DK1406907T3 - Antitumorderivater af ET-743 - Google Patents

Antitumorderivater af ET-743

Info

Publication number: DK1406907T3
Authority: DK; Denmark
Prior art keywords: substituted; unsubstituted; alkenyl; alkyl; alkynyl
Prior art date: 2001-07-17

Application number

DK02747577T

Other languages

English (en)

Inventor

Valentin Martinez

Maria Flores

Pilar Gallego

Carmen Cuevas

Simon Munt

Ignacio Manzanares

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2002-07-17

Publication date

2008-02-04

2002-07-17 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2008-02-04 Application granted granted Critical

2008-02-04 Publication of DK1406907T3 publication Critical patent/DK1406907T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK02747577T 2001-07-17 2002-07-17 Antitumorderivater af ET-743 DK1406907T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0117402.8A GB0117402D0 (en)	2001-07-17	2001-07-17	New antitumoral derivatives of et-743
PCT/GB2002/003288 WO2003008423A1 (en)	2001-07-17	2002-07-17	New antitumoral derivatives of et-743

Publications (1)

Publication Number	Publication Date
DK1406907T3 true DK1406907T3 (da)	2008-02-04

Family

ID=9918658

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK02747577T DK1406907T3 (da)	2001-07-17	2002-07-17	Antitumorderivater af ET-743
DK10180049.8T DK2298780T3 (da)	2001-07-17	2002-07-17	Tumorhæmmende derivater af Ecteinascidin ET-743
DK07011446.7T DK1854800T3 (da)	2001-07-17	2002-07-17	Tumorhæmmende derivater af ecteinascidin ET-743

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK10180049.8T DK2298780T3 (da)	2001-07-17	2002-07-17	Tumorhæmmende derivater af Ecteinascidin ET-743
DK07011446.7T DK1854800T3 (da)	2001-07-17	2002-07-17	Tumorhæmmende derivater af ecteinascidin ET-743

Country Status (16)

Country	Link
US (2)	US7759345B2 (da)
EP (3)	EP1854800B1 (da)
JP (1)	JP4653950B2 (da)
AT (1)	ATE371661T1 (da)
AU (2)	AU2002317967C1 (da)
CA (1)	CA2453991C (da)
CY (2)	CY1107809T1 (da)
DE (1)	DE60222135T2 (da)
DK (3)	DK1406907T3 (da)
ES (3)	ES2389671T3 (da)
GB (1)	GB0117402D0 (da)
MX (1)	MXPA04000506A (da)
NO (2)	NO335262B1 (da)
PT (3)	PT2298780E (da)
SI (2)	SI2298780T1 (da)
WO (1)	WO2003008423A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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MXPA02011319A (es)	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
CA2583464A1 (en) *	2004-09-29	2006-04-06	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti -inflammatory agents
GB0521536D0 (en) *	2005-10-22	2005-11-30	Invibio Ltd	Fiducial marker
ES2534331T3 (es)	2010-05-25	2015-04-21	Pharma Mar S.A.	Proceso sintético para la producción de compuestos e intermedios de ecteinascidina
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
WO2024186263A1 (en) *	2023-03-07	2024-09-12	Axcynsis Therapeutics Pte. Ltd.	Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives
WO2025055920A1 (zh) *	2023-09-11	2025-03-20	泰诚思(上海)生物医药有限公司	新型海鞘素衍生物、其制备方法及用途、抗体药物偶联物及其应用
WO2025077996A1 (en)	2023-10-09	2025-04-17	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds
TW202535413A (zh) *	2024-02-08	2025-09-16	大陸商映恩生物科技（上海）有限公司	海鞘素類化合物及其應用

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JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
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US5089273A (en)	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) *	1990-11-30	1992-09-22	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 736 and 722
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US5256663A (en)	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5478932A (en) *	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US20040059112A1 (en) *	1994-02-18	2004-03-25	Rinehart Kenneth L.	Ecteinascidins
US5721362A (en)	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US5985876A (en) *	1997-04-15	1999-11-16	Univ Illinois	Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
DE69936845T2 (de) *	1998-04-06	2008-05-08	The Board Of Trustees Of The University Of Illinois, Urbana	Halbsynthetische ectein-ascidine
DE69927014T2 (de) *	1998-05-05	2006-06-14	Pharma Mar Sa	Kultivierung von sessilen meerestieren
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EP1254140A4 (en) *	2000-01-19	2003-03-12	Univ Columbia	SAFRAMYCIN-ECTEINASCIDIN SERIES COMPOUNDS, USES AND SYNTHESIS
US6815544B2 (en) *	2000-02-11	2004-11-09	President And Fellows Of Harvard College	Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) *	2000-02-22	2003-05-27	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
ATE299146T1 (de)	2000-04-12	2005-07-15	Pharma Mar Sa	Ecteinaschidin derivate mit antikrebs wirkung
US7919493B2 (en) *	2000-04-12	2011-04-05	Pharma Mar, S.A.	Anititumoral ecteinascidin derivatives
US7420051B2 (en) *	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
KR100718946B1 (ko) *	2000-11-06	2007-05-16	파르마 마르, 에스.에이.	효과적인 항종양 치료
IL161430A0 (en) *	2001-10-19	2004-09-27	Pharma Mar Sa	Pharmaceutical compositions containing ecteinascidin 743
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) *	2002-08-13	2002-09-18	Pharma Mar Sa	DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) *	2002-12-20	2003-01-29	Pharma Mar Sa	The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
SI1689404T1 (sl) *	2003-11-13	2009-02-28	Pharma Mar Sau	Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
CN1897949A (zh) *	2003-11-14	2007-01-17	马尔药品公司	包含使用et－743和紫杉醇来治疗癌症的联合疗法
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
MX2007000360A (es) *	2004-07-09	2007-06-12	Pharma Mar Sa	Marcadores moleculares de pronostico.
CA2583464A1 (en) *	2004-09-29	2006-04-06	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti -inflammatory agents
US20090117176A1 (en) *	2004-10-26	2009-05-07	Pharma Mar, S.A. Sociedad Unipersonal	Anticancer Treatments
NZ554761A (en) *	2004-10-29	2010-01-29	Pharma Mar Sa	Formulations comprising ecteinascidin and a disaccharide
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
WO2007062413A2 (en) *	2005-11-25	2007-05-31	University Of Medicine And Dentistry Of New Jersey	Use of parp-1 inhibitors
WO2007134203A2 (en) *	2006-05-12	2007-11-22	Pharma Mar, S.A.	Anticancer treatments with a combination of docetaxel and ecteinascidin
JP2011500046A (ja)	2007-10-19	2011-01-06	ファルマ・マール・ソシエダード・アノニマ	Ｅｔ−７４３治療のための予後分子マーカー
WO2009140675A2 (en)	2008-05-16	2009-11-19	Pharma Mar, S.A.	Combination therapy with an antitumor alkaloid
RU2519750C2 (ru)	2008-05-16	2014-06-20	Фарма Мар, С.А.	Способы лечения множественной миеломы

2001
- 2001-07-17 GB GBGB0117402.8A patent/GB0117402D0/en not_active Ceased
2002
- 2002-07-17 PT PT101800498T patent/PT2298780E/pt unknown
- 2002-07-17 DK DK02747577T patent/DK1406907T3/da active
- 2002-07-17 DK DK10180049.8T patent/DK2298780T3/da active
- 2002-07-17 DK DK07011446.7T patent/DK1854800T3/da active
- 2002-07-17 ES ES07011446T patent/ES2389671T3/es not_active Expired - Lifetime
- 2002-07-17 JP JP2003513982A patent/JP4653950B2/ja not_active Expired - Lifetime
- 2002-07-17 US US10/484,060 patent/US7759345B2/en not_active Expired - Lifetime
- 2002-07-17 AT AT02747577T patent/ATE371661T1/de active
- 2002-07-17 MX MXPA04000506A patent/MXPA04000506A/es active IP Right Grant
- 2002-07-17 SI SI200231015T patent/SI2298780T1/sl unknown
- 2002-07-17 SI SI200231003T patent/SI1854800T1/sl unknown
- 2002-07-17 AU AU2002317967A patent/AU2002317967C1/en not_active Expired
- 2002-07-17 ES ES10180049T patent/ES2394772T3/es not_active Expired - Lifetime
- 2002-07-17 EP EP07011446A patent/EP1854800B1/en not_active Expired - Lifetime
- 2002-07-17 WO PCT/GB2002/003288 patent/WO2003008423A1/en not_active Ceased
- 2002-07-17 CA CA2453991A patent/CA2453991C/en not_active Expired - Lifetime
- 2002-07-17 ES ES02747577T patent/ES2291479T3/es not_active Expired - Lifetime
- 2002-07-17 PT PT02747577T patent/PT1406907E/pt unknown
- 2002-07-17 DE DE60222135T patent/DE60222135T2/de not_active Expired - Lifetime
- 2002-07-17 EP EP10180049A patent/EP2298780B1/en not_active Expired - Lifetime
- 2002-07-17 PT PT07011446T patent/PT1854800E/pt unknown
- 2002-07-17 EP EP02747577A patent/EP1406907B1/en not_active Expired - Lifetime
2004
- 2004-01-16 NO NO20040189A patent/NO335262B1/no not_active IP Right Cessation
2007
- 2007-11-21 CY CY20071101494T patent/CY1107809T1/el unknown
2008
- 2008-08-20 AU AU2008207381A patent/AU2008207381B2/en not_active Expired
2010
- 2010-04-06 US US12/755,218 patent/US8076337B2/en not_active Expired - Fee Related
2012
- 2012-09-20 CY CY20121100864T patent/CY1113359T1/el unknown
2014
- 2014-06-06 NO NO20140711A patent/NO340213B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
MXPA04000506A (es)	2004-07-23
US20060106021A1 (en)	2006-05-18
WO2003008423A1 (en)	2003-01-30
EP1854800A1 (en)	2007-11-14
ES2394772T3 (es)	2013-02-05
GB0117402D0 (en)	2001-09-05
NO340213B1 (no)	2017-03-20
PT2298780E (pt)	2012-12-17
SI1854800T1 (sl)	2012-11-30
ES2291479T3 (es)	2008-03-01
EP1406907A1 (en)	2004-04-14
EP1406907B1 (en)	2007-08-29
JP2004536132A (ja)	2004-12-02
NO20140711L (no)	2004-03-16
JP4653950B2 (ja)	2011-03-16
AU2002317967C1 (en)	2009-01-22
AU2002317967B2 (en)	2008-06-05
CY1113359T1 (el)	2016-06-22
US8076337B2 (en)	2011-12-13
EP1854800B1 (en)	2012-06-27
US20100197695A1 (en)	2010-08-05
PT1406907E (pt)	2007-12-10
DK2298780T3 (da)	2013-01-07
AU2008207381A1 (en)	2008-09-11
NO20040189L (no)	2004-03-16
ES2389671T3 (es)	2012-10-30
EP2298780B1 (en)	2012-09-12
PT1854800E (pt)	2012-09-25
SI2298780T1 (sl)	2013-01-31
CA2453991C (en)	2011-12-20
EP2298780A1 (en)	2011-03-23
AU2008207381B2 (en)	2011-07-14
CY1107809T1 (el)	2013-06-19
US7759345B2 (en)	2010-07-20
DK1854800T3 (da)	2012-10-01
DE60222135T2 (de)	2008-05-21
DE60222135D1 (de)	2007-10-11
NO335262B1 (no)	2014-10-27
ATE371661T1 (de)	2007-09-15
CA2453991A1 (en)	2003-01-30

Publication	Publication Date	Title
CY1113359T1 (el)	2016-06-22	Αντι-νεοπλασιακα παραγωγα του et-743
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
DE60033857D1 (de)	2007-04-19	Derivate des N-((Chinolinyl)oxy)-phenyl)-Harnstoffs und des N-((Chinazolinyl)oxy)-phenyl)-Harnstoffs mit Antitumor Aktivität
DK1117297T3 (da)	2006-01-09	Syntetiske analoger af ecteinascidin-743
PT1280809E (pt)	2005-11-30	Derivados antitumorais de ecteinascidina
FI965020A0 (fi)	1996-12-13	Uusia yhdisteitä, menetelmiä niiden valmistamiseksi ja kasvaintenvastaisia aineita
TW325473B (en)	1998-01-21	Azoamine derivative having methylene or substituted methylene on the amino ring
ATE88714T1 (de)	1993-05-15	2'-desoxy-5-fluoruridinderivate.
DE60027131D1 (de)	2006-05-18	Inhibitoren für asparagin-proteasen
ATE232528T1 (de)	2003-02-15	Pyrimidinylpyrazolderivate
IE811580L (en)	1982-01-16	Herbicidal compounds
FI894783A0 (fi)	1989-10-09	Substituerade aromatiska foereningar med verkan pao det centrala nervsystemet.
GB0116966D0 (en)	2001-09-05	Anittumoral compounds
NO961537D0 (no)	1996-04-18	Salpetersyreestere fra derivater av 2-(2,6-dihalofenylamino)-fenylacetoksyeddiksyre, og deres fremstillingsprosedyrer
WO2003068737A3 (en)	2003-12-24	Synthesis of [2h1, 13c], [2h2, 13c], and [2h3, 13c]methyl aryl sulfides
DK1532139T3 (da)	2007-10-15	Totalsyntese af myriaporoner
DK162388A (da)	1988-09-27	Vinylaminderivater