DK1105387T3 - Prolægemidler for protonpumpeinhibitorer - Google Patents
Prolægemidler for protonpumpeinhibitorerInfo
- Publication number
- DK1105387T3 DK1105387T3 DK99942057T DK99942057T DK1105387T3 DK 1105387 T3 DK1105387 T3 DK 1105387T3 DK 99942057 T DK99942057 T DK 99942057T DK 99942057 T DK99942057 T DK 99942057T DK 1105387 T3 DK1105387 T3 DK 1105387T3
- Authority
- DK
- Denmark
- Prior art keywords
- proton pump
- prodrugs
- drugs
- pump inhibitor
- inhibitor drugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Fertilizing (AREA)
- Reciprocating Pumps (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/131,481 US6093734A (en) | 1998-08-10 | 1998-08-10 | Prodrugs of proton pump inhibitors |
| US36438199A | 1999-07-29 | 1999-07-29 | |
| PCT/US1999/018048 WO2000009498A1 (fr) | 1998-08-10 | 1999-08-09 | Promedicaments d'inhibiteurs de la pompe a protons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1105387T3 true DK1105387T3 (da) | 2003-06-23 |
Family
ID=26829517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99942057T DK1105387T3 (da) | 1998-08-10 | 1999-08-09 | Prolægemidler for protonpumpeinhibitorer |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6559167B1 (fr) |
| EP (1) | EP1105387B1 (fr) |
| JP (1) | JP4346243B2 (fr) |
| KR (1) | KR100472126B1 (fr) |
| CN (1) | CN100396675C (fr) |
| AT (1) | ATE231857T1 (fr) |
| AU (1) | AU752292B2 (fr) |
| BG (1) | BG64870B1 (fr) |
| BR (1) | BR9912937A (fr) |
| CA (1) | CA2338311C (fr) |
| DE (1) | DE69905171T2 (fr) |
| DK (1) | DK1105387T3 (fr) |
| ES (1) | ES2192394T3 (fr) |
| FI (1) | FI20010248A7 (fr) |
| HR (1) | HRP20010106A2 (fr) |
| HU (1) | HUP0103464A3 (fr) |
| ID (1) | ID28273A (fr) |
| IL (2) | IL141083A0 (fr) |
| IS (1) | IS5826A (fr) |
| MX (1) | MXPA01001464A (fr) |
| NO (1) | NO322490B1 (fr) |
| NZ (1) | NZ510180A (fr) |
| PL (1) | PL346000A1 (fr) |
| TR (1) | TR200100431T2 (fr) |
| UA (1) | UA67788C2 (fr) |
| WO (1) | WO2000009498A1 (fr) |
| YU (1) | YU10101A (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1453493A2 (fr) * | 2001-11-19 | 2004-09-08 | ALTANA Pharma AG | Inhibiteurs reversibles de la pompe a protons pour le traitement des troubles des voies aeriennes |
| PT1556371E (pt) * | 2002-07-19 | 2006-09-29 | Winston Pharmateuticals Llc | Derivados de benzimidazole e sua utilizacao como pro-farmacos de inibadores da bomba de protoes. |
| JP2006188432A (ja) * | 2003-02-25 | 2006-07-20 | Zeria Pharmaceut Co Ltd | 四環系スルフェンアミド化合物 |
| AU2004264401A1 (en) * | 2003-07-15 | 2005-02-24 | Allergan, Inc. | Process for preparing isomerically pure prodrugs of proton pump inhibitors |
| JP2007507425A (ja) * | 2003-08-29 | 2007-03-29 | ダイノゲン ファーマシューティカルズ，インコーポレイテッド | 胃腸管運動障害を処置するために有用な組成物 |
| TWI372066B (en) * | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
| US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
| WO2005039640A1 (fr) * | 2003-10-03 | 2005-05-06 | Allergan Inc. | Compositions contenant des peptides en trefle et/ou des mucoadhesifs et des promedicaments d'un inhibiteur de pompe a proton |
| JP2007523164A (ja) * | 2004-02-18 | 2007-08-16 | アラーガン、インコーポレイテッド | プロトンポンプインヒビターに関連する化合物の静脈内投与のための方法および組成物 |
| WO2005082337A2 (fr) * | 2004-02-18 | 2005-09-09 | Allergan, Inc. | Methodes et compositions d'administration de promedicaments d'inhibiteurs de la pompe a protons |
| AU2005249367A1 (en) * | 2004-04-16 | 2005-12-15 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
| WO2005105786A1 (fr) * | 2004-04-28 | 2005-11-10 | Hetero Drugs Limited | Methode servant a preparer des composes de pyridinylmethyl-1h-benzimidazole sous forme d'enantiomeres simples ou enrichis |
| EP1748998B1 (fr) * | 2004-05-28 | 2010-01-27 | Hetero Drugs Limited | Nouveau procede de synthese stereoselective de sulfoxydes de benzimidazole |
| BRPI0512239A (pt) * | 2004-06-17 | 2008-02-19 | Wyeth Corp | processos para preparação de antagonistas de receptores de hormÈnios liberadores de gonatropina |
| BRPI0512261A (pt) * | 2004-06-17 | 2008-02-26 | Wyeth Corp | antagonistas de receptor de hormÈnio liberador de gonadotropina |
| CA2581454A1 (fr) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Nouveaux composes de pyrimidine, leur procede de preparation, et compositions les contenant |
| EP1814866A2 (fr) * | 2004-11-23 | 2007-08-08 | Wyeth a Corporation of the State of Delaware | Antagonistes du recepteur d'hormone de liberation de gonadotropine |
| US7538113B2 (en) * | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) * | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7534796B2 (en) * | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US20060189619A1 (en) * | 2005-02-24 | 2006-08-24 | Wyeth | 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds |
| US20070015782A1 (en) | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
| US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) * | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| US20090036406A1 (en) * | 2005-06-13 | 2009-02-05 | Takeda Pharmaceutical Company Limited | Injection |
| WO2007073301A1 (fr) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Derives du benzoimidazole en tant que promedicaments d'inhibiteurs de la pompe a protons |
| WO2008036201A1 (fr) * | 2006-09-19 | 2008-03-27 | Alevium Pharmaceuticals, Inc. | Promédicaments d'inhibiteurs de pompes à protons comprenant le groupe fonctionnel 1h-imidazo[4,5-b] pyridine |
| US20100113524A1 (en) * | 2006-09-19 | 2010-05-06 | Garst Michael E | Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety |
| AU2007317561A1 (en) | 2006-10-27 | 2008-05-15 | The Curators Of The University Of Missouri | Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same |
| CN101497622B (zh) * | 2008-01-30 | 2011-04-27 | 山东轩竹医药科技有限公司 | 吡啶甲基亚磺酰基咪唑并吡啶衍生物 |
| AU2009215514B9 (en) | 2008-02-20 | 2014-01-30 | The Curators Of The University Of Missouri | Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same |
| UA100192C2 (en) * | 2008-11-11 | 2012-11-26 | УАЙТ ЭлЭлСи | 1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands |
| WO2014075575A1 (fr) * | 2012-11-19 | 2014-05-22 | 江苏豪森药业股份有限公司 | Dérivé pyrrole sulfonamide, procédé de préparation et application médicale associés |
| US9487485B2 (en) | 2013-02-28 | 2016-11-08 | Takeda Pharmaceutical Company Limited | Method for producing sulfonyl chloride compound |
| PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
| WO2020010003A1 (fr) | 2018-07-02 | 2020-01-09 | Incyte Corporation | DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ |
| JP2023527155A (ja) | 2020-05-20 | 2023-06-27 | エフ． ホフマン－ラ ロシュ アーゲー | 質量分析のための試薬 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
| SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| FI90544C (fi) | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
| US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| ES2140391T3 (es) * | 1990-06-20 | 2000-03-01 | Astra Ab | Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico. |
| SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| WO1995029897A1 (fr) * | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | Procede d'utilisation d'inhibiteurs de (h+/k+)atpase comme agents antiviraux |
| US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
| SE9602442D0 (sv) | 1996-06-20 | 1996-06-20 | Astra Ab | Administration of pharmaceuticals |
-
1999
- 1999-08-09 EP EP99942057A patent/EP1105387B1/fr not_active Expired - Lifetime
- 1999-08-09 AT AT99942057T patent/ATE231857T1/de not_active IP Right Cessation
- 1999-08-09 JP JP2000564950A patent/JP4346243B2/ja not_active Expired - Fee Related
- 1999-08-09 IL IL14108399A patent/IL141083A0/xx active IP Right Grant
- 1999-08-09 TR TR2001/00431T patent/TR200100431T2/xx unknown
- 1999-08-09 KR KR10-2001-7001705A patent/KR100472126B1/ko not_active Expired - Fee Related
- 1999-08-09 MX MXPA01001464A patent/MXPA01001464A/es not_active IP Right Cessation
- 1999-08-09 ID IDW20010545A patent/ID28273A/id unknown
- 1999-08-09 CA CA002338311A patent/CA2338311C/fr not_active Expired - Lifetime
- 1999-08-09 HR HR20010106A patent/HRP20010106A2/hr not_active Application Discontinuation
- 1999-08-09 DE DE69905171T patent/DE69905171T2/de not_active Expired - Lifetime
- 1999-08-09 HU HU0103464A patent/HUP0103464A3/hu unknown
- 1999-08-09 DK DK99942057T patent/DK1105387T3/da active
- 1999-08-09 YU YU10101A patent/YU10101A/sh unknown
- 1999-08-09 NZ NZ510180A patent/NZ510180A/xx not_active IP Right Cessation
- 1999-08-09 PL PL99346000A patent/PL346000A1/xx not_active IP Right Cessation
- 1999-08-09 CN CNB998095125A patent/CN100396675C/zh not_active Expired - Fee Related
- 1999-08-09 WO PCT/US1999/018048 patent/WO2000009498A1/fr not_active Ceased
- 1999-08-09 ES ES99942057T patent/ES2192394T3/es not_active Expired - Lifetime
- 1999-08-09 BR BR9912937-0A patent/BR9912937A/pt not_active Application Discontinuation
- 1999-08-09 AU AU55518/99A patent/AU752292B2/en not_active Expired
- 1999-09-08 UA UA2001020908A patent/UA67788C2/uk unknown
-
2001
- 2001-01-24 IL IL141083A patent/IL141083A/en not_active IP Right Cessation
- 2001-01-26 BG BG105191A patent/BG64870B1/bg unknown
- 2001-01-26 IS IS5826A patent/IS5826A/is unknown
- 2001-02-09 FI FI20010248A patent/FI20010248A7/fi unknown
- 2001-02-09 NO NO20010693A patent/NO322490B1/no not_active IP Right Cessation
- 2001-02-14 US US09/783,807 patent/US6559167B1/en not_active Expired - Lifetime
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