NO20040189L - Nye antitumorderivater av ET-743 - Google Patents

Nye antitumorderivater av ET-743

Info

Publication number: NO20040189L
Authority: NO; Norway
Prior art keywords: substituted; unsubstituted; alkenyl; alkyl; alkynyl
Prior art date: 2001-07-17

Application number

NO20040189A

Other languages

English (en)

Other versions

NO335262B1 (no

Inventor

Carmen Cuevas

Pilar Gallego

Ignacio Manzanares

Maria Flores

Simon Munt

Valentin Martinez

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2004-01-16

Publication date

2004-03-16

2004-01-16 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2004-03-16 Publication of NO20040189L publication Critical patent/NO20040189L/no

2014-10-27 Publication of NO335262B1 publication Critical patent/NO335262B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

NO20040189A 2001-07-17 2004-01-16 Nye antitumorderivater av ET-743, anvendelse derav for fremstilling av et medikament, og farmasøytisk preparat omfattende forbindelsen NO335262B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0117402.8A GB0117402D0 (en)	2001-07-17	2001-07-17	New antitumoral derivatives of et-743
PCT/GB2002/003288 WO2003008423A1 (en)	2001-07-17	2002-07-17	New antitumoral derivatives of et-743

Publications (2)

Publication Number	Publication Date
NO20040189L true NO20040189L (no)	2004-03-16
NO335262B1 NO335262B1 (no)	2014-10-27

Family

ID=9918658

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20040189A NO335262B1 (no)	2001-07-17	2004-01-16	Nye antitumorderivater av ET-743, anvendelse derav for fremstilling av et medikament, og farmasøytisk preparat omfattende forbindelsen
NO20140711A NO340213B1 (no)	2001-07-17	2014-06-06	Nye antitumorderivater av ecteinascidinen ET-743, farmasøytisk preparat derav og anvendelse derav ved fremstillingen av et medikament for behandling av en kreftsykdom

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20140711A NO340213B1 (no)	2001-07-17	2014-06-06	Nye antitumorderivater av ecteinascidinen ET-743, farmasøytisk preparat derav og anvendelse derav ved fremstillingen av et medikament for behandling av en kreftsykdom

Country Status (16)

Country	Link
US (2)	US7759345B2 (no)
EP (3)	EP1406907B1 (no)
JP (1)	JP4653950B2 (no)
AT (1)	ATE371661T1 (no)
AU (2)	AU2002317967C1 (no)
CA (1)	CA2453991C (no)
CY (2)	CY1107809T1 (no)
DE (1)	DE60222135T2 (no)
DK (3)	DK1406907T3 (no)
ES (3)	ES2389671T3 (no)
GB (1)	GB0117402D0 (no)
MX (1)	MXPA04000506A (no)
NO (2)	NO335262B1 (no)
PT (3)	PT1854800E (no)
SI (2)	SI1854800T1 (no)
WO (1)	WO2003008423A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA02011319A (es)	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
JP2008514688A (ja) *	2004-09-29	2008-05-08	ファルマ・マル・エス・アー，ソシエダッド・ユニペルソナル	抗炎症剤としてのエクテイナシジン化合物
GB0521536D0 (en) *	2005-10-22	2005-11-30	Invibio Ltd	Fiducial marker
CN107033164A (zh)	2010-05-25	2017-08-11	法马马有限公司	制备海鞘素化合物的合成方法
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
WO2024186263A1 (en) *	2023-03-07	2024-09-12	Axcynsis Therapeutics Pte. Ltd.	Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives
CN119591621A (zh) *	2023-09-11	2025-03-11	泰诚思(上海)生物医药有限公司	新型海鞘素衍生物、其制备方法及用途、抗体药物偶联物及其应用
WO2025077996A1 (en)	2023-10-09	2025-04-17	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds
WO2025168077A1 (zh) *	2024-02-08	2025-08-14	映恩生物科技(上海)有限公司	海鞘素类化合物及其应用

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
JPS6084288A (ja)	1983-10-13	1985-05-13	Shionogi & Co Ltd	シアノキノナミンアセテ−ト類およびその製造法
US5089273A (en)	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
DE3774435D1 (de)	1986-06-09	1991-12-12	Univ Pennsylvania	Ekteinascidine 729, 743, 745, 759a, 759b and 770.
US5256663A (en)	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) *	1990-11-30	1992-09-22	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 736 and 722
US5478932A (en) *	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US20040059112A1 (en) *	1994-02-18	2004-03-25	Rinehart Kenneth L.	Ecteinascidins
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US5985876A (en) *	1997-04-15	1999-11-16	Univ Illinois	Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
EP1876180A3 (en)	1998-04-06	2009-12-16	The Board Of Trustees Of The University Of Illinois	Semi-synthetic ecteinascidins
IL139472A0 (en) *	1998-05-05	2001-11-25	Ruffles Graham Keith	Culture of sessile marine animals
KR100643092B1 (ko) *	1998-05-11	2006-11-10	파르마 마르, 에스.에이.	엑테인아시딘 743의 대사산물
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MY164077A (en) *	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
AR035842A1 (es)	1999-05-14	2004-07-21	Pharma Mar Sa	Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
JP2003520801A (ja) *	2000-01-19	2003-07-08	ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク	サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
US6815544B2 (en) *	2000-02-11	2004-11-09	President And Fellows Of Harvard College	Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) *	2000-02-22	2003-05-27	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MXPA02010088A (es)	2000-04-12	2004-08-19	Pharma Mar Sa	Derivados de ecteinascidina antitumorales.
US7919493B2 (en) *	2000-04-12	2011-04-05	Pharma Mar, S.A.	Anititumoral ecteinascidin derivatives
US7420051B2 (en) *	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
BR0115162A (pt) *	2000-11-06	2003-10-21	Pharma Mar Sa	Tratamentos antitumorais eficazes
EP1435988A4 (en) *	2001-10-19	2008-01-09	Pharmamar Sa	IMPROVED USE OF ANTI-TUMORAL COMPOUND IN THE TREATMENT OF CANCER
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) *	2002-08-13	2002-09-18	Pharma Mar Sa	DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) *	2002-12-20	2003-01-29	Pharma Mar Sa	The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
PT1689404E (pt) *	2003-11-13	2008-12-15	Pharma Mar Sau	Combinação de et-743 com pró-fármacos de fluorouracil para o tratamento do cancro
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
US20080255132A1 (en) *	2003-11-14	2008-10-16	Eric Rowinsky	Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
JP2008505862A (ja) *	2004-07-09	2008-02-28	ファルマ、マール、ソシエダード、アノニマ	予後分子マーカー
JP2008514688A (ja) *	2004-09-29	2008-05-08	ファルマ・マル・エス・アー，ソシエダッド・ユニペルソナル	抗炎症剤としてのエクテイナシジン化合物
PL1827500T3 (pl) *	2004-10-26	2009-09-30	Pharma Mar Sa	Pegylowana liposomalna doksorubicyna w kombinacji z ekteinascydyną 743
DK1658848T3 (da) *	2004-10-29	2007-11-26	Pharma Mar Sa	Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
CA2630900A1 (en) *	2005-11-25	2007-05-31	University Of Medicine And Dentistry Of New Jersey	Use of parp-1 inhibitors
EP2023931A2 (en) *	2006-05-12	2009-02-18	Pharma Mar S.A.	Anticancer treatments with a combination of docetaxel and ecteinascidin
AU2008313634A1 (en)	2007-10-19	2009-04-23	Pharma Mar, S.A.	Prognostic molecular markers for ET-743 treatment
KR20110028454A (ko)	2008-05-16	2011-03-18	파르마 마르 에스.에이.	다발성 골수종 치료법
US20110070232A1 (en)	2008-05-16	2011-03-24	Pharma Mar, S.A.	Combination Therapy with an Antitumor Alkaloid

2001
- 2001-07-17 GB GBGB0117402.8A patent/GB0117402D0/en not_active Ceased
2002
- 2002-07-17 ES ES07011446T patent/ES2389671T3/es not_active Expired - Lifetime
- 2002-07-17 SI SI200231003T patent/SI1854800T1/sl unknown
- 2002-07-17 DK DK02747577T patent/DK1406907T3/da active
- 2002-07-17 WO PCT/GB2002/003288 patent/WO2003008423A1/en not_active Ceased
- 2002-07-17 PT PT07011446T patent/PT1854800E/pt unknown
- 2002-07-17 DK DK07011446.7T patent/DK1854800T3/da active
- 2002-07-17 AU AU2002317967A patent/AU2002317967C1/en not_active Expired
- 2002-07-17 EP EP02747577A patent/EP1406907B1/en not_active Expired - Lifetime
- 2002-07-17 ES ES10180049T patent/ES2394772T3/es not_active Expired - Lifetime
- 2002-07-17 JP JP2003513982A patent/JP4653950B2/ja not_active Expired - Lifetime
- 2002-07-17 DK DK10180049.8T patent/DK2298780T3/da active
- 2002-07-17 CA CA2453991A patent/CA2453991C/en not_active Expired - Lifetime
- 2002-07-17 MX MXPA04000506A patent/MXPA04000506A/es active IP Right Grant
- 2002-07-17 AT AT02747577T patent/ATE371661T1/de active
- 2002-07-17 DE DE60222135T patent/DE60222135T2/de not_active Expired - Lifetime
- 2002-07-17 PT PT02747577T patent/PT1406907E/pt unknown
- 2002-07-17 US US10/484,060 patent/US7759345B2/en not_active Expired - Lifetime
- 2002-07-17 ES ES02747577T patent/ES2291479T3/es not_active Expired - Lifetime
- 2002-07-17 SI SI200231015T patent/SI2298780T1/sl unknown
- 2002-07-17 EP EP10180049A patent/EP2298780B1/en not_active Expired - Lifetime
- 2002-07-17 EP EP07011446A patent/EP1854800B1/en not_active Expired - Lifetime
- 2002-07-17 PT PT101800498T patent/PT2298780E/pt unknown
2004
- 2004-01-16 NO NO20040189A patent/NO335262B1/no not_active IP Right Cessation
2007
- 2007-11-21 CY CY20071101494T patent/CY1107809T1/el unknown
2008
- 2008-08-20 AU AU2008207381A patent/AU2008207381B2/en not_active Expired
2010
- 2010-04-06 US US12/755,218 patent/US8076337B2/en not_active Expired - Fee Related
2012
- 2012-09-20 CY CY20121100864T patent/CY1113359T1/el unknown
2014
- 2014-06-06 NO NO20140711A patent/NO340213B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
US7759345B2 (en)	2010-07-20
NO335262B1 (no)	2014-10-27
AU2002317967B2 (en)	2008-06-05
AU2008207381A1 (en)	2008-09-11
SI2298780T1 (sl)	2013-01-31
ES2389671T3 (es)	2012-10-30
ES2291479T3 (es)	2008-03-01
DK1854800T3 (da)	2012-10-01
ATE371661T1 (de)	2007-09-15
EP2298780B1 (en)	2012-09-12
PT2298780E (pt)	2012-12-17
ES2394772T3 (es)	2013-02-05
PT1406907E (pt)	2007-12-10
DK2298780T3 (da)	2013-01-07
PT1854800E (pt)	2012-09-25
US8076337B2 (en)	2011-12-13
EP1406907A1 (en)	2004-04-14
CY1113359T1 (el)	2016-06-22
DK1406907T3 (da)	2008-02-04
EP1854800A1 (en)	2007-11-14
GB0117402D0 (en)	2001-09-05
DE60222135T2 (de)	2008-05-21
DE60222135D1 (de)	2007-10-11
CA2453991C (en)	2011-12-20
WO2003008423A1 (en)	2003-01-30
CA2453991A1 (en)	2003-01-30
MXPA04000506A (es)	2004-07-23
JP4653950B2 (ja)	2011-03-16
NO340213B1 (no)	2017-03-20
CY1107809T1 (el)	2013-06-19
NO20140711L (no)	2004-03-16
EP1854800B1 (en)	2012-06-27
JP2004536132A (ja)	2004-12-02
US20060106021A1 (en)	2006-05-18
AU2002317967C1 (en)	2009-01-22
EP1406907B1 (en)	2007-08-29
AU2008207381B2 (en)	2011-07-14
EP2298780A1 (en)	2011-03-23
SI1854800T1 (sl)	2012-11-30
US20100197695A1 (en)	2010-08-05

Publication	Publication Date	Title
CY1113359T1 (el)	2016-06-22	Αντι-νεοπλασιακα παραγωγα του et-743
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
ATE356117T1 (de)	2007-03-15	Derivate des n-((chinolinyl)oxy)-phenyl)- harnstoffs und des n-((chinazolinyl)oxy)-phenyl)- harnstoffs mit antitumor aktivität
DK1117297T3 (da)	2006-01-09	Syntetiske analoger af ecteinascidin-743
NO307255B1 (no)	2000-03-06	Nye forbindelser og antitumormidler
PT1280809E (pt)	2005-11-30	Derivados antitumorais de ecteinascidina
TW325473B (en)	1998-01-21	Azoamine derivative having methylene or substituted methylene on the amino ring
CY1108313T1 (el)	2014-02-12	Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6
DE69129611D1 (de)	1998-07-23	Sulfonamid-Derivate
ATE88714T1 (de)	1993-05-15	2'-desoxy-5-fluoruridinderivate.
DE60027131D1 (de)	2006-05-18	Inhibitoren für asparagin-proteasen
DE60024610D1 (de)	2006-01-12	Pestizid wirkende triazin-derivate
ATE232528T1 (de)	2003-02-15	Pyrimidinylpyrazolderivate
GB0116966D0 (en)	2001-09-05	Anittumoral compounds
DK1532139T3 (da)	2007-10-15	Totalsyntese af myriaporoner

Legal Events

Date	Code	Title	Description
2022-08-15	MK1K	Patent expired