DK1664093T3 - Antitumorforbindelser baseret på kahalalid F - Google Patents

Antitumorforbindelser baseret på kahalalid F

Info

Publication number: DK1664093T3
Authority: DK; Denmark
Prior art keywords: kahalalide; compounds based; tumor compounds; tumor; new analogues
Prior art date: 2003-09-09

Application number

DK04768394T

Other languages

English (en)

Inventor

Garcia Jose-Carlos Jimenez

Palomera Fernando Albericio

Donis Ariadna Fernandez

Cantador Carolina Gracia

Rodriguez Pilar Lopez

Colomer Sonia Varon

Marchante Carmen Cuevas

Macia Angel Lopez

Solloso Andres Francesch

Exposito Miriam Royo

Lledo Ernest Giralt

Original Assignee

Pharma Mar Sau

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-09

Filing date

2004-09-09

Publication date

2008-08-18

2004-09-09 Application filed by Pharma Mar Sau filed Critical Pharma Mar Sau

2008-08-18 Application granted granted Critical

2008-08-18 Publication of DK1664093T3 publication Critical patent/DK1664093T3/da

Links

RCGXNDQKCXNWLO-WLEIXIPESA-N (2r)-n-[(2s)-5-amino-1-[[(2r,3r)-1-[[(3s,6z,9s,12r,15r,18r,19s)-9-benzyl-15-[(2r)-butan-2-yl]-6-ethylidene-19-methyl-2,5,8,11,14,17-hexaoxo-3,12-di(propan-2-yl)-1-oxa-4,7,10,13,16-pentazacyclononadec-18-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent Chemical compound N([C@@H](CCCN)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H]1C(N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NC(/C(=O)N[C@H](C(=O)O[C@H]1C)C(C)C)=C\C)C(C)C)[C@H](C)CC)=O)C(=O)[C@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CCCC(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C RCGXNDQKCXNWLO-WLEIXIPESA-N 0.000 title abstract 2
230000000259 anti-tumor effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
108010091711 kahalalide F Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Dermatology (AREA)
Virology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK04768394T 2003-09-09 2004-09-09 Antitumorforbindelser baseret på kahalalid F DK1664093T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0321066.3A GB0321066D0 (en)	2003-09-09	2003-09-09	New antitumoral compounds
PCT/GB2004/003847 WO2005023846A1 (en)	2003-09-09	2004-09-09	New antitumoral compounds

Publications (1)

Publication Number	Publication Date
DK1664093T3 true DK1664093T3 (da)	2008-08-18

Family

ID=29226738

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK04768394T DK1664093T3 (da)	2003-09-09	2004-09-09	Antitumorforbindelser baseret på kahalalid F
DK13180582.2T DK2664623T3 (da)	2003-09-09	2004-09-09	Nye antitumorale forbindelser

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK13180582.2T DK2664623T3 (da)	2003-09-09	2004-09-09	Nye antitumorale forbindelser

Country Status (23)

Country	Link
US (1)	US20070117743A1 (da)
EP (6)	EP2280027A3 (da)
JP (4)	JP4874796B2 (da)
KR (1)	KR20060073618A (da)
CN (2)	CN101531707A (da)
AT (1)	ATE393776T1 (da)
AU (2)	AU2004270471B2 (da)
CA (1)	CA2537128A1 (da)
CY (1)	CY1108226T1 (da)
DE (1)	DE602004013454T2 (da)
DK (2)	DK1664093T3 (da)
ES (2)	ES2305843T3 (da)
GB (1)	GB0321066D0 (da)
HR (1)	HRP20080330T3 (da)
HU (1)	HUE025308T2 (da)
IL (1)	IL173929A (da)
MX (1)	MXPA06002741A (da)
NZ (4)	NZ580124A (da)
PL (1)	PL1664093T3 (da)
PT (1)	PT1664093E (da)
RU (2)	RU2395520C2 (da)
SI (1)	SI1664093T1 (da)
WO (1)	WO2005023846A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0002952D0 (en) *	2000-02-09	2000-03-29	Pharma Mar Sa	Process for producing kahalalide F compounds
GB0304367D0 (en)	2003-02-26	2003-04-02	Pharma Mar Sau	Methods for treating psoriasis
US7507708B2 (en)	2003-02-26	2009-03-24	Pharma Mar, S.A.U.	Antitumoral compounds
CA2703720A1 (en) *	2007-10-19	2009-04-23	Albert Einstein College Of Medicine Of Yeshiva University	Improved antitumoral treatments
EP2252315A1 (en) *	2008-01-30	2010-11-24	Pharma Mar, S.A.	Improved antitumoral treatments
MX2010009782A (es) *	2008-03-07	2010-09-30	Pharma Mar Sa	Tratamientos antitumorales mejorados.
CN101519437B (zh) *	2009-04-09	2012-05-02	中国人民解放军第二军医大学	西沙海绵中一种环七肽类化合物及其用途
CN104725266B (zh) *	2014-04-10	2016-08-10	申俊	酰亚胺类化合物的合成方法
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CU22545A1 (es) *	1994-11-18	1999-03-31	Centro Inmunologia Molecular	Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4943533A (en) *	1984-03-01	1990-07-24	The Regents Of The University Of California	Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
JPS6178719A (ja) *	1984-09-25	1986-04-22	Tanabe Seiyaku Co Ltd	総合輸液剤
ES2204890T3 (es) *	1991-03-06	2004-05-01	Merck Patent Gmbh	Anticuerpos monoclonales humanizados.
AU661533B2 (en) *	1992-01-20	1995-07-27	Astrazeneca Ab	Quinazoline derivatives
GB9302046D0 (en)	1993-02-03	1993-03-24	Pharma Mar Sa	Antiumoral compound-v
US6274551B1 (en) *	1994-02-03	2001-08-14	Pharmamar, S.A.	Cytotoxic and antiviral compound
US5705511A (en) *	1994-10-14	1998-01-06	Cephalon, Inc.	Fused pyrrolocarbazoles
GB9508538D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
US5747498A (en) *	1996-05-28	1998-05-05	Pfizer Inc.	Alkynyl and azido-substituted 4-anilinoquinazolines
ATE227283T1 (de) *	1996-07-13	2002-11-15	Glaxo Group Ltd	Kondensierte heterozyklische verbindungen als protein kinase inhibitoren
US6235883B1 (en) *	1997-05-05	2001-05-22	Abgenix, Inc.	Human monoclonal antibodies to epidermal growth factor receptor
RS49779B (sr) *	1998-01-12	2008-06-05	Glaxo Group Limited,	Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
US6200598B1 (en) *	1998-06-18	2001-03-13	Duke University	Temperature-sensitive liposomal formulation
US6344455B1 (en) *	1998-11-19	2002-02-05	Warner-Lambert Company	N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, and irreversible inhibitor of tyrosine kinases
US7311924B2 (en) *	1999-04-01	2007-12-25	Hana Biosciences, Inc.	Compositions and methods for treating cancer
UA74803C2 (uk) *	1999-11-11	2006-02-15	Осі Фармасьютікалз, Інк.	Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
GB0002952D0 (en) *	2000-02-09	2000-03-29	Pharma Mar Sa	Process for producing kahalalide F compounds
BR0114912A (pt) *	2000-10-31	2003-10-14	Pharma Mar Sa	Kahalalide f
EP1435990A1 (en)	2001-10-19	2004-07-14	Pharma Mar, S.A.	Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) *	2003-02-26	2003-04-02	Pharma Mar Sau	Methods for treating psoriasis
KR101149095B1 (ko) *	2002-10-18	2012-05-30	파르마 마르 에스.에이.유.	4-메틸헥사노 카할라리드 ｆ 화합물
WO2004035613A2 (en)	2002-10-18	2004-04-29	Pharma Mar, S.A.U.	4-methylhexanoic kahalaide f compound
US7507708B2 (en) *	2003-02-26	2009-03-24	Pharma Mar, S.A.U.	Antitumoral compounds

2003
- 2003-09-09 GB GBGB0321066.3A patent/GB0321066D0/en not_active Ceased
2004
- 2004-09-09 NZ NZ580124A patent/NZ580124A/en not_active IP Right Cessation
- 2004-09-09 EP EP10179452A patent/EP2280027A3/en not_active Withdrawn
- 2004-09-09 RU RU2006111491/04A patent/RU2395520C2/ru not_active IP Right Cessation
- 2004-09-09 JP JP2006525886A patent/JP4874796B2/ja not_active Expired - Fee Related
- 2004-09-09 DE DE602004013454T patent/DE602004013454T2/de not_active Expired - Lifetime
- 2004-09-09 NZ NZ545700A patent/NZ545700A/en not_active IP Right Cessation
- 2004-09-09 EP EP13180582.2A patent/EP2664623B1/en not_active Expired - Lifetime
- 2004-09-09 CA CA002537128A patent/CA2537128A1/en not_active Abandoned
- 2004-09-09 CN CN200910001891A patent/CN101531707A/zh active Pending
- 2004-09-09 WO PCT/GB2004/003847 patent/WO2005023846A1/en not_active Ceased
- 2004-09-09 AT AT04768394T patent/ATE393776T1/de active
- 2004-09-09 PL PL04768394T patent/PL1664093T3/pl unknown
- 2004-09-09 ES ES04768394T patent/ES2305843T3/es not_active Expired - Lifetime
- 2004-09-09 KR KR1020067004786A patent/KR20060073618A/ko not_active Abandoned
- 2004-09-09 CN CNB2004800258906A patent/CN100467482C/zh not_active Expired - Fee Related
- 2004-09-09 US US10/570,734 patent/US20070117743A1/en not_active Abandoned
- 2004-09-09 NZ NZ595490A patent/NZ595490A/xx not_active IP Right Cessation
- 2004-09-09 SI SI200430765T patent/SI1664093T1/sl unknown
- 2004-09-09 HU HUE13180582A patent/HUE025308T2/en unknown
- 2004-09-09 ES ES13180582.2T patent/ES2536285T3/es not_active Expired - Lifetime
- 2004-09-09 AU AU2004270471A patent/AU2004270471B2/en not_active Ceased
- 2004-09-09 PT PT04768394T patent/PT1664093E/pt unknown
- 2004-09-09 HR HR20080330T patent/HRP20080330T3/xx unknown
- 2004-09-09 NZ NZ589890A patent/NZ589890A/en not_active IP Right Cessation
- 2004-09-09 EP EP08100973A patent/EP1918296B1/en not_active Expired - Lifetime
- 2004-09-09 DK DK04768394T patent/DK1664093T3/da active
- 2004-09-09 EP EP04768394A patent/EP1664093B8/en not_active Expired - Lifetime
- 2004-09-09 EP EP10179442A patent/EP2280026A3/en not_active Withdrawn
- 2004-09-09 EP EP10179425A patent/EP2280025A3/en not_active Withdrawn
- 2004-09-09 MX MXPA06002741A patent/MXPA06002741A/es active IP Right Grant
- 2004-09-09 DK DK13180582.2T patent/DK2664623T3/da active
2006
- 2006-02-26 IL IL173929A patent/IL173929A/en not_active IP Right Cessation
2008
- 2008-07-30 CY CY20081100794T patent/CY1108226T1/el unknown
2009
- 2009-12-18 RU RU2009147217/04A patent/RU2009147217A/ru not_active Application Discontinuation
2011
- 2011-05-17 AU AU2011202286A patent/AU2011202286B2/en not_active Ceased
- 2011-09-29 JP JP2011214681A patent/JP2012031187A/ja active Pending
- 2011-09-29 JP JP2011214680A patent/JP2012051899A/ja active Pending
- 2011-09-29 JP JP2011214682A patent/JP5372096B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1849333A (zh)	2006-10-18
SI1664093T1 (sl)	2008-12-31
CN100467482C (zh)	2009-03-11
NZ595490A (en)	2013-04-26
US20070117743A1 (en)	2007-05-24
EP1664093B8 (en)	2008-08-13
EP2664623B1 (en)	2015-03-04
EP2280026A2 (en)	2011-02-02
NZ580124A (en)	2011-01-28
EP1918296B1 (en)	2012-11-14
AU2011202286B2 (en)	2013-08-01
EP2280025A2 (en)	2011-02-02
JP2012031187A (ja)	2012-02-16
NZ545700A (en)	2010-03-26
JP2007526904A (ja)	2007-09-20
CN101531707A (zh)	2009-09-16
DK2664623T3 (da)	2015-05-11
ES2536285T3 (es)	2015-05-22
DE602004013454T2 (de)	2009-06-18
AU2011202286A1 (en)	2011-06-09
EP1918296A3 (en)	2009-06-24
IL173929A (en)	2014-01-30
HUE025308T2 (en)	2016-01-28
HRP20080330T3 (en)	2009-04-30
JP5372096B2 (ja)	2013-12-18
EP1664093A1 (en)	2006-06-07
EP1664093B1 (en)	2008-04-30
EP2280026A3 (en)	2011-05-25
JP2012031188A (ja)	2012-02-16
EP1918296A2 (en)	2008-05-07
EP2280027A3 (en)	2011-05-04
JP2012051899A (ja)	2012-03-15
PT1664093E (pt)	2008-08-07
ATE393776T1 (de)	2008-05-15
AU2004270471B2 (en)	2011-06-02
KR20060073618A (ko)	2006-06-28
EP2664623A1 (en)	2013-11-20
CA2537128A1 (en)	2005-03-17
WO2005023846A1 (en)	2005-03-17
IL173929A0 (en)	2006-07-05
EP2280027A2 (en)	2011-02-02
DE602004013454D1 (de)	2008-06-12
MXPA06002741A (es)	2006-06-05
PL1664093T3 (pl)	2008-10-31
RU2009147217A (ru)	2011-06-27
CY1108226T1 (el)	2014-02-12
EP2280025A3 (en)	2011-05-25
JP4874796B2 (ja)	2012-02-15
NZ589890A (en)	2011-11-25
GB0321066D0 (en)	2003-10-08
RU2006111491A (ru)	2007-11-20
AU2004270471A1 (en)	2005-03-17
ES2305843T3 (es)	2008-11-01
RU2395520C2 (ru)	2010-07-27

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DE602004032105D1 (de)	2011-05-19	Elektronenquelle
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ITMI20031904A1 (it)	2005-04-04	Lampada abbronzante.
FI20021234A7 (fi)	2003-12-25	Kasvunedistäjä
FR2856807B1 (fr)	2005-09-16	Source lumineuse.
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ITFO20030011A1 (it)	2005-04-28	Paratia removibile antialluvione.
ES1051818Y (es)	2003-02-01	Fuente.
SK3735U (sk)	2004-03-02	Štartovací zdroj
FI20022201A0 (fi)	2002-12-16	Aromilähde
ES1052699Y (es)	2003-05-16	Piragua desmontable.
ITMI20022591A1 (it)	2004-06-07	Compasso.
ES1052131Y (es)	2003-03-01	Luminaria estanca mejorada.