DK1412368T3 - Sukkerderivater af hydromorfon, dihydromorfin, dihydroisomorfin, sammensætninger deraf og anvendelser til behandling eller forebyggelse af smerter - Google Patents
Sukkerderivater af hydromorfon, dihydromorfin, dihydroisomorfin, sammensætninger deraf og anvendelser til behandling eller forebyggelse af smerterInfo
- Publication number
- DK1412368T3 DK1412368T3 DK02765874T DK02765874T DK1412368T3 DK 1412368 T3 DK1412368 T3 DK 1412368T3 DK 02765874 T DK02765874 T DK 02765874T DK 02765874 T DK02765874 T DK 02765874T DK 1412368 T3 DK1412368 T3 DK 1412368T3
- Authority
- DK
- Denmark
- Prior art keywords
- dihydroisomorphine
- dihydromorphine
- hydromorphone
- pain
- compositions
- Prior art date
Links
- IJVCSMSMFSCRME-NOSXKOESSA-N (4r,4ar,7r,7ar,12bs)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol Chemical compound O([C@H]1[C@@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-NOSXKOESSA-N 0.000 title abstract 4
- IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 title abstract 4
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical class O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 229930182478 glucoside Natural products 0.000 abstract 3
- 150000008131 glucosides Chemical class 0.000 abstract 3
- 229930182480 glucuronide Natural products 0.000 abstract 3
- -1 glucuronide derivatives of hydromorphone Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/033—Uronic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30784501P | 2001-07-27 | 2001-07-27 | |
| PCT/US2002/023553 WO2003011881A2 (en) | 2001-07-27 | 2002-07-24 | Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1412368T3 true DK1412368T3 (da) | 2008-01-02 |
Family
ID=23191416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02765874T DK1412368T3 (da) | 2001-07-27 | 2002-07-24 | Sukkerderivater af hydromorfon, dihydromorfin, dihydroisomorfin, sammensætninger deraf og anvendelser til behandling eller forebyggelse af smerter |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6740641B2 (da) |
| EP (1) | EP1412368B1 (da) |
| JP (1) | JP4679055B2 (da) |
| AT (1) | ATE371665T1 (da) |
| AU (1) | AU2002329634B2 (da) |
| CA (1) | CA2455774C (da) |
| CY (1) | CY1107813T1 (da) |
| DE (1) | DE60222137T2 (da) |
| DK (1) | DK1412368T3 (da) |
| ES (1) | ES2292806T3 (da) |
| IL (2) | IL160085A0 (da) |
| MX (1) | MXPA04000825A (da) |
| PT (1) | PT1412368E (da) |
| WO (1) | WO2003011881A2 (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US7375082B2 (en) * | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| US20070066537A1 (en) * | 2002-02-22 | 2007-03-22 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US7338939B2 (en) * | 2003-09-30 | 2008-03-04 | New River Pharmaceuticals Inc. | Abuse-resistant hydrocodone compounds |
| AU2003213259C1 (en) * | 2002-02-22 | 2009-07-16 | Shire Llc | Use of peptide-drug conjugation to reduce inter-subject variability of drug serum levels |
| AU2003219863C1 (en) * | 2002-02-22 | 2009-03-05 | Shire Llc | Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances |
| US7659253B2 (en) * | 2002-02-22 | 2010-02-09 | Shire Llc | Abuse-resistant amphetamine prodrugs |
| US7105486B2 (en) * | 2002-02-22 | 2006-09-12 | New River Pharmaceuticals Inc. | Abuse-resistant amphetamine compounds |
| US7700561B2 (en) * | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
| GB0218811D0 (en) * | 2002-08-14 | 2002-09-18 | Cenes Ltd | Salts of morphine-6-glucuronide |
| US8133881B2 (en) | 2003-01-13 | 2012-03-13 | Shire Llc | Carbohydrate conjugates to prevent abuse of controlled substances |
| ES2380622T5 (es) * | 2003-05-29 | 2018-05-30 | Shire Llc | Compuestos de anfetamina resistentes al abuso |
| CA2540678C (en) * | 2003-09-30 | 2011-02-22 | New River Pharmaceuticals Inc. | Pharmaceutical compositions for prevention of overdose or abuse |
| JP5176188B2 (ja) * | 2006-04-21 | 2013-04-03 | ディーエスエム アイピー アセッツ ビー．ブイ． | オピオイド受容体拮抗薬の使用 |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| FR2939436B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Synthese de morphine-6-glucuronide ou de l'un de ses derives |
| US8716350B2 (en) * | 2010-03-30 | 2014-05-06 | Algynomics Inc. | Compositions and methods for the treatment of somatosensory disorders |
| EP2552433A4 (en) | 2010-03-30 | 2013-11-06 | Algynomics Inc | COMPOSITIONS AND METHODS OF TREATING SOMATOSENSORY DISEASES |
| MX2013003354A (es) | 2010-09-21 | 2013-06-24 | Purdue Pharma Lp | Analogos de buprenorfina. |
| BR112014010099A8 (pt) | 2011-10-26 | 2018-01-16 | Kempharm Inc | ácido benzóico, derivados de ácidos benzóicos e ácidos carboxílicos heteroarílicos conjugados de hidromorfona, pró-fármacos, métodos de fabricação e uso dos mesmos. |
| TW201431842A (zh) | 2012-11-09 | 2014-08-16 | Purdue Pharma Lp | 苯並嗎啡烷類似物及其應用 |
| US9175000B2 (en) | 2012-12-07 | 2015-11-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| TWI513697B (zh) | 2012-12-14 | 2015-12-21 | Purdue Pharma Lp | 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性 |
| JP6141444B2 (ja) | 2012-12-14 | 2017-06-07 | パーデュー、ファーマ、リミテッド、パートナーシップ | スピロ環式モルフィナンおよびこれらの使用 |
| WO2014118618A1 (en) | 2013-01-31 | 2014-08-07 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| HU231191B1 (hu) | 2013-04-15 | 2021-08-30 | Szegedi Tudományegyetem | Izotóp tartalmú morfin molekulák |
| EP3087057A4 (en) | 2013-12-26 | 2017-06-28 | Purdue Pharma LP | Ring-contracted morphinans and the use thereof |
| EP3087079B1 (en) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| WO2015097547A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| US9340542B2 (en) | 2013-12-26 | 2016-05-17 | Purdue Pharma L.P. | Propellane-based compounds and the use thereof |
| US9988392B2 (en) | 2013-12-26 | 2018-06-05 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| US10550088B2 (en) | 2013-12-27 | 2020-02-04 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| US10030021B2 (en) | 2014-05-27 | 2018-07-24 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| MA40171A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés d'azamophinan et leur utilisation |
| MX2017006935A (es) | 2014-12-02 | 2017-08-10 | Kempharm Inc * | Acido benzoico, derivados de acido benzoico y conjugados de acido heteroaril carboxilico de oximorfona, profarmacos, metodos de elaboracion y uso de los mismos. |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| ITUB20154996A1 (it) | 2015-10-27 | 2017-04-27 | Nobili S P A | Attrezzatura per l?erogazione di un liquido di trattamento ad una rispettiva coltura o piantagione agricola. |
| LT3490560T (lt) | 2016-07-29 | 2025-02-25 | Janssen Pharmaceutica, N.V. | Būdas prostatos vėžiui gydyti naudojant niraparibą |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| US10799496B2 (en) | 2018-07-13 | 2020-10-13 | Alkermes Pharma Ireland Limited | Naphthylenyl compounds for long-acting injectable compositions and related methods |
| US10807995B2 (en) | 2018-07-13 | 2020-10-20 | Alkermes Pharma Ireland Limited | Thienothiophene compounds for long-acting injectable compositions and related methods |
| WO2020094634A1 (en) | 2018-11-05 | 2020-05-14 | Alkermes Pharma Ireland Limited | Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods |
| EP4577667A2 (en) * | 2022-08-25 | 2025-07-02 | Biosynth GmbH | Procedure for production of opioid-antagonist-releasing compounds and their use as a medicine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2058243T3 (es) | 1988-01-12 | 1994-11-01 | Baker Norton Pharma | Derivados del acido glucuronico de antagonistas de opiaceos. |
| FR2680786B1 (fr) * | 1991-09-04 | 1995-03-10 | Irepa | Procede de synthese de glucuronides d'epoxy-4,5 morphinanes. |
| EP0816375A1 (en) * | 1995-11-29 | 1998-01-07 | Rolabo Sl | Glycoconjugates of opiated substances |
| GB9711118D0 (en) | 1997-05-29 | 1997-07-23 | Rolabo Sl | Compound |
-
2002
- 2002-07-22 US US10/199,526 patent/US6740641B2/en not_active Expired - Lifetime
- 2002-07-24 AU AU2002329634A patent/AU2002329634B2/en not_active Ceased
- 2002-07-24 IL IL16008502A patent/IL160085A0/xx unknown
- 2002-07-24 PT PT02765874T patent/PT1412368E/pt unknown
- 2002-07-24 WO PCT/US2002/023553 patent/WO2003011881A2/en not_active Ceased
- 2002-07-24 DE DE60222137T patent/DE60222137T2/de not_active Expired - Lifetime
- 2002-07-24 ES ES02765874T patent/ES2292806T3/es not_active Expired - Lifetime
- 2002-07-24 DK DK02765874T patent/DK1412368T3/da active
- 2002-07-24 AT AT02765874T patent/ATE371665T1/de active
- 2002-07-24 EP EP02765874A patent/EP1412368B1/en not_active Expired - Lifetime
- 2002-07-24 JP JP2003517072A patent/JP4679055B2/ja not_active Expired - Fee Related
- 2002-07-24 MX MXPA04000825A patent/MXPA04000825A/es active IP Right Grant
- 2002-07-24 CA CA2455774A patent/CA2455774C/en not_active Expired - Fee Related
-
2004
- 2004-01-27 IL IL160085A patent/IL160085A/en not_active IP Right Cessation
-
2007
- 2007-11-26 CY CY20071101510T patent/CY1107813T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60222137D1 (de) | 2007-10-11 |
| MXPA04000825A (es) | 2004-05-17 |
| IL160085A0 (en) | 2004-06-20 |
| US6740641B2 (en) | 2004-05-25 |
| ES2292806T3 (es) | 2008-03-16 |
| DE60222137T2 (de) | 2008-06-05 |
| CA2455774A1 (en) | 2003-02-13 |
| CY1107813T1 (el) | 2013-06-19 |
| EP1412368B1 (en) | 2007-08-29 |
| EP1412368A2 (en) | 2004-04-28 |
| AU2002329634B2 (en) | 2009-01-29 |
| PT1412368E (pt) | 2007-11-06 |
| ATE371665T1 (de) | 2007-09-15 |
| IL160085A (en) | 2010-12-30 |
| JP4679055B2 (ja) | 2011-04-27 |
| JP2005500357A (ja) | 2005-01-06 |
| WO2003011881A2 (en) | 2003-02-13 |
| CA2455774C (en) | 2011-06-07 |
| WO2003011881A3 (en) | 2003-10-30 |
| US20030050257A1 (en) | 2003-03-13 |
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