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DK145119C - Analogifremgangsmaade til fremstilling af phenolethere eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af phenolethere eller syreadditionssalte deraf

Info

Publication number
DK145119C
DK145119C DK495476A DK495476A DK145119C DK 145119 C DK145119 C DK 145119C DK 495476 A DK495476 A DK 495476A DK 495476 A DK495476 A DK 495476A DK 145119 C DK145119 C DK 145119C
Authority
DK
Denmark
Prior art keywords
phenolethers
analogue
preparation
acid addition
addition salts
Prior art date
Application number
DK495476A
Other languages
Danish (da)
English (en)
Other versions
DK145119B (da
DK495476A (da
Inventor
P M J Manoury
I A G Cavero
H Najer
D P R L Giudicelli
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9162099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK145119(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo filed Critical Synthelabo
Publication of DK495476A publication Critical patent/DK495476A/da
Publication of DK145119B publication Critical patent/DK145119B/da
Application granted granted Critical
Publication of DK145119C publication Critical patent/DK145119C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK495476A 1975-11-06 1976-11-02 Analogifremgangsmaade til fremstilling af phenolethere eller syreadditionssalte deraf DK145119C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7533899 1975-11-06
FR7533899A FR2330383A1 (fr) 1975-11-06 1975-11-06 Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment

Publications (3)

Publication Number Publication Date
DK495476A DK495476A (da) 1977-05-07
DK145119B DK145119B (da) 1982-09-06
DK145119C true DK145119C (da) 1983-02-14

Family

ID=9162099

Family Applications (1)

Application Number Title Priority Date Filing Date
DK495476A DK145119C (da) 1975-11-06 1976-11-02 Analogifremgangsmaade til fremstilling af phenolethere eller syreadditionssalte deraf

Country Status (24)

Country Link
US (2) US4252984A (xx)
JP (1) JPS5848543B2 (xx)
AR (1) AR214303A1 (xx)
AT (1) AT344683B (xx)
AU (1) AU501581B2 (xx)
BE (1) BE847801A (xx)
CA (1) CA1072981A (xx)
CH (1) CH602582A5 (xx)
DE (1) DE2649605C3 (xx)
DK (1) DK145119C (xx)
ES (1) ES452920A1 (xx)
FI (1) FI62829C (xx)
FR (1) FR2330383A1 (xx)
GB (1) GB1515978A (xx)
GR (1) GR61363B (xx)
IE (1) IE43645B1 (xx)
IL (1) IL50814A (xx)
LU (1) LU76117A1 (xx)
NL (1) NL179051C (xx)
NO (1) NO142034C (xx)
NZ (1) NZ182498A (xx)
PT (1) PT65780B (xx)
SE (1) SE433208B (xx)
ZA (1) ZA766338B (xx)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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FR2409980A1 (fr) * 1977-11-24 1979-06-22 Synthelabo Ethers de phenols et leur application en therapeutique
IT1147311B (it) * 1980-02-13 1986-11-19 Stabil Bioterapico Farmachim Eteri basici di 4-idrossi-benzofenoni con attivita' quali agenti betabloccanti e relativi procedimento di preparazione
ZW9881A1 (en) * 1980-06-02 1981-12-23 Hoffmann La Roche Substituted phenoxyaminopropanol derivatives
DE3125870C2 (de) * 1980-07-09 1994-09-15 William John Louis 3-Aminopropoxyphenyl Derivate, ihre Herstellung und sie enthaltende Arzneimittel
CH643527A5 (en) * 1980-10-24 1984-06-15 Ciba Geigy Ag Process for the preparation of 1-alkylamino-3-(4-(2-lower alkoxy-ethyl)phenoxy)-2-propanols
JPS57108047A (en) * 1980-11-06 1982-07-05 Sandoz Ag 3-aminopropoxyphenyl derivative, manufacture and pharmaceutical composition containing same
US5347050A (en) * 1980-11-06 1994-09-13 Richard Berthold 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
FI76551C (fi) 1980-11-06 1988-11-10 Sandoz Ag Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-aminopropoxifenylderivat.
DE3125636A1 (de) * 1981-06-30 1983-01-13 Merck Patent Gmbh, 6100 Darmstadt 1-(p-2-isopropoxyethoxymethyl-phenoxy)-3-isopropylamino-propan-2-ol zur senkung des augeninnendrucks und ophtalmikum, enthalten diese verbindung
FR2512443A1 (fr) * 1981-09-10 1983-03-11 Synthelabo Derives de phenoxy-3 propanol-2, leur preparation et leur application en therapeutique
DE3151201A1 (de) * 1981-12-23 1983-07-28 Beiersdorf Ag, 2000 Hamburg Substituierte phenoxyalkanolamine und phenoxyalkanol-cycloalkylamine, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische zubereitungen und zwischenprodukte
US4450172A (en) * 1982-03-10 1984-05-22 E. I. Du Pont De Nemours And Company Antihypertensive polyhalohydroxyisopropyl phenylalka(e)noic acid esters of alkylaminohydroxypropyloxyphenylalkyl alcohols
FR2536390B1 (fr) * 1982-11-22 1986-03-21 Synthelabo Isomere s du betaxolol, sa preparation et son application en therapeutique
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
US5166218A (en) * 1983-10-19 1992-11-24 Hoffmann-La Roche Inc. Phenoxypropanolamines and pharmaceutical compositions thereof
ZA852843B (en) * 1984-05-15 1985-11-27 Warner Lambert Co Bevantolol preparation
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US5554367A (en) * 1984-10-31 1996-09-10 Alcon Laboratories, Inc. Compositions for treatment of glaucoma
ES8609190A1 (es) * 1985-02-07 1986-07-16 Pharma Investi S A Un procedimiento para preparar eteres fenolicos
US5095151A (en) * 1985-05-21 1992-03-10 American Home Products Corporation Preparation of propranolol hydrochloride macrocrystals
EP0252007A3 (en) * 1986-06-28 1989-07-05 Ciba-Geigy Ag 2-propanol derivatives as corrosion inhibitors
US4694022A (en) * 1986-12-24 1987-09-15 Alcon Laboratories, Inc. Fatty acid salts of betaxolol useful in the treatment of glaucoma
DE3866984D1 (en) * 1987-07-21 1992-01-30 Hoffmann La Roche Phenoxypropanolamine.
FR2672594B1 (fr) * 1991-02-08 1994-07-01 Synthelabo Derives d'ethers de phenols, leur preparation et leur application en therapeutique.
WO1997013744A1 (en) * 1995-10-10 1997-04-17 The University Of Melbourne 3-amino-propoxyphenyl derivatives (i)
CA2193149C (en) * 1995-12-22 2002-04-23 David H. Donabedian Cationic therapuetic agents and delivery systems
US5942633A (en) * 1996-06-19 1999-08-24 Abbott Laboratories Process for the selective alkylation of betaxolol intermediates
US5731463A (en) * 1996-09-23 1998-03-24 Abbott Laboratories Selective alkylation of an alcohol substituted phenol compound
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
US6258350B1 (en) 1999-01-20 2001-07-10 Alcon Manufacturing, Ltd. Sustained release ophthalmic formulation
US7081482B2 (en) 1999-11-30 2006-07-25 Alcon, Inc. Use of β-adrenoceptor antagonists for the manufacture of a medicament for the treatment of disorders of the outer retina
ES2265437T3 (es) * 2000-07-27 2007-02-16 Pharmacia Corporation Terapia de combinacion antagonista epoxi-esteroidal de aldosterona y antagonista beta-adrenergico para tratamiento de la insuficiencia cardiaca congestiva.
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
US7001615B1 (en) 2001-12-07 2006-02-21 Alcon, Inc. Sustained release ophthalmic, otic and nasal suspension
RS20050106A (sr) 2002-08-19 2007-11-15 Pfizer Products Inc., Kombinovana terapija hiperproliferativnih bolesti
BRPI0410840A (pt) * 2003-05-30 2006-07-04 Ranbaxy Lab Ltd derivados substituìdos de pirrol, composição farmacêutica contendo os mesmos e processo para sua preparação
CN1300079C (zh) * 2004-12-03 2007-02-14 南京大学 合成4－[2－(环丙基甲氧基)乙基]苯酚的新工艺
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US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
JP2009514851A (ja) * 2005-11-08 2009-04-09 ランバクシー ラボラトリーズ リミテッド （３ｒ，５ｒ）−７−［２−（４−フルオロフェニル）−５−イソプロピル−３−フェニル−４−［（４−ヒドロキシメチルフェニルアミノ）カルボニル］−ピロール−１−イル］−３，５−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
MX2009000439A (es) * 2006-07-14 2009-02-04 Ranbaxy Lab Ltd Formas polimorficas de un inhibidor de hmg-coa reductasa y usos de las mismas.
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
CN101622243B (zh) 2007-02-28 2013-12-04 旭化成制药株式会社 磺酰胺衍生物
US9782488B2 (en) 2007-03-12 2017-10-10 Nektar Therapeutics Oligomer-beta blocker conjugates
US8987262B2 (en) 2007-10-19 2015-03-24 Universite de Bordeaux Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas
EP2050441A1 (en) * 2007-10-19 2009-04-22 Université Victor Segalen Bordeaux 2 Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas
JP2009040769A (ja) * 2008-07-09 2009-02-26 William John Louis ３−アミノ−プロポキシフェニル誘導体（ｉ）
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
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DK3911648T3 (da) 2019-01-18 2025-01-13 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf

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AT325022B (de) * 1935-11-15 1975-09-25 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen racemischen oder optisch aktiven n,n'- bis - (3-subst. phenoxy-2-hydroxy - 1 - propyl) - alfa, omega - diaminoalkanen sowie deren säureadditionssalzen
GB1078852A (en) * 1964-09-30 1967-08-09 Ici Ltd Alkanolamine derivatives
CA956632A (en) * 1969-05-16 1974-10-22 Yoshitomi Pharmaceutical Industries Phenoxy-aminopropanol derivatives
SE372762B (xx) * 1969-05-21 1975-01-13 Haessle Ab
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SE354851B (xx) * 1970-02-18 1973-03-26 Haessle Ab
GB1458392A (en) * 1973-11-09 1976-12-15 Ici Ltd Optically-active 1-aryloxy-2,3-epoxypropane derivatives

Also Published As

Publication number Publication date
DK145119B (da) 1982-09-06
FI763132A7 (xx) 1977-05-07
GB1515978A (en) 1978-06-28
IL50814A0 (en) 1977-01-31
FI62829B (fi) 1982-11-30
NL179051B (nl) 1986-02-03
SE7612177L (sv) 1977-05-07
NO142034C (no) 1980-06-18
NL7612123A (nl) 1977-05-10
DE2649605C3 (de) 1981-04-02
CH602582A5 (xx) 1978-07-31
FI62829C (fi) 1983-03-10
ATA812076A (de) 1977-12-15
ES452920A1 (es) 1977-11-01
LU76117A1 (xx) 1978-07-10
SE433208B (sv) 1984-05-14
IE43645B1 (en) 1981-04-22
US4252984A (en) 1981-02-24
BE847801A (fr) 1977-02-14
AU501581B2 (en) 1979-06-21
FR2330383B1 (xx) 1979-09-21
US4311708A (en) 1982-01-19
AT344683B (de) 1978-08-10
PT65780A (fr) 1976-12-01
IE43645L (en) 1977-05-06
PT65780B (fr) 1978-05-10
IL50814A (en) 1979-11-30
JPS5285146A (en) 1977-07-15
NO763732L (no) 1977-05-09
NO142034B (no) 1980-03-10
AR214303A1 (es) 1979-05-31
NZ182498A (en) 1978-04-03
DE2649605B2 (de) 1980-07-10
ZA766338B (en) 1977-10-26
CA1072981A (en) 1980-03-04
JPS5848543B2 (ja) 1983-10-28
FR2330383A1 (fr) 1977-06-03
DK495476A (da) 1977-05-07
GR61363B (en) 1978-10-30
AU1925976A (en) 1978-05-11
NL179051C (nl) 1986-07-01
DE2649605A1 (de) 1977-05-18

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