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DK1212320T3 - Phenylpiperazinderivater som inhibitorer for genoptag af serotonin - Google Patents

Phenylpiperazinderivater som inhibitorer for genoptag af serotonin

Info

Publication number
DK1212320T3
DK1212320T3 DK00962355T DK00962355T DK1212320T3 DK 1212320 T3 DK1212320 T3 DK 1212320T3 DK 00962355 T DK00962355 T DK 00962355T DK 00962355 T DK00962355 T DK 00962355T DK 1212320 T3 DK1212320 T3 DK 1212320T3
Authority
DK
Denmark
Prior art keywords
inhibitors
serotonin reuptake
phenylpiperazine derivatives
phenylpiperazine
derivatives
Prior art date
Application number
DK00962355T
Other languages
Danish (da)
English (en)
Inventor
Roelof Van Hes
Johannes A M Van Der Heijden
Cornelis G Kruse
Jacobus Tipker
Martinus T M Tulp
Gerben M Visser
Bernard J Van Vliet
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Application granted granted Critical
Publication of DK1212320T3 publication Critical patent/DK1212320T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK00962355T 1999-08-23 2000-08-22 Phenylpiperazinderivater som inhibitorer for genoptag af serotonin DK1212320T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP99202710 1999-08-23
NL1012888 1999-08-23
EP00962355A EP1212320B1 (fr) 1999-08-23 2000-08-22 Phenylpiperazines comme inhibiteurs de recapture de serotonine
PCT/EP2000/008190 WO2001014330A2 (fr) 1999-08-23 2000-08-22 Nouvelles phenylpiperazines

Publications (1)

Publication Number Publication Date
DK1212320T3 true DK1212320T3 (da) 2005-08-08

Family

ID=26153354

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00962355T DK1212320T3 (da) 1999-08-23 2000-08-22 Phenylpiperazinderivater som inhibitorer for genoptag af serotonin

Country Status (29)

Country Link
US (3) US7067513B1 (fr)
EP (1) EP1212320B1 (fr)
JP (1) JP4919565B2 (fr)
KR (1) KR100634039B1 (fr)
CN (1) CN1155596C (fr)
AR (1) AR031526A1 (fr)
AT (1) ATE299142T1 (fr)
AU (1) AU772189B2 (fr)
BR (1) BR0013498A (fr)
CA (1) CA2379021C (fr)
CZ (1) CZ298533B6 (fr)
DE (1) DE60021194T2 (fr)
DK (1) DK1212320T3 (fr)
ES (1) ES2244469T3 (fr)
HU (1) HUP0203194A3 (fr)
IL (2) IL148218A0 (fr)
MX (1) MXPA02001919A (fr)
NO (1) NO321887B1 (fr)
NZ (1) NZ517900A (fr)
PL (1) PL201178B1 (fr)
PT (1) PT1212320E (fr)
RU (1) RU2246494C2 (fr)
SI (1) SI1212320T1 (fr)
SK (1) SK287018B6 (fr)
TR (1) TR200200460T2 (fr)
TW (1) TWI286136B (fr)
UA (1) UA74160C2 (fr)
WO (1) WO2001014330A2 (fr)
ZA (1) ZA200201829B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067513B1 (en) 1999-08-23 2006-06-27 Solvay Pharmaceuticals B.V. Phenylpiperazines
AR032711A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
WO2002085896A1 (fr) * 2001-04-24 2002-10-31 Wyeth Derives azaheterocyclylmethyle antidepresseurs de 2,3-dihydro-1,4-benzodioxane
US6656950B2 (en) * 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
WO2003007956A1 (fr) 2001-07-20 2003-01-30 Psychogenics, Inc. Traitement des troubles de deficit de l'attention/hyperactivite
EP1336406A1 (fr) * 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Agonistes partiels du récepteur D2 de la dopamine et inhibiteurs de la sérotonine et/ou de la noradrénaline
NZ536230A (en) * 2002-05-13 2007-05-31 Hoffmann La Roche Benzoxazine derivatives as 5-hydroxytryptamine-6 (5-HT6) modulatory neurotransmitter in the brain
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
WO2004041792A1 (fr) 2002-11-08 2004-05-21 F. Hoffmann-La Roche Ag Benzoxazinones substitues et utilisations associees
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
WO2004108671A1 (fr) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant
MX2007006758A (es) * 2004-12-07 2007-11-09 Solvay Pharm Bv Derivados de benzdioxanpiperazina con una afinidad combinada para receptores de dopamina-d2 y sitios de reabsorcion de serotonina.
CA2587928A1 (fr) * 2004-12-07 2006-06-15 Solvay Pharmaceuticals B.V. Phenylpiperazines comportant une combinaison de sites a affinite avec des recepteurs de dopamine d2
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20060122247A1 (en) 2004-12-08 2006-06-08 Solvay Pharmaceuticals B.V. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
JP2008523031A (ja) * 2004-12-08 2008-07-03 ソルベイ・フアーマシユーチカルズ・ベー・ブイ 部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体
PE20070523A1 (es) 2005-09-12 2007-06-28 Wyeth Corp Formulacion de liberacion sostenida del glucuronato de (8-{4-[3-(5-fluoro-1h-indol-3-il)-propil]-piperazin-1-il}-2-metil-4h-benzo[1,4]oxazin-3-ona
GT200600416A (es) * 2005-09-12 2007-09-20 Sales salicilato y gentisato de un compuesto de piperazina
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
FR2941946B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique
AU2010266040B2 (en) * 2009-06-25 2015-01-15 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
EP3027607B1 (fr) 2013-07-29 2020-08-26 Sunshine Lake Pharma Co., Ltd. Composés hétéroaryliques substitués et procédés d'utilisation
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途

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US5576321A (en) 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
AR004229A1 (es) 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
DE19730989A1 (de) 1997-07-18 1999-01-21 Merck Patent Gmbh Piperazin-Derivate
EP1007523B9 (fr) * 1997-07-25 2004-09-08 H. Lundbeck A/S Derives indole et 2,3-dihydro-indole, leur preparation et utilisation
DE69819266T2 (de) * 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP0900792B1 (fr) 1997-09-02 2003-10-29 Duphar International Research B.V Dérivés de pipéridine et de pipérazine comme agonistes du récepteur 5-HT1
SK19412000A3 (sk) * 1998-06-19 2001-07-10 H. Lundbeck A/S Substituované 4,5,6 a 7-indolové alebo indolínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
EP1089997A1 (fr) * 1998-06-19 2001-04-11 H.Lundbeck A/S Derives de 4, 5, 6, et 7-indole ou d'indoline, leur preparation, et leur utilisation
AR020773A1 (es) 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
US7067513B1 (en) 1999-08-23 2006-06-27 Solvay Pharmaceuticals B.V. Phenylpiperazines
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR032711A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
EP1336406A1 (fr) 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Agonistes partiels du récepteur D2 de la dopamine et inhibiteurs de la sérotonine et/ou de la noradrénaline

Also Published As

Publication number Publication date
NO321887B1 (no) 2006-07-17
EP1212320B1 (fr) 2005-07-06
SK2492002A3 (en) 2002-09-10
CN1390214A (zh) 2003-01-08
ZA200201829B (en) 2003-08-27
WO2001014330A2 (fr) 2001-03-01
US20060293313A1 (en) 2006-12-28
KR20020057949A (ko) 2002-07-12
SK287018B6 (sk) 2009-09-07
WO2001014330A3 (fr) 2001-08-02
BR0013498A (pt) 2002-05-14
KR100634039B1 (ko) 2006-10-17
DE60021194D1 (de) 2005-08-11
SI1212320T1 (en) 2005-10-31
CN1155596C (zh) 2004-06-30
TR200200460T2 (tr) 2002-06-21
CZ2002619A3 (cs) 2002-08-14
AR031526A1 (es) 2003-09-24
CA2379021A1 (fr) 2001-03-01
CA2379021C (fr) 2009-10-27
PL201178B1 (pl) 2009-03-31
AU7411800A (en) 2001-03-19
US7605162B2 (en) 2009-10-20
NO20020810L (no) 2002-02-19
IL148218A (en) 2007-05-15
HUP0203194A3 (en) 2004-01-28
RU2246494C2 (ru) 2005-02-20
CZ298533B6 (cs) 2007-10-31
MXPA02001919A (es) 2003-07-21
HK1051199A1 (en) 2003-07-25
IL148218A0 (en) 2002-09-12
PT1212320E (pt) 2005-11-30
PL364821A1 (en) 2004-12-13
JP4919565B2 (ja) 2012-04-18
JP2003507454A (ja) 2003-02-25
HUP0203194A2 (hu) 2003-01-28
US7456182B2 (en) 2008-11-25
DE60021194T2 (de) 2005-12-22
NZ517900A (en) 2003-08-29
UA74160C2 (uk) 2005-11-15
ES2244469T3 (es) 2005-12-16
NO20020810D0 (no) 2002-02-19
AU772189B2 (en) 2004-04-08
TWI286136B (en) 2007-09-01
EP1212320A2 (fr) 2002-06-12
US7067513B1 (en) 2006-06-27
ATE299142T1 (de) 2005-07-15
US20090143406A1 (en) 2009-06-04

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