DK1446478T3 - Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling heraf - Google Patents
Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling herafInfo
- Publication number
- DK1446478T3 DK1446478T3 DK02773824T DK02773824T DK1446478T3 DK 1446478 T3 DK1446478 T3 DK 1446478T3 DK 02773824 T DK02773824 T DK 02773824T DK 02773824 T DK02773824 T DK 02773824T DK 1446478 T3 DK1446478 T3 DK 1446478T3
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- polypeptide chains
- amino acid
- making
- materials
- Prior art date
Links
- 239000000463 material Substances 0.000 title abstract 2
- 239000003102 growth factor Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 1
- 108091008606 PDGF receptors Proteins 0.000 abstract 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 abstract 1
- 102100040682 Platelet-derived growth factor D Human genes 0.000 abstract 1
- 101710170209 Platelet-derived growth factor D Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Glass Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34611701P | 2001-10-19 | 2001-10-19 | |
| PCT/US2002/033563 WO2003033677A2 (fr) | 2001-10-19 | 2002-10-18 | Facteur de croissance dimerise et materiaux et procedes utilises pour sa production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1446478T3 true DK1446478T3 (da) | 2008-06-02 |
Family
ID=23358033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02773824T DK1446478T3 (da) | 2001-10-19 | 2002-10-18 | Dimeriseret vækstfaktor samt materialer og fremgangmåder til fremstilling heraf |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7122351B2 (fr) |
| EP (1) | EP1446478B1 (fr) |
| JP (1) | JP2005506073A (fr) |
| AT (1) | ATE384783T1 (fr) |
| AU (1) | AU2002337920A1 (fr) |
| CA (1) | CA2463003A1 (fr) |
| DE (1) | DE60224822T2 (fr) |
| DK (1) | DK1446478T3 (fr) |
| ES (1) | ES2302845T3 (fr) |
| WO (1) | WO2003033677A2 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
| PT1234031T (pt) | 1999-11-30 | 2017-06-26 | Mayo Foundation | B7-h1, uma nova molécula imunoregulatória |
| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| AU2003210996A1 (en) * | 2002-02-11 | 2003-09-04 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
| US7432351B1 (en) | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
| AR046594A1 (es) * | 2003-10-16 | 2005-12-14 | Applied Research Systems | Usos terapeuticos de variantes de quemoquina |
| US7381794B2 (en) | 2004-03-08 | 2008-06-03 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
| PT3428191T (pt) | 2004-10-06 | 2024-12-30 | Mayo Found Medical Education & Res | B7-h1 e tratamento do carcinona de células renais |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| WO2007061889A2 (fr) | 2005-11-17 | 2007-05-31 | Biomimetic Therapeutics, Inc. | Augmentation osseuse maxillo-faciale au moyen de rhpdgf-bb et d'une matrice biocompatible |
| EP1801121A1 (fr) * | 2005-12-23 | 2007-06-27 | CONARIS research institute AG | Variantes solubles de la molécule gp130 utiles comme médicament |
| ES2427993T3 (es) * | 2006-02-09 | 2013-11-05 | Biomimetic Therapeutics, Llc | Composiciones y métodos para el tratamiento de hueso |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| WO2008005427A2 (fr) * | 2006-06-30 | 2008-01-10 | Biomimetic Therapeutics, Inc. | Compositions et procédés destinés au traitement de lésions de la coiffe des rotateurs |
| EP2462895B1 (fr) | 2006-11-03 | 2016-11-02 | BioMimetic Therapeutics, LLC | Compositions et procédé pour des procédures arthrodétiques |
| EP2514762B1 (fr) | 2007-07-13 | 2015-04-08 | The Johns Hopkins University | Variants de B7-DC |
| EP2268301B1 (fr) * | 2008-01-24 | 2020-02-26 | Remedor Biomed Ltd. | Compositions d'érythropoiétine et de fibronectine pour la régénération osseuse |
| CA2715254A1 (fr) * | 2008-02-07 | 2009-08-13 | Biomimetic Therapeutics, Inc. | Compositions et procedes associes a une osteogenese par distraction |
| EP2927240A1 (fr) | 2008-08-25 | 2015-10-07 | Amplimmune, Inc. | Compositions d'antagonistes pd-1 et procédés d'utilisation |
| CN102231992B (zh) | 2008-09-09 | 2015-05-20 | 生物模拟治疗公司 | 用于治疗肌腱和韧带损伤的血小板衍生生长因子的组合物和方法 |
| JP2012519556A (ja) * | 2009-03-05 | 2012-08-30 | バイオミメティック セラピューティクス， インコーポレイテッド | 骨軟骨欠損を治療するための血小板由来増殖因子組成物および方法 |
| BR112012020566B1 (pt) | 2010-02-22 | 2021-09-21 | Biomimetic Therapeutics, Llc | Composição de fator de crescimento derivado de plaqueta |
| US9133486B2 (en) * | 2012-03-12 | 2015-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogenase fusion protein for improved hydrogen production |
| RU2014143639A (ru) | 2012-03-30 | 2016-05-27 | Байер Хелскеа Ллк | Регулируемые протеазой антитела |
| US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| US10259875B2 (en) | 2013-10-01 | 2019-04-16 | Mayo Foundation For Medical Education And Research | Methods for treating cancer in patients with elevated levels of BIM |
| WO2015179654A1 (fr) | 2014-05-22 | 2015-11-26 | Mayo Foundation For Medical Education And Research | Distinction d'anticorps anti-b7-h1 agonistes et antagonistes |
| US10517875B2 (en) | 2014-07-23 | 2019-12-31 | Mayo Foundation for Medical Engineering and Research | Targeting DNA-PKcs and B7-H1 to treat cancer |
| US10875923B2 (en) | 2015-10-30 | 2020-12-29 | Mayo Foundation For Medical Education And Research | Antibodies to B7-H1 |
| WO2020092839A1 (fr) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Méthodes et matériaux de traitement du cancer |
| EP3873540A4 (fr) | 2018-10-31 | 2022-07-27 | Mayo Foundation for Medical Education and Research | Procédés et matériaux pour le traitement du cancer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013653A (en) * | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
| US5336603A (en) * | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
| ATE140963T1 (de) * | 1988-01-22 | 1996-08-15 | Zymogenetics Inc | Verfahren zur herstellung von sekretierten rezeptoranalogen |
| EP0452364B1 (fr) | 1988-12-22 | 2002-05-22 | Genentech, Inc. | Procede de preparation de polypeptides solubles dans l'eau |
| US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| WO1995021258A1 (fr) * | 1994-02-01 | 1995-08-10 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Proteines de fusion comprenant des parties anticorpales et non anticorpales |
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| GB9720054D0 (en) * | 1997-09-19 | 1997-11-19 | Celltech Therapeutics Ltd | Biological products |
| EP2151454B1 (fr) * | 1998-11-10 | 2012-05-02 | Ludwig Institute For Cancer Research | Facteur de croissance D dérivés de plaquettes tronquée, l'ADN codant pour celui-ci et ses utilisations |
| US6468543B1 (en) * | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
| EP1686134A3 (fr) | 1999-12-01 | 2006-08-09 | Genentech, Inc. | Polypeptides transmembranaires et secrétés et les acides nucléiques codant ceux-ci |
| EP1254242A4 (fr) | 2000-01-31 | 2005-02-23 | Human Genome Sciences Inc | 17 proteines secretees humaines |
| AU2001270609A1 (en) | 2000-06-30 | 2002-01-14 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Heterodimeric fusion proteins |
| AU2002245652A1 (en) | 2001-03-09 | 2002-09-24 | Zymogenetics, Inc. | Soluble heterodimeric cytokine receptor |
-
2002
- 2002-10-18 AT AT02773824T patent/ATE384783T1/de not_active IP Right Cessation
- 2002-10-18 US US10/274,638 patent/US7122351B2/en not_active Expired - Fee Related
- 2002-10-18 DK DK02773824T patent/DK1446478T3/da active
- 2002-10-18 AU AU2002337920A patent/AU2002337920A1/en not_active Abandoned
- 2002-10-18 EP EP02773824A patent/EP1446478B1/fr not_active Expired - Lifetime
- 2002-10-18 CA CA002463003A patent/CA2463003A1/fr not_active Abandoned
- 2002-10-18 DE DE60224822T patent/DE60224822T2/de not_active Expired - Fee Related
- 2002-10-18 WO PCT/US2002/033563 patent/WO2003033677A2/fr not_active Ceased
- 2002-10-18 JP JP2003536407A patent/JP2005506073A/ja active Pending
- 2002-10-18 ES ES02773824T patent/ES2302845T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1446478B1 (fr) | 2008-01-23 |
| US7122351B2 (en) | 2006-10-17 |
| ATE384783T1 (de) | 2008-02-15 |
| WO2003033677A3 (fr) | 2003-07-10 |
| WO2003033677A2 (fr) | 2003-04-24 |
| JP2005506073A (ja) | 2005-03-03 |
| US20030109000A1 (en) | 2003-06-12 |
| DE60224822T2 (de) | 2009-01-22 |
| DE60224822D1 (de) | 2008-03-13 |
| CA2463003A1 (fr) | 2003-04-24 |
| ES2302845T3 (es) | 2008-08-01 |
| EP1446478A4 (fr) | 2005-03-16 |
| EP1446478A2 (fr) | 2004-08-18 |
| AU2002337920A1 (en) | 2003-04-28 |
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