DK1325033T3 - Inhibering af komplement C5 aktivering til behandlingen og forebyggelsen af forsinket xenograf- eller akut vaskulær afstødning - Google Patents
Inhibering af komplement C5 aktivering til behandlingen og forebyggelsen af forsinket xenograf- eller akut vaskulær afstødningInfo
- Publication number
- DK1325033T3 DK1325033T3 DK01977478.5T DK01977478T DK1325033T3 DK 1325033 T3 DK1325033 T3 DK 1325033T3 DK 01977478 T DK01977478 T DK 01977478T DK 1325033 T3 DK1325033 T3 DK 1325033T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibition
- treatment
- delayed
- acute vascular
- activation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23930900P | 2000-10-10 | 2000-10-10 | |
| PCT/US2001/031103 WO2002030985A2 (en) | 2000-10-10 | 2001-10-04 | Inhibition of complement c5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1325033T3 true DK1325033T3 (da) | 2010-04-06 |
Family
ID=22901599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01977478.5T DK1325033T3 (da) | 2000-10-10 | 2001-10-04 | Inhibering af komplement C5 aktivering til behandlingen og forebyggelsen af forsinket xenograf- eller akut vaskulær afstødning |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6534058B2 (da) |
| EP (5) | EP2281840A3 (da) |
| AT (1) | ATE449791T1 (da) |
| AU (1) | AU2001296594A1 (da) |
| CA (1) | CA2424379C (da) |
| DE (1) | DE60140618D1 (da) |
| DK (1) | DK1325033T3 (da) |
| ES (2) | ES2333775T3 (da) |
| HK (2) | HK1211043A1 (da) |
| PT (1) | PT1325033E (da) |
| WO (1) | WO2002030985A2 (da) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20021527A1 (it) | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
| NZ540735A (en) * | 2002-12-02 | 2008-08-29 | Resistentia Pharmaceuticals Ab | Methods and materials for treating inflammatory conditions using a polypeptide comprising a self-C5 amino acid segment and a non-self amino acid segment |
| US20070123466A1 (en) * | 2003-05-13 | 2007-05-31 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Method of treating recurrent miscarriages |
| ATE498010T1 (de) * | 2004-03-01 | 2011-02-15 | Immune Disease Inst Inc | Natürliche igm-antikörper und inhibitoren davon |
| EP3056218A1 (en) | 2004-05-14 | 2016-08-17 | Alexion Pharmaceuticals, Inc. | Prolongation of survival of an allograft by inhibiting complement activity |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| ES2551202T5 (es) * | 2005-11-04 | 2018-11-30 | Genentech, Inc. | Uso de inhibidores de la vía del complemento para tratar enfermedades oculares |
| AU2013200223B2 (en) * | 2005-11-04 | 2015-08-20 | Genentech, Inc. | Use of Complement Pathway Inhibitors to Treat Ocular Diseases |
| EP1988882B1 (en) | 2006-03-02 | 2014-12-17 | Alexion Pharmaceuticals, Inc. | Prolongation of survival of an allograft by inhibiting complement activity |
| DK2359834T5 (da) | 2006-03-15 | 2017-02-06 | Alexion Pharma Inc | Behandling af paroxysmal natlig hæmoglobinuripatienter med en hæmmer af komplement |
| DK2006381T3 (da) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | Fremgangsmåde til regulering af antistoffers blodfarmakokinetik |
| EP2380907B1 (en) * | 2006-09-05 | 2016-11-30 | Alexion Pharmaceuticals, Inc. | Methods and compositions for the treatment of antibody mediated neuropathies |
| CN106084054A (zh) * | 2006-11-02 | 2016-11-09 | 健泰科生物技术公司 | 人源化的抗‑d因子抗体 |
| EP2148691B1 (en) | 2007-02-05 | 2015-05-20 | Apellis Pharmaceuticals, Inc. | Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system |
| DK2202245T3 (da) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | Fremgangsmåde til modificering af et antistofs isoelektriske punkt via aminosyresubstitution i cdr |
| US12492253B1 (en) | 2008-02-25 | 2025-12-09 | Xencor, Inc. | Anti-human C5 antibodies |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| WO2010015608A1 (en) | 2008-08-05 | 2010-02-11 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c5 |
| AU2014201433B2 (en) * | 2008-08-05 | 2016-05-26 | Novartis Ag | Compositions and methods for antibodies targeting complement protein C5 |
| HRP20230487T1 (hr) | 2009-02-13 | 2023-07-21 | Immunomedics, Inc. | Imunokonjugati s unutarstaničnom vezom koja se može rascijepiti |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| CA2782194C (en) | 2009-12-02 | 2018-01-16 | Immunomedics, Inc. | Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer |
| MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
| CN103796667A (zh) | 2011-06-22 | 2014-05-14 | 艾普莱斯制药公司 | 用补体抑制剂治疗慢性障碍的方法 |
| CA2859493A1 (en) | 2011-12-21 | 2013-06-27 | Novartis Ag | Compositions and methods for antibodies targeting factor p |
| WO2013126006A1 (en) | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
| AU2013302696B9 (en) | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| TW201418707A (zh) * | 2012-09-21 | 2014-05-16 | Alexion Pharma Inc | 補體組分c5拮抗劑之篩選分析 |
| CA2891673C (en) | 2012-11-15 | 2025-10-07 | Apellis Pharmaceuticals Inc | Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods |
| PL2900277T3 (pl) | 2012-12-13 | 2022-05-16 | Immunomedics, Inc. | Dawkowanie immunokoniugatów przeciwciał i sn-38 dla poprawy skuteczności i zmniejszenia toksyczności |
| AU2014213147B2 (en) * | 2013-01-31 | 2019-01-17 | lmmunAbs Inc. | C5 antibody and method for preventing and treating complement-related diseases |
| WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| CR20160132A (es) | 2013-08-12 | 2016-08-25 | Genentech Inc | Composiciones y método para tratar condiciones asociadas con el complemento |
| KR102497083B1 (ko) | 2013-08-28 | 2023-02-07 | 애피바디 에이비 | 돌연변이된 스캐폴드를 갖는 결합 폴리펩티드 |
| PT3038633T (pt) | 2013-08-28 | 2021-01-14 | Ipc Res Llc | Polipéptidos estáveis que se ligam ao complemento humano c5 |
| JP6447933B2 (ja) | 2014-02-21 | 2019-01-09 | アイビーシー ファーマスーティカルズ,インコーポレイテッド | Trop−2発現細胞に対する免疫応答を誘発することによる疾患治療 |
| US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
| SG11201608868PA (en) | 2014-05-01 | 2016-11-29 | Genentech Inc | Anti-factor d antibody variants and uses thereof |
| WO2015200260A1 (en) | 2014-06-24 | 2015-12-30 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| AU2015328370B2 (en) | 2014-10-07 | 2021-08-05 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| HUE056489T2 (hu) | 2014-12-19 | 2022-02-28 | Chugai Pharmaceutical Co Ltd | Anti-C5 antitestek és alkalmazási eljárások |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| JP2018511557A (ja) | 2015-01-22 | 2018-04-26 | 中外製薬株式会社 | 2種以上の抗c5抗体の組み合わせおよび使用方法 |
| CA2981543A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| PT3313443T (pt) | 2015-06-25 | 2023-08-30 | Immunomedics Inc | Combinação de anticorpos anti-hla-dr ou anti-trop-2 com inibidores de microtúbulos, inibidores de parp, inibidores de bruton quinase ou inibidores de fosfoinositídeo 3-quinase melhora significativamente o resultado terapêutico no cancro |
| PL3316885T3 (pl) | 2015-07-01 | 2021-12-06 | Immunomedics, Inc. | Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a |
| JP6968787B2 (ja) | 2015-10-07 | 2021-11-17 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals, Inc. | 投与レジメン |
| TW201718014A (zh) | 2015-10-12 | 2017-06-01 | 諾華公司 | C5抑制劑於移植相關微血管病之用途 |
| EP3368090A1 (en) | 2015-10-30 | 2018-09-05 | H. Hoffnabb-La Roche Ag | Anti-factor d antibody variant conjugates and uses thereof |
| EP3368074A2 (en) | 2015-10-30 | 2018-09-05 | Hoffmann-La Roche AG | Anti-factor d antibodies and conjugates |
| MY191668A (en) | 2016-06-14 | 2022-07-06 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| KR102538749B1 (ko) | 2016-08-05 | 2023-06-01 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
| CN110167961A (zh) | 2017-01-31 | 2019-08-23 | 中外制药株式会社 | 用于治疗或预防c5相关疾病的药物组合物和治疗或预防c5相关疾病的方法 |
| US11040107B2 (en) | 2017-04-07 | 2021-06-22 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
| JP2021506241A (ja) | 2017-12-13 | 2021-02-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 抗c5抗体組み合わせ物およびその使用 |
| KR20240167712A (ko) | 2017-12-15 | 2024-11-27 | 아펠리스 파마슈티컬스 인코포레이티드 | 투여 요법 및 관련 조성물 및 방법 |
| MY210523A (en) | 2018-08-01 | 2025-09-29 | Univ Osaka | A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease |
| CN114929273A (zh) | 2019-07-31 | 2022-08-19 | 豪夫迈·罗氏有限公司 | 通过使用抗c5抗体可伐利单抗来治疗或预防c5相关疾病的剂量和施用方案 |
| AU2020319677A1 (en) | 2019-07-31 | 2022-01-06 | F. Hoffmann-La Roche Ag | Dosage and administration regimen for the treatment or prevention of C5-related diseases by the use of the anti-C5 antibody Crovalimab |
| WO2021067526A1 (en) | 2019-10-02 | 2021-04-08 | Alexion Pharmaceuticals, Inc. | Complement inhibitors for treating drug-induced complement-mediated response |
| CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
| WO2021231720A1 (en) | 2020-05-15 | 2021-11-18 | Alexion Pharmaceuticals, Inc. | Method of using extracellular vesicles to detect complement activation, and uses thereof to assess and/or monitor treatment of a complement-mediated disease |
| CN114149501B (zh) * | 2020-12-11 | 2023-05-26 | 天士力生物医药股份有限公司 | 抗c5抗体及其应用 |
| US20250073349A1 (en) | 2021-05-10 | 2025-03-06 | Kawasaki Institute Of Industrial Promotion | Antibody having reduced binding affinity for antigen |
| WO2024238422A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of a panel of lectins for detection of complement biomarkers in urine extracellular vesicles |
| WO2024238421A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of biomarkers for the identification and treatment of complement-mediated disorders |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5506247A (en) | 1988-04-15 | 1996-04-09 | T Cell Sciences, Inc. | Compounds that inhibit complement and/or suppress immune activity |
| US6395888B1 (en) * | 1996-02-01 | 2002-05-28 | Gilead Sciences, Inc. | High affinity nucleic acid ligands of complement system proteins |
| US5679546A (en) | 1993-09-24 | 1997-10-21 | Cytomed, Inc. | Chimeric proteins which block complement activation |
| DE69533921T2 (de) * | 1994-03-23 | 2005-12-01 | Alexion Pharmaceuticals, Inc., New Haven | Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs |
| US6074642A (en) * | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5679345A (en) | 1994-06-02 | 1997-10-21 | The Johns Hopkins University | Method for preventing complement-dependent rejection of organ or tissue transplants |
| US5546808A (en) | 1994-09-06 | 1996-08-20 | Harris Instrument Corporation | Apparatus and method for binocular measurement system |
| US5463564A (en) | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
| JP2000505068A (ja) | 1996-03-13 | 2000-04-25 | トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | 補体活性化を阻害する新規ペプチド類 |
| WO1998046248A1 (en) | 1997-04-14 | 1998-10-22 | Anderson Byron E | Method and material for inhibiting complement |
| ES2258817T3 (es) | 1997-05-21 | 2006-09-01 | Biovation Limited | Metodo para la produccion de proteinas no inmunogenas. |
| US6333034B1 (en) | 1997-08-26 | 2001-12-25 | Gliatech, Inc. | Process for inhibiting complement activation via the alternative pathway |
-
2001
- 2001-10-04 AU AU2001296594A patent/AU2001296594A1/en not_active Abandoned
- 2001-10-04 EP EP10179315A patent/EP2281840A3/en not_active Withdrawn
- 2001-10-04 WO PCT/US2001/031103 patent/WO2002030985A2/en not_active Ceased
- 2001-10-04 EP EP01977478A patent/EP1325033B1/en not_active Expired - Lifetime
- 2001-10-04 AT AT01977478T patent/ATE449791T1/de active
- 2001-10-04 ES ES01977478T patent/ES2333775T3/es not_active Expired - Lifetime
- 2001-10-04 PT PT01977478T patent/PT1325033E/pt unknown
- 2001-10-04 EP EP16152143.0A patent/EP3031827A1/en not_active Withdrawn
- 2001-10-04 DK DK01977478.5T patent/DK1325033T3/da active
- 2001-10-04 CA CA2424379A patent/CA2424379C/en not_active Expired - Lifetime
- 2001-10-04 DE DE60140618T patent/DE60140618D1/de not_active Expired - Lifetime
- 2001-10-04 EP EP15154800.5A patent/EP2896631A1/en not_active Withdrawn
- 2001-10-04 US US09/682,672 patent/US6534058B2/en not_active Expired - Lifetime
- 2001-10-04 ES ES09167955.5T patent/ES2483991T3/es not_active Expired - Lifetime
- 2001-10-04 EP EP09167955.5A patent/EP2113516B1/en not_active Expired - Lifetime
-
2015
- 2015-12-02 HK HK15111863.4A patent/HK1211043A1/en unknown
-
2016
- 2016-12-07 HK HK16113934.4A patent/HK1225741A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2896631A1 (en) | 2015-07-22 |
| ES2483991T3 (es) | 2014-08-08 |
| US20020041875A1 (en) | 2002-04-11 |
| PT1325033E (pt) | 2010-04-15 |
| WO2002030985A2 (en) | 2002-04-18 |
| EP2113516A1 (en) | 2009-11-04 |
| WO2002030985A3 (en) | 2002-12-05 |
| HK1225741A1 (en) | 2017-09-15 |
| HK1211043A1 (en) | 2016-05-13 |
| ES2333775T3 (es) | 2010-03-01 |
| CA2424379A1 (en) | 2002-04-18 |
| EP3031827A1 (en) | 2016-06-15 |
| ATE449791T1 (de) | 2009-12-15 |
| DE60140618D1 (de) | 2010-01-07 |
| EP1325033B1 (en) | 2009-11-25 |
| US6534058B2 (en) | 2003-03-18 |
| EP1325033A2 (en) | 2003-07-09 |
| CA2424379C (en) | 2013-10-01 |
| EP2113516B1 (en) | 2014-05-21 |
| HK1134508A1 (en) | 2010-04-30 |
| AU2001296594A1 (en) | 2002-04-22 |
| EP2281840A2 (en) | 2011-02-09 |
| EP2281840A3 (en) | 2012-05-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1325033T3 (da) | Inhibering af komplement C5 aktivering til behandlingen og forebyggelsen af forsinket xenograf- eller akut vaskulær afstødning | |
| NO2006008I2 (no) | Natalizumab, anti alfa-4 integrin humanized monoclonal antibody | |
| DK1054693T3 (da) | Inhibitorer af komplementaktivering | |
| DK1265929T3 (da) | Anti-C2/C2a-inhibitorer til komplement aktivering | |
| KR960704576A (ko) | CD40에 대한 항체(Antibodies to CD40) | |
| WO2007062245A3 (en) | Human monoclonal antibody human cd134 (ox40) and methods of making and using same | |
| BRPI9809387B8 (pt) | anticorpo humanizado anti-fator de crescimento endotelial vascular humano e composição que o compreende | |
| WO1998057994A3 (en) | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria | |
| NZ611387A (en) | Selected antibodies binding to anionic phospholipids and aminophospholipids and their use in treatment | |
| ATE421976T1 (de) | Fab fragmentbibliotheken und verfahren für deren verwendung | |
| TW200722518A (en) | Sc(fv)2 structural isomers | |
| ATE509955T1 (de) | Humanisierte kollagen-antikörper und damit verbundene verfahren | |
| PE20061323A1 (es) | Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos | |
| EP1411962A4 (en) | TREATMENT OF PANCREATIC CANCER WITH A MONOCLONAL ANTIBODY | |
| DE69942668D1 (de) | Humanisierter monoklonaler antikörper gegen von-willebrand faktor | |
| WO2003075846A3 (en) | Uses of monoclonal antibody 8h9 | |
| ATE486892T1 (de) | Verfahren zur kontrolle von krebs | |
| DE69922834D1 (de) | Humanisierter antikörper spezifisch für das oberflächenantigen pre-s1 von hbv und dessen präparation | |
| EA200870072A1 (ru) | ПРОТИВОВОСПАЛИТЕЛЬНЫЕ dAb | |
| WO2001051644A3 (de) | ANTI-CD3-EINZELKETTEN-ANTIKÖRPER MIT HUMANEN Cν3- und Cν4- DOMÄNEN | |
| GB0031448D0 (en) | Inhibition of the vWF-collagen interaction by anti-human vWF monoclonal antibody (82D6A3) results in abolition of in vivo arterial platelet thrombus formation | |
| ATE370163T1 (de) | Antikörper zur isolierung und/oder identifizierung mesenchymaler stammzellen und verfahren zur isolierung und/oder identifizierung mesenchymaler stammzellen | |
| DK1222929T3 (da) | Fremgangsmåde og farmaceutisk sammensætning til forebyggelse og/eller behandling af systematisk betændelsesreaktionssyndrom | |
| DK1334983T3 (da) | Inhiberende monoklonalt antistof med proeasen, som aktiverer blodkoaguleringsfaktor VII | |
| IL139571A0 (en) | A humanized antibody that binds to verotoxin, methods for the production thereof and pharmaceutical compositions containing the same |