DK1448607T3 - Sammensætning og fremgangsmåde til homogen modificering eller krydsbinding af chitosan under neutrale betingelser - Google Patents
Sammensætning og fremgangsmåde til homogen modificering eller krydsbinding af chitosan under neutrale betingelserInfo
- Publication number
- DK1448607T3 DK1448607T3 DK02779062.5T DK02779062T DK1448607T3 DK 1448607 T3 DK1448607 T3 DK 1448607T3 DK 02779062 T DK02779062 T DK 02779062T DK 1448607 T3 DK1448607 T3 DK 1448607T3
- Authority
- DK
- Denmark
- Prior art keywords
- chitosan
- cross
- solution
- linking
- reagent
- Prior art date
Links
- 229920001661 Chitosan Polymers 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 3
- 238000004132 cross linking Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000007935 neutral effect Effects 0.000 title abstract 2
- 238000012986 modification Methods 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000006172 buffering agent Substances 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Composite Materials (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33141501P | 2001-11-15 | 2001-11-15 | |
| PCT/CA2002/001756 WO2003042250A1 (en) | 2001-11-15 | 2002-11-15 | Composition and method to homogeneously modify or cross-link chitosan under neutral conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1448607T3 true DK1448607T3 (da) | 2011-04-26 |
Family
ID=23293865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02779062.5T DK1448607T3 (da) | 2001-11-15 | 2002-11-15 | Sammensætning og fremgangsmåde til homogen modificering eller krydsbinding af chitosan under neutrale betingelser |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7098194B2 (da) |
| EP (1) | EP1448607B1 (da) |
| AT (1) | ATE494309T1 (da) |
| CA (1) | CA2467049C (da) |
| DE (1) | DE60238858D1 (da) |
| DK (1) | DK1448607T3 (da) |
| ES (1) | ES2357889T3 (da) |
| WO (1) | WO2003042250A1 (da) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1229940T3 (da) | 1999-11-15 | 2014-08-18 | Piramal Healthcare Canada Ltd | Temperaturstyret og ph-afhængig selvgelerende, vandig biopolymeropløsning |
| CA2493083C (en) * | 2002-07-16 | 2012-11-06 | Bio Syntech Canada Inc. | Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors |
| US7745532B2 (en) * | 2002-08-02 | 2010-06-29 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
| US7485670B2 (en) * | 2002-08-02 | 2009-02-03 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
| AU2004253463B2 (en) * | 2003-06-16 | 2010-12-09 | Loma Linda University Medical Center | Deployable multifunctional hemostatic agent |
| AU2004285406B2 (en) * | 2003-06-16 | 2010-06-17 | Loma Linda University Medical Center | Deployable hemostatic agent |
| GB0329907D0 (en) * | 2003-12-23 | 2004-01-28 | Innomed Ltd | Compositions |
| EP1718147B1 (en) * | 2004-02-23 | 2012-03-28 | Loma Linda University Medical Center | Hemostatic agent for topical and internal use |
| US20090076168A1 (en) * | 2005-03-04 | 2009-03-19 | Tien Canh Le | Amine-based and imine-based polymers, uses and preparation thereof |
| EP1943305B1 (en) | 2005-10-12 | 2016-07-20 | Thomas Freier | Processing of chitosan and chitosan derivatives |
| US20070087059A1 (en) * | 2005-10-17 | 2007-04-19 | Frank Everaerts | Bioactive delivery matrix compositions and methods |
| EP1945712A4 (en) * | 2005-11-04 | 2013-05-01 | Piramal Healthcare Canada Ltd | BINDING OF AQUEOUS POLYELECTROLYTE SOLUTIONS BY THERMALLY INDUCED CHANGES IN THE IONIZATION CONDITION |
| FR2897775B1 (fr) * | 2006-02-24 | 2013-05-03 | Elisabeth Laugier | Biomateriau, implant injectable le comprenant, son procede de preparation et ses utilisations |
| ITMI20061335A1 (it) * | 2006-07-10 | 2008-01-11 | Sirc S P A Natural & Dietetic Foods | Chitosano reticolato e processo di reticolazione |
| US20080187568A1 (en) * | 2007-02-06 | 2008-08-07 | Sawhney Amarpreet S | Polymerization with precipitation of proteins for elution in physiological solution |
| US7776840B2 (en) | 2007-02-21 | 2010-08-17 | Cutanea Life Sciences, Inc. | Methods of use of biomaterial and injectable implant containing biomaterial |
| US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
| WO2008130590A2 (en) * | 2007-04-19 | 2008-10-30 | Surmodics, Inc. | Biodegradable matrix materials |
| EP1992364A1 (en) * | 2007-05-16 | 2008-11-19 | Biosuma S.r.l. | Carboxylated polysaccharides phosphated or bisphosphonated derivatives, optionally cross-linked, and their preparation and biomedical uses |
| CA2709546C (en) | 2007-08-28 | 2017-09-26 | Theodore Athanasiadis | Surgical hydrogel |
| FR2920777B1 (fr) * | 2007-09-11 | 2009-11-27 | Centre Nat Rech Scient | Procede de preparation de derives (poly(oxyde d'ethylene) poly(oxyde de propylene) thermosensibles utiles pour fonctionnaliser le chitosane |
| JP5725862B2 (ja) * | 2007-10-30 | 2015-05-27 | ヴィスコゲル アーベーViscogel Ab | キトサン組成物 |
| US9345809B2 (en) * | 2007-11-28 | 2016-05-24 | Fziomed, Inc. | Carboxymethylcellulose polyethylene glycol compositions for medical uses |
| WO2009086067A2 (en) * | 2007-12-28 | 2009-07-09 | Boston Scientific Scimed, Inc. | Particles for injection and processes fo forming the same |
| JP2011511123A (ja) * | 2008-01-31 | 2011-04-07 | ザ プロクター アンド ギャンブル カンパニー | キトサンのアセチル化 |
| HUE044239T2 (hu) | 2008-03-27 | 2019-10-28 | Purdue Research Foundation | Kollagén-kötõ szintetikus peptidoglikánok, elõállításuk és alkalmazási eljárásaik |
| EP2310002B1 (en) | 2008-04-24 | 2016-11-02 | Medtronic, Inc | Protective gel based on chitosan and oxidized polysaccharide |
| WO2009132229A2 (en) | 2008-04-24 | 2009-10-29 | Medtronic, Inc. | Cold ionizing radiation sterilization |
| CA2721938C (en) | 2008-04-24 | 2016-08-09 | Medtronic, Inc. | Chitosan-containing protective composition |
| CA2722145A1 (en) | 2008-04-24 | 2009-10-29 | Medtronic, Inc. | Rehydratable thiolated polysaccharide particles and sponge |
| WO2011004399A2 (en) | 2009-07-09 | 2011-01-13 | Manoj Vinoy Mojamdar | Liquid filmogenic chitosan skin for wound healing and a method for preparation thereof |
| EP2498820B1 (en) | 2009-11-13 | 2019-01-09 | University of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
| WO2011066471A1 (en) | 2009-11-25 | 2011-06-03 | Loma Linda University Medical Center | Chitosan-based hemostatic textile |
| US8877907B2 (en) * | 2010-06-07 | 2014-11-04 | The Johns Hopkins University | Molecularly imprinted polymers |
| EP2688940B1 (en) | 2011-03-24 | 2017-07-12 | Sofradim Production | Enzymatically degradable compositions |
| CN102727925B (zh) * | 2011-04-02 | 2014-09-17 | 佛山市优特医疗科技有限公司 | 酰化壳聚糖伤口敷料、其制备方法及其应用 |
| HUE031596T2 (en) | 2011-05-24 | 2017-07-28 | Symic Ip Llc | Synthetic peptidoglycans that bind hyaluronic acid, their production and use |
| US8617519B2 (en) | 2011-07-07 | 2013-12-31 | DePuy Synthes Products, LLC | Injectable cross-linked hydrogels for biomaterial applications |
| JP2014528406A (ja) | 2011-09-30 | 2014-10-27 | ソフラディム・プロダクション | 治療薬を送達するための多層インプラント |
| JP6195569B2 (ja) * | 2011-10-11 | 2017-09-13 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 止血組成物 |
| AU2012318258B2 (en) * | 2011-10-11 | 2015-07-09 | Baxter Healthcare S.A. | Hemostatic compositions |
| KR102143252B1 (ko) * | 2011-10-11 | 2020-08-11 | 백스터 인터내셔널 인코포레이티드 | 지혈 조성물 |
| CN102949754A (zh) * | 2012-05-25 | 2013-03-06 | 江西圣济药业有限公司 | 一种宫腔止血防粘连温敏凝胶及其制法 |
| TWI624270B (zh) | 2013-01-17 | 2018-05-21 | 財團法人工業技術研究院 | 藥物組合物 |
| AU2014241492A1 (en) | 2013-03-12 | 2015-09-17 | Wellstat Vaccines, Llc | Antibodies targeted to fungal cell wall polysaccharides |
| US9616088B2 (en) | 2013-03-13 | 2017-04-11 | Gel-E, Inc. | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
| EP3569262A1 (en) | 2013-03-14 | 2019-11-20 | Tricol Biomedical, Inc. | Biocompatible and bioabsorbable derivatized chitosan compositions |
| WO2014144969A1 (en) | 2013-03-15 | 2014-09-18 | Purdue Research Foundation | Extracellular matrix-binding synthetic peptidoglycans |
| US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| US9259357B2 (en) | 2014-04-16 | 2016-02-16 | Loma Linda University | Composition, preparation, and use of chitosan shards for biomedical applications |
| WO2015164822A1 (en) | 2014-04-25 | 2015-10-29 | Purdue Research Foundation | Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction |
| FR3035327B1 (fr) * | 2015-04-23 | 2021-07-02 | Cytosial Biomedic | Solution aqueuse homogene de chitosane ou derive de chitosane injectable presentant un ph proche du ph physiologique |
| US10213521B2 (en) | 2015-06-11 | 2019-02-26 | Medtronic Xomed, Inc. | Useful polysaccharide after radiation sterilization |
| BR112018068794A2 (pt) | 2016-03-18 | 2019-04-09 | Her Majesty The Queen In Right Of Canada As Represented By The Mini Of Agriculture And Agri Food | composição para a prevenção de infecção intramamária e método de prevenção de infecção intramamária |
| US10576099B2 (en) | 2016-10-21 | 2020-03-03 | Covidien Lp | Injectable scaffold for treatment of intracranial aneurysms and related technology |
| FR3057778B1 (fr) | 2016-10-25 | 2020-05-22 | Bioxis Pharmaceuticals | Nouvelles compositions actives sur les adipocytes |
| IT201600111352A1 (it) * | 2016-11-04 | 2018-05-04 | Univ Campus Bio Medico Di Roma | Materiale poroso per l’inclusione di preparati citologici, procedimento per l’ottenimento dello stesso e suo uso |
| CN106632730B (zh) * | 2017-01-06 | 2019-01-22 | 浙江医药高等专科学校 | 一种具有内涵体逃逸功能的壳聚糖衍生物及其制备方法和应用 |
| AU2018298224B2 (en) | 2017-07-07 | 2024-08-15 | Symic Ip, Llc | Synthetic bioconjugates |
| CN109529094A (zh) * | 2018-11-05 | 2019-03-29 | 首都师范大学 | 一种可促进伤口愈合的高效止血材料及其制备方法 |
| US12357727B2 (en) | 2019-01-07 | 2025-07-15 | Regeltec, Inc. | Hydrogels and method of making the same |
| WO2020149756A2 (en) * | 2019-01-19 | 2020-07-23 | Qatar Foundation For Education, Science And Community Development | Chitosan-based nanocomposite as an antimicrobial agent and corrosion inhibitor |
| FR3091995B1 (fr) | 2019-01-30 | 2022-11-11 | Bioxis Pharmaceuticals | Modelage de Gel de Chitosane |
| EP3722357A1 (en) * | 2019-04-10 | 2020-10-14 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Chitosan open porous materials containing hydrophilic and/or hydro-phobic functional groups |
| WO2021092618A1 (en) | 2019-11-04 | 2021-05-14 | Covidien Lp | Devices, systems, and methods for treatment of intracranial aneurysms |
| CN111499874B (zh) * | 2020-01-14 | 2022-03-15 | 哈尔滨师范大学 | 一种巯基化胆固醇修饰的mPEG接枝壳聚糖及其制备方法和应用 |
| WO2021216541A1 (en) | 2020-04-20 | 2021-10-28 | Board Of Regents, The University Of Texas System | Biologically active dry powder compositions and method of their manufacture and use |
| CN114763543A (zh) * | 2021-01-15 | 2022-07-19 | 百瑞全球有限公司 | 膜状固定化细胞、多肽、寡肽或蛋白质及其制备方法 |
| WO2022198208A1 (en) | 2021-03-16 | 2022-09-22 | Covidien Lp | Injectable biopolymer compositions and associated systems and methods |
| CN113294198B (zh) * | 2021-05-20 | 2024-01-23 | 太原理工大学 | 一种可溶缓释温敏阻化剂及其制备方法 |
| CN113289588A (zh) * | 2021-05-24 | 2021-08-24 | 江苏乐尔环境科技股份有限公司 | 一种壳聚糖改性的重金属螯合剂 |
| CN113797385B (zh) * | 2021-08-18 | 2022-05-24 | 山东大学 | 一种壳聚糖/聚乙二醇水凝胶及其制备方法与应用 |
| CN114225098B (zh) * | 2021-11-24 | 2023-04-11 | 中国科学院理化技术研究所 | 一种具有抗菌和促进伤口愈合的医用敷料 |
| CN114957711B (zh) * | 2022-06-06 | 2024-06-21 | 中国医科大学附属盛京医院 | 一种壳聚糖溶液及壳聚糖温敏凝胶的制备方法 |
| CN117285724B (zh) * | 2022-06-16 | 2024-04-30 | 上海其胜生物制剂有限公司 | 一种壳聚糖均相溶液及其制备方法与应用 |
| CN115353184B (zh) * | 2022-08-30 | 2024-01-26 | 湖南仁和环境股份有限公司 | 一种表面改性的壳聚糖-琼脂絮凝剂及其制备方法和应用 |
| CN116396414B (zh) * | 2023-04-10 | 2024-08-06 | 华侨大学 | 一种壳聚糖基农药增溶剂的制备方法及其增溶方法 |
| CN116791398A (zh) * | 2023-08-04 | 2023-09-22 | 郑州大学 | 一种用于纸质保护的cs-pl-fec/芋艿淀粉磷酸酯多功能保护液 |
| CN118755324B (zh) * | 2024-07-25 | 2024-11-29 | 珠海市澜诺新材料科技有限公司 | 一种负氧离子净味多功能装饰涂料及制备方法 |
| CN120118431B (zh) * | 2025-04-18 | 2025-10-17 | 湖北润烨新能源有限公司 | 一种轻质复合动力电池盖板的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4424346A (en) * | 1981-06-04 | 1984-01-03 | Canadian Patents And Development Ltd. | Derivatives of chitins, chitosans and other polysaccharides |
| US4605623A (en) * | 1982-11-08 | 1986-08-12 | Malette William Graham | Method of altering growth and development and suppressing contamination microorganisms in cell or tissue culture |
| JPS624702A (ja) * | 1985-06-28 | 1987-01-10 | Lion Corp | 水溶性アシル化キトサンの製造方法 |
| IL100096A (en) * | 1991-11-20 | 1996-03-31 | Univ Ramot | Method for entrapment of active materials in chitosan |
| US5708152A (en) * | 1992-03-27 | 1998-01-13 | Ciba Specialty Chemicals Corporation | N-substituted chitosan derivatives in a process for their preparation |
-
2002
- 2002-11-15 DE DE60238858T patent/DE60238858D1/de not_active Expired - Lifetime
- 2002-11-15 AT AT02779062T patent/ATE494309T1/de not_active IP Right Cessation
- 2002-11-15 WO PCT/CA2002/001756 patent/WO2003042250A1/en not_active Ceased
- 2002-11-15 DK DK02779062.5T patent/DK1448607T3/da active
- 2002-11-15 EP EP02779062A patent/EP1448607B1/en not_active Expired - Lifetime
- 2002-11-15 US US10/298,257 patent/US7098194B2/en not_active Expired - Lifetime
- 2002-11-15 ES ES02779062T patent/ES2357889T3/es not_active Expired - Lifetime
- 2002-11-15 CA CA2467049A patent/CA2467049C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2467049A1 (en) | 2003-05-22 |
| ES2357889T3 (es) | 2011-05-03 |
| WO2003042250A1 (en) | 2003-05-22 |
| EP1448607B1 (en) | 2011-01-05 |
| US7098194B2 (en) | 2006-08-29 |
| CA2467049C (en) | 2011-04-12 |
| ATE494309T1 (de) | 2011-01-15 |
| DE60238858D1 (de) | 2011-02-17 |
| US20030129730A1 (en) | 2003-07-10 |
| EP1448607A1 (en) | 2004-08-25 |
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