DK1328538T3 - Fremgangsmåde og mellemprodukter til fremstilling af 7-substituerede antiöstrogener - Google Patents

Fremgangsmåde og mellemprodukter til fremstilling af 7-substituerede antiöstrogener

Info

Publication number: DK1328538T3
Authority: DK; Denmark
Prior art keywords: antiestrogens; intermediates; substituted; preparation; substituted antiestrogens
Prior art date: 2000-10-14

Application number

DK01972358T

Other languages

English (en)

Inventor

Robert Stevenson

Fraser Witton Kerr

Anthony Raymond Lane

Eve Joanne Brazier

Philip John Hogan

David Dermot Patrick Laffan

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-14

Filing date

2001-10-09

Publication date

2008-11-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9901292&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1328538(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-10-09 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-11-03 Application granted granted Critical

2008-11-03 Publication of DK1328538T3 publication Critical patent/DK1328538T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK01972358T 2000-10-14 2001-10-09 Fremgangsmåde og mellemprodukter til fremstilling af 7-substituerede antiöstrogener DK1328538T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0025221.3A GB0025221D0 (en)	2000-10-14	2000-10-14	New process
PCT/GB2001/004485 WO2002032922A1 (en)	2000-10-14	2001-10-09	Process and intermediates for the production of 7-substituted antiestrogens

Publications (1)

Publication Number	Publication Date
DK1328538T3 true DK1328538T3 (da)	2008-11-03

Family

ID=9901292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01972358T DK1328538T3 (da)	2000-10-14	2001-10-09	Fremgangsmåde og mellemprodukter til fremstilling af 7-substituerede antiöstrogener

Country Status (26)

Country	Link
US (1)	US7947667B2 (da)
EP (2)	EP1328538B1 (da)
JP (2)	JP4363846B2 (da)
KR (2)	KR20080056029A (da)
CN (1)	CN1255425C (da)
AR (2)	AR034561A1 (da)
AT (1)	ATE403667T1 (da)
AU (3)	AU9213201A (da)
BR (1)	BR0114649A (da)
CA (1)	CA2425572C (da)
CY (1)	CY1108398T1 (da)
DE (1)	DE60135240D1 (da)
DK (1)	DK1328538T3 (da)
EG (1)	EG23373A (da)
ES (2)	ES2309094T3 (da)
GB (1)	GB0025221D0 (da)
IL (2)	IL155172A0 (da)
MX (1)	MXPA03003302A (da)
MY (2)	MY145819A (da)
NO (1)	NO326020B1 (da)
NZ (1)	NZ525096A (da)
PT (1)	PT1328538E (da)
SA (1)	SA01220570B1 (da)
SI (1)	SI1328538T1 (da)
WO (1)	WO2002032922A1 (da)
ZA (1)	ZA200302526B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0025221D0 (en)	2000-10-14	2000-11-29	Astrazeneca Ab	New process
GB0123961D0 (en)	2001-10-05	2001-11-28	Astrazeneca Ab	Process and intermediates
KR20070061526A (ko) *	2004-07-27	2007-06-13	시코르, 인크.	7α-알킬화 19-노르스테로이드의 제조 방법
WO2009039700A1 (en) *	2007-09-24	2009-04-02	Xi'an Libang Pharmaceutical Co., Ltd.	Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentvlsulphinvl) nonvllestra-l,3,5-(10)- triene-3,17-beta-diol
EP2070942A1 (de) *	2007-12-13	2009-06-17	Bayer Schering Pharma Aktiengesellschaft	Verfahren zur Aromatisierung von 19-Nor-androst-4-en-3-onen zu Estra-1,3,5(10)-trienen
CN101525364B (zh) *	2008-03-07	2012-12-12	杭州九源基因工程有限公司	一种氟维司群的晶型及其制备方法
US8063249B1 (en)	2008-04-25	2011-11-22	Olema Pharmaceuticals, Inc.	Substituted triphenyl butenes
CN102391341B (zh) *	2011-08-09	2013-05-22	福建省微生物研究所	制备6,7-脱氢-17β-烃酰氧基诺龙的方法
CN102600064A (zh) *	2012-03-31	2012-07-25	西安力邦制药有限公司	氟维司群或其衍生物缓释制剂及其制备方法
US9315540B2 (en)	2012-10-22	2016-04-19	Intas Pharmaceuticals Ltd.	Process for the preparation of fulvestrant
CN103788164A (zh) *	2012-10-31	2014-05-14	正大天晴药业集团股份有限公司	一种氟维司群的制备方法
CN103965280B (zh) *	2014-05-21	2016-04-20	天津孚音生物科技发展有限公司	一种氟维司群中间体的制备方法
WO2015181116A1 (en)	2014-05-26	2015-12-03	Crystal Pharma, S.A.U.	Process and intermediades for the preparation of 7-alkylated steroids
CN104387435B (zh) *	2014-12-10	2017-05-10	天津孚音生物科技发展有限公司	一种化合物及其制备方法与应用
KR101640747B1 (ko)	2015-05-20	2016-07-19	이금운	확장 가능형 끼움식 엘이디 조명 등기구
CN107488205A (zh) *	2016-06-13	2017-12-19	重庆圣华曦药业股份有限公司	一种氟维司群有关物质的制备方法及其在制剂中的检测方法
CN110818764A (zh) *	2018-08-07	2020-02-21	重庆圣华曦药业股份有限公司	一种应用加料监测系统制备氟维斯群中间体的方法
CN111018936B (zh) *	2019-11-12	2021-10-29	广州曼翔医药有限公司	一种氟维司群有关物质e的合成方法
CN116041412A (zh) *	2023-01-13	2023-05-02	香港中文大学（深圳）	氟维司群衍生物及其制备方法、应用和治疗乳腺癌的药物
CN116284195B (zh) *	2023-02-08	2025-07-01	湖南欧亚药业有限公司	一种氟维司群的制备方法
CN116535454A (zh) *	2023-04-28	2023-08-04	香港中文大学（深圳）	氟维司群类化合物及其制备方法和应用
WO2025195993A1 (en)	2024-03-18	2025-09-25	Minakem	Process for the preparation of fulvestrant

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7305171A (da) *	1973-04-13	1974-10-15
GB8327256D0 (en) *	1983-10-12	1983-11-16	Ici Plc	Steroid derivatives
US5595985A (en) *	1989-03-10	1997-01-21	Endorecherche Inc.	Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
DE4132182A1 (de)	1991-09-24	1993-03-25	Schering Ag	11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln
US5211831A (en)	1991-11-27	1993-05-18	Mcgean-Rohco, Inc.	Process for extending the life of a displacement plating bath
DE19622457A1 (de) *	1996-05-24	1997-11-27	Schering Ag	7alpha-(5-Methylaminopentyl)-estratriene, Verfahren zu deren Herstellung, pharmazeutische Präparate, die diese 7alpha-(5-Methylaminopentyl)-estratriene enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
US5952319A (en) *	1997-11-26	1999-09-14	Research Triangle Institute	Androgenic steroid compounds and a method of making and using the same
EP1272196B1 (en) *	2000-03-31	2006-08-02	THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES	Methods of making the 4-n-butylcyclohexanoic and the undecanoic acid esters of (7 alpha,11 beta)-dimethyl-17 beta-hydroxy-4-estren-3-one and their medical use
GB0025221D0 (en)	2000-10-14	2000-11-29	Astrazeneca Ab	New process
GB0123961D0 (en)	2001-10-05	2001-11-28	Astrazeneca Ab	Process and intermediates

2000
- 2000-10-14 GB GBGB0025221.3A patent/GB0025221D0/en not_active Ceased
2001
- 2001-10-09 CA CA002425572A patent/CA2425572C/en not_active Expired - Lifetime
- 2001-10-09 WO PCT/GB2001/004485 patent/WO2002032922A1/en not_active Ceased
- 2001-10-09 AU AU9213201A patent/AU9213201A/xx active Pending
- 2001-10-09 SI SI200130863T patent/SI1328538T1/sl unknown
- 2001-10-09 DE DE60135240T patent/DE60135240D1/de not_active Expired - Lifetime
- 2001-10-09 CN CNB018202705A patent/CN1255425C/zh not_active Expired - Lifetime
- 2001-10-09 DK DK01972358T patent/DK1328538T3/da active
- 2001-10-09 NZ NZ525096A patent/NZ525096A/en not_active IP Right Cessation
- 2001-10-09 EP EP01972358A patent/EP1328538B1/en not_active Expired - Lifetime
- 2001-10-09 ES ES01972358T patent/ES2309094T3/es not_active Expired - Lifetime
- 2001-10-09 KR KR1020087013092A patent/KR20080056029A/ko not_active Ceased
- 2001-10-09 EP EP08150796.4A patent/EP1918295B1/en not_active Expired - Lifetime
- 2001-10-09 PT PT01972358T patent/PT1328538E/pt unknown
- 2001-10-09 BR BR0114649-1A patent/BR0114649A/pt not_active Application Discontinuation
- 2001-10-09 JP JP2002536303A patent/JP4363846B2/ja not_active Expired - Lifetime
- 2001-10-09 MX MXPA03003302A patent/MXPA03003302A/es active IP Right Grant
- 2001-10-09 IL IL15517201A patent/IL155172A0/xx unknown
- 2001-10-09 KR KR1020037005110A patent/KR100864266B1/ko not_active Expired - Lifetime
- 2001-10-09 AU AU2001292132A patent/AU2001292132B2/en not_active Expired
- 2001-10-09 US US10/398,924 patent/US7947667B2/en not_active Expired - Fee Related
- 2001-10-09 AT AT01972358T patent/ATE403667T1/de active
- 2001-10-09 ES ES08150796.4T patent/ES2581379T3/es not_active Expired - Lifetime
- 2001-10-10 EG EG20011065A patent/EG23373A/xx active
- 2001-10-12 MY MYPI20014756A patent/MY145819A/en unknown
- 2001-10-12 AR ARP010104814A patent/AR034561A1/es active IP Right Grant
- 2001-10-12 MY MYPI2010001633A patent/MY149146A/en unknown
- 2001-12-04 SA SA01220570A patent/SA01220570B1/ar unknown
2003
- 2003-03-31 ZA ZA200302526A patent/ZA200302526B/en unknown
- 2003-03-31 IL IL155172A patent/IL155172A/en active IP Right Grant
- 2003-04-11 NO NO20031701A patent/NO326020B1/no not_active IP Right Cessation
2007
- 2007-04-19 AU AU2007201740A patent/AU2007201740B2/en not_active Expired
2008
- 2008-10-07 CY CY20081101106T patent/CY1108398T1/el unknown
2009
- 2009-05-08 JP JP2009113404A patent/JP5133937B2/ja not_active Expired - Lifetime
2011
- 2011-07-28 AR ARP110102734A patent/AR082409A2/es active IP Right Grant

Also Published As

Publication number	Publication date
ES2581379T3 (es)	2016-09-05
JP4363846B2 (ja)	2009-11-11
AU2007201740B2 (en)	2010-04-08
MXPA03003302A (es)	2003-08-07
CA2425572C (en)	2010-03-09
EP1918295B1 (en)	2016-04-06
GB0025221D0 (en)	2000-11-29
EG23373A (en)	2005-02-28
IL155172A0 (en)	2003-10-31
NO20031701D0 (no)	2003-04-11
ATE403667T1 (de)	2008-08-15
KR100864266B1 (ko)	2008-10-20
WO2002032922A1 (en)	2002-04-25
DE60135240D1 (de)	2008-09-18
SA01220570B1 (ar)	2007-03-18
NZ525096A (en)	2004-10-29
JP2009215303A (ja)	2009-09-24
CY1108398T1 (el)	2014-02-12
NO326020B1 (no)	2008-09-01
NO20031701L (no)	2003-05-23
KR20030081319A (ko)	2003-10-17
CN1479746A (zh)	2004-03-03
EP1328538B1 (en)	2008-08-06
EP1918295A3 (en)	2012-10-17
EP1328538A1 (en)	2003-07-23
JP5133937B2 (ja)	2013-01-30
ES2309094T3 (es)	2008-12-16
EP1918295A2 (en)	2008-05-07
CN1255425C (zh)	2006-05-10
CA2425572A1 (en)	2002-04-25
IL155172A (en)	2012-04-30
MY149146A (en)	2013-07-15
AR082409A2 (es)	2012-12-05
AU9213201A (en)	2002-04-29
BR0114649A (pt)	2004-02-10
ZA200302526B (en)	2004-02-16
JP2004511567A (ja)	2004-04-15
SI1328538T1 (sl)	2008-12-31
US7947667B2 (en)	2011-05-24
AR034561A1 (es)	2004-03-03
PT1328538E (pt)	2008-09-30
AU2001292132B2 (en)	2007-01-25
KR20080056029A (ko)	2008-06-19
US20050101583A1 (en)	2005-05-12
MY145819A (en)	2012-04-30
AU2007201740A1 (en)	2007-05-10

Publication	Publication Date	Title
DK1328538T3 (da)	2008-11-03	Fremgangsmåde og mellemprodukter til fremstilling af 7-substituerede antiöstrogener
DK1044969T3 (da)	2007-04-23	Fremgangsmåde og mellemprodukter til fremstilling af anti-cancer forbindelser
DK1296935T3 (da)	2009-06-22	Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1334182T3 (da)	2011-01-17	Fremgangsmåde til fremstilling af ikke-bovint chymosin og anvendelse heraf
DK1277722T3 (da)	2005-04-25	Fremgangsmåde til fremstilling af methanol
CY2007029I1 (el)	2009-11-04	Μεθοδος για την παρασκευη υποκατεστημενων οκτανοϋλ-αμιδιων
DK1667986T3 (da)	2013-05-06	Acetonesolvat af dimethoxydocetaxel og fremgangsmåde til fremstilling heraf
DK1451143T3 (da)	2008-11-10	Fremgangsmåder til fremstilling af O-desmethylvenlafaxin
DK1726658T3 (da)	2010-05-17	Fremgangsmåde til fremstilling af dihydroxyestere og derivater deraf
DK1309582T3 (da)	2005-03-14	Fremgangsmåde til fremstilling af citalopram
DK1309545T3 (da)	2007-10-29	Fremgangsmåde til fremstilling af alkylarylsulfonater
DK1448205T3 (da)	2011-12-12	Kombinationer til behandling af immunoinflammatoriske sygdomme
DK2189162T3 (da)	2014-02-03	Fremgangsmåder til behandling af cellulære proliferative forstyrrelser
FI20010558L (fi)	2002-09-20	Kappaleiden paikannus
DK1407037T3 (da)	2006-05-22	Fremgangsmåde til fremstilling af tagatose
DK1326836T3 (da)	2004-06-01	Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-methylpyridin
DK1456229T3 (da)	2010-01-04	Fremgangsmåe til fremstilling af echinocandin-derivater
DK1296970T3 (da)	2008-07-14	Fremgangsmåde til fremstilling af citalopram
DK1292586T3 (da)	2004-08-30	Fremgangsmåde til fremstilling af pyrazolopyrimidinoner
DK1400522T3 (da)	2014-11-10	Forbindelser til behandling af impotens
DK1339723T3 (da)	2006-06-12	Fremgangsmåde og ester derivater anvendelige til fremstilling af cefalosporiner
DK1519936T3 (da)	2008-03-03	Fremgangsmåde til fremstilling af nevirapin
DK1294694T3 (da)	2004-12-27	Fremgangsmåde til fremstilling af quinolinderivater
DK1341758T3 (da)	2006-10-30	Coniosetin og derivater af denne, fremgangsmåde til fremstilling og anvendelse af samme
DK1254159T3 (da)	2006-09-11	Fremgangsmåde til fremstilling af acetylamidiniophenylalanylcyclohexylglycylpyridylalaninamider