DK1492881T3 - Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanaler - Google Patents
Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanalerInfo
- Publication number
- DK1492881T3 DK1492881T3 DK03727297T DK03727297T DK1492881T3 DK 1492881 T3 DK1492881 T3 DK 1492881T3 DK 03727297 T DK03727297 T DK 03727297T DK 03727297 T DK03727297 T DK 03727297T DK 1492881 T3 DK1492881 T3 DK 1492881T3
- Authority
- DK
- Denmark
- Prior art keywords
- light
- controlled ion
- direct light
- ion channels
- biological
- Prior art date
Links
- 102000004310 Ion Channels Human genes 0.000 title abstract 2
- 108091008695 photoreceptors Proteins 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000006410 Apoproteins Human genes 0.000 abstract 1
- 108010083590 Apoproteins Proteins 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 230000028161 membrane depolarization Effects 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 150000004291 polyenes Chemical class 0.000 abstract 1
- 230000002207 retinal effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/405—Assays involving biological materials from specific organisms or of a specific nature from algae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Radiation-Therapy Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Magnetic Treatment Devices (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10216005A DE10216005A1 (de) | 2002-04-11 | 2002-04-11 | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| PCT/EP2003/003799 WO2003084994A2 (de) | 2002-04-11 | 2003-04-11 | Verwendung von biologischen photorezeptoren als direkt lichtgesteuerte ionenkanäle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1492881T3 true DK1492881T3 (da) | 2009-02-16 |
Family
ID=28684950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03727297T DK1492881T3 (da) | 2002-04-11 | 2003-04-11 | Anvendelse af biologiske fotoreceptorer som direkte lysstyrede ionkanaler |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7824869B2 (da) |
| EP (2) | EP1492881B1 (da) |
| AT (1) | ATE412063T1 (da) |
| AU (1) | AU2003233968A1 (da) |
| DE (2) | DE10216005A1 (da) |
| DK (1) | DK1492881T3 (da) |
| ES (1) | ES2315495T3 (da) |
| WO (1) | WO2003084994A2 (da) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10216005A1 (de) * | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| US8906360B2 (en) | 2005-07-22 | 2014-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated cation channel and uses thereof |
| US20090093403A1 (en) | 2007-03-01 | 2009-04-09 | Feng Zhang | Systems, methods and compositions for optical stimulation of target cells |
| US20190321651A1 (en) * | 2005-07-22 | 2019-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | System for Optical Stimulation of Target Cells |
| US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
| US10052497B2 (en) * | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
| US9238150B2 (en) * | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
| EP2019588A4 (en) * | 2006-05-04 | 2010-11-24 | Univ Wayne State | RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN |
| EP1891976A1 (en) * | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| US8398692B2 (en) | 2007-01-10 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
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| US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
| US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
| PT2271369E (pt) | 2008-04-18 | 2014-07-10 | Novartis Forschungsstiftung | Novas ferramentas terapêuticas e métodos para tratar a cegueira |
| DE102008020152B4 (de) * | 2008-04-22 | 2012-04-05 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| EP3165534B1 (en) | 2008-04-23 | 2018-09-26 | The Board of Trustees of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
| US20120093772A1 (en) | 2008-05-20 | 2012-04-19 | Alan Horsager | Vectors for delivery of light sensitive proteins and methods of use |
| ES2532235T3 (es) | 2008-05-29 | 2015-03-25 | The Board Of Trustees Of The Leland Stanford Junior University | Línea celular, sistema y procedimiento para el control óptico de mensajeros secundarios |
| JP5887136B2 (ja) | 2008-06-17 | 2016-03-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 細胞発達を制御するための装置および方法 |
| JP2011525130A (ja) | 2008-06-17 | 2011-09-15 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | 光伝送素子を用いた標的細胞の光刺激のための方法、システム、および装置 |
| WO2010006049A1 (en) | 2008-07-08 | 2010-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
| NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
| MY175954A (en) | 2010-03-17 | 2020-07-16 | The Board Of Trustees Of Leland Stanford Junior Univ | Light-sensitive ion-passing molecules |
| GB2492719A (en) | 2010-04-05 | 2013-01-09 | Eos Neuroscience Inc | Methods and compositions for decreasing chronic pain |
| US9453241B2 (en) | 2010-05-04 | 2016-09-27 | Wayne State University | AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
| US9207237B2 (en) | 2010-08-23 | 2015-12-08 | President And Fellows Of Harvard College | Systems, methods, and workflows for optogenetics analysis |
| EP2609425A1 (en) | 2010-08-23 | 2013-07-03 | President and Fellows of Harvard College | Optogenetic probes for measuring membrane potential |
| BR112013005634A2 (pt) | 2010-09-08 | 2017-06-27 | Max Planck Gesellschaft | canal-rodopsina 2 mutante |
| WO2012051599A2 (en) | 2010-10-15 | 2012-04-19 | Eos Neuroscience, Inc. | Modulation neural pathways |
| CN110215614A (zh) | 2010-11-05 | 2019-09-10 | 斯坦福大学托管董事会 | 用于光遗传学方法的光的上转换 |
| CA3056186A1 (en) | 2010-11-05 | 2012-05-10 | Board Of Trustees Of The Leland Stanford Junior University | Optically-controlled cns dysfunction |
| JP6355335B2 (ja) | 2010-11-05 | 2018-07-11 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 報酬関連行動の光遺伝学的制御 |
| CA2816971A1 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
| CN106376525A (zh) | 2010-11-05 | 2017-02-08 | 斯坦福大学托管董事会 | 记忆功能的控制和表征 |
| WO2012061744A2 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Stabilized step function opsin proteins and methods of using the same |
| US20120214188A1 (en) * | 2010-11-12 | 2012-08-23 | Nathan Klapoetke | Light-activated ion channel molecules and uses thereof |
| US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
| US8973531B2 (en) * | 2010-12-09 | 2015-03-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Automated continuous zooplankton culture system |
| DK2699270T3 (da) | 2011-04-22 | 2017-10-02 | Univ California | Adenoassocieret virus-virions med variant capsid og fremgangsmåder til anvendelse deraf |
| US9163094B2 (en) | 2011-09-27 | 2015-10-20 | Massachusetts Institute Of Technology | Light-activated fusion proteins and uses therefor |
| US10472398B2 (en) | 2011-11-12 | 2019-11-12 | Massachusetts Institute Of Technology | Channelrhodopsins for optical control of cells |
| CA3036859A1 (en) | 2011-12-16 | 2013-06-20 | The Board Of Trustees Of The Leland Stanford Junior University | Opsin polypeptides and methods of use thereof |
| EP3205374B1 (en) | 2012-02-21 | 2019-03-27 | The Board of Trustees of The Leland Stanford Junior University | Compositions for treating neurogenic disorders of the pelvic floor |
| CN104334575A (zh) | 2012-03-05 | 2015-02-04 | 韦恩州立大学 | 通道视蛋白-2(Chop2)突变的鉴定及使用方法 |
| US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
| US10974064B2 (en) | 2013-03-15 | 2021-04-13 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of behavioral state |
| CA2908864A1 (en) | 2013-04-29 | 2014-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Devices, systems and methods for optogenetic modulation of action potentials in target cells |
| CN105829538A (zh) | 2013-08-14 | 2016-08-03 | 小利兰·斯坦福大学托管委员会 | 用于控制疼痛的组合物和方法 |
| EP3102290A1 (en) | 2014-02-07 | 2016-12-14 | Massachusetts Institute Of Technology | Blue light-activated ion channel molecules and uses thereof |
| WO2015164383A1 (en) | 2014-04-22 | 2015-10-29 | Q-State Biosciences, Inc. | Models for parkinson's disease studies |
| EP3158338B1 (en) | 2014-06-18 | 2020-03-11 | President and Fellows of Harvard College | Optogenetic probes for measuring membrane potential |
| US10882892B2 (en) | 2014-08-05 | 2021-01-05 | Massachusetts Institute Of Technology | Channelrhodopsin variants and uses thereof |
| WO2016115333A1 (en) | 2015-01-15 | 2016-07-21 | President And Fellows Of Harvard College | Optical selection of cells |
| US10048275B2 (en) | 2015-03-13 | 2018-08-14 | Q-State Biosciences, Inc. | Cardiotoxicity screening methods |
| CA2979975A1 (en) | 2015-03-19 | 2016-09-22 | Board Of Regents Of The University Of Texas System | Compositions and methods for use of anion channel rhodopsins |
| CA2986583A1 (en) | 2015-05-21 | 2016-11-24 | Q-State Biosciences, Inc. | Optogenetics microscope |
| US10568516B2 (en) | 2015-06-22 | 2020-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
| WO2017046084A1 (en) | 2015-09-15 | 2017-03-23 | Friedrich Miescher Institute For Biomedical Research | Novel therapeutical tools and methods for treating blindness by targeting photoreceptors |
| JP6942789B2 (ja) | 2016-04-29 | 2021-09-29 | ジェンサイト バイオロジクス エスアー | Chrimsonを用いた光遺伝学的視覚回復 |
| US20190209708A1 (en) | 2016-05-17 | 2019-07-11 | Friedrich Miescher Institute For Biomedical Research | Novel therapeutic tools and methods for treating blindness |
| US20190218256A1 (en) * | 2016-06-03 | 2019-07-18 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Mutant light-inducible ion channel of channelrhodopsin |
| KR102471929B1 (ko) * | 2016-06-03 | 2022-11-28 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | 크림슨의 돌연변이 광-유도성 이온 채널 |
| WO2018134168A1 (en) | 2017-01-17 | 2018-07-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of expressing a polynucleotide of interest in the cone photoreceptors |
| US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
| US11723988B2 (en) | 2017-10-20 | 2023-08-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising the subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector |
| KR102048458B1 (ko) * | 2018-01-26 | 2019-11-25 | 한국과학기술연구원 | 테트라셀미스를 포함하는 눈 건강 개선용 조성물 |
| EP4223768A1 (en) | 2022-02-04 | 2023-08-09 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Novel mutant bacteriorhodopsin-like-channelrhodopsin ion channel |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2580277B1 (fr) * | 1985-04-15 | 1988-06-10 | Oreal | Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant |
| DE68916080T2 (de) * | 1988-03-28 | 1994-09-22 | Canon Kk | Ionenpermeable Membran und Ionentransportverfahren unter Verwendung dieser Membran. |
| JP3128386B2 (ja) * | 1993-04-07 | 2001-01-29 | 三洋電機株式会社 | 神経モデル素子 |
| US7144733B2 (en) * | 2001-08-16 | 2006-12-05 | Sloan-Kettering Institute For Cancer Research | Bio-synthetic photostimulators and methods of use |
| DE10216005A1 (de) * | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
-
2002
- 2002-04-11 DE DE10216005A patent/DE10216005A1/de not_active Ceased
-
2003
- 2003-04-11 DK DK03727297T patent/DK1492881T3/da active
- 2003-04-11 DE DE50310674T patent/DE50310674D1/de not_active Expired - Lifetime
- 2003-04-11 EP EP03727297A patent/EP1492881B1/de not_active Expired - Lifetime
- 2003-04-11 US US10/510,628 patent/US7824869B2/en not_active Expired - Lifetime
- 2003-04-11 WO PCT/EP2003/003799 patent/WO2003084994A2/de not_active Ceased
- 2003-04-11 ES ES03727297T patent/ES2315495T3/es not_active Expired - Lifetime
- 2003-04-11 AT AT03727297T patent/ATE412063T1/de active
- 2003-04-11 AU AU2003233968A patent/AU2003233968A1/en not_active Abandoned
- 2003-04-11 EP EP08016563.2A patent/EP2055714B1/de not_active Expired - Lifetime
-
2010
- 2010-05-18 US US12/781,962 patent/US8202699B2/en not_active Expired - Fee Related
-
2012
- 2012-04-23 US US13/453,154 patent/US8647870B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2315495T3 (es) | 2009-04-01 |
| EP1492881A2 (de) | 2005-01-05 |
| DE50310674D1 (de) | 2008-12-04 |
| EP2055714A2 (de) | 2009-05-06 |
| US7824869B2 (en) | 2010-11-02 |
| WO2003084994A3 (de) | 2004-02-05 |
| AU2003233968A1 (en) | 2003-10-20 |
| EP1492881B1 (de) | 2008-10-22 |
| EP2055714A3 (de) | 2009-08-12 |
| DE10216005A1 (de) | 2003-10-30 |
| US20110086421A1 (en) | 2011-04-14 |
| ATE412063T1 (de) | 2008-11-15 |
| US20050202398A1 (en) | 2005-09-15 |
| WO2003084994A2 (de) | 2003-10-16 |
| US8647870B2 (en) | 2014-02-11 |
| US8202699B2 (en) | 2012-06-19 |
| EP2055714B1 (de) | 2014-05-07 |
| US20130017597A1 (en) | 2013-01-17 |
| AU2003233968A8 (en) | 2003-10-20 |
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