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DK1632483T3 - Heterocykliske, substituerede carbonylderivater og deres anvendelse som dopamin-D3-receptorligander - Google Patents

Heterocykliske, substituerede carbonylderivater og deres anvendelse som dopamin-D3-receptorligander

Info

Publication number
DK1632483T3
DK1632483T3 DK05018120T DK05018120T DK1632483T3 DK 1632483 T3 DK1632483 T3 DK 1632483T3 DK 05018120 T DK05018120 T DK 05018120T DK 05018120 T DK05018120 T DK 05018120T DK 1632483 T3 DK1632483 T3 DK 1632483T3
Authority
DK
Denmark
Prior art keywords
disorders
dopamine
compounds
substituted carbonyl
heterocyclic substituted
Prior art date
Application number
DK05018120T
Other languages
English (en)
Inventor
James A Hendrix
Horst Hemmerle
Matthias Urmann
Gregory M Shutske
Joseph T Strupczewski
Kenneth J Bordeau
John G Jurcak
Thaddeus Nieduzak
Sharon Anne Jackson
Paul Angell
James P Carey
George E Lee
David M Fink
Jean-Francois Sabuco
Yulin Chiang
Nicola Collar
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0117577.7A external-priority patent/GB0117577D0/en
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK1632483T3 publication Critical patent/DK1632483T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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DK05018120T 2001-02-16 2002-02-15 Heterocykliske, substituerede carbonylderivater og deres anvendelse som dopamin-D3-receptorligander DK1632483T3 (da)

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US26967201P 2001-02-16 2001-02-16
GBGB0117577.7A GB0117577D0 (en) 2001-02-16 2001-07-19 Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
PCT/US2002/004713 WO2002066446A1 (en) 2001-02-16 2002-02-15 Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands

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CA2438264A1 (en) 2002-08-29
ATE313534T1 (de) 2006-01-15
EP1935887B1 (en) 2010-01-13
DE60208157T2 (de) 2006-08-10
AU2002250107B8 (en) 2008-06-12
JP2009185054A (ja) 2009-08-20
ATE412638T1 (de) 2008-11-15
PT1632483E (pt) 2009-01-12
ES2317116T3 (es) 2009-04-16
MXPA03006943A (es) 2005-04-29
WO2002066446A1 (en) 2002-08-29
AU2002250107B2 (en) 2008-05-29
EP1362039B1 (en) 2005-12-21
EP1632483A1 (en) 2006-03-08
ES2253526T3 (es) 2006-06-01
EP1632483B1 (en) 2008-10-29
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