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NO20045504L - Substituted thiophenes, methods of preparation, their use as a drug or diagnostic agent, and a drug containing these - Google Patents

Substituted thiophenes, methods of preparation, their use as a drug or diagnostic agent, and a drug containing these

Info

Publication number
NO20045504L
NO20045504L NO20045504A NO20045504A NO20045504L NO 20045504 L NO20045504 L NO 20045504L NO 20045504 A NO20045504 A NO 20045504A NO 20045504 A NO20045504 A NO 20045504A NO 20045504 L NO20045504 L NO 20045504L
Authority
NO
Norway
Prior art keywords
drug
preparation
methods
diagnostic agent
substituted thiophenes
Prior art date
Application number
NO20045504A
Other languages
Norwegian (no)
Other versions
NO329351B1 (en
Inventor
Klaus Wirth
Hans-Jochen Lang
Armin Hofmeister
Markus Bleich
Michael Gekle
Uwe Heinelt
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20045504L publication Critical patent/NO20045504L/en
Publication of NO329351B1 publication Critical patent/NO329351B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20045504A 2002-06-04 2004-12-16 Substituted thiophene, its use and drug for human or veterinary use NO329351B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10224892A DE10224892A1 (en) 2002-06-04 2002-06-04 Substituted thiophenes, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
PCT/EP2003/005465 WO2003101984A1 (en) 2002-06-04 2003-05-26 Substituted thiophenes, method for the production thereof, their use as a medicament or diagnostic reagent, and a medicament containing the same

Publications (2)

Publication Number Publication Date
NO20045504L true NO20045504L (en) 2005-01-25
NO329351B1 NO329351B1 (en) 2010-10-04

Family

ID=29557542

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20045504A NO329351B1 (en) 2002-06-04 2004-12-16 Substituted thiophene, its use and drug for human or veterinary use

Country Status (32)

Country Link
EP (1) EP1513834B1 (en)
JP (1) JP4511924B2 (en)
KR (1) KR101087966B1 (en)
CN (1) CN1324024C (en)
AR (1) AR040239A1 (en)
AT (1) ATE320425T1 (en)
AU (1) AU2003273553B2 (en)
BR (1) BR0311548A (en)
CA (1) CA2488242C (en)
CR (1) CR7577A (en)
DE (2) DE10224892A1 (en)
DK (1) DK1513834T3 (en)
EC (1) ECSP045471A (en)
ES (1) ES2258722T3 (en)
HR (1) HRP20041153A2 (en)
IL (1) IL165519A (en)
MA (1) MA27204A1 (en)
ME (1) MEP27608A (en)
MX (1) MXPA04011986A (en)
MY (1) MY129832A (en)
NO (1) NO329351B1 (en)
OA (1) OA12827A (en)
PE (1) PE20040534A1 (en)
PL (1) PL372589A1 (en)
PT (1) PT1513834E (en)
RS (1) RS51141B (en)
RU (1) RU2315766C2 (en)
TN (1) TNSN04240A1 (en)
TW (1) TWI283675B (en)
UA (1) UA77551C2 (en)
WO (1) WO2003101984A1 (en)
ZA (1) ZA200409095B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10323701A1 (en) 2003-05-22 2004-12-23 Aventis Pharma Deutschland Gmbh Process for the synthesis of heterocyclic compounds
US20040242560A1 (en) 2003-05-22 2004-12-02 Aventis Pharma Deutschland Gmbh Process for synthesizing heterocyclic compounds
WO2005000803A2 (en) 2003-06-30 2005-01-06 Sumitomo Chemical Co Asymmetric urea compound and process for producing asymmetric compound by asymmetric conjugate addition reaction with the same as catalyst
US20100056515A1 (en) * 2006-10-25 2010-03-04 Kazuyoshi Aso Benzimidazole compounds
US8822449B2 (en) 2008-09-02 2014-09-02 Sanofi Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
RU2373929C1 (en) * 2008-11-11 2009-11-27 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) Haemostasis system corrector manifesting inhibitory action on adhesive aggregative function of thrombocytes to prevent pathological thrombosis
BR112012011109A2 (en) * 2009-11-12 2019-09-24 Selvita S A a compound a process for its preparation a pharmaceutical composition use of a compound a modular or regular method serine threonine kinases
RU2518740C1 (en) * 2013-03-22 2014-06-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" METHOD, INHIBITING Na+/H+-EXCHANGE, AND DIHYDROCHLORIDE OF 2-(3,4-METHYLENEDIOXYPHENYL)-9-MORPHOLINOETHYLIMIDAZO[1,2-a]BENZIMIDAZOLE
TWI666206B (en) 2014-07-25 2019-07-21 日商大正製藥股份有限公司 Heteroaryl substituted phenyl tetrahydroisoquinoline compounds
KR102840252B1 (en) * 2023-04-27 2025-07-30 한국화학연구원 Cyanobenzimidazole derivatives, pharmaceutically acceptable salt thereof, process for preparation thereof and pharmaceutical composition containing the same as an active ingredient
WO2025067474A1 (en) * 2023-09-28 2025-04-03 四川大学华西医院 Pyridine-containing compound, preparation method therefor, and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754935A (en) * 1969-08-13 1971-02-17 Hoechst Ag 2- (THIENYL-3'-AMINO) -1,3-DIAZACYCLOALCENES AND THEIR PREPARATION
BR6915362D0 (en) * 1969-08-16 1973-01-04 Hoechst Ag PROCESS FOR THE PREPARATION OF 2 (TIENIL-3-AMINO) 1,3-DIAZACYCLEALCHENE
DE2830279A1 (en) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim 2-CORNER CLAMP ON N- (2'-CHLOR-4'-METHYL-THIENYL-3 ') - N- (CYCLOPROPYLMETHYL) - AMINO CORNER CLAMP ON-IMIDAZOLINE- (2), THE ACID ADDITION SALTS THAT IT INCLUDES HIS PRODUCTION
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
WO2000006169A1 (en) * 1998-07-29 2000-02-10 Merck & Co., Inc. Integrin receptor antagonists
DE19921883A1 (en) * 1999-05-12 2000-11-16 Bayer Ag New thienylcycloalkylamino-1,3,5-triazine and thienylcycloalkenylamino-1,3,5-triazine derivatives are herbicides useful as desiccants and defoliants and especially for weed control
DE19960204A1 (en) * 1999-12-14 2001-06-28 Aventis Pharma Gmbh Substituted norlbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
BR0308854A (en) * 2002-03-29 2005-02-22 Chiron Corp Substituted benzazoles and their uses as raf kinase inhibitors

Also Published As

Publication number Publication date
BR0311548A (en) 2005-04-12
TWI283675B (en) 2007-07-11
WO2003101984A1 (en) 2003-12-11
RS51141B (en) 2010-10-31
RU2315766C2 (en) 2008-01-27
MY129832A (en) 2007-05-31
HK1076460A1 (en) 2006-01-20
JP4511924B2 (en) 2010-07-28
CN1659163A (en) 2005-08-24
MEP27608A (en) 2010-06-10
HRP20041153A2 (en) 2005-06-30
AR040239A1 (en) 2005-03-23
EP1513834B1 (en) 2006-03-15
NO329351B1 (en) 2010-10-04
JP2005533038A (en) 2005-11-04
TNSN04240A1 (en) 2007-03-12
TW200406409A (en) 2004-05-01
IL165519A0 (en) 2006-01-15
KR101087966B1 (en) 2011-12-01
ECSP045471A (en) 2005-01-28
CR7577A (en) 2005-06-16
UA77551C2 (en) 2006-12-15
CA2488242C (en) 2011-08-02
PL372589A1 (en) 2005-07-25
CN1324024C (en) 2007-07-04
OA12827A (en) 2006-07-11
PE20040534A1 (en) 2004-10-25
EP1513834A1 (en) 2005-03-16
MA27204A1 (en) 2005-01-03
MXPA04011986A (en) 2005-03-07
RS103804A (en) 2006-12-15
CA2488242A1 (en) 2003-12-11
ZA200409095B (en) 2005-05-10
ATE320425T1 (en) 2006-04-15
DE10224892A1 (en) 2003-12-18
PT1513834E (en) 2006-06-30
RU2004138812A (en) 2005-07-20
AU2003273553A1 (en) 2003-12-19
DK1513834T3 (en) 2006-07-17
KR20050005532A (en) 2005-01-13
ES2258722T3 (en) 2006-09-01
DE50302673D1 (en) 2006-05-11
AU2003273553B2 (en) 2008-12-04
IL165519A (en) 2010-05-31

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Legal Events

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