DK1668368T3 - Detektion af histon-modifikation i cellefrie nukleosomer - Google Patents
Detektion af histon-modifikation i cellefrie nukleosomerInfo
- Publication number
- DK1668368T3 DK1668368T3 DK04768123T DK04768123T DK1668368T3 DK 1668368 T3 DK1668368 T3 DK 1668368T3 DK 04768123 T DK04768123 T DK 04768123T DK 04768123 T DK04768123 T DK 04768123T DK 1668368 T3 DK1668368 T3 DK 1668368T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell
- free nucleosomes
- detection
- nucleosomes
- histone modification
- Prior art date
Links
- 108010047956 Nucleosomes Proteins 0.000 title abstract 4
- 210000001623 nucleosome Anatomy 0.000 title abstract 4
- 108010033040 Histones Proteins 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102100039869 Histone H2B type F-S Human genes 0.000 abstract 1
- 101001035372 Homo sapiens Histone H2B type F-S Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000013060 biological fluid Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Geophysics And Detection Of Objects (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0319376.0A GB0319376D0 (en) | 2003-08-18 | 2003-08-18 | Histone modification detection |
| PCT/GB2004/003564 WO2005019826A1 (en) | 2003-08-18 | 2004-08-18 | Detection of histone modification in cell-free nucleosomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1668368T3 true DK1668368T3 (da) | 2009-02-23 |
Family
ID=28052702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04768123T DK1668368T3 (da) | 2003-08-18 | 2004-08-18 | Detektion af histon-modifikation i cellefrie nukleosomer |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9128086B2 (da) |
| EP (1) | EP1668368B1 (da) |
| AT (1) | ATE411525T1 (da) |
| DE (1) | DE602004017201D1 (da) |
| DK (1) | DK1668368T3 (da) |
| ES (1) | ES2315697T3 (da) |
| GB (1) | GB0319376D0 (da) |
| SI (1) | SI1668368T1 (da) |
| WO (1) | WO2005019826A1 (da) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0319376D0 (en) * | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| EP2267450B1 (en) * | 2005-04-29 | 2015-01-28 | The Regents of The University of California | Antibodies against histone modifications for clinical diagnosis and prognosis of cancer |
| US8119572B2 (en) | 2005-10-24 | 2012-02-21 | Wisconsin Alumni Research Foundation | Methods for determining protein binding specificity using peptide libraries |
| WO2012040523A2 (en) | 2010-09-24 | 2012-03-29 | The Rockefeller University | Phosphohistidine analogs |
| GB201115095D0 (en) * | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| GB201115098D0 (en) * | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| GB201115099D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes |
| AU2012349855B2 (en) | 2011-12-07 | 2017-12-07 | Belgian Volition Sprl | Method for detecting nucleosome adducts |
| GB201303576D0 (en) * | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for predicting therapy efficacy using nucleosome structure biomarkers |
| GB201303575D0 (en) * | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for detecting histone modifications in nucleosomes |
| EP2775304A1 (en) * | 2013-03-07 | 2014-09-10 | Universitätsspital Basel | Methods for detecting inflammatory disorder |
| WO2015138774A1 (en) | 2014-03-13 | 2015-09-17 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3809140A1 (en) * | 2014-10-29 | 2021-04-21 | Belgian Volition SPRL | Method for the enrichment of circulating tumor dna |
| GB201518665D0 (en) * | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for enrichment of cell free nucleosomes |
| GB201518674D0 (en) * | 2015-10-21 | 2015-12-02 | Singapore Volition Pte Ltd | Method for detecting nuleosomes containing histone modifications and variants |
| CN109415431A (zh) * | 2016-04-20 | 2019-03-01 | 爱兰细胞技术公司 | 与k180二甲基化h1.0蛋白相关的组合物和方法 |
| TWI726009B (zh) * | 2016-11-28 | 2021-05-01 | 比利時商比利時意志有限公司 | 用親和純化法分析生物樣品中源自腫瘤之無細胞核小體、分離生物樣品中純化之腫瘤dna、檢測生物樣品中源自腫瘤之核小體表觀遺傳表位或在動物或人類受試者中檢測癌症之方法或包括組蛋白h1結合劑之套組之用途 |
| CN117138146A (zh) | 2017-09-18 | 2023-12-01 | 圣特萨斯股份公司 | 用于针对循环无细胞dna纯化血液的方法和装置 |
| WO2019084332A1 (en) | 2017-10-25 | 2019-05-02 | Aelan Cell Technologies, Inc. | ANTI-H1.0K180ME2 ANTIBODIES, PREPARATION METHODS AND USES THEREOF |
| GB201721569D0 (en) | 2017-12-21 | 2018-02-07 | Belgian Volition Sprl | Method for the detection and treatment of colorectal adenomas |
| AU2019206547A1 (en) * | 2018-01-10 | 2020-07-30 | EpiCypher Inc. | Methods for quantification of nucleosome modifications and mutations at genomic loci and clinical applications thereof |
| DK4215621T3 (da) * | 2018-03-01 | 2025-08-04 | Epicypher Inc | Kvantificering af nukleosommodificeringer ved anvendelse af kemisk definerede rekombinante nukleosomer |
| US11781183B2 (en) * | 2018-03-13 | 2023-10-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Diagnostic use of cell free DNA chromatin immunoprecipitation |
| GB2587939B (en) | 2018-04-02 | 2023-06-14 | Grail Llc | Methylation markers and targeted methylation probe panels |
| CN113286881A (zh) | 2018-09-27 | 2021-08-20 | 格里尔公司 | 甲基化标记和标靶甲基化探针板 |
| GB201818965D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Method for the detection of colorectal cancer |
| GB201818963D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Methof for the detection of prostate cancer |
| GB201906201D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Voltion Sprl | Method for the detection of protate cancer |
| GB201906199D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| US20220290252A1 (en) | 2019-08-27 | 2022-09-15 | Belgian Volition Srl | Method of isolating circulating nucleosomes |
| GB201912251D0 (en) | 2019-08-27 | 2019-10-09 | Belgian Volition Sprl | Method of isolating circulating nucleosomes |
| BR112022010774A2 (pt) | 2019-12-02 | 2022-08-23 | Belgian Volition Srl | Uso de nucleossomos livres de células como biomarcadores |
| BR112022018792A2 (pt) | 2020-03-20 | 2022-11-01 | Belgian Volition Srl | Método de triagem usando níveis de nucleossomos livres de células |
| EP4213909A1 (en) | 2020-09-21 | 2023-07-26 | Belgian Volition SRL | Device for inline monitoring of free nucleosomes in blood |
| CA3195344A1 (en) * | 2020-11-02 | 2022-05-05 | Matthew R. MARUNDE | Improved assays to quantify chromatin targets using antibody-targeted enzyme digestion |
| TW202238131A (zh) | 2020-11-25 | 2022-10-01 | 比利時商比利時意志有限公司 | 測量無細胞核蛋白染色質片段之方法 |
| TW202238132A (zh) | 2020-12-08 | 2022-10-01 | 比利時商比利時意志有限公司 | 多發性硬化症之診斷方法 |
| TW202242145A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析 |
| TW202242130A (zh) | 2020-12-29 | 2022-11-01 | 比利時商比利時意志有限公司 | 循環轉錄因子分析 |
| TW202242146A (zh) | 2021-01-13 | 2022-11-01 | 比利時商比利時意志有限公司 | 肺癌的檢測方法 |
| GB202108185D0 (en) | 2021-06-08 | 2021-07-21 | Belgian Volition Sprl | Standardisation of nucleosome assays using biologically derived calibrants |
| GB202108452D0 (en) | 2021-06-14 | 2021-07-28 | Belgian Volition Sprl | Triaging method using cell free nucleosome levels |
| WO2023073179A1 (en) | 2021-10-29 | 2023-05-04 | Belgian Volition Srl | Homogeneous immunoassay method |
| GB202117799D0 (en) | 2021-12-09 | 2022-01-26 | Belgian Volition Srl | Method for the detection of blood cancer |
| US12053567B2 (en) | 2021-12-27 | 2024-08-06 | Santersus Ag | Method and device for removal of circulating cell free DNA |
| US20250197944A1 (en) | 2022-03-11 | 2025-06-19 | Belgian Volition Srl | Differential diagnosis method |
| GB202205212D0 (en) | 2022-04-08 | 2022-05-25 | Belgian Volition Sprl | Method for transplant organ health assessment |
| CA3265699A1 (en) | 2022-08-25 | 2024-02-29 | Belgian Volition Srl | METHOD FOR DETECTING DEMENTIA |
| EP4577833A1 (en) | 2022-08-25 | 2025-07-02 | Belgian Volition SRL | Method for measuring cell free chromatin |
| EP4639173A1 (en) | 2022-12-19 | 2025-10-29 | Belgian Volition SRL | Calibration |
| WO2024133222A1 (en) | 2022-12-19 | 2024-06-27 | Belgian Volition Srl | Assessment of biological samples for nucleic acid analysis |
| GB202300607D0 (en) | 2023-01-16 | 2023-03-01 | Belgian Volition Srl | Proteins and methods for isolating circulating nucleosomes |
| GB202303562D0 (en) | 2023-03-10 | 2023-04-26 | Belgian Volition Sprl | Sample collection for liquid biopsy |
| WO2024213795A1 (en) | 2023-04-14 | 2024-10-17 | Belgian Volition Srl | Diagnosis method using cell free nucleosome levels |
| WO2024223947A1 (en) | 2023-04-28 | 2024-10-31 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers of carcinomas |
| GB202307768D0 (en) | 2023-05-24 | 2023-07-05 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers |
| GB202310137D0 (en) | 2023-07-03 | 2023-08-16 | Belgian Volition Srl | Method for the detection of cancer |
| WO2025012440A1 (en) | 2023-07-13 | 2025-01-16 | Belgian Volition Srl | Method for detection of the potential of a body fluid sample to produce extracellular traps |
| WO2025061853A1 (en) | 2023-09-19 | 2025-03-27 | Belgian Volition Srl | Lateral flow test device |
| WO2025093747A1 (en) | 2023-11-02 | 2025-05-08 | Belgian Volition Srl | Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules |
| WO2025181348A1 (en) | 2024-03-01 | 2025-09-04 | Belgian Volition Srl | Method for determining the origin of circulating dna |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999047924A1 (en) | 1998-03-18 | 1999-09-23 | Roche Diagnostics Gmbh | Detection of apoptotic products |
| WO2003014142A2 (en) | 2001-08-03 | 2003-02-20 | University Of Virginia Patent Foundation | Phosphorylated histone h2b as an apoptosis marker |
| IL161856A0 (en) * | 2001-11-30 | 2005-11-20 | Pfizer Prod Inc | Methods for detecting cells with numerical chromosomal abnormalities |
| JP2005517431A (ja) * | 2002-02-20 | 2005-06-16 | ユニバーシティ オブ バージニア パテント ファウンデーション | ヒストン修飾マーカーを利用した非侵襲的診断検査 |
| US20060073517A1 (en) * | 2003-03-10 | 2006-04-06 | Allis C D | Post-translational modifications of proteins as regulatory switches |
| GB0319376D0 (en) | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| EP2267450B1 (en) * | 2005-04-29 | 2015-01-28 | The Regents of The University of California | Antibodies against histone modifications for clinical diagnosis and prognosis of cancer |
-
2003
- 2003-08-18 GB GBGB0319376.0A patent/GB0319376D0/en not_active Ceased
-
2004
- 2004-08-18 ES ES04768123T patent/ES2315697T3/es not_active Expired - Lifetime
- 2004-08-18 AT AT04768123T patent/ATE411525T1/de active
- 2004-08-18 WO PCT/GB2004/003564 patent/WO2005019826A1/en not_active Ceased
- 2004-08-18 US US10/568,691 patent/US9128086B2/en active Active
- 2004-08-18 SI SI200430992T patent/SI1668368T1/sl unknown
- 2004-08-18 DE DE602004017201T patent/DE602004017201D1/de not_active Expired - Lifetime
- 2004-08-18 EP EP04768123A patent/EP1668368B1/en not_active Expired - Lifetime
- 2004-08-18 DK DK04768123T patent/DK1668368T3/da active
-
2015
- 2015-08-03 US US14/816,329 patent/US10408831B2/en not_active Expired - Lifetime
-
2019
- 2019-07-26 US US16/523,096 patent/US20190353653A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004017201D1 (de) | 2008-11-27 |
| US9128086B2 (en) | 2015-09-08 |
| US20070160989A1 (en) | 2007-07-12 |
| ES2315697T3 (es) | 2009-04-01 |
| WO2005019826A1 (en) | 2005-03-03 |
| US20190353653A1 (en) | 2019-11-21 |
| EP1668368A1 (en) | 2006-06-14 |
| SI1668368T1 (sl) | 2009-04-30 |
| GB0319376D0 (en) | 2003-09-17 |
| US20150330996A1 (en) | 2015-11-19 |
| US10408831B2 (en) | 2019-09-10 |
| ATE411525T1 (de) | 2008-10-15 |
| EP1668368B1 (en) | 2008-10-15 |
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