DK162716C - Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det - Google Patents

Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det

Info

Publication number: DK162716C
Authority: DK; Denmark
Prior art keywords: mammals; mesoporphyrine; tin; heme; pharmaceutical preparations
Prior art date: 1985-03-25

Application number

DK565786A

Other languages

English (en)

Other versions

DK565786A (da

DK565786D0 (da

DK162716B (da

Inventor

Attallah Kappas

George S Drummond

Original Assignee

Univ Rockefeller

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-25

Filing date

1986-11-25

Publication date

1992-05-11

1986-11-25 Application filed by Univ Rockefeller filed Critical Univ Rockefeller

1986-11-25 Publication of DK565786A publication Critical patent/DK565786A/da

1986-11-25 Publication of DK565786D0 publication Critical patent/DK565786D0/da

1991-12-02 Publication of DK162716B publication Critical patent/DK162716B/da

1992-05-11 Application granted granted Critical

1992-05-11 Publication of DK162716C publication Critical patent/DK162716C/da

Links

239000000825 pharmaceutical preparation Substances 0.000 title 1
241000124008 Mammalia Species 0.000 abstract 3
150000003278 haem Chemical class 0.000 abstract 3
LLDZJTIZVZFNCM-UHFFFAOYSA-J 3-[18-(2-carboxyethyl)-8,13-diethyl-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;dichlorotin(2+) Chemical compound [H+].[H+].[Cl-].[Cl-].[Sn+4].[N-]1C(C=C2C(=C(C)C(=CC=3C(=C(C)C(=C4)N=3)CC)[N-]2)CCC([O-])=O)=C(CCC([O-])=O)C(C)=C1C=C1C(C)=C(CC)C4=N1 LLDZJTIZVZFNCM-UHFFFAOYSA-J 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
230000004060 metabolic process Effects 0.000 abstract 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
208000027119 bilirubin metabolic disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002440 hepatic effect Effects 0.000 abstract 1
208000036796 hyperbilirubinemia Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Compositions Of Macromolecular Compounds (AREA)
Epoxy Resins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK565786A 1985-03-25 1986-11-25 Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det DK162716C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US71551585		1985-03-25
US06/715,515 US4657902A (en)	1985-03-25	1985-03-25	Therapeutic use of tin mesoporphyrin
PCT/US1986/000445 WO1986005685A1 (en)	1985-03-25	1986-02-28	Therapeutic use of tin mesoporphyrin
US8600445		1986-02-28

Publications (4)

Publication Number	Publication Date
DK565786A DK565786A (da)	1986-11-25
DK565786D0 DK565786D0 (da)	1986-11-25
DK162716B DK162716B (da)	1991-12-02
DK162716C true DK162716C (da)	1992-05-11

Family

ID=24874343

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK565786A DK162716C (da)	1985-03-25	1986-11-25	Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det

Country Status (15)

Country	Link
US (1)	US4657902A (da)
EP (1)	EP0196079B1 (da)
JP (1)	JPS62500787A (da)
KR (1)	KR870700341A (da)
AT (1)	ATE61221T1 (da)
AU (1)	AU567041B2 (da)
CA (1)	CA1293504C (da)
DE (1)	DE3677804D1 (da)
DK (1)	DK162716C (da)
ES (1)	ES8800670A1 (da)
GR (1)	GR860768B (da)
IE (1)	IE58532B1 (da)
PH (2)	PH23102A (da)
WO (1)	WO1986005685A1 (da)
ZA (1)	ZA861793B (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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US4657902A (en) *	1985-03-25	1987-04-14	The Rockefeller University	Therapeutic use of tin mesoporphyrin
US4849207A (en) *	1985-10-23	1989-07-18	Nihon Medi-Physics Co., Ltd.	Porphyrin derivatives
EP0249966A1 (en) *	1986-06-20	1987-12-23	The Rockefeller University	Tin diiododeuteroporphyrin, its preparation and use, and pharmaceutical compositions thereof
US4782049A (en) *	1986-12-08	1988-11-01	The Rockefeller University	Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US4831024A (en) *	1987-10-15	1989-05-16	The Board Of Trustees Of The Leland Stanford Junior University	Method to prevent neonatal jaundice
US4997828A (en) *	1989-02-14	1991-03-05	The Rockefeller University	Method of weight control by low level administration of cobalt protoporphyrin or cobalt mesoporphyrin
DE69004417T2 (de) *	1989-09-25	1994-02-24	Rockefeller University New Yor	Oral verabreichte porphyrine zur regelung der eisenabsorption.
US5010073A (en) *	1989-10-05	1991-04-23	The Rockefeller University	Use of liposomes as carriers for metalloporphyrins
US5192757A (en) *	1990-12-20	1993-03-09	Glaxo Inc.	Cobalt porphyrins
US5149697A (en) *	1991-04-18	1992-09-22	Glaxo Inc.	Cobalt porphyrin pharmaceutical compositions
FR2676738B1 (fr) *	1991-05-22	1995-05-05	Ir2M	Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante.
US5599924A (en) *	1992-08-14	1997-02-04	Trustees Of The University Of Pennsylvania	Electron-deficient porphyrins and processes and intermediates for preparing same
US5493017A (en) *	1992-08-14	1996-02-20	The Trustees Of The University Of Pennsylvania	Ring-metalated porphyrins
US5371199B1 (en) *	1992-08-14	1995-12-26	Univ Pennsylvania	Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5817830A (en) *	1992-08-14	1998-10-06	Trustees Of The University Of Pennsylvania	Pyrrolic compounds
WO1994028906A1 (en) *	1993-06-14	1994-12-22	The Rockefeller University	Treatment of neonatal hyperbilirubin with metalloporphyrin
US6127356A (en)	1993-10-15	2000-10-03	Duke University	Oxidant scavengers
FI100454B (fi) *	1995-01-30	1997-12-15	Leiras Oy	Hemi-tuotteiden uusi lääkinnällinen käyttö
WO1997005152A1 (en) *	1995-08-02	1997-02-13	Warner-Lambert Company	Amino acid complexes of cobalt (iii) mesoporphyrin ix and cobalt (iii) protoporphyrin ix
CA2309154C (en)	1997-11-03	2010-02-16	Duke University	Substituted porphyrins
CN1093541C (zh) *	1998-01-19	2002-10-30	徐濂	金属卟啉及其生产工艺
ES2163951B1 (es)	1998-07-29	2003-05-16	Airbus Espana Sl	Un sistema de proteccion contra descargas electricas, especialmente rayos, de componentes estructurales de aviones.
ES2162718A1 (es)	1998-07-29	2002-01-01	Const Aeronauticas Sa	Un sistema de proteccion contra descargas electricas, especialmente rayos, de componentes estructurales de aviones.
AU6283299A (en) *	1998-10-01	2000-04-17	Elan Pharma International Limited	Controlled release nanoparticulate compositions
CA2359116C (en) *	1999-01-25	2009-03-17	National Jewish Medical And Research Center	Substituted porphyrins
US20030050297A1 (en) *	2001-01-19	2003-03-13	Crapo James D.	Cancer therapy
GB0111872D0 (en) *	2001-05-15	2001-07-04	Northwick Park Inst For Medica	Therapeutic agents and methods
AU2002312194B8 (en) *	2001-06-01	2008-05-15	Aeolus Sciences, Inc.	Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
US7968605B2 (en) *	2002-02-04	2011-06-28	ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.	Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) *	2002-02-04	2008-01-31	Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda	Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP1476168A2 (en) *	2002-02-04	2004-11-17	ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda.	Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
AU2003237349B2 (en)	2002-06-04	2010-06-03	Infacare Pharmaceutical Corporation	Preparation of metal mesoporphyrin halide compounds
US7375216B2 (en) *	2002-06-04	2008-05-20	Infacare Pharmaceutical Corporation	Preparation of metal mesoporphyrin compounds
CA2488500A1 (en) *	2002-06-07	2003-12-18	Duke University	Substituted porphyrins
US20040097481A1 (en) *	2002-11-20	2004-05-20	Benjamin Levinson	Water-soluble mesoporphyrin compounds and methods of preparation
GB2395432B (en) *	2002-11-20	2005-09-14	Northwick Park Inst For Medica	Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US7008937B2 (en) *	2003-06-10	2006-03-07	Frontier Scientific, Inc.	Porphyrins and metalloporphyrins for inhibiting heme iron uptake
US20060222668A1 (en) *	2005-04-01	2006-10-05	Wellspring Pharmaceutical Corporation	Stannsoporfin compositions, drug products and methods of manufacture
EP1865777A4 (en) *	2005-04-01	2008-07-16	Infacare Pharmaceutical Corp	STANNSOPORFIN COMPOSITIONS AND ADMINISTRATION
WO2007073226A1 (en) *	2005-12-20	2007-06-28	Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda	Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en)	2006-01-24	2006-03-01	Hemocorm Ltd	Therapeutic delivery of carbon monoxide
RS52185B (sr)	2006-10-04	2012-10-31	Infacare Pharmaceutical Corporation	Preparat stansoporfina sa visokim stepenom čistoće
CN102105146A (zh)	2008-05-23	2011-06-22	国立犹太保健医院	用于治疗与暴露于烷化物质有关的损伤的方法
WO2012135686A1 (en)	2011-03-30	2012-10-04	Infacare Pharmaceutical Corporation	Methods for synthesizing metal mesoporphyrins
WO2012145520A2 (en)	2011-04-19	2012-10-26	Alfama, Inc.	Carbon monoxide releasing molecules and uses thereof
WO2013013179A1 (en)	2011-07-21	2013-01-24	Alfama, Inc.	Ruthenium carbon monoxide releasing molecules and uses thereof
GB201120860D0 (en)	2011-12-05	2012-01-18	Cambridge Entpr Ltd	Cancer immunotherapy
CA3220985A1 (en)	2014-09-29	2016-04-07	Seattle Cancer Care Alliance	Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
US10676490B2 (en)	2015-07-07	2020-06-09	Florida Southwestern State College	Use of amine carboxyboranes as therapeutic delivery of carbon monoxide and as general drug delivery system in the presence of reactive oxygen species
CN111603472A (zh) *	2020-06-09	2020-09-01	上海市闵行区中心医院	一种锡-中卟啉与青蒿素联合应用在制备抗肿瘤药物中的用途

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US3579533A (en) *	1968-03-18	1971-05-18	Antioch College	Preparation of porphin,substituted porphin and metal chelates thereof
US3687863A (en) *	1970-05-25	1972-08-29	Gen Telephone & Elect	Optical filters containing tetraphenyl-porphins and method of making same
US4393071A (en) *	1975-03-17	1983-07-12	Naoharu Fujii	Method of treating gastric, mammary, lung and uterus tumors
JPS53109929A (en) *	1977-03-04	1978-09-26	Nippon Oil Co Ltd	Medicin for malignant tumor
EP0084053B1 (en) *	1981-07-15	1987-09-09	The Rockefeller University	Pharmaceutical composition and the use of sn- or cr-protoporphyrin for the manufacture thereof
EP0127797B1 (de) *	1983-06-03	1987-06-16	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung
US4657902A (en) *	1985-03-25	1987-04-14	The Rockefeller University	Therapeutic use of tin mesoporphyrin

1985
- 1985-03-25 US US06/715,515 patent/US4657902A/en not_active Expired - Lifetime
1986
- 1986-02-28 JP JP61501642A patent/JPS62500787A/ja active Granted
- 1986-02-28 AU AU55495/86A patent/AU567041B2/en not_active Expired
- 1986-02-28 WO PCT/US1986/000445 patent/WO1986005685A1/en not_active Ceased
- 1986-03-11 ZA ZA861793A patent/ZA861793B/xx unknown
- 1986-03-20 PH PH33560A patent/PH23102A/en unknown
- 1986-03-21 GR GR860768A patent/GR860768B/el unknown
- 1986-03-24 ES ES553306A patent/ES8800670A1/es not_active Expired
- 1986-03-24 IE IE75186A patent/IE58532B1/en not_active IP Right Cessation
- 1986-03-25 AT AT86104120T patent/ATE61221T1/de not_active IP Right Cessation
- 1986-03-25 EP EP86104120A patent/EP0196079B1/en not_active Expired - Lifetime
- 1986-03-25 CA CA000505076A patent/CA1293504C/en not_active Expired - Lifetime
- 1986-03-25 DE DE8686104120T patent/DE3677804D1/de not_active Expired - Lifetime
- 1986-11-24 KR KR860700831A patent/KR870700341A/ko not_active Ceased
- 1986-11-25 DK DK565786A patent/DK162716C/da not_active IP Right Cessation
1988
- 1988-04-22 PH PH36831A patent/PH24689A/en unknown

Also Published As

Publication number	Publication date
JPH0317806B2 (da)	1991-03-11
DK565786A (da)	1986-11-25
ATE61221T1 (de)	1991-03-15
ES8800670A1 (es)	1987-11-16
WO1986005685A1 (en)	1986-10-09
ES553306A0 (es)	1987-11-16
EP0196079B1 (en)	1991-03-06
IE58532B1 (en)	1993-10-06
DE3677804D1 (de)	1991-04-11
IE860751L (en)	1986-09-25
EP0196079A1 (en)	1986-10-01
US4657902A (en)	1987-04-14
AU5549586A (en)	1986-10-23
PH24689A (en)	1990-09-07
CA1293504C (en)	1991-12-24
DK565786D0 (da)	1986-11-25
DK162716B (da)	1991-12-02
AU567041B2 (en)	1987-11-05
GR860768B (en)	1986-07-22
KR870700341A (ko)	1987-12-28
ZA861793B (en)	1986-10-29
PH23102A (en)	1989-04-10
JPS62500787A (ja)	1987-04-02

Publication	Publication Date	Title
DK162716C (da)	1992-05-11	Tin-mesoporphyrin og farmaceutisk praeparat, der indeholder det
DK593886D0 (da)	1986-12-10	Forbindelser og farmaceutiske praeparater der inhiberer 5-lipoxygenase-vejen
SE8804036D0 (sv)	1988-11-08	New use of 11,28-dioxa-4-azatricyclo(22.3.1.0?724,9 )octacos-18-ene derivatives and pharmaceutical compositions containing them
IS3156A7 (is)	1987-04-30	Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
IT1127322B (it)	1986-05-21	Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
ATE81858T1 (de)	1992-11-15	6-thioxanthinderivate.
DE3682541D1 (de)	1992-01-02	Herbizid wirkende derivate des n-phenyl-3,4,5,6-tetrahydrophthalsaeureimides.
ES2002083A6 (es)	1988-07-01	Un metodo para preparar derivados de piroglutamida
DK166323C (da)	1993-08-30	Griseolsyrederivater og farmaceutiske midler indeholdende disse
FI860018A0 (fi)	1986-01-02	Laekemedelspreparat med reducerad toxisitet.
NO862534D0 (no)	1986-06-24	Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-oxy-4h-3,1-benzoxazin-4-on-derivater og beslektede forbindelser.
ATE56207T1 (de)	1990-09-15	Dopamin-beta-hydroxylase-inhibitoren.
ITMI921556A1 (it)	1993-12-24	Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
IT8026233A0 (it)	1980-11-26	Derivato della n-acetil-cisteina ad attivita' terapeutica, procedimento per la sua preparazione e relative composizioni farmaceutiche.
DK229089A (da)	1989-11-12	Peptid-laegemiddelpraeparater indeholdende alfa-aminoborsyrederivater til indgift via slimhinden
NO882724L (no)	1988-10-10	Smertepreparat.
IT8026232A0 (it)	1980-11-26	Composizioni farmaceutiche. derivato dell'alfa-mercapto propionilglicina ad attivita'terapeutica, procedimento per lasua preparazione e relative
ES8706651A1 (es)	1987-07-01	Un procedimiento para preparar derivados de tetrazol.
ATE87477T1 (de)	1993-04-15	Chromoglycinsaeure-natriumsalz enthaltende aerosolzubereitungen.
SU1139143A1 (ru)	1996-09-20	Гидрохлорид 3-(2-диэтиламиноэтилтио)-9-метил-1,2,4-триазино/6,5-в/ индола, обладающий противогипоксической активностью
ES8301230A1 (es)	1982-12-01	Un procedimiento para la preparacion de 1-fenil-5-amidotetrazoles.
JPS56166115A (en)	1981-12-21	Carcinostatic agent
SU993624A1 (ru)	1996-09-20	2,3-дифенилтиазоло (3',2',2,3)(1,2,4)триазино (6,5-в) индол, обладающий противовоспалительной активностью
IT8620302A0 (it)	1986-05-05	Procedimento e composizione per combattere la piralide sparganothis pilleriana.
IT8019080A0 (it)	1980-01-08	Derivati dell'indometacina adattivita' terapeutica e procedimenti per ottenerli.

Legal Events

Date	Code	Title	Description
2006-03-20	PUP	Patent expired