[go: up one dir, main page]

DK1265698T3 - Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament - Google Patents

Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament

Info

Publication number
DK1265698T3
DK1265698T3 DK01911828T DK01911828T DK1265698T3 DK 1265698 T3 DK1265698 T3 DK 1265698T3 DK 01911828 T DK01911828 T DK 01911828T DK 01911828 T DK01911828 T DK 01911828T DK 1265698 T3 DK1265698 T3 DK 1265698T3
Authority
DK
Denmark
Prior art keywords
nanocapsules
lipid
medicament
preparation
producing
Prior art date
Application number
DK01911828T
Other languages
Danish (da)
English (en)
Inventor
Joel Richard
Jean-Pierre Benoit
Beatrice Heurtault
Patrick Saulnier
Jacques-Emile Proust
Brigitte Pech
Original Assignee
Mainelab
Univ Angers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mainelab, Univ Angers filed Critical Mainelab
Application granted granted Critical
Publication of DK1265698T3 publication Critical patent/DK1265698T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0026—Preparation of sols containing a liquid organic phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/017—Mixtures of compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/14—Derivatives of phosphoric acid
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/34—Higher-molecular-weight carboxylic acid esters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
DK01911828T 2000-03-02 2001-03-02 Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament DK1265698T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0002688A FR2805761B1 (fr) 2000-03-02 2000-03-02 Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
PCT/FR2001/000621 WO2001064328A1 (fr) 2000-03-02 2001-03-02 Nanocapsules lipidiques, procede de preparation et utilisation comme medicament

Publications (1)

Publication Number Publication Date
DK1265698T3 true DK1265698T3 (da) 2004-10-25

Family

ID=8847644

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01911828T DK1265698T3 (da) 2000-03-02 2001-03-02 Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament

Country Status (22)

Country Link
US (2) US8057823B2 (xx)
EP (1) EP1265698B1 (xx)
JP (1) JP4790187B2 (xx)
KR (1) KR100638527B1 (xx)
CN (1) CN1257011C (xx)
AT (1) ATE269154T1 (xx)
AU (2) AU4075301A (xx)
BR (1) BRPI0108921B8 (xx)
CA (1) CA2401766C (xx)
DE (1) DE60103863T2 (xx)
DK (1) DK1265698T3 (xx)
ES (1) ES2221640T3 (xx)
FR (1) FR2805761B1 (xx)
HU (1) HU226483B1 (xx)
IL (1) IL151560A0 (xx)
MX (1) MXPA02008638A (xx)
NO (1) NO334188B1 (xx)
PT (1) PT1265698E (xx)
SI (1) SI1265698T1 (xx)
TR (1) TR200401812T4 (xx)
WO (1) WO2001064328A1 (xx)
ZA (1) ZA200206985B (xx)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0104698D0 (en) * 2001-02-26 2001-04-11 Syngenta Ltd Process for producing microcapsules
FR2835430A1 (fr) * 2002-05-31 2003-08-08 Oreal Composition comprenant des nanocapsules enrobees de lecithine et un polymere d'acrylamide
FR2840532B1 (fr) * 2002-06-11 2005-05-06 Ethypharm Sa Nanocapsules lipidiques furtives, procede de preparation et utilisation comme vecteur de principes(s) actif(s)
BR0314767A (pt) * 2002-06-11 2005-07-26 Ethypharm Sa Nanocápsulas lipidìcas furtivas, processos para a preparação das mesmas e uso das mesmas como um veìculo para princìpio(s) ativo(s)
ES2411961T5 (es) * 2002-11-01 2017-04-27 Rutgers, The State University Of New Jersey Vehículos de suministro en forma de geoda
FR2849379B1 (fr) * 2002-12-26 2005-02-11 Cosnessens Encapsulation d'actifs liposolubles
US20060073196A1 (en) * 2003-02-12 2006-04-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of p-glycoprotein inhibitor surfactants at the surface of a colloidal carrier
FR2864900B1 (fr) 2004-01-09 2007-10-12 Oreal Dispersion aqueuse de nanocapsules a coeur huileux
WO2005102507A1 (en) * 2004-04-20 2005-11-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem A method for the preparation of nanoparticles from nanoemulsions
DE102005037844A1 (de) * 2005-08-04 2007-04-05 Intendis Gmbh Wasserfreies Mehr-Phasen-Gel-System
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
FR2907012B1 (fr) * 2006-10-12 2012-09-21 Galderma Sa Composition dermatologique comprenant des nanocapsules d'avermectine, son procede de preparation et son utilisation
GB0623838D0 (en) * 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
EP1955695A1 (en) * 2007-02-06 2008-08-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nanocapsules of lipophilic complexes of nucleic acids
FR2916973B1 (fr) 2007-06-11 2010-02-26 Univ Angers Nanocapsules a coeur lipidique chargees en actif(s) hydrosoluble(s) ou hydrodispersible(s)
FR2916974B1 (fr) * 2007-06-11 2010-11-26 Univ Angers Procede de preparation de nanoparticules lipidiques
FR2917976B1 (fr) * 2007-06-29 2010-05-28 Galderma Sa Composition dermatologique comprenant des vehicules lipidiques de calcitriol, son procede de preparation et son utilisation
EP2036577A1 (de) * 2007-09-14 2009-03-18 mivenion GmbH Diagnostische Stoffe für die optische bildgebende Untersuchung auf der Basis von nanopartikulären Formulierungen
EP2039352A1 (en) * 2007-09-18 2009-03-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Aqueous-core lipid nanocapsules for encapsulating hydrophilic and/or lipophilic molecules
FR2934954B1 (fr) 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
FR2934953B1 (fr) 2008-08-14 2011-01-21 Commissariat Energie Atomique Nanoemulsions de nanocristaux
FR2934955B1 (fr) * 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
FR2939699B1 (fr) 2008-12-12 2011-05-06 Univ Angers Procede de preparation de nanoparticules lipidiques
FR2943544B1 (fr) 2009-03-31 2012-04-20 Univ Angers Procede de preparation de capsules lipidiques fonctionnalisees.
FR2949063B1 (fr) * 2009-08-11 2011-09-30 Pf Medicament Composition pharmaceutique comprenant un ester de dha destinee a etre administree par voie parenterale
FR2950253B1 (fr) * 2009-09-24 2011-09-23 Ethypharm Sa Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
KR20240119180A (ko) * 2011-01-24 2024-08-06 안테리오스, 인코퍼레이티드 나노입자 조성물, 이의 제형, 및 그의 용도
US9492398B2 (en) 2011-02-25 2016-11-15 Eydo Pharma Nanocapsulation of essential oils for preventing or curing infectious diseases alone or with an antibiotic
FR2988609B1 (fr) * 2012-03-30 2015-09-04 Commissariat Energie Atomique Formulation pour l'hormonotherapie
US10511150B2 (en) 2012-04-06 2019-12-17 Furukawa Electric Co., Ltd. Wavelength-variable laser
WO2013178749A1 (fr) 2012-06-01 2013-12-05 Galderma Research & Development Nanocapsules lipidiques comprenant un rétinoide, nanodispersion et composition les contenant, leur procédé de préparation et leur utilisation en dermatologie
PL3795141T3 (pl) * 2013-01-14 2025-11-12 Infirst Healthcare Limited Kompozycje w postaci roztworu stałego
EP2789619A1 (en) 2013-04-12 2014-10-15 Kemotech S.r.l. Pharmaceutical compounds wiht angiogenesis inbhibitory activity
FR3008900B1 (fr) 2013-07-25 2018-03-30 Centre Nat Rech Scient Nanoparticules lipidiques multicompartimentees
US10302819B2 (en) * 2013-11-22 2019-05-28 Dsm Ip Assets B.V. Process for making an anti-reflective coating composition and a porous coating made therefrom
US10772807B2 (en) 2013-12-04 2020-09-15 Galderma Research & Development Lipid microcapsules preferably comprising a retinoid, and composition containing same, method for the production thereof, and use of same in dermatology
FR3017294B1 (fr) * 2014-02-07 2021-10-01 Atlangram Nanoparticules lipidiques comprenant un antibiotique et leurs utilisations en therapie
AU2015265874B2 (en) * 2014-05-30 2020-05-14 AbbVie Deutschland GmbH & Co. KG Highly drug-loaded poly(alkyl 2-cyanoacrylate) nanocapsules
JP2016163851A (ja) * 2015-03-06 2016-09-08 国立大学法人福井大学 コンポジット型可溶化ナノリポソーム及びその製造方法
EP3302421B1 (fr) 2015-05-29 2021-07-07 Galderma Research & Development Compositions comprenant au moins un principe actif disperse et des microcapsules lipidiques
CN117731591A (zh) 2016-11-21 2024-03-22 艾里奥治疗公司 大试剂的透皮递送
JPWO2018180966A1 (ja) * 2017-03-28 2019-06-27 富士フイルム株式会社 マイクロカプセル及びその製造方法
AU2018307361A1 (en) * 2017-07-27 2020-03-12 Locus Ip Company, Llc Compositions for enhancing bioavailability of pharmaceuticals, supplements and ingested substances
EP3453386A1 (en) 2017-09-08 2019-03-13 Universite D'angers Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof
GB201721832D0 (en) * 2017-12-22 2018-02-07 Waterford Institute Of Tech Ocular drug delivery
WO2020021052A2 (en) 2018-07-27 2020-01-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of acyclic terpene alcohols for enhancing the antimicrobial activity of colistin
EP3679928A1 (fr) 2019-01-08 2020-07-15 Atlangram Composition pharmaceutique de type gel pour traiter/prevenir une infection
IT201900009258A1 (it) 2019-06-17 2020-12-17 R Bio Transfer S R L Metodo per la preparazione di nanoparticelle lipidiche
FR3099069A1 (fr) * 2019-07-24 2021-01-29 Université D`Angers Procede continu de nano-emulsification par inversion de phase en concentration
CN112773776B (zh) * 2019-11-11 2023-06-20 上海胜联医药科技有限公司 一种载药纳米粒体系
CN115006369B (zh) * 2021-03-03 2023-08-29 浙江大学 一种脑靶向类脂纳米囊载药系统及其制备方法和应用
IT202100023570A1 (it) 2021-09-13 2023-03-13 Bioema S R L S Biotecnologia Energia Mat Ambiente Metodo per la preparazione di nanoparticelle lipidiche

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5174930A (en) * 1986-12-31 1992-12-29 Centre National De La Recherche Scientifique (Cnrs) Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions
CA2068216C (en) * 1989-11-13 1999-04-13 Abraham J. Domb Lipospheres for controlled delivery of substances
FR2659554B1 (fr) * 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
FR2681248B1 (fr) * 1991-09-13 1995-04-28 Oreal Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau.
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
FR2692167B1 (fr) 1992-06-16 1994-09-16 Centre Nat Rech Scient Préparation et application de nouveaux systèmes colloïdaux nanovésiculaires dispersibles à base de cyclodextrine, sous forme de nanocapsules.
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
DE4337030A1 (de) * 1993-10-29 1995-05-04 Henkel Kgaa Verfahren zur Herstellung von Wachsdispersionen
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
US5578298A (en) * 1994-05-27 1996-11-26 General Electric Company Microemulsions for high viscosity amino silicone fluids and gums and their preparation
FR2725369B1 (fr) * 1994-10-07 1997-01-03 Oreal Composition cosmetique ou dermatologique constituee d'une emulsion huile dans eau a base de globules huileux pourvus d'un enrobage cristal liquide lamellaire
US6245349B1 (en) * 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
FR2755856B1 (fr) * 1996-11-21 1999-01-29 Merck Clevenot Laboratoires Microcapsules de chitine ou de derives de chitine contenant une substance hydrophobe, notamment un filtre solaire et procede de preparation de telles microcapsules
PL192080B1 (pl) * 1997-07-29 2006-08-31 Upjohn Co Kompozycja farmaceutyczna zawierająca związek piranonowy
TWI241915B (en) * 1998-05-11 2005-10-21 Ciba Sc Holding Ag A method of preparing a pharmaceutical end formulation using a nanodispersion
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions

Also Published As

Publication number Publication date
SI1265698T1 (en) 2004-10-31
ZA200206985B (en) 2003-10-07
AU2001240753B2 (en) 2005-04-14
US8057823B2 (en) 2011-11-15
AU4075301A (en) 2001-09-12
CA2401766A1 (fr) 2001-09-07
KR20030003692A (ko) 2003-01-10
MXPA02008638A (es) 2004-09-06
FR2805761B1 (fr) 2002-08-30
DE60103863T2 (de) 2005-06-30
ATE269154T1 (de) 2004-07-15
JP2003525257A (ja) 2003-08-26
HUP0300209A2 (hu) 2003-06-28
BR0108921A (pt) 2003-01-21
WO2001064328A1 (fr) 2001-09-07
US20030152635A1 (en) 2003-08-14
CN1257011C (zh) 2006-05-24
PT1265698E (pt) 2004-11-30
TR200401812T4 (tr) 2004-09-21
CN1419472A (zh) 2003-05-21
ES2221640T3 (es) 2005-01-01
NO20024181L (no) 2002-10-22
DE60103863D1 (de) 2004-07-22
BR0108921B1 (pt) 2014-09-30
HU226483B1 (en) 2009-03-02
US20090238865A1 (en) 2009-09-24
BRPI0108921B8 (pt) 2021-05-25
EP1265698B1 (fr) 2004-06-16
JP4790187B2 (ja) 2011-10-12
HUP0300209A3 (en) 2005-04-28
NO20024181D0 (no) 2002-09-02
CA2401766C (fr) 2009-05-19
IL151560A0 (en) 2003-04-10
FR2805761A1 (fr) 2001-09-07
NO334188B1 (no) 2014-01-13
KR100638527B1 (ko) 2006-10-25
EP1265698A1 (fr) 2002-12-18

Similar Documents

Publication Publication Date Title
DK1265698T3 (da) Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament
ATE253912T1 (de) Verwendung von nikotinergen acetylcholinrezeptor- agonisten zur herstellung eines medikaments zur behandlung von keratoconjuctivitis sicca
JP2004525194A5 (xx)
DE69202207D1 (de) Verfahren zur Herstellung von 1-Chlor-1,1,3,3,3-Pentafluorpropan und von 1,1,1,3,3,3-Hexafluorpropan.
NO964639L (no) Substituerte sulfonimidamider, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
PT1255531E (pt) Preparacao para o bronzeamento da pele
ATE397972T1 (de) Verfahren zur herstellung einer mehrfach- wasser/öl/wasser-emulsion
NO20033305L (no) Nytt filmbelegg
WO2020173431A3 (zh) 包含抗cd47抗体的制剂及其制备方法和用途
DK0799035T3 (da) Emulsion egnet til indgivelse af et sphingolipid og anvendelse deraf
FR2697418B1 (fr) Assise multipositions notamment pour personnes handicapées.
NO960364L (no) Basisk-substituerte benzolguanidiner, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
DE59407043D1 (de) Wässrige Wachs- und Silicondispersionen, deren Herstellung und Verwendung
BR9902639B1 (pt) processo para preparação de acetato de vinila bruto, lìquido.
ITTO20010264A0 (it) Procedimento per l'aggiornamento delle condizioni di programmazione di server di rete, relativo sistema e prodotto informatico.
ITMO20020221A1 (it) Cannula per l'erogazione di prodotti fluidi, particolarmente pomate, creme e paste medicinali o simili.
JP2002275230A5 (xx)
BR0313230A (pt) Uso de carboxamidas para o tratamento de tinido
NO964905D0 (no) Substituerte benzendikarboksylsyre-diguanidiner, fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
JP2001106610A5 (xx)
ATA20322000A (de) Verfahren zur herstellung von zumindest einseitig beschichteten warm- oder kaltprodukten in form eines bandes
ITRM20000433A0 (it) Uso di fibrati per la preparazione di un medicamento utile nel trattamento dell'insufficenza cardiaca congestizia.
NO952308L (no) Anvendelse av ruluzoler som radiorestaurator
ITMO20030036A0 (it) Sistema infusionale per la somministrazione di liquido medicale,diagnostico o simile.
NO20021857D0 (no) 5-halo-4-fluor-4,7,7-trimetyl-3-oksabicyklo[4.1.0]heptan-2- on, dets fremstilling samt dets anvendelse for fremstilling avcyklopropankarboksylsyrer