DK1370663T3 - Mikrobiologisk metode til fremstilling af L-carnitin - Google Patents
Mikrobiologisk metode til fremstilling af L-carnitinInfo
- Publication number
- DK1370663T3 DK1370663T3 DK02712878T DK02712878T DK1370663T3 DK 1370663 T3 DK1370663 T3 DK 1370663T3 DK 02712878 T DK02712878 T DK 02712878T DK 02712878 T DK02712878 T DK 02712878T DK 1370663 T3 DK1370663 T3 DK 1370663T3
- Authority
- DK
- Denmark
- Prior art keywords
- carnitine
- betaine
- hydrolases
- preparing
- ester
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 4
- 238000013048 microbiological method Methods 0.000 title 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 5
- 229960003237 betaine Drugs 0.000 abstract 5
- 102000004157 Hydrolases Human genes 0.000 abstract 3
- 108090000604 Hydrolases Proteins 0.000 abstract 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 abstract 3
- -1 betaine ester Chemical class 0.000 abstract 3
- 244000005700 microbiome Species 0.000 abstract 2
- JHPNVNIEXXLNTR-UHFFFAOYSA-N 4-(trimethylammonio)butanoate Chemical compound C[N+](C)(C)CCCC([O-])=O JHPNVNIEXXLNTR-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/41—Rhizobium
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01102214 | 2001-01-31 | ||
| PCT/EP2002/001009 WO2002061094A2 (de) | 2001-01-31 | 2002-01-31 | Mikrobiologisches verfahren zur herstellung von l-carnitin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1370663T3 true DK1370663T3 (da) | 2007-07-02 |
Family
ID=8176358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02712878T DK1370663T3 (da) | 2001-01-31 | 2002-01-31 | Mikrobiologisk metode til fremstilling af L-carnitin |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1370663B1 (da) |
| CN (1) | CN1233832C (da) |
| AT (1) | ATE356214T1 (da) |
| DE (1) | DE50209655D1 (da) |
| DK (1) | DK1370663T3 (da) |
| ES (1) | ES2282399T3 (da) |
| WO (1) | WO2002061094A2 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2611901C (en) | 2005-07-05 | 2012-12-11 | Lonza Ag | Spray-drying process for producing a dry carnitine powder or granulate |
| EP2325164A1 (en) * | 2009-11-18 | 2011-05-25 | Lonza Ltd. | Methods for the production of l-carnitine |
| CN107879944B (zh) * | 2017-10-30 | 2020-05-22 | 杭州海尔希畜牧科技有限公司 | 一种制备丁基甜菜碱的方法 |
| CN119120398B (zh) * | 2024-07-22 | 2025-09-09 | 华南师范大学 | 酶突变体、酶组合物或其固定化酶及其制备l-左旋肉碱的应用和方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI86889C (fi) * | 1984-03-29 | 1992-10-26 | Lonza Ag | Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett |
| JPH0291049A (ja) * | 1988-09-21 | 1990-03-30 | Lonza Ag | ｒ―ブチロベタインの製造方法 |
| RU2099418C1 (ru) * | 1991-11-21 | 1997-12-20 | Лонца Аг | Фрагмент днк, обеспечивающий использование бетаина, рекомбинантная плазмидная днк с фрагментом днк, обеспечивающим использование бетаина, штамм бактерий rhizobium/agrobacterium, предназначенный для стабильного хранения плазмиды с фрагментом днк, способ получения штамма бактерий |
| CN1157480C (zh) * | 1993-10-08 | 2004-07-14 | 瑞士隆萨股份公司 | 丁内铵盐/巴豆甜菜碱-l-肉毒碱代谢基因及其在微生物法生产l-肉毒碱中的用途 |
-
2002
- 2002-01-31 ES ES02712878T patent/ES2282399T3/es not_active Expired - Lifetime
- 2002-01-31 WO PCT/EP2002/001009 patent/WO2002061094A2/de not_active Ceased
- 2002-01-31 AT AT02712878T patent/ATE356214T1/de active
- 2002-01-31 EP EP02712878A patent/EP1370663B1/de not_active Expired - Lifetime
- 2002-01-31 DE DE50209655T patent/DE50209655D1/de not_active Expired - Lifetime
- 2002-01-31 CN CNB028043634A patent/CN1233832C/zh not_active Expired - Fee Related
- 2002-01-31 DK DK02712878T patent/DK1370663T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2282399T3 (es) | 2007-10-16 |
| ATE356214T1 (de) | 2007-03-15 |
| WO2002061094A3 (de) | 2003-10-02 |
| CN1233832C (zh) | 2005-12-28 |
| CN1489629A (zh) | 2004-04-14 |
| EP1370663B1 (de) | 2007-03-07 |
| WO2002061094A2 (de) | 2002-08-08 |
| EP1370663A2 (de) | 2003-12-17 |
| DE50209655D1 (de) | 2007-04-19 |
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