DK1682545T3 - Imidazopyridinsubstituerede tropanderivater med CCR5 receptorantagonistaktivitet til behandling af HIV og inflammation - Google Patents

Imidazopyridinsubstituerede tropanderivater med CCR5 receptorantagonistaktivitet til behandling af HIV og inflammation

Info

Publication number: DK1682545T3
Authority: DK; Denmark
Prior art keywords: imidazopyridine; hiv; inflammation; treatment; receptor antagonist
Prior art date: 2003-10-03

Application number

DK04769496T

Other languages

Danish (da)

English (en)

Inventor

Paul Anthony Stupple

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-03

Filing date

2004-09-28

Publication date

2008-03-17

2003-10-03 Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en

2003-10-27 Priority claimed from GB0325020A external-priority patent/GB0325020D0/en

2004-08-19 Priority claimed from GB0418566A external-priority patent/GB0418566D0/en

2004-09-28 Application filed by Pfizer filed Critical Pfizer

2008-03-17 Application granted granted Critical

2008-03-17 Publication of DK1682545T3 publication Critical patent/DK1682545T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Immunology (AREA)
Cardiology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Biotechnology (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)

DK04769496T 2003-10-03 2004-09-28 Imidazopyridinsubstituerede tropanderivater med CCR5 receptorantagonistaktivitet til behandling af HIV og inflammation DK1682545T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB0323236.0A GB0323236D0 (en)	2003-10-03	2003-10-03	Chemical compounds
GB0325020A GB0325020D0 (en)	2003-10-27	2003-10-27	Chemical compounds
GB0418566A GB0418566D0 (en)	2004-08-19	2004-08-19	Tropane derivatives
PCT/IB2004/003153 WO2005033107A1 (en)	2003-10-03	2004-09-28	Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation

Publications (1)

Publication Number	Publication Date
DK1682545T3 true DK1682545T3 (da)	2008-03-17

Family

ID=34426592

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04769496T DK1682545T3 (da)	2003-10-03	2004-09-28	Imidazopyridinsubstituerede tropanderivater med CCR5 receptorantagonistaktivitet til behandling af HIV og inflammation

Country Status (35)

Country	Link
US (2)	US7309790B2 (sr)
EP (1)	EP1682545B1 (sr)
JP (1)	JP4874107B2 (sr)
KR (1)	KR100777885B1 (sr)
AP (1)	AP2174A (sr)
AR (1)	AR045856A1 (sr)
AT (1)	ATE380813T1 (sr)
AU (1)	AU2004278158B2 (sr)
BR (1)	BRPI0414862A (sr)
CA (1)	CA2540834C (sr)
CY (1)	CY1107281T1 (sr)
DE (1)	DE602004010708T2 (sr)
DK (1)	DK1682545T3 (sr)
EA (1)	EA009941B1 (sr)
EC (1)	ECSP066475A (sr)
ES (1)	ES2295924T3 (sr)
GE (1)	GEP20084417B (sr)
HN (1)	HN2004000383A (sr)
HR (1)	HRP20080052T3 (sr)
IL (1)	IL174208A0 (sr)
MA (1)	MA28080A1 (sr)
MX (1)	MXPA06003749A (sr)
MY (1)	MY137609A (sr)
NO (1)	NO20061978L (sr)
NZ (1)	NZ545837A (sr)
OA (1)	OA13266A (sr)
PA (1)	PA8614301A1 (sr)
PE (1)	PE20050961A1 (sr)
PL (1)	PL1682545T3 (sr)
PT (1)	PT1682545E (sr)
RS (1)	RS20060198A (sr)
SI (1)	SI1682545T1 (sr)
TW (1)	TWI280244B (sr)
UY (1)	UY28546A1 (sr)
WO (1)	WO2005033107A1 (sr)

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TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
ES2421139T3 (es)	2003-07-30	2013-08-29	Rigel Pharmaceuticals, Inc.	Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias
US20070203161A1 (en)	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
US7491732B2 (en)	2005-06-08	2009-02-17	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the JAK pathway
WO2007098507A2 (en)	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
EP2997964A1 (en)	2006-04-05	2016-03-23	OPKO Health, Inc.	Pharmaceutical formulations comprising salts of (5s,8s)-8-[{(1 r)-1-(3,5-bis-trifluoromethyl)phenyl]- ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one and their medical use
WO2008030853A2 (en) *	2006-09-06	2008-03-13	Incyte Corporation	Combination therapy for human immunodeficiency virus infection
WO2008049123A2 (en)	2006-10-19	2008-04-24	Rigel Pharmaceuticals, Inc.	2,4-pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases
US20090325936A1 (en) *	2006-12-20	2009-12-31	Bilodeau Mark T	Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
AR065802A1 (es) *	2007-03-22	2009-07-01	Schering Corp	Formulaciones de comprimidos que contienen sales de 8- [( 1- ( 3,5- bis- (trifluorometil) fenil) -etoxi ) - metil) -8- fenil -1, 7- diaza- spiro [ 4,5] decan -2- ona y comprimidos elaborados a partir de estas
US8012956B2 (en) *	2007-10-25	2011-09-06	Exelixis, Inc.	Tropane compounds
MX2010008926A (es)	2008-02-15	2011-02-23	Rigel Pharmaceuticals Inc	Compuestos de pirimidin-2-amina y su uso como inhibidores de jak cinasas.
NZ589315A (en)	2008-04-16	2012-11-30	Portola Pharm Inc	2,6-diamino-pyrimidin-5-yl-carboxamides as Spleen tryosine kinase (syk) or Janus kinase (JAK) inhibitors
US8138339B2 (en)	2008-04-16	2012-03-20	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
NZ588830A (en)	2008-04-22	2012-11-30	Portola Pharm Inc	Inhibitors of protein kinases
SG176464A1 (en)	2008-05-09	2011-12-29	Agency Science Tech & Res	Diagnosis and treatment of kawasaki disease
WO2011019911A1 (en)	2009-08-14	2011-02-17	Opko Health, Inc.	Intravenous formulations of neurokinin-1 antagonists
CA2794443A1 (en)	2010-04-02	2011-10-06	Phivco-1 Llc	Combination therapy comprising a ccr5 antagonist, a hiv-1 protease inhibitor and a pharmacokinetic enhancer
US9102625B2 (en)	2010-11-01	2015-08-11	Portola Pharmaceuticals, Inc.	Nicotinamides as JAK kinase modulators
US20140271680A1 (en)	2011-08-12	2014-09-18	Universite Paris-Est Creteil Val De Marne	Methods and pharmaceutical compositions for treatment of pulmonary hypertension
EP2782579B1 (en)	2011-11-23	2019-01-02	Portola Pharmaceuticals, Inc.	Pyrazine kinase inhibitors
US9676756B2 (en)	2012-10-08	2017-06-13	Portola Pharmaceuticals, Inc.	Substituted pyrimidinyl kinase inhibitors
PL3049378T3 (pl) *	2013-09-25	2019-06-28	SpecGx LLC	Wytwarzanie radiojodowanego 3-fluoropropylo-nor-beta-CIT
GB201321748D0 (en)	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
EP4499097A1 (en) *	2022-03-31	2025-02-05	IncellDx, Inc.	Methods of treating a subject for post-treatment lyme disease (ptld) and compositions for use in the same
WO2023192361A1 (en) *	2022-03-31	2023-10-05	Incelldx, Inc.	Methods of treating a subject for fibromyalgia and compositions for use in the same

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ATE222587T1 (de)	1994-04-19	2002-09-15	Neurosearch As	TROPAN-2-ALDOXIMDERIVATE ALS NEUROTRANSMITTER ßREUPTAKEß INHIBITOREN
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JP3238414B2 (ja)	1996-02-22	2001-12-17	ニューロサーチ・アクティーゼルスカブ	トロパン―誘導体、その製造方法及びその使用方法
WO2000035298A1 (en)	1996-11-27	2000-06-22	Wm. Wrigley Jr. Company	Chewing gum containing medicament active agents
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PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
ATE260914T1 (de) *	2000-05-26	2004-03-15	Pfizer	Triazolyltropanderivate als ccr5-modulatoren
EP1492789B1 (en) *	2002-04-08	2006-06-07	Pfizer Limited	Tropane derivatives as ccr5 modulators
US6855724B2 (en) *	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy

2004
- 2004-09-28 EP EP04769496A patent/EP1682545B1/en not_active Expired - Lifetime
- 2004-09-28 SI SI200430564T patent/SI1682545T1/sl unknown
- 2004-09-28 JP JP2006530737A patent/JP4874107B2/ja not_active Expired - Fee Related
- 2004-09-28 AT AT04769496T patent/ATE380813T1/de active
- 2004-09-28 NZ NZ545837A patent/NZ545837A/en not_active IP Right Cessation
- 2004-09-28 DE DE602004010708T patent/DE602004010708T2/de not_active Expired - Lifetime
- 2004-09-28 OA OA1200600114A patent/OA13266A/en unknown
- 2004-09-28 AP AP2006003580A patent/AP2174A/xx active
- 2004-09-28 KR KR1020067006293A patent/KR100777885B1/ko not_active Expired - Fee Related
- 2004-09-28 US US10/953,136 patent/US7309790B2/en not_active Expired - Fee Related
- 2004-09-28 RS YUP-2006/0198A patent/RS20060198A/sr unknown
- 2004-09-28 WO PCT/IB2004/003153 patent/WO2005033107A1/en not_active Ceased
- 2004-09-28 ES ES04769496T patent/ES2295924T3/es not_active Expired - Lifetime
- 2004-09-28 CA CA2540834A patent/CA2540834C/en not_active Expired - Fee Related
- 2004-09-28 HR HR20080052T patent/HRP20080052T3/xx unknown
- 2004-09-28 AU AU2004278158A patent/AU2004278158B2/en not_active Ceased
- 2004-09-28 MX MXPA06003749A patent/MXPA06003749A/es active IP Right Grant
- 2004-09-28 BR BRPI0414862-2A patent/BRPI0414862A/pt not_active IP Right Cessation
- 2004-09-28 GE GEAP20049330A patent/GEP20084417B/en unknown
- 2004-09-28 PT PT04769496T patent/PT1682545E/pt unknown
- 2004-09-28 DK DK04769496T patent/DK1682545T3/da active
- 2004-09-28 EA EA200600480A patent/EA009941B1/ru not_active IP Right Cessation
- 2004-09-28 PL PL04769496T patent/PL1682545T3/pl unknown
- 2004-09-29 HN HN2004000383A patent/HN2004000383A/es unknown
- 2004-09-29 TW TW093129475A patent/TWI280244B/zh not_active IP Right Cessation
- 2004-10-01 UY UY28546A patent/UY28546A1/es unknown
- 2004-10-01 PE PE2004000965A patent/PE20050961A1/es not_active Application Discontinuation
- 2004-10-01 MY MYPI20044043A patent/MY137609A/en unknown
- 2004-10-01 AR ARP040103581A patent/AR045856A1/es not_active Application Discontinuation
- 2004-10-01 PA PA20048614301A patent/PA8614301A1/es unknown
2006
- 2006-03-09 IL IL174208A patent/IL174208A0/en unknown
- 2006-04-03 EC EC2006006475A patent/ECSP066475A/es unknown
- 2006-04-03 MA MA28906A patent/MA28080A1/fr unknown
- 2006-05-03 NO NO20061978A patent/NO20061978L/no not_active Application Discontinuation
2007
- 2007-08-27 US US11/845,500 patent/US7790740B2/en not_active Expired - Fee Related
2008
- 2008-02-14 CY CY20081100178T patent/CY1107281T1/el unknown

Also Published As

Publication number	Publication date
US20080045563A1 (en)	2008-02-21
MXPA06003749A (es)	2006-06-14
RS20060198A (sr)	2008-09-29
EP1682545A1 (en)	2006-07-26
DE602004010708D1 (de)	2008-01-24
NO20061978L (no)	2006-07-03
KR100777885B1 (ko)	2007-11-28
EA200600480A1 (ru)	2006-08-25
NZ545837A (en)	2009-12-24
CA2540834C (en)	2010-06-22
HRP20080052T3 (hr)	2008-02-29
AP2006003580A0 (en)	2006-04-30
EP1682545B1 (en)	2007-12-12
TWI280244B (en)	2007-05-01
PE20050961A1 (es)	2005-11-29
PL1682545T3 (pl)	2008-04-30
AP2174A (en)	2010-11-20
BRPI0414862A (pt)	2006-11-28
US7309790B2 (en)	2007-12-18
AR045856A1 (es)	2005-11-16
US20050131011A1 (en)	2005-06-16
KR20060070571A (ko)	2006-06-23
PA8614301A1 (es)	2005-05-10
GEP20084417B (en)	2008-07-10
ECSP066475A (es)	2006-10-10
MA28080A1 (fr)	2006-08-01
HN2004000383A (es)	2008-10-14
MY137609A (en)	2009-02-27
SI1682545T1 (sl)	2008-04-30
UY28546A1 (es)	2005-05-31
ATE380813T1 (de)	2007-12-15
US7790740B2 (en)	2010-09-07
CA2540834A1 (en)	2005-04-14
JP4874107B2 (ja)	2012-02-15
PT1682545E (pt)	2008-02-11
DE602004010708T2 (de)	2008-12-04
TW200519112A (en)	2005-06-16
IL174208A0 (en)	2006-08-01
OA13266A (en)	2007-01-31
JP2007507483A (ja)	2007-03-29
AU2004278158B2 (en)	2009-08-13
EA009941B1 (ru)	2008-04-28
CY1107281T1 (el)	2012-11-21
ES2295924T3 (es)	2008-04-16
AU2004278158A1 (en)	2005-04-14
WO2005033107A1 (en)	2005-04-14

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