-01-28 | 2007-07-26 | Astellas Pharma Inc | アリールスルフィド誘導体 |
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2004
- 2004-05-19 AT AT04752678T patent/ATE537825T1/de active
- 2004-05-19 PL PL04752678T patent/PL1638551T3/pl unknown
- 2004-05-19 SI SI200431832T patent/SI1638551T1/sl unknown
- 2004-05-19 CN CN2004800139502A patent/CN1791592B/zh not_active Expired - Fee Related
- 2004-05-19 AU AU2004240649A patent/AU2004240649A1/en not_active Abandoned
- 2004-05-19 CA CA2524054A patent/CA2524054C/en not_active Expired - Fee Related
- 2004-05-19 US US10/849,079 patent/US7060697B2/en not_active Expired - Fee Related
- 2004-05-19 US US10/849,450 patent/US7462629B2/en not_active Expired - Fee Related
- 2004-05-19 MX MXPA05012459A patent/MXPA05012459A/es active IP Right Grant
- 2004-05-19 PT PT04752678T patent/PT1638551E/pt unknown
- 2004-05-19 EP EP04752678A patent/EP1638551B1/en not_active Expired - Lifetime
- 2004-05-19 CN CN2004800131943A patent/CN1787817B/zh not_active Expired - Fee Related
- 2004-05-19 CN CN2004800188602A patent/CN1816544B/zh not_active Expired - Fee Related
- 2004-05-19 BR BRPI0410454-4A patent/BRPI0410454A/pt not_active IP Right Cessation
- 2004-05-19 CN CN2004800132486A patent/CN1791395B/zh not_active Expired - Lifetime
- 2004-05-19 DK DK04752678.5T patent/DK1638551T3/da active
- 2004-05-19 JP JP2006533219A patent/JP4575920B2/ja not_active Expired - Fee Related
- 2004-05-19 ES ES04752678T patent/ES2379169T3/es not_active Expired - Lifetime
- 2004-05-19 WO PCT/US2004/015701 patent/WO2004103309A2/en not_active Ceased
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2005
- 2005-10-11 ZA ZA200508203A patent/ZA200508203B/en unknown
-
2008
- 2008-07-11 AU AU2008203088A patent/AU2008203088A1/en not_active Abandoned
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2012
- 2012-03-16 CY CY20121100286T patent/CY1112505T1/el unknown
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| Publication number | Publication date |
|---|---|
| US7462629B2 (en) | 2008-12-09 |
| CA2524054A1 (en) | 2004-12-02 |
| HK1090559A1 (en) | 2006-12-29 |
| CN1791395A (zh) | 2006-06-21 |
| BRPI0410454A (pt) | 2006-06-13 |
| JP4575920B2 (ja) | 2010-11-04 |
| CN1791592B (zh) | 2012-07-04 |
| PL1638551T3 (pl) | 2012-05-31 |
| ZA200508203B (en) | 2007-02-28 |
| CA2524054C (en) | 2012-04-24 |
| US20050009786A1 (en) | 2005-01-13 |
| CN1816544B (zh) | 2011-06-08 |
| JP2006528987A (ja) | 2006-12-28 |
| EP1638551A2 (en) | 2006-03-29 |
| SI1638551T1 (sl) | 2012-04-30 |
| AU2008203088A1 (en) | 2008-08-07 |
| CN1787817B (zh) | 2011-09-07 |
| CN1791592A (zh) | 2006-06-21 |
| MXPA05012459A (es) | 2006-02-22 |
| EP1638551A4 (en) | 2008-12-31 |
| CN1787817A (zh) | 2006-06-14 |
| CN1791395B (zh) | 2012-09-26 |
| US7060697B2 (en) | 2006-06-13 |
| AU2004240649A1 (en) | 2004-12-02 |
| US20050014724A1 (en) | 2005-01-20 |
| ES2379169T3 (es) | 2012-04-23 |
| EP1638551B1 (en) | 2011-12-21 |
| CY1112505T1 (el) | 2015-12-09 |
| CN1816544A (zh) | 2006-08-09 |
| WO2004103309A3 (en) | 2005-03-03 |
| WO2004103309A2 (en) | 2004-12-02 |
| ATE537825T1 (de) | 2012-01-15 |
| PT1638551E (pt) | 2012-03-28 |
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