[go: up one dir, main page]

NO20024181D0 - Lipidnanokapsler, fremgangsmåte for fremstilling derav, samt anvendelse av medikamentet - Google Patents

Lipidnanokapsler, fremgangsmåte for fremstilling derav, samt anvendelse av medikamentet

Info

Publication number
NO20024181D0
NO20024181D0 NO20024181A NO20024181A NO20024181D0 NO 20024181 D0 NO20024181 D0 NO 20024181D0 NO 20024181 A NO20024181 A NO 20024181A NO 20024181 A NO20024181 A NO 20024181A NO 20024181 D0 NO20024181 D0 NO 20024181D0
Authority
NO
Norway
Prior art keywords
nanocapsules
lipid
drug
preparation
producing
Prior art date
Application number
NO20024181A
Other languages
English (en)
Other versions
NO20024181L (no
NO334188B1 (no
Inventor
Beatrice Heurtault
Patrick Saulnier
Jean-Pierre Benoit
Jacques-Emilie Proust
Brigitte Pech
Joel Richard
Original Assignee
Univ Angers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Angers filed Critical Univ Angers
Publication of NO20024181D0 publication Critical patent/NO20024181D0/no
Publication of NO20024181L publication Critical patent/NO20024181L/no
Publication of NO334188B1 publication Critical patent/NO334188B1/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0026—Preparation of sols containing a liquid organic phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/017—Mixtures of compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/14—Derivatives of phosphoric acid
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/34—Higher-molecular-weight carboxylic acid esters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20024181A 2000-03-02 2002-09-02 Lipidnanokapsler, fremgangsmåte for fremstilling derav, samt deres anvendelse NO334188B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0002688A FR2805761B1 (fr) 2000-03-02 2000-03-02 Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
PCT/FR2001/000621 WO2001064328A1 (fr) 2000-03-02 2001-03-02 Nanocapsules lipidiques, procede de preparation et utilisation comme medicament

Publications (3)

Publication Number Publication Date
NO20024181D0 true NO20024181D0 (no) 2002-09-02
NO20024181L NO20024181L (no) 2002-10-22
NO334188B1 NO334188B1 (no) 2014-01-13

Family

ID=8847644

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024181A NO334188B1 (no) 2000-03-02 2002-09-02 Lipidnanokapsler, fremgangsmåte for fremstilling derav, samt deres anvendelse

Country Status (22)

Country Link
US (2) US8057823B2 (no)
EP (1) EP1265698B1 (no)
JP (1) JP4790187B2 (no)
KR (1) KR100638527B1 (no)
CN (1) CN1257011C (no)
AT (1) ATE269154T1 (no)
AU (2) AU4075301A (no)
BR (1) BRPI0108921B8 (no)
CA (1) CA2401766C (no)
DE (1) DE60103863T2 (no)
DK (1) DK1265698T3 (no)
ES (1) ES2221640T3 (no)
FR (1) FR2805761B1 (no)
HU (1) HU226483B1 (no)
IL (1) IL151560A0 (no)
MX (1) MXPA02008638A (no)
NO (1) NO334188B1 (no)
PT (1) PT1265698E (no)
SI (1) SI1265698T1 (no)
TR (1) TR200401812T4 (no)
WO (1) WO2001064328A1 (no)
ZA (1) ZA200206985B (no)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0104698D0 (en) * 2001-02-26 2001-04-11 Syngenta Ltd Process for producing microcapsules
FR2835430A1 (fr) * 2002-05-31 2003-08-08 Oreal Composition comprenant des nanocapsules enrobees de lecithine et un polymere d'acrylamide
FR2840532B1 (fr) * 2002-06-11 2005-05-06 Ethypharm Sa Nanocapsules lipidiques furtives, procede de preparation et utilisation comme vecteur de principes(s) actif(s)
US20050214378A1 (en) * 2002-06-11 2005-09-29 Ethypharm Stealth lipid nanocapsules, methods for the preparation thereof and use thereof as a carrier for active principle(s)
CA2504329C (en) 2002-11-01 2013-08-20 Biodelivery Sciences International, Inc. Geodate delivery vehicles
FR2849379B1 (fr) * 2002-12-26 2005-02-11 Cosnessens Encapsulation d'actifs liposolubles
EP1596840A1 (en) * 2003-02-12 2005-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of p-glycoprotein inhibitor surfactants at the surface of a colloidal carrier
FR2864900B1 (fr) 2004-01-09 2007-10-12 Oreal Dispersion aqueuse de nanocapsules a coeur huileux
US20110135734A1 (en) * 2004-04-20 2011-06-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method For the Preparation of Nanoparticles From Nanoemulsions
DE102005037844A1 (de) * 2005-08-04 2007-04-05 Intendis Gmbh Wasserfreies Mehr-Phasen-Gel-System
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
FR2907012B1 (fr) 2006-10-12 2012-09-21 Galderma Sa Composition dermatologique comprenant des nanocapsules d'avermectine, son procede de preparation et son utilisation
GB0623838D0 (en) 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
EP1955695A1 (en) * 2007-02-06 2008-08-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nanocapsules of lipophilic complexes of nucleic acids
FR2916974B1 (fr) 2007-06-11 2010-11-26 Univ Angers Procede de preparation de nanoparticules lipidiques
FR2916973B1 (fr) * 2007-06-11 2010-02-26 Univ Angers Nanocapsules a coeur lipidique chargees en actif(s) hydrosoluble(s) ou hydrodispersible(s)
FR2917976B1 (fr) * 2007-06-29 2010-05-28 Galderma Sa Composition dermatologique comprenant des vehicules lipidiques de calcitriol, son procede de preparation et son utilisation
EP2036577A1 (de) * 2007-09-14 2009-03-18 mivenion GmbH Diagnostische Stoffe für die optische bildgebende Untersuchung auf der Basis von nanopartikulären Formulierungen
EP2039352A1 (en) * 2007-09-18 2009-03-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Aqueous-core lipid nanocapsules for encapsulating hydrophilic and/or lipophilic molecules
FR2934954B1 (fr) 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
FR2934955B1 (fr) * 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
FR2934953B1 (fr) 2008-08-14 2011-01-21 Commissariat Energie Atomique Nanoemulsions de nanocristaux
FR2939699B1 (fr) * 2008-12-12 2011-05-06 Univ Angers Procede de preparation de nanoparticules lipidiques
FR2943544B1 (fr) 2009-03-31 2012-04-20 Univ Angers Procede de preparation de capsules lipidiques fonctionnalisees.
FR2949063B1 (fr) * 2009-08-11 2011-09-30 Pf Medicament Composition pharmaceutique comprenant un ester de dha destinee a etre administree par voie parenterale
FR2950253B1 (fr) 2009-09-24 2011-09-23 Ethypharm Sa Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
SG10201804552WA (en) * 2011-01-24 2018-07-30 Anterios Inc Nanoparticle compositions, formulations thereof, and uses therefor
CA2827239A1 (en) 2011-02-25 2012-08-30 Universite D'angers Nanocapsulation of essential oils for preventing or curing infectious diseases alone or with an antibiotic
FR2988609B1 (fr) * 2012-03-30 2015-09-04 Commissariat Energie Atomique Formulation pour l'hormonotherapie
US10511150B2 (en) 2012-04-06 2019-12-17 Furukawa Electric Co., Ltd. Wavelength-variable laser
WO2013178749A1 (fr) 2012-06-01 2013-12-05 Galderma Research & Development Nanocapsules lipidiques comprenant un rétinoide, nanodispersion et composition les contenant, leur procédé de préparation et leur utilisation en dermatologie
RU2674982C2 (ru) * 2013-01-14 2018-12-14 ИнФерст Хэлткэр Лимитед Композиции твердых растворов и их применение при сердечно-сосудистом заболевании
EP2789619A1 (en) 2013-04-12 2014-10-15 Kemotech S.r.l. Pharmaceutical compounds wiht angiogenesis inbhibitory activity
FR3008900B1 (fr) 2013-07-25 2018-03-30 Centre Nat Rech Scient Nanoparticules lipidiques multicompartimentees
ES2959939T3 (es) * 2013-11-22 2024-02-29 Covestro Netherlands Bv Procedimiento de fabricación de una composición de recubrimiento antirreflectante y de un recubrimiento poroso fabricado a partir de la misma
JP2016539150A (ja) * 2013-12-04 2016-12-15 ガルデルマ・リサーチ・アンド・デヴェロップメント 好ましくはレチノイドを含む脂質マイクロカプセル、及びそれを含有する組成物、それらの製造のための方法、並びに皮膚科学におけるそれらの使用
FR3017294B1 (fr) * 2014-02-07 2021-10-01 Atlangram Nanoparticules lipidiques comprenant un antibiotique et leurs utilisations en therapie
AU2015265874B2 (en) * 2014-05-30 2020-05-14 AbbVie Deutschland GmbH & Co. KG Highly drug-loaded poly(alkyl 2-cyanoacrylate) nanocapsules
JP2016163851A (ja) * 2015-03-06 2016-09-08 国立大学法人福井大学 コンポジット型可溶化ナノリポソーム及びその製造方法
WO2016193588A1 (fr) 2015-05-29 2016-12-08 Galderma Research & Development Compositions comprenant au moins un principe actif disperse et des microcapsules lipidiques
BR112019010131A2 (pt) 2016-11-21 2019-10-08 Eirion Therapeutics Inc entrega transdérmica de agentes grandes
WO2018180966A1 (ja) 2017-03-28 2018-10-04 富士フイルム株式会社 マイクロカプセル及びその製造方法
BR112020001759A2 (pt) * 2017-07-27 2020-07-21 Locus Ip Company, Llc composições para a intensificação da biodisponibilidade de produtos farmacêuticos, suplementos e substâncias ingeridas
EP3453386A1 (en) 2017-09-08 2019-03-13 Universite D'angers Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof
GB201721832D0 (en) * 2017-12-22 2018-02-07 Waterford Institute Of Tech Ocular drug delivery
WO2020021052A2 (en) 2018-07-27 2020-01-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of acyclic terpene alcohols for enhancing the antimicrobial activity of colistin
EP3679928A1 (fr) 2019-01-08 2020-07-15 Atlangram Composition pharmaceutique de type gel pour traiter/prevenir une infection
IT201900009258A1 (it) 2019-06-17 2020-12-17 R Bio Transfer S R L Metodo per la preparazione di nanoparticelle lipidiche
FR3099069A1 (fr) * 2019-07-24 2021-01-29 Université D`Angers Procede continu de nano-emulsification par inversion de phase en concentration
CN112773776B (zh) * 2019-11-11 2023-06-20 上海胜联医药科技有限公司 一种载药纳米粒体系
CN115006369B (zh) * 2021-03-03 2023-08-29 浙江大学 一种脑靶向类脂纳米囊载药系统及其制备方法和应用
IT202100023570A1 (it) 2021-09-13 2023-03-13 Bioema S R L S Biotecnologia Energia Mat Ambiente Metodo per la preparazione di nanoparticelle lipidiche

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US5174930A (en) * 1986-12-31 1992-12-29 Centre National De La Recherche Scientifique (Cnrs) Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
AU655162B2 (en) * 1989-11-13 1994-12-08 Nova Pharmaceutical Corporation Lipospheres for controlled delivery of substances
FR2659554B1 (fr) 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
FR2681248B1 (fr) * 1991-09-13 1995-04-28 Oreal Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau.
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
FR2692167B1 (fr) * 1992-06-16 1994-09-16 Centre Nat Rech Scient Préparation et application de nouveaux systèmes colloïdaux nanovésiculaires dispersibles à base de cyclodextrine, sous forme de nanocapsules.
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
DE4337030A1 (de) * 1993-10-29 1995-05-04 Henkel Kgaa Verfahren zur Herstellung von Wachsdispersionen
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
US5578298A (en) * 1994-05-27 1996-11-26 General Electric Company Microemulsions for high viscosity amino silicone fluids and gums and their preparation
FR2725369B1 (fr) * 1994-10-07 1997-01-03 Oreal Composition cosmetique ou dermatologique constituee d'une emulsion huile dans eau a base de globules huileux pourvus d'un enrobage cristal liquide lamellaire
US6245349B1 (en) * 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
FR2755856B1 (fr) * 1996-11-21 1999-01-29 Merck Clevenot Laboratoires Microcapsules de chitine ou de derives de chitine contenant une substance hydrophobe, notamment un filtre solaire et procede de preparation de telles microcapsules
ES2174462T3 (es) * 1997-07-29 2002-11-01 Upjohn Co Formulacion autoestimulante para compuestos lipofilos.
TWI241915B (en) * 1998-05-11 2005-10-21 Ciba Sc Holding Ag A method of preparing a pharmaceutical end formulation using a nanodispersion
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions

Also Published As

Publication number Publication date
JP2003525257A (ja) 2003-08-26
AU4075301A (en) 2001-09-12
AU2001240753B2 (en) 2005-04-14
ZA200206985B (en) 2003-10-07
IL151560A0 (en) 2003-04-10
NO20024181L (no) 2002-10-22
US20030152635A1 (en) 2003-08-14
BR0108921B1 (pt) 2014-09-30
EP1265698B1 (fr) 2004-06-16
KR100638527B1 (ko) 2006-10-25
CA2401766A1 (fr) 2001-09-07
HUP0300209A3 (en) 2005-04-28
TR200401812T4 (tr) 2004-09-21
DK1265698T3 (da) 2004-10-25
EP1265698A1 (fr) 2002-12-18
CA2401766C (fr) 2009-05-19
MXPA02008638A (es) 2004-09-06
US8057823B2 (en) 2011-11-15
CN1419472A (zh) 2003-05-21
FR2805761A1 (fr) 2001-09-07
BRPI0108921B8 (pt) 2021-05-25
CN1257011C (zh) 2006-05-24
HU226483B1 (en) 2009-03-02
BR0108921A (pt) 2003-01-21
PT1265698E (pt) 2004-11-30
ATE269154T1 (de) 2004-07-15
FR2805761B1 (fr) 2002-08-30
NO334188B1 (no) 2014-01-13
DE60103863T2 (de) 2005-06-30
DE60103863D1 (de) 2004-07-22
ES2221640T3 (es) 2005-01-01
JP4790187B2 (ja) 2011-10-12
HUP0300209A2 (hu) 2003-06-28
SI1265698T1 (en) 2004-10-31
US20090238865A1 (en) 2009-09-24
KR20030003692A (ko) 2003-01-10
WO2001064328A1 (fr) 2001-09-07

Similar Documents

Publication Publication Date Title
NO20024181D0 (no) Lipidnanokapsler, fremgangsmåte for fremstilling derav, samt anvendelse av medikamentet
RU2159761C2 (ru) Замещенные 4-биарилмасляные или 5-биарилпентановые кислоты или их производные, способы их получения, фармацевтическая композиция и способ лечения
ATE253912T1 (de) Verwendung von nikotinergen acetylcholinrezeptor- agonisten zur herstellung eines medikaments zur behandlung von keratoconjuctivitis sicca
NO991942D0 (no) FremgangsmÕte for fremstilling av malonat metyliden nanopartikler, nanopartikler eventuelt inneholdende en eller flere biologisk aktive molekyler
AU2002216097A1 (en) Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
DE69202207D1 (de) Verfahren zur Herstellung von 1-Chlor-1,1,3,3,3-Pentafluorpropan und von 1,1,1,3,3,3-Hexafluorpropan.
WO2004069169A3 (en) Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same
ATE464050T1 (de) Aripiprazole wirkstoff mit niedriger hygroskopie und verfahren zu ihrer herstellung
NO940319D0 (no) Framstilling av mikropartikler
NL193956B (nl) Werkwijze voor het regelen van de geleringssnelheid in een waterige breekvloeistof.
ATE429903T1 (de) Pharmazeutische zubereitung mit verzögerter wirkstoff-freisetzung enthaltend milchsäure- glycolsäure copolymer, und verfahren zu deren herstellung
NO20033305L (no) Nytt filmbelegg
ES2108138T3 (es) Matriz termocoloide controlada por la forma sol a base de gelatina para formas perorales de liberacion retardada.
DE59407043D1 (de) Wässrige Wachs- und Silicondispersionen, deren Herstellung und Verwendung
ITTO20010264A0 (it) Procedimento per l'aggiornamento delle condizioni di programmazione di server di rete, relativo sistema e prodotto informatico.
ITMO20020221A1 (it) Cannula per l'erogazione di prodotti fluidi, particolarmente pomate, creme e paste medicinali o simili.
RU2004112422A (ru) Роувастатин в преддеменционных состояниях
DE59600661D1 (de) Verfahren zur Herstellung von d,I-Menthol
TR199700109A2 (tr) Sübstitüe edilmis olan tiofenilalkenil karbonik asit guanidid'leri, bunlarin üretilmesine mahsus usul, bunlarin ilac veya diyagnostik olarak kullanilmalari ve bunlari iceren ilac.
JP2001106610A5 (no)
AU2002311175A1 (en) 3,3-dialkoxy-2-hydroxyiminopropionitriles, process for preparation thereof and process of preparing 5-amino -4-nitrosopyrazoles or salts thereof by the use of the same
IT9083632A0 (it) Procedimento di trasformazione e utilizzazione tridimensionale degli spazi di veicoli, particolarmente destinati all'esercizio di negozi itineranti quali bancarelle e simili
ITRG980002A1 (it) Metodo sull'uso dell'nacl per la preparazione di farmaci e alimenti per la cura e la profilassi della leishmaniosi.
TH21240A (th) ควิโนแซลีน กรรมวิธีสำหรับการเตรียมสารเหล่านี้และการใช้สารเหล่านี้
ITMI20000079A0 (it) Metodo per la preparazione di essenze e rimedi floreali particolarmente idonei per la floriterapia

Legal Events

Date Code Title Description
MK1K Patent expired