DK1181294T3 - Hidtil ukendte derivater og analoger af galanthamin - Google Patents
Hidtil ukendte derivater og analoger af galanthaminInfo
- Publication number
- DK1181294T3 DK1181294T3 DK01914813T DK01914813T DK1181294T3 DK 1181294 T3 DK1181294 T3 DK 1181294T3 DK 01914813 T DK01914813 T DK 01914813T DK 01914813 T DK01914813 T DK 01914813T DK 1181294 T3 DK1181294 T3 DK 1181294T3
- Authority
- DK
- Denmark
- Prior art keywords
- galanthamine
- analogs
- novel derivatives
- derivatives
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT5462000 | 2000-03-31 | ||
| AT2382001 | 2001-02-15 | ||
| PCT/AT2001/000082 WO2001074820A1 (de) | 2000-03-31 | 2001-03-22 | Neue derivate und analoga von galanthamin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1181294T3 true DK1181294T3 (da) | 2004-08-02 |
Family
ID=25608130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01914813T DK1181294T3 (da) | 2000-03-31 | 2001-03-22 | Hidtil ukendte derivater og analoger af galanthamin |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7166588B2 (da) |
| EP (1) | EP1181294B1 (da) |
| JP (1) | JP2003529602A (da) |
| CN (1) | CN1380883A (da) |
| AT (1) | ATE263171T1 (da) |
| AU (1) | AU785385B2 (da) |
| BG (1) | BG65134B1 (da) |
| BR (1) | BR0105563A (da) |
| CA (1) | CA2368966A1 (da) |
| CZ (1) | CZ300160B6 (da) |
| DE (1) | DE50101827D1 (da) |
| DK (1) | DK1181294T3 (da) |
| ES (1) | ES2215885T3 (da) |
| HK (1) | HK1049832A1 (da) |
| HU (1) | HUP0202233A3 (da) |
| IS (1) | IS2287B (da) |
| MX (1) | MXPA01012275A (da) |
| NO (1) | NO326458B1 (da) |
| NZ (1) | NZ516302A (da) |
| PL (1) | PL202463B1 (da) |
| PT (1) | PT1181294E (da) |
| RU (1) | RU2241001C2 (da) |
| SI (1) | SI1181294T1 (da) |
| SK (1) | SK285909B6 (da) |
| TR (1) | TR200400857T4 (da) |
| WO (1) | WO2001074820A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4721386B2 (ja) * | 2001-07-10 | 2011-07-13 | 第一三共株式会社 | 新規ガランタミン類縁体 |
| AU2003205403A1 (en) * | 2002-03-25 | 2003-10-08 | Sanochemia Pharmazeutika Aktiengesellschaft | Methods for producing norgalanthamine, as well as isomers, salts and hydrates thereof |
| AT414125B (de) * | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
| AT500143A1 (de) * | 2004-04-22 | 2005-11-15 | Sanochemia Pharmazeutika Ag | Cholinesterase-inhibitoren in liposomen sowie deren herstellung und verwendung |
| US7877350B2 (en) * | 2005-06-27 | 2011-01-25 | Ab Initio Technology Llc | Managing metadata for graph-based computations |
| DE602006015338D1 (de) * | 2005-09-22 | 2010-08-19 | Galantos Pharma Gmbh | Cholinerge enhancer mit verbesserter durchgängigkeit durch die blut-hirn-schranke zur behandlung von krankheiten, die mit kognitiven störungen einhergehen |
| US20090253654A1 (en) | 2005-09-22 | 2009-10-08 | Galantos Pharma Gmbh | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
| WO2008022365A2 (de) * | 2006-08-24 | 2008-02-28 | Sanochemia Ltd. | Mittel zum beeinflussen der wirkungen von organophosphorverbindungen und verwendung von galanthamin, dessen derivaten und analoga zum herstellen solcher mittel |
| ES2463715T3 (es) | 2008-04-14 | 2014-05-29 | Neurodyn Life Sciences Inc. | Derivados de galantamina como profármacos para el tratamiento de enfermedades del cerebro humano |
| BG110141A (en) * | 2008-05-23 | 2009-12-31 | "Софарма" Ад | GALANTAMINE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USE |
| CN107066241B (zh) | 2010-06-15 | 2021-03-09 | 起元技术有限责任公司 | 用于动态加载基于图的计算的系统和方法 |
| WO2013160728A1 (en) | 2012-04-26 | 2013-10-31 | Alma Mater Studiorum - Universita' Di Bologna | Dual targeting compounds for the treatment of alzheimer's disease |
| US10108521B2 (en) * | 2012-11-16 | 2018-10-23 | Ab Initio Technology Llc | Dynamic component performance monitoring |
| JP6626823B2 (ja) | 2013-12-05 | 2019-12-25 | アビニシオ テクノロジー エルエルシー | サブグラフから構成されるデータフローグラフ用のインターフェースの管理 |
| EP3189418B1 (en) | 2014-09-02 | 2022-02-23 | AB Initio Technology LLC | Visually specifying subsets of components in graph-based programs through user interactions |
| AU2015312012B2 (en) | 2014-09-02 | 2020-02-27 | Ab Initio Technology Llc | Compiling graph-based program specifications |
| US10657134B2 (en) | 2015-08-05 | 2020-05-19 | Ab Initio Technology Llc | Selecting queries for execution on a stream of real-time data |
| US12006301B1 (en) | 2021-05-13 | 2024-06-11 | Florida A&M University | And synthesis of dual 5-HT1A and 5-HT7 receptor ligands |
| CN116082352A (zh) * | 2023-02-16 | 2023-05-09 | 西南交通大学 | 一种加兰他敏衍生物及其制备方法和用途 |
| CN118908968B (zh) * | 2024-10-09 | 2025-03-04 | 威胜生物医药(苏州)股份有限公司 | 一种加兰他敏中间体衍生物及其催化氧化制备方法 |
| CN119528922B (zh) * | 2024-11-22 | 2025-12-09 | 泰安汉威集团有限公司 | 一种氢溴酸加兰他敏关键杂质-氢溴酸表加兰他敏的手性合成方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947445A (en) * | 1974-05-09 | 1976-03-30 | Stanford Research Institute | Diazabicyclooctanes and diazabicycloheptanes |
| US4663318A (en) | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
| JP2755403B2 (ja) * | 1987-05-04 | 1998-05-20 | デイービス、ボニー | アルツハイマー病の治療のための化合物 |
| NL8800350A (nl) | 1988-02-12 | 1989-09-01 | Stichting Biomedical Research | Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen. |
| US4954502A (en) | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| US5336675A (en) * | 1991-05-14 | 1994-08-09 | Ernir Snorrason | Method of treating mania in humans |
| US5153193A (en) * | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
| US6323196B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6323195B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US5428159A (en) * | 1994-04-08 | 1995-06-27 | Ciba-Geigy Corporation | Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine |
| PL184590B1 (pl) * | 1994-10-21 | 2002-11-29 | Sanochemia Pharmazeutika Ag | Sposób wytwarzania pochodnych a heksahydro H benzofuro[ a ef][ ] benzoazepiny sposób odbromowania tych pochodnych sposób wytwarzania związków typu N demetylobromo i epibromo galantaminy oraz nowe związki z określonego zbioru |
| AT401058B (de) | 1994-10-21 | 1996-06-25 | Waldheim Pharmazeutika Gmbh | Verfahren zum herstellen von derivaten des 4a,5, 9,10,11,12,-hexahydro-6h-benzofuro(3a,-3,2-ef) (2)benzazepins |
| US6407229B1 (en) | 1994-10-21 | 2002-06-18 | Sanochemia Pharmazeutika Ag | Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine |
| GB9514821D0 (en) * | 1995-07-19 | 1995-09-20 | Sod Conseils Rech Applic | Galanthamine derivatives |
| GB9519268D0 (en) | 1995-09-21 | 1995-11-22 | Chiroscience Ltd | Preparation of alkaloids |
| AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| GB9716879D0 (en) * | 1997-08-08 | 1997-10-15 | Shire Int Licensing Bv | Treatment of attention deficit disorders |
| WO2000032199A1 (de) * | 1998-12-01 | 2000-06-08 | Sanochemia Pharmazeutika Aktiengesellschaft | Verwendung von galanthamin und galanthaminderivaten bei akuten funktionellen hirnschäden |
| AT414125B (de) | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | Neue derivate des 4a,5,9,10,11,12-hexahydro- benzofuro(3a,3,2)(2) benzazepin, verfahren zu deren herstellung sowie deren verwendung zur herstellung von arzneimitteln |
-
2001
- 2001-03-22 JP JP2001572510A patent/JP2003529602A/ja active Pending
- 2001-03-22 HK HK03101873.7A patent/HK1049832A1/zh unknown
- 2001-03-22 ES ES01914813T patent/ES2215885T3/es not_active Expired - Lifetime
- 2001-03-22 SK SK1702-2001A patent/SK285909B6/sk not_active IP Right Cessation
- 2001-03-22 DE DE50101827T patent/DE50101827D1/de not_active Expired - Lifetime
- 2001-03-22 TR TR2004/00857T patent/TR200400857T4/xx unknown
- 2001-03-22 CA CA002368966A patent/CA2368966A1/en not_active Abandoned
- 2001-03-22 PT PT01914813T patent/PT1181294E/pt unknown
- 2001-03-22 CZ CZ20014178A patent/CZ300160B6/cs not_active IP Right Cessation
- 2001-03-22 AU AU42085/01A patent/AU785385B2/en not_active Ceased
- 2001-03-22 EP EP01914813A patent/EP1181294B1/de not_active Expired - Lifetime
- 2001-03-22 SI SI200130081T patent/SI1181294T1/xx unknown
- 2001-03-22 CN CN01801342A patent/CN1380883A/zh active Pending
- 2001-03-22 AT AT01914813T patent/ATE263171T1/de not_active IP Right Cessation
- 2001-03-22 RU RU2001135839/04A patent/RU2241001C2/ru not_active IP Right Cessation
- 2001-03-22 HU HU0202233A patent/HUP0202233A3/hu unknown
- 2001-03-22 DK DK01914813T patent/DK1181294T3/da active
- 2001-03-22 NZ NZ516302A patent/NZ516302A/xx unknown
- 2001-03-22 MX MXPA01012275A patent/MXPA01012275A/es active IP Right Grant
- 2001-03-22 PL PL352638A patent/PL202463B1/pl not_active IP Right Cessation
- 2001-03-22 WO PCT/AT2001/000082 patent/WO2001074820A1/de not_active Ceased
- 2001-03-22 BR BR0105563-1A patent/BR0105563A/pt not_active IP Right Cessation
- 2001-05-22 US US09/980,025 patent/US7166588B2/en not_active Expired - Fee Related
- 2001-11-23 IS IS6174A patent/IS2287B/is unknown
- 2001-11-28 BG BG106155A patent/BG65134B1/bg unknown
- 2001-11-30 NO NO20015857A patent/NO326458B1/no not_active IP Right Cessation
-
2006
- 2006-06-28 US US11/478,170 patent/US20070027138A1/en not_active Abandoned
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