[go: up one dir, main page]

DK1386660T3 - Isolering af immunoglobuliner - Google Patents

Isolering af immunoglobuliner

Info

Publication number
DK1386660T3
DK1386660T3 DK03078126T DK03078126T DK1386660T3 DK 1386660 T3 DK1386660 T3 DK 1386660T3 DK 03078126 T DK03078126 T DK 03078126T DK 03078126 T DK03078126 T DK 03078126T DK 1386660 T3 DK1386660 T3 DK 1386660T3
Authority
DK
Denmark
Prior art keywords
immunoglobulins
solid phase
phase matrix
matrix
designates
Prior art date
Application number
DK03078126T
Other languages
Danish (da)
English (en)
Inventor
Marie Bendix Hansen
Allan Otto Fog Lihme
Original Assignee
Upfront Chromatography As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upfront Chromatography As filed Critical Upfront Chromatography As
Application granted granted Critical
Publication of DK1386660T3 publication Critical patent/DK1386660T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3253—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DK03078126T 1996-08-30 1997-09-01 Isolering af immunoglobuliner DK1386660T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK93296 1996-08-30
PCT/DK1997/000359 WO1998008603A1 (fr) 1996-08-30 1997-09-01 Isolement d'immunoglobulines

Publications (1)

Publication Number Publication Date
DK1386660T3 true DK1386660T3 (da) 2009-12-21

Family

ID=8099153

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03078126T DK1386660T3 (da) 1996-08-30 1997-09-01 Isolering af immunoglobuliner

Country Status (10)

Country Link
US (4) US6498236B1 (fr)
EP (3) EP2095873A1 (fr)
JP (1) JP4425994B2 (fr)
AT (2) ATE254502T1 (fr)
AU (1) AU729039C (fr)
CA (2) CA2264177C (fr)
DE (2) DE69726285T2 (fr)
DK (1) DK1386660T3 (fr)
ES (1) ES2332893T3 (fr)
WO (1) WO1998008603A1 (fr)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2095873A1 (fr) * 1996-08-30 2009-09-02 Upfront Chromatography A/S Isolation d'immunoglobulines
US6096872A (en) * 1997-10-14 2000-08-01 Ortho Diagnostic Systems, Inc. Viral clearance process
SE9804465D0 (sv) * 1998-12-22 1998-12-22 Amersham Pharm Biotech Ab A method for the removal/purification of serum albumins and means for use in the method
SE0002688D0 (sv) * 2000-07-17 2000-07-17 Amersham Pharm Biotech Ab Adsorption method and ligands
JP4291572B2 (ja) 2001-02-01 2009-07-08 シグマ−アルドリッチ・カンパニー 分子プルダウンおよび免疫沈降用途のための視感度を強化した改善親和性マトリックス
EP1584242B1 (fr) 2001-06-01 2010-01-20 Upfront Chromatography A/S Fractionnement de mélanges contenant des protéines
US6957672B2 (en) * 2001-07-25 2005-10-25 Imperial Chemical Industries Plc Method for ensuring that coating compositions have correct color
DE10155984A1 (de) * 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
ATE555666T1 (de) 2002-05-23 2012-05-15 Ortho Clinical Diagnostics Inc Einfang, konzentration und quantifizierung eines abnormalen prionproteins aus biologischen flüssigkeiten mittels tiefenfiltration
US6984806B2 (en) * 2002-07-23 2006-01-10 Illinois Tool Works Inc. Method and apparatus for retracting and advancing a welding wire
GB0220894D0 (en) * 2002-09-09 2002-10-16 Millipore Uk Ltd Method of separation
US7072616B2 (en) * 2002-09-09 2006-07-04 Conexant Systems, Inc. Multi-protocol interchip interface
WO2004024318A1 (fr) 2002-09-13 2004-03-25 Pall Corporation Preparation et utilisation de substrats solides en mode mixte pour adsorbants en chromatographie et reseaux de biopuces
NZ542956A (en) * 2003-03-21 2007-11-30 Upfront Chromatography As Method for high throughput volumes in the fractionation of bio-molecules by chromatographic systems
US7700743B2 (en) * 2003-07-22 2010-04-20 Millipore Corporation Immobilised affinity medium and its use in separation
US20040106131A1 (en) * 2003-08-18 2004-06-03 Swapan Roy Compositions and methods for proteomic investigations
SE0303532D0 (sv) * 2003-12-23 2003-12-23 Amersham Biosciences Ab Purification of immunoglobulins
US7479222B2 (en) * 2004-02-05 2009-01-20 Millipore Corporation Porous adsorptive or chromatographic media
SE0400490D0 (sv) 2004-02-26 2004-02-26 Amersham Biosciences Ab Plasmid purification
AU2005216847B2 (en) * 2004-02-27 2010-04-01 Cytiva Bioprocess R&D Ab A process for the purification of antibodies
SE0400501D0 (sv) * 2004-02-27 2004-02-27 Amersham Biosciences Ab Antibody purification
KR20070091098A (ko) * 2004-06-07 2007-09-07 에이브이티 플라즈마 리미티드 단백질 분리 방법
WO2005121163A2 (fr) 2004-06-07 2005-12-22 Upfront Chromatography A/S Isolation de proteines du plasma ou du serum
SE0401665D0 (sv) 2004-06-24 2004-06-24 Amersham Biosciences Ab Purification of immunoglobulins
EP1796832A1 (fr) * 2004-09-01 2007-06-20 Cobento A/S Procedes de purification de molecules contenant de la corrine
RU2541429C2 (ru) * 2004-10-21 2015-02-10 Джи-И Хелткер Байо-Сайенсиз АБ Хроматографический лиганд
AU2005229674B2 (en) 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
US20060202922A1 (en) * 2005-03-10 2006-09-14 Hanna Christopher P Method for optimizing a purification procedure
US20080220968A1 (en) * 2005-07-05 2008-09-11 Ge Healthcare Bio-Sciences Ab [1, 2, 4] Triazolo [1, 5-A] Pyrimidine Derivatives as Chromatographic Adsorbent for the Selective Adsorption of Igg
US20080299671A1 (en) * 2005-12-02 2008-12-04 Ge Healthcare Bio-Sciences Ab Hydrophobic Interaction Chromatography
WO2008039136A1 (fr) * 2006-09-29 2008-04-03 Ge Healthcare Bio-Sciences Ab Matrice de séparation pour une purification virale
DK2089429T3 (en) * 2006-10-19 2015-01-12 Janssen Biotech Inc PROCEDURE FOR MANUFACTURING NON-AGGREGATED ANTIBODY-FC DOMAINS
US7691980B2 (en) * 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
WO2008086431A1 (fr) 2007-01-09 2008-07-17 Biova, L.L.C. Procédé de séparation de composants d'œufs techniques, d'œufs comestibles, de jaunes et de blancs et de leurs produits
US7999085B2 (en) * 2007-01-09 2011-08-16 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
SG144809A1 (en) * 2007-01-11 2008-08-28 Millipore U K Ltd Benzimidazole compounds and their use as chromatographic ligands
CN102895797B (zh) * 2007-01-15 2016-01-20 厄普弗朗特色谱公司 从原料生产生物燃料和蛋白质
DK2139573T3 (da) 2007-03-28 2017-02-20 Patheon Holdings I B V Kolonne med ekpanderet leje og engangskromatografi
US20100113746A1 (en) * 2007-04-23 2010-05-06 Arvind Mallinath Lali Process for purification of immunoglobulins using a pseudobioaffinity adsorbent
TWI580694B (zh) 2007-11-30 2017-05-01 建南德克公司 抗-ｖｅｇｆ抗體
CA2720615C (fr) 2008-04-08 2016-06-07 Bio-Rad Laboratories, Inc. Purification d'anticorps par chromatographie
DK2355664T3 (da) 2008-09-30 2014-10-06 Upfront Chromatography As Fremgangsmade til tilvejebringelse af et beta-lactoglobulin-produkt og et alfa-beriget valleproteinisolat
DE102009057993A1 (de) 2009-06-13 2011-01-20 Sartorius Stedim Biotech Gmbh Polysaccharidmatrix mit aufgepfropftem Polymer, Verfahren zu ihrer Herstellung und Verwendung
TW201106972A (en) 2009-07-27 2011-03-01 Genentech Inc Combination treatments
EP2459308A1 (fr) * 2009-07-28 2012-06-06 instrAction GmbH Sorbant spécifique pour la fixation de protéines et de peptides et procédé de séparation l'utilisant
CA2772715C (fr) 2009-09-02 2019-03-26 Genentech, Inc. Mutant smoothened et ses methodes d'utilisation
WO2011071577A1 (fr) 2009-12-11 2011-06-16 Genentech, Inc. Anticorps anti-vegf-c et leurs procédés d'utilisation
MX2012006983A (es) * 2009-12-17 2013-02-06 Instraction Gmbh Absorbente especifico para unir proteinas y peptidos, y metodo de separacion que utiliza el mismo.
CN102770158B (zh) 2009-12-21 2016-10-19 霍夫曼-拉罗奇有限公司 抗体配制剂
CA2813738A1 (fr) 2010-10-05 2012-04-12 Genentech, Inc. Mutant smoothened et ses procedes d'utilisation
EP2570184A1 (fr) * 2011-09-15 2013-03-20 InstrAction GmbH Sorbant comportant à sa surface un système de cycle aromatique doté d'un groupe anionique ou déprotonisable pour la purification de molécules organiques
US8802448B2 (en) 2011-07-27 2014-08-12 Pall Corporation Mixed mode ligands
US9309282B2 (en) * 2011-10-19 2016-04-12 Bio-Rad Laboratories, Inc. Solid phase for mixed-mode chromatographic purification of proteins
WO2013062841A1 (fr) * 2011-10-26 2013-05-02 Bio-Rad Laboratories, Inc. Élimination des agents virucides en chromatographie en mode mixte
RU2645082C2 (ru) * 2011-12-30 2018-02-15 Инномед С.А. Комбинация факторов роста, цитокинов, антибактериальных/антивирусных факторов, факторов стволовых клеток, белков комплемента с3а/с4а и хемотаксических факторов
DK2797609T3 (en) 2011-12-30 2017-01-09 Innomed S A COMBINING growth factors, cytokines, anti-bacterial / ANTIVIRALS FACTORS STEM CELL-STIMULATING FACTORS, complement C3A / C4A, immunoglobulins, and chemotactic factors
GB201202762D0 (en) 2012-02-17 2012-04-04 Autology Health Ltd High efficiency cell capture
BR112015000188B1 (pt) 2012-07-11 2020-03-03 Coöperatie Avebe U.A. Processo para o isolamento de uma fração de proteína de batata nativa do suco de batata
CN104968403A (zh) 2012-09-17 2015-10-07 格雷斯公司 色谱介质和装置
US9765111B2 (en) 2012-10-23 2017-09-19 Upfront Chromatography A/S Separation processes for soy protein
US11718643B2 (en) 2012-11-13 2023-08-08 Cytiva Bioprocess R&D Ab Multimodal anion exchange matrices
CN103030713A (zh) * 2012-12-21 2013-04-10 江南大学 一种具有降血脂活性的低分子量葡聚糖-烟酸聚合物的制备方法
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US10653779B2 (en) 2013-03-13 2020-05-19 Genentech, Inc. Formulations with reduced oxidation
EP2968553B1 (fr) 2013-03-13 2020-08-12 F.Hoffmann-La Roche Ag Formulations d'anticorps
PL2968466T3 (pl) 2013-03-13 2018-11-30 F.Hoffmann-La Roche Ag Preparaty o zmniejszonym utlenianiu
US20140314778A1 (en) 2013-03-13 2014-10-23 Genentech, Inc. Formulations with reduced oxidation
HUE049707T2 (hu) 2013-03-13 2020-11-30 Hoffmann La Roche Csökkent oxidációjú kiszerelések
CA2903589A1 (fr) 2013-03-15 2014-09-18 Genentech, Inc. Support de culture cellulaire et procedes de production d'anticorps
GB2513405A (en) * 2013-04-26 2014-10-29 Adc Biotechnology Ltd Method of synthesising ADCs using affinity resins
US9661868B2 (en) 2013-07-16 2017-05-30 Mead Johnson Nutrition Company Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
PT3049441T (pt) 2013-09-27 2020-01-21 Hoffmann La Roche Formulações de anticorpos anti-pdl1
US20150190506A1 (en) 2013-12-17 2015-07-09 Genentech, Inc. Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
EP3647324A1 (fr) 2013-12-17 2020-05-06 F. Hoffmann-La Roche AG Procédés de traitement de cancers au moyen d'antagonistes de liaison d'axe pd-1 et de taxanes
EP3083690A1 (fr) 2013-12-17 2016-10-26 F.Hoffmann-La Roche Ag Méthodes de traitement du cancer à l'aide d'antagonistes se liant à l'axe pd-1 et d'anticorps anti-cd20
US11229896B2 (en) 2014-01-16 2022-01-25 W.R. Grace & Co.—Conn. Affinity chromatography media and chromatography devices
DK3102197T3 (en) 2014-02-04 2018-11-19 Genentech Inc Smoothened mutant and methods for its use
CN105980485B (zh) * 2014-02-04 2018-11-27 巴斯夫欧洲公司 使用特定的蒽醌染料配体结构来纯化抗体、抗体片段或其工程变体的方法
WO2015138928A2 (fr) * 2014-03-14 2015-09-17 Bio-Rad Laboratories, Inc. Ligands en mode mixte
AU2015241038A1 (en) 2014-03-31 2016-10-13 Genentech, Inc. Combination therapy comprising anti-angiogenesis agents and OX40 binding agonists
ES2929099T3 (es) 2014-05-02 2022-11-24 Grace W R & Co Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado
EP3193932B1 (fr) 2014-09-15 2023-04-26 F. Hoffmann-La Roche AG Formulations d'anticorps
GB201419185D0 (en) 2014-10-28 2014-12-10 Adc Biotechnology Ltd Method of synthesising ADCs using affinity resin
GB201419184D0 (en) 2014-10-28 2014-12-10 Adc Biotechnology Ltd Method of synthesising biomolecule-effector/reporter-conjugates using affinity resins
KR20170096112A (ko) 2014-11-17 2017-08-23 제넨테크, 인크. Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법
AU2016215227A1 (en) 2015-02-04 2017-09-21 Assistance Publique-Hopitaux De Paris Mutant smoothened and methods of using the same
PL3302784T3 (pl) 2015-06-05 2022-01-17 W.R. Grace & Co.-Conn. Adsorbentowe środki klarujące do bioprzetwarzania oraz sposoby ich wytwarzania i stosowania
JP6896650B2 (ja) 2015-06-17 2021-06-30 ジェネンテック， インコーポレイテッド Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用した局所進行性または転移性乳癌の治療方法
SG11201804951SA (en) 2015-12-30 2018-07-30 Genentech Inc Use of tryptophan derivatives for protein formulations
IL299759A (en) 2015-12-30 2023-03-01 Genentech Inc Formulations with reduced polysorbate dissolution
CN108368179B (zh) 2016-01-08 2022-08-23 豪夫迈·罗氏有限公司 使用pd-1轴结合拮抗剂和抗cea/抗cd3双特异性抗体治疗cea阳性癌症的方法
EP3411396A1 (fr) 2016-02-04 2018-12-12 Curis, Inc. Mutant smoothened et méthodes d'utilisation dudit mutant
MX2018010546A (es) 2016-03-15 2019-02-20 Chugai Pharmaceutical Co Ltd Metodos de tratamiento de cancer que usan antagonistas de union al eje de muerte programada 1 (pd-1) y anticuerpos anti glipicano 3 (gpc3).
WO2018029124A1 (fr) 2016-08-08 2018-02-15 F. Hoffmann-La Roche Ag Méthodes thérapeutiques et de diagnostic du cancer
WO2018162501A1 (fr) 2017-03-07 2018-09-13 Jmva Biotech Ab Surfaces adsorbantes modifiées
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
CN115318256A (zh) 2018-03-08 2022-11-11 生物辐射实验室股份有限公司 阴离子交换-疏水混合模式色谱树脂
PL3781280T3 (pl) 2018-04-20 2022-08-16 Propharma Group Europe B.V. Sposób oddzielania z symulowanym ruchomym złożem
MY205645A (en) 2018-06-23 2024-11-02 Genentech Inc Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
TW202011991A (zh) 2018-07-18 2020-04-01 美商建南德克公司 用pd-1軸結合拮抗劑、抗代謝劑及鉑劑治療肺癌之方法
MX2021001453A (es) 2018-08-08 2021-04-12 Genentech Inc Uso de derivados de triptofano y l-metionina para una formulacion de proteinas.
US12172108B2 (en) 2018-08-16 2024-12-24 Emd Millipore Corporation Closed bioprocessing device
JP7475336B2 (ja) 2018-09-21 2024-04-26 ジェネンテック， インコーポレイテッド トリプルネガティブ乳癌のための診断方法
JP6927247B2 (ja) * 2019-04-08 2021-08-25 昭和電工マテリアルズ株式会社 抗体の精製方法
JP7717627B2 (ja) 2019-09-05 2025-08-04 バイオ－ラッド・ラボラトリーズ・インコーポレーテッド アニオン交換－疎水性混合モードクロマトグラフィー樹脂
MX2022015877A (es) 2020-06-16 2023-01-24 Genentech Inc Metodos y composiciones para tratar cancer de mama triple negativo.

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH594696A5 (fr) * 1975-03-18 1978-01-31 Battelle Memorial Institute
IL49752A (en) * 1975-07-09 1979-07-25 Kabi Ab Compositions having affinity for hepatitis virus and method for hepatitis virus removal or concentration
US4043997A (en) * 1976-05-28 1977-08-23 Cutter Laboratories, Inc. Method for isolating albumin using insoluble supports coupled to a dye
SE470099B (sv) * 1984-05-17 1993-11-08 Jerker Porath Sulfonaktiverade tioeteradsorbenter för separation av t ex protein
SE470261B (sv) 1984-05-17 1993-12-20 Jerker Porath Adsorbent för separation och immobilisering av proteiner, sätt att framställa ett adsorbent, samt dess användning för biopolymer fraktionering
EP0197521B1 (fr) * 1985-04-09 1989-08-02 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Adsorbant d'immunoglobuline et appareil d'adsorption
DK158224C (da) * 1985-08-23 1990-09-24 Danske Sukkerfab Fremgangsmaade til fremstilling af indolderivater
SE500574C2 (sv) * 1986-02-13 1994-07-18 Gel Innovation Handelsbolag Nitrilofor adsorbent för separation och immobilisering av proteiner, sätt att framställa adsorbentet, samt dess användning för fraktionering och immobilisering av biopolymerer
FR2596177B1 (fr) 1986-03-19 1992-01-17 Infoscript Procede et dispositif de sauvegarde qualitative de donnees numerisees
EP0242222A3 (fr) 1986-04-16 1988-05-11 Bata Industries Limited Méthode de fabrication d'une forme de chaussure
FR2619568B1 (fr) * 1987-08-21 1989-07-07 Centre Nat Rech Scient Polymeres derives du polystyrene, leurs procedes de preparation et leurs applications pour l'analyse et la purification de molecules d'origine biologique
SE462165B (sv) * 1988-02-26 1990-05-14 Porath Jerker Saett att paa en baerare adsorbera sammansatta proteinkomplex, saerskilt vid biospecifika bestaemningsmetoder
US4981961A (en) 1988-09-12 1991-01-01 Bioprobe International, Inc. Synthetic affinity ligand compositions and methods for purification and recovery of organic molecules
DK165090D0 (da) 1990-07-09 1990-07-09 Kem En Tec As Konglomererede partikler
DK52791D0 (da) 1991-03-22 1991-03-22 Kem En Tec As Adsorptionsmatricer
US5502022A (en) 1994-05-16 1996-03-26 Biosepra, Inc. Chromatography adsorbents utilizing mercapto heterocyclic ligands
SE9401960L (sv) * 1994-06-07 1995-12-08 Sven Oscarsson Alkalibeständigt proteinadsorbent
US20040214157A1 (en) 1994-06-29 2004-10-28 Simon C. Burton Chromatographic resins and methods for using same
US5652348A (en) 1994-09-23 1997-07-29 Massey University Chromatographic resins and methods for using same
GB9519197D0 (en) * 1995-09-20 1995-11-22 Affinity Chromatography Ltd Novel affinity ligands and their use
EP2095873A1 (fr) * 1996-08-30 2009-09-02 Upfront Chromatography A/S Isolation d'immunoglobulines
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US7514579B2 (en) * 2002-06-13 2009-04-07 Johns Hopkins University Boronic chalcone derivatives and uses thereof
US7767817B2 (en) * 2003-09-05 2010-08-03 Binghe Wang Water soluble boronic acid fluorescent reporter compounds and methods of use thereof

Also Published As

Publication number Publication date
ATE254502T1 (de) 2003-12-15
EP2095873A1 (fr) 2009-09-02
WO1998008603A1 (fr) 1998-03-05
CA2876986A1 (fr) 1998-03-05
AU729039B2 (en) 2001-01-25
US20080132683A1 (en) 2008-06-05
DE69726285T2 (de) 2004-09-09
DE69739567D1 (de) 2009-10-15
DE69726285D1 (de) 2003-12-24
US20030187227A1 (en) 2003-10-02
US20050176122A1 (en) 2005-08-11
AU729039C (en) 2001-08-02
EP1386660B1 (fr) 2009-09-02
US6919436B2 (en) 2005-07-19
CA2876986C (fr) 2017-08-29
US6498236B1 (en) 2002-12-24
ES2332893T3 (es) 2010-02-15
EP0921855A1 (fr) 1999-06-16
AU4112397A (en) 1998-03-19
EP1386660A1 (fr) 2004-02-04
CA2264177A1 (fr) 1998-03-05
US7442779B2 (en) 2008-10-28
JP2001501595A (ja) 2001-02-06
EP0921855B1 (fr) 2003-11-19
CA2264177C (fr) 2015-03-17
JP4425994B2 (ja) 2010-03-03
US7745582B2 (en) 2010-06-29
ATE441476T1 (de) 2009-09-15

Similar Documents

Publication Publication Date Title
DK1386660T3 (da) Isolering af immunoglobuliner
SE8901687D0 (sv) Fibronectin binding protein as well as its preparation
UA27763C2 (uk) Рекомбінантна молекула днк, що кодує молекулу адгезії icam-3, молекула адгезії icam-3, антитіло, здатне зв'язуватись з такою молекулою, фармацевтична композиція
FI940270L (fi) Menetelmiä immuunivasteen säätelemiseksi käyttämällä CTLA4:ää sitovia molekyylejä ja IL4:ää sitovia molekyylejä
CA2085134A1 (fr) Gdf-1
ATE252830T1 (de) Neue psoralene zur inaktivierung von pathogenen
DE69329877D1 (de) Von L Protein abgeleitete Immunoglobulin-bindende Proteine und deren anwendungen
DE69707849D1 (de) Verfahren zur reinigung von 1,4-butandiol
DE59306762D1 (de) Aktivierte Trägermaterialien, ihre Herstellung und Verwendung
EP0496473A3 (en) Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use
DE3779461D1 (de) Durch alkylgruppen substituiertes phenylcarbamat von polysaccharid.
ATE355319T1 (de) Composit-ionenaustauschmembranen
DE19581676T1 (de) Immobilisierte, verzweigte Polyalkylenimine
DK0705846T3 (da) Höjmolekylære og lavmolekylære fraktioner af von Willebrand-faktor
DE3580637D1 (de) N,n',n"-tris((2,2,6,6-tetramethyl-4-piperidyl)triazinyl)-undecane-triamine als stabilisatoren fuer synthetische polymere.
IL105769A0 (en) Immobilized buffered gels and membranes of hydroxy group-containing polymers
ATE256183T1 (de) Neue proteine von parasitischen würmern
ATE236659T1 (de) Entfernen von viren durch ultrafiltration aus proteinlösungen
ATE85058T1 (de) Jodhaltige polymere mit skeletten von dextran, verfahren zu ihrer herstellung und ihre verwendungen als kontrastmittel.
PT1105508E (pt) Metodo de purificacao de complexos de biomoleculas ou de proteinas
WO1999054349A3 (fr) Molecules d'acides nucleiques dermatophagoides, proteines et leurs utilisations
DE68916293D1 (de) Von Polyketonen abgeleitete Polymere.
DK0820468T3 (da) Fremgangsmåde til rensning af glycoproteiner, såsom erythropoietin
DE68913346D1 (de) Bisharnstoffe als Lichtstabilisatoren für organische Polymere.
FR2704161B1 (fr) Catalyseur d'alkylation de paraffines.