[go: up one dir, main page]

DK1513834T3 - Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them - Google Patents

Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them

Info

Publication number
DK1513834T3
DK1513834T3 DK03740148T DK03740148T DK1513834T3 DK 1513834 T3 DK1513834 T3 DK 1513834T3 DK 03740148 T DK03740148 T DK 03740148T DK 03740148 T DK03740148 T DK 03740148T DK 1513834 T3 DK1513834 T3 DK 1513834T3
Authority
DK
Denmark
Prior art keywords
drug
diagnostic
preparation
methods
substituted thiophenes
Prior art date
Application number
DK03740148T
Other languages
Danish (da)
Inventor
Hans-Jochen Lang
Uwe Heinelt
Armin Hofmeister
Klaus Wirth
Michael Gekle
Markus Bleich
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Application granted granted Critical
Publication of DK1513834T3 publication Critical patent/DK1513834T3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41681,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK03740148T 2002-06-04 2003-05-26 Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them DK1513834T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10224892A DE10224892A1 (en) 2002-06-04 2002-06-04 Substituted thiophenes, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them

Publications (1)

Publication Number Publication Date
DK1513834T3 true DK1513834T3 (en) 2006-07-17

Family

ID=29557542

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03740148T DK1513834T3 (en) 2002-06-04 2003-05-26 Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them

Country Status (32)

Country Link
EP (1) EP1513834B1 (en)
JP (1) JP4511924B2 (en)
KR (1) KR101087966B1 (en)
CN (1) CN1324024C (en)
AR (1) AR040239A1 (en)
AT (1) ATE320425T1 (en)
AU (1) AU2003273553B2 (en)
BR (1) BR0311548A (en)
CA (1) CA2488242C (en)
CR (1) CR7577A (en)
DE (2) DE10224892A1 (en)
DK (1) DK1513834T3 (en)
EC (1) ECSP045471A (en)
ES (1) ES2258722T3 (en)
HR (1) HRP20041153A2 (en)
IL (1) IL165519A (en)
MA (1) MA27204A1 (en)
ME (1) MEP27608A (en)
MX (1) MXPA04011986A (en)
MY (1) MY129832A (en)
NO (1) NO329351B1 (en)
OA (1) OA12827A (en)
PE (1) PE20040534A1 (en)
PL (1) PL372589A1 (en)
PT (1) PT1513834E (en)
RS (1) RS51141B (en)
RU (1) RU2315766C2 (en)
TN (1) TNSN04240A1 (en)
TW (1) TWI283675B (en)
UA (1) UA77551C2 (en)
WO (1) WO2003101984A1 (en)
ZA (1) ZA200409095B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040242560A1 (en) 2003-05-22 2004-12-02 Aventis Pharma Deutschland Gmbh Process for synthesizing heterocyclic compounds
DE10323701A1 (en) 2003-05-22 2004-12-23 Aventis Pharma Deutschland Gmbh Process for the synthesis of heterocyclic compounds
EP1640361B9 (en) 2003-06-30 2015-11-04 Sumitomo Chemical Company, Limited Asymmetric urea compounds and process for producing asymmetric compounds by asymmetric conjugate addition reaction using the same as catalyst
EP2088861A4 (en) * 2006-10-25 2010-07-07 Takeda Pharmaceutical BENZIMIDAZOLE COMPOUNDS
EP2342178B1 (en) 2008-09-02 2016-09-28 Sanofi Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
RU2373929C1 (en) * 2008-11-11 2009-11-27 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) Haemostasis system corrector manifesting inhibitory action on adhesive aggregative function of thrombocytes to prevent pathological thrombosis
WO2011058139A1 (en) * 2009-11-12 2011-05-19 Selvita Sp. Z O. O. A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent
RU2518740C1 (en) * 2013-03-22 2014-06-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" METHOD, INHIBITING Na+/H+-EXCHANGE, AND DIHYDROCHLORIDE OF 2-(3,4-METHYLENEDIOXYPHENYL)-9-MORPHOLINOETHYLIMIDAZO[1,2-a]BENZIMIDAZOLE
ME03311B (en) 2014-07-25 2019-10-20 Taisho Pharmaceutical Co Ltd Phenyl tetrahydroisoquinoline compound substituted with heteroaryl
KR102840252B1 (en) * 2023-04-27 2025-07-30 한국화학연구원 Cyanobenzimidazole derivatives, pharmaceutically acceptable salt thereof, process for preparation thereof and pharmaceutical composition containing the same as an active ingredient
WO2025067474A1 (en) * 2023-09-28 2025-04-03 四川大学华西医院 Pyridine-containing compound, preparation method therefor, and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754935A (en) 1969-08-13 1971-02-17 Hoechst Ag 2- (THIENYL-3'-AMINO) -1,3-DIAZACYCLOALCENES AND THEIR PREPARATION
BR6915362D0 (en) * 1969-08-16 1973-01-04 Hoechst Ag PROCESS FOR THE PREPARATION OF 2 (TIENIL-3-AMINO) 1,3-DIAZACYCLEALCHENE
DE2830279A1 (en) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim 2-CORNER CLAMP ON N- (2'-CHLOR-4'-METHYL-THIENYL-3 ') - N- (CYCLOPROPYLMETHYL) - AMINO CORNER CLAMP ON-IMIDAZOLINE- (2), THE ACID ADDITION SALTS THAT IT INCLUDES HIS PRODUCTION
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
WO2000006169A1 (en) * 1998-07-29 2000-02-10 Merck & Co., Inc. Integrin receptor antagonists
DE19921883A1 (en) * 1999-05-12 2000-11-16 Bayer Ag New thienylcycloalkylamino-1,3,5-triazine and thienylcycloalkenylamino-1,3,5-triazine derivatives are herbicides useful as desiccants and defoliants and especially for weed control
DE19960204A1 (en) * 1999-12-14 2001-06-28 Aventis Pharma Gmbh Substituted norlbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
DK1499311T3 (en) * 2002-03-29 2010-03-08 Novartis Vaccines & Diagnostic Substituted benzols and their use as RAF kinase inhibitors

Also Published As

Publication number Publication date
KR101087966B1 (en) 2011-12-01
CR7577A (en) 2005-06-16
RS51141B (en) 2010-10-31
MY129832A (en) 2007-05-31
MA27204A1 (en) 2005-01-03
RU2004138812A (en) 2005-07-20
HRP20041153A2 (en) 2005-06-30
MEP27608A (en) 2010-06-10
EP1513834B1 (en) 2006-03-15
JP4511924B2 (en) 2010-07-28
MXPA04011986A (en) 2005-03-07
AU2003273553B2 (en) 2008-12-04
PE20040534A1 (en) 2004-10-25
UA77551C2 (en) 2006-12-15
TW200406409A (en) 2004-05-01
CA2488242C (en) 2011-08-02
CN1324024C (en) 2007-07-04
AR040239A1 (en) 2005-03-23
PT1513834E (en) 2006-06-30
ECSP045471A (en) 2005-01-28
RU2315766C2 (en) 2008-01-27
DE50302673D1 (en) 2006-05-11
CA2488242A1 (en) 2003-12-11
KR20050005532A (en) 2005-01-13
WO2003101984A1 (en) 2003-12-11
IL165519A (en) 2010-05-31
TNSN04240A1 (en) 2007-03-12
DE10224892A1 (en) 2003-12-18
NO20045504L (en) 2005-01-25
CN1659163A (en) 2005-08-24
IL165519A0 (en) 2006-01-15
PL372589A1 (en) 2005-07-25
ZA200409095B (en) 2005-05-10
BR0311548A (en) 2005-04-12
TWI283675B (en) 2007-07-11
HK1076460A1 (en) 2006-01-20
EP1513834A1 (en) 2005-03-16
OA12827A (en) 2006-07-11
ES2258722T3 (en) 2006-09-01
ATE320425T1 (en) 2006-04-15
AU2003273553A1 (en) 2003-12-19
RS103804A (en) 2006-12-15
JP2005533038A (en) 2005-11-04
NO329351B1 (en) 2010-10-04

Similar Documents

Publication Publication Date Title
DK1558600T3 (en) Selected CGRP antagonists, methods of preparation thereof, and their use as a drug
DK1732917T3 (en) Selected CGRP antagonists, processes for their preparation, and their use as a drug
DK1953162T3 (en) Xanthine derivatives, their preparation and their use as a drug.
DK1532149T3 (en) 8- [3-Amino-piperiden-1-yl] -xanthines, their preparation and their use as a drug
DK1294682T3 (en) Acylphenylurea derivatives, processes for their preparation and their use as a drug
DK1562946T3 (en) New xanthine derivatives, their preparation and their use as a drug
DK1673352T3 (en) Sulfoxime substituted pyrimidines as CDK and / or VEGF inhibitors, their preparation and use as a drug
DK1730131T3 (en) Glucopyranosyl-substituted benzene derivatives, drug containing these compounds, their use and methods for their preparation
NO20052493D0 (en) Selected CGRP antagonists, processes for their preparation and their use as pharmaceutical compositions.
DK1218341T3 (en) Sulfonylcarboxamide derivatives, process for their preparation and their use as a drug
NO20032735L (en) Diphenyllazetidinone derivatives, process for their preparation, drugs containing these compounds and their use
NO20044322L (en) Benzoxanone-derived compounds, their preparation and use as a drug
NO20052739D0 (en) CCR5 antagonists as drugs
DK1670458T3 (en) 1-Amino-2-oxy-substituted tetrahydronaphthalane derivatives, processes for their preparation and their use as antiphlogistics
NO20054329D0 (en) Adamantan derivatives, processes for their preparation, and pharmaceutical compositions which include them
DK1492789T3 (en) Tropane derivatives as CCR5 modulators
DK1445252T3 (en) Sulfonamide derivatives, their preparation and use as drugs
DK1222163T3 (en) 2'-Substituted 1,1'-biphenyl-2-carboxamides, methods of preparation thereof, their use as a medicament, and pharmaceutical compositions containing them
NO20005146L (en) Thienylazolylalkoxyethanamines, their preparation and their use as drugs
DK1453810T3 (en) Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as a drug containing the same
DK1513834T3 (en) Substituted thiophenes, methods for their preparation, their use as a drug or diagnostic, and drug containing them
NO20054876D0 (en) Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as drug and drug containing such compounds
DK1509498T3 (en) Pentafluorosulfanyl benzoylguanidines, processes for their preparation, use thereof as a medicament or diagnostic, and medicament containing them
NO20022801D0 (en) Substituted norbornylamino derivatives, process for their preparation, their use as a drug or diagnostic as well as drugs containing these
DK1838315T3 (en) SUBSTITUTED 4-PHENYLTETRAHYDROISOQUINOLINES, METHOD OF PREPARING IT, THEIR USE AS MEDICINE AND MEDICINES CONTAINING THEM