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MXPA03006943A - Derivados de carbonilo sustituidos heterocicliclos y su uso como ligandos para el receptor d3 de la dopamina. - Google Patents

Derivados de carbonilo sustituidos heterocicliclos y su uso como ligandos para el receptor d3 de la dopamina.

Info

Publication number
MXPA03006943A
MXPA03006943A MXPA03006943A MXPA03006943A MXPA03006943A MX PA03006943 A MXPA03006943 A MX PA03006943A MX PA03006943 A MXPA03006943 A MX PA03006943A MX PA03006943 A MXPA03006943 A MX PA03006943A MX PA03006943 A MXPA03006943 A MX PA03006943A
Authority
MX
Mexico
Prior art keywords
disorders
dopamine
compounds
substituted carbonyl
heterocyclic substituted
Prior art date
Application number
MXPA03006943A
Other languages
English (en)
Inventor
Collar Nicola
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0117577.7A external-priority patent/GB0117577D0/en
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of MXPA03006943A publication Critical patent/MXPA03006943A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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Abstract

La invencion se refiere a derivados heterocilicos sustituidos de carbonilo que presentan un enlace selectivo con receptores D3 de la dopamina. En otro aspecto, la invencion se refiere a un metodo para el tratamiento de trastornos del sistema nervioso central asociados con la actividad de receptor D3 de la dopamina en un paciente que requiere de dicho tratamiento, que comprende la administracion al sujeto de una cantidad terapeuticamente efectiva de dichos compuestos para mitigar dicho trastorno. Los trastornos del sistema nervioso central que pueden ser tratados con estos compuestos incluyen trastornos piscoticos, dependencia de sustancias, abuso de sustancias, trastornos disquimericos (por ejemplo, enfermedad de Parkinson, parkinsonismo, disquinesia tardia inducida por neurolepticos, sindrome de Gilles de la Tourette asi como enfermedad de Huntington), demencia, trastornos de ansiedad, trastornos del sueno, trastornos del ritmo circadiano asi como trastornos del humor. La presente invencion se enfoca tambien hacia procesos para la preparacion de los compuestos descritos aqui y a metodos para preparar y utilizar los compuestos como agentes de formacion de imagen para receptores D3 de la dopamina.
MXPA03006943A 2001-02-16 2002-02-15 Derivados de carbonilo sustituidos heterocicliclos y su uso como ligandos para el receptor d3 de la dopamina. MXPA03006943A (es)

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US26967201P 2001-02-16 2001-02-16
GBGB0117577.7A GB0117577D0 (en) 2001-02-16 2001-07-19 Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
PCT/US2002/004713 WO2002066446A1 (en) 2001-02-16 2002-02-15 Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands

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ATE412638T1 (de) 2008-11-15
AU2002250107B2 (en) 2008-05-29
JP2009185055A (ja) 2009-08-20
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IL157413A0 (en) 2004-03-28
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DE60235130D1 (de) 2010-03-04
DK1632483T3 (da) 2009-03-02
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DE60208157T2 (de) 2006-08-10
ATE313534T1 (de) 2006-01-15
WO2002066446A1 (en) 2002-08-29
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