DK1379262T3 - Fremgangsmåde til fremstilling af et med aktive stoffer höjt beriget ekstrakt af Ginkgo Biloba-blade - Google Patents
Fremgangsmåde til fremstilling af et med aktive stoffer höjt beriget ekstrakt af Ginkgo Biloba-bladeInfo
- Publication number
- DK1379262T3 DK1379262T3 DK02761922T DK02761922T DK1379262T3 DK 1379262 T3 DK1379262 T3 DK 1379262T3 DK 02761922 T DK02761922 T DK 02761922T DK 02761922 T DK02761922 T DK 02761922T DK 1379262 T3 DK1379262 T3 DK 1379262T3
- Authority
- DK
- Denmark
- Prior art keywords
- ginkgo biloba
- biloba leaves
- ethyl acetate
- liquid
- extract
- Prior art date
Links
- 235000008100 Ginkgo biloba Nutrition 0.000 title abstract 3
- 244000194101 Ginkgo biloba Species 0.000 title abstract 3
- 239000013543 active substance Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000000622 liquid--liquid extraction Methods 0.000 abstract 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 2
- 239000012071 phase Substances 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 238000000638 solvent extraction Methods 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- 208000018152 Cerebral disease Diseases 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Neurosurgery (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0104942A FR2823116B1 (fr) | 2001-04-10 | 2001-04-10 | Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs |
| PCT/FR2002/001219 WO2002083158A1 (fr) | 2001-04-10 | 2002-04-09 | Procede de preparation d'un extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1379262T3 true DK1379262T3 (da) | 2005-02-14 |
Family
ID=8862215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02761922T DK1379262T3 (da) | 2001-04-10 | 2002-04-09 | Fremgangsmåde til fremstilling af et med aktive stoffer höjt beriget ekstrakt af Ginkgo Biloba-blade |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7048954B2 (ru) |
| EP (1) | EP1379262B1 (ru) |
| JP (1) | JP4416404B2 (ru) |
| KR (1) | KR100876233B1 (ru) |
| CN (1) | CN1245167C (ru) |
| AT (1) | ATE278411T1 (ru) |
| AU (1) | AU2002307981B2 (ru) |
| CA (1) | CA2443302C (ru) |
| CZ (1) | CZ299652B6 (ru) |
| DE (1) | DE60201525T8 (ru) |
| DK (1) | DK1379262T3 (ru) |
| ES (1) | ES2230512T3 (ru) |
| FR (1) | FR2823116B1 (ru) |
| HU (1) | HUP0303797A3 (ru) |
| NZ (1) | NZ528571A (ru) |
| PL (1) | PL204867B1 (ru) |
| PT (1) | PT1379262E (ru) |
| RU (1) | RU2297235C2 (ru) |
| WO (1) | WO2002083158A1 (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1416949B1 (en) | 2001-07-11 | 2006-10-25 | The Trustees of Columbia University in the City of New York | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba |
| AU2003243158A1 (en) | 2002-03-29 | 2003-10-13 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from ginkgo biloba and related compounds and uses thereof |
| JP2004307396A (ja) * | 2003-04-07 | 2004-11-04 | Kao Corp | デオドラント剤 |
| WO2005021496A2 (en) | 2003-08-27 | 2005-03-10 | The Trustees Of Columbia University In The City Of New York | Synthesis of derivatives of ginkgolide c |
| WO2005046829A2 (en) | 2003-11-12 | 2005-05-26 | The Trustees Of Columbia University In The City Of New York | Separation of ginkgolides and bilobalide from g. biloba |
| EP1537874B1 (de) * | 2003-12-04 | 2007-06-13 | Cognis IP Management GmbH | Verfahren zur Herstellung von Extrakten des Ginkgo Biloba |
| WO2006004386A1 (es) * | 2004-07-02 | 2006-01-12 | Rojas Castaneda Patricia | Uso de un extracto del ginkgo biloba para preparar una medicina para tratar la enfermedad de parkinson |
| CN1891242B (zh) * | 2005-07-06 | 2012-01-04 | 徐州技源天然保健品有限公司 | 一种从银杏叶提取物中脱除多环芳烃的生产工艺 |
| FR2904222A1 (fr) * | 2006-07-27 | 2008-02-01 | Sod Conseils Rech Applic | Utilisation d4extraits de ginkgo biloba pour le traitement de maladies mitochondriales |
| CZ299802B6 (cs) * | 2006-10-12 | 2008-11-26 | Kalvoda@Jaroslav | Príprava zálivky obsahující extrakt z náprstníku cerveného, extrakt z jinanu dvoulalocného a dusicnan draselný, a její vliv na rostliny |
| HUE041715T2 (hu) * | 2007-12-21 | 2019-05-28 | Dr Willmar Schwabe Gmbh & Co Kg | Ginkgo biloba levél-kivonat alkalmazása |
| FR2926994B1 (fr) * | 2008-02-06 | 2010-08-27 | Sod Conseils Rech Applic | Nouveau procede pour la preparation d'extraits de ginkgo biloba |
| WO2011012141A1 (en) * | 2009-07-28 | 2011-02-03 | Velleja Research S.R.L. | Ginkgo biloba extract with a standardised ginkgo flavone glycosides content deprived of the paf-antagonist terpenic fraction, and compositions containing it, for the prevention and treatment of circulatory, cognitive, geriatric and sensory disorders |
| CN110893183A (zh) * | 2018-09-13 | 2020-03-20 | 成都百裕制药股份有限公司 | 银杏萜内酯在制备预防、缓解或治疗肌萎缩侧索硬化药物中的应用 |
| FR3152724A1 (fr) * | 2023-09-13 | 2025-03-14 | Chromavis France | Extrait de ginkgo biloba pour stimuler la croissance des cils |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044659C (zh) * | 1987-06-30 | 1999-08-18 | 吴羽化学工业株式会社 | 含有唑类衍生物的农业和园艺用的农药组合物 |
| DE3832056A1 (de) * | 1988-09-21 | 1990-03-22 | Scholle Helmut Dr Med | Verwendung eines ginkgo-extraktes |
| JPH02193907A (ja) * | 1989-01-19 | 1990-07-31 | Daicel Chem Ind Ltd | イチョウエキスの製法 |
| KR940002796B1 (ko) * | 1989-06-16 | 1994-04-02 | 주식회사 선경인더스트리 | 은행잎에서 징코라이드를 분리 및 정제하는 방법 |
| DE3940094A1 (de) * | 1989-12-04 | 1991-06-06 | Montana Ltd | Wirkstoffkonzentrate und neue wirkstoff-kombinationen aus blaettern von ginkgo biloba, ein verfahren zu ihrer herstellung und die wirkstoff-konzentrate bzw. die wirkstoff-kombinationen enthaltenden arzneimittel |
| DE3940092A1 (de) * | 1989-12-04 | 1991-06-06 | Schwabe Willmar Gmbh & Co | Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel |
| DE3940095A1 (de) * | 1989-12-04 | 1991-06-06 | Schwabe Willmar Gmbh & Co | Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel |
| DE3940091A1 (de) * | 1989-12-04 | 1991-06-06 | Schwabe Willmar Gmbh & Co | Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel |
| GB9107425D0 (en) * | 1991-04-09 | 1991-05-22 | Scras | Preparation of ginkgolide b |
| DE4308443C2 (de) * | 1993-03-17 | 1996-09-19 | Laves Hans Georg | Arzneimittel zur Behandlung von Retrovirusinfektionen |
| GB9408044D0 (en) * | 1994-04-22 | 1994-06-15 | Sod Conseils Rech Applic | Conversion of ginkgolide c to ginkgolide b |
| DE19756848C2 (de) * | 1997-12-19 | 2003-01-16 | Schwabe Willmar Gmbh & Co | Extrakte aus Blättern von Ginkgo biloba mit vermindertem Gehalt an 4'-O-Methylpyridoxin und Biflavonen |
| US6030621A (en) * | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
| DE19829516B4 (de) * | 1998-07-02 | 2004-08-26 | Dr. Willmar Schwabe Gmbh & Co. Kg | Wasserlöslicher nativer Trockenextrakt aus Gingko biloba mit hohem Gehalt an Terpenoiden und Flavonglykosiden |
| CN1124275C (zh) * | 2000-06-02 | 2003-10-15 | 天津大学 | 由银杏叶或银杏叶浸膏制备药物银杏内酯a、b的方法 |
| EP1163908B1 (en) * | 2000-06-16 | 2004-05-06 | Linnea S.A. | Water-soluble complex of an extract of Ginkgo Bilboa, process for the preparation thereof and composition comprising the same |
| EP1416949B1 (en) * | 2001-07-11 | 2006-10-25 | The Trustees of Columbia University in the City of New York | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba |
| CN1287121C (zh) * | 2004-04-05 | 2006-11-29 | 广东科龙电器股份有限公司 | 可实现冷媒充灌量动态控制的空调器节流装置 |
-
2001
- 2001-04-10 FR FR0104942A patent/FR2823116B1/fr not_active Expired - Fee Related
-
2002
- 2002-04-09 AT AT02761922T patent/ATE278411T1/de active
- 2002-04-09 PT PT02761922T patent/PT1379262E/pt unknown
- 2002-04-09 ES ES02761922T patent/ES2230512T3/es not_active Expired - Lifetime
- 2002-04-09 AU AU2002307981A patent/AU2002307981B2/en not_active Ceased
- 2002-04-09 US US10/472,408 patent/US7048954B2/en not_active Expired - Fee Related
- 2002-04-09 DE DE60201525T patent/DE60201525T8/de active Active
- 2002-04-09 CZ CZ20033055A patent/CZ299652B6/cs not_active IP Right Cessation
- 2002-04-09 KR KR1020037013205A patent/KR100876233B1/ko not_active Expired - Fee Related
- 2002-04-09 RU RU2003132470/15A patent/RU2297235C2/ru not_active IP Right Cessation
- 2002-04-09 WO PCT/FR2002/001219 patent/WO2002083158A1/fr not_active Ceased
- 2002-04-09 CN CNB028080998A patent/CN1245167C/zh not_active Expired - Fee Related
- 2002-04-09 PL PL366938A patent/PL204867B1/pl not_active IP Right Cessation
- 2002-04-09 CA CA2443302A patent/CA2443302C/fr not_active Expired - Fee Related
- 2002-04-09 HU HU0303797A patent/HUP0303797A3/hu unknown
- 2002-04-09 EP EP02761922A patent/EP1379262B1/fr not_active Expired - Lifetime
- 2002-04-09 NZ NZ528571A patent/NZ528571A/en not_active IP Right Cessation
- 2002-04-09 JP JP2002580960A patent/JP4416404B2/ja not_active Expired - Fee Related
- 2002-04-09 DK DK02761922T patent/DK1379262T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20033055A3 (cs) | 2004-06-16 |
| ES2230512T3 (es) | 2005-05-01 |
| DE60201525T2 (de) | 2006-03-02 |
| DE60201525D1 (de) | 2004-11-11 |
| NZ528571A (en) | 2005-06-24 |
| JP2004538263A (ja) | 2004-12-24 |
| CN1245167C (zh) | 2006-03-15 |
| KR100876233B1 (ko) | 2008-12-26 |
| US7048954B2 (en) | 2006-05-23 |
| PL366938A1 (en) | 2005-02-07 |
| US20040109907A1 (en) | 2004-06-10 |
| CZ299652B6 (cs) | 2008-10-01 |
| KR20030087068A (ko) | 2003-11-12 |
| CA2443302A1 (fr) | 2002-10-24 |
| ATE278411T1 (de) | 2004-10-15 |
| JP4416404B2 (ja) | 2010-02-17 |
| HUP0303797A3 (en) | 2005-05-30 |
| PT1379262E (pt) | 2005-02-28 |
| EP1379262A1 (fr) | 2004-01-14 |
| CN1501806A (zh) | 2004-06-02 |
| RU2297235C2 (ru) | 2007-04-20 |
| PL204867B1 (pl) | 2010-02-26 |
| FR2823116B1 (fr) | 2004-11-19 |
| HK1066164A1 (en) | 2005-03-18 |
| AU2002307981B2 (en) | 2006-11-23 |
| FR2823116A1 (fr) | 2002-10-11 |
| CA2443302C (fr) | 2012-09-18 |
| RU2003132470A (ru) | 2005-03-10 |
| WO2002083158A1 (fr) | 2002-10-24 |
| DE60201525T8 (de) | 2006-08-24 |
| HUP0303797A2 (hu) | 2004-03-29 |
| EP1379262B1 (fr) | 2004-10-06 |
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