[go: up one dir, main page]

DK1178973T3 - Pyrazinyl-piperazin-forbindelser, deres anvendelse og fremstilling - Google Patents

Pyrazinyl-piperazin-forbindelser, deres anvendelse og fremstilling

Info

Publication number
DK1178973T3
DK1178973T3 DK00931877T DK00931877T DK1178973T3 DK 1178973 T3 DK1178973 T3 DK 1178973T3 DK 00931877 T DK00931877 T DK 00931877T DK 00931877 T DK00931877 T DK 00931877T DK 1178973 T3 DK1178973 T3 DK 1178973T3
Authority
DK
Denmark
Prior art keywords
ring
saturated
disorders
substituted
ring members
Prior art date
Application number
DK00931877T
Other languages
Danish (da)
English (en)
Inventor
Benjamin Pelcman
Markus Thor
Mattias Joensson
Bjoern Nilsson
Jan Tejbrant
Erik Ringberg
Jonas Nilsson
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9901884A external-priority patent/SE9901884D0/xx
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Application granted granted Critical
Publication of DK1178973T3 publication Critical patent/DK1178973T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00931877T 1999-05-21 2000-05-19 Pyrazinyl-piperazin-forbindelser, deres anvendelse og fremstilling DK1178973T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9901884A SE9901884D0 (sv) 1999-05-21 1999-05-21 Novel compounds their use and preparation
US13752799P 1999-06-03 1999-06-03

Publications (1)

Publication Number Publication Date
DK1178973T3 true DK1178973T3 (da) 2006-05-08

Family

ID=26663577

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00931877T DK1178973T3 (da) 1999-05-21 2000-05-19 Pyrazinyl-piperazin-forbindelser, deres anvendelse og fremstilling

Country Status (17)

Country Link
EP (1) EP1178973B1 (fr)
KR (1) KR100722090B1 (fr)
CN (1) CN1242995C (fr)
AT (1) ATE313535T1 (fr)
AU (1) AU777276C (fr)
BR (1) BR0010783A (fr)
CA (1) CA2374898C (fr)
DE (1) DE60024986T2 (fr)
DK (1) DK1178973T3 (fr)
EA (1) EA005820B1 (fr)
ES (1) ES2252004T3 (fr)
HK (1) HK1048311B (fr)
IL (2) IL146582A0 (fr)
MX (1) MXPA01011905A (fr)
NO (1) NO322220B1 (fr)
NZ (1) NZ515786A (fr)
WO (1) WO2000076984A2 (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
ATE433962T1 (de) 2000-11-20 2009-07-15 Biovitrum Ab Publ Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors
SE0004244D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
US20030207857A1 (en) 2001-04-11 2003-11-06 Adam Mavis D. Phenyl heterocyclyl ethers
GB0109103D0 (en) * 2001-04-11 2001-05-30 Pfizer Ltd Novel compounds
US6825198B2 (en) 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
WO2003045313A2 (fr) * 2001-11-27 2003-06-05 Merck & Co. Inc. Composés de 2-aminoquinoline
JP2005526826A (ja) * 2002-03-29 2005-09-08 シェーリング　コーポレイション キラル２−メチル−４−保護化ピペラジンの立体選択的アルキル化
US6989392B2 (en) 2002-06-18 2006-01-24 Abbott Laboratories 2-Aminoquinolines as melanin concentrating hormone receptor antagonists
WO2003105850A1 (fr) * 2002-06-18 2003-12-24 Abbott Laboratories 2-aminoquinolines servant d'antagonistes de recepteur de l'hormone de concentration de melanine
DE60321606D1 (de) * 2002-06-19 2008-07-24 Biovitrum Ab Publ Piperazinylpyrazine als Modulatoren des Serotonin 5-HT2C Rezeptors
AU2003243089B2 (en) * 2002-06-19 2010-01-07 Biovitrum Ab (Publ) Novel compounds, their use and preparation
US7226925B2 (en) 2002-06-19 2007-06-05 Biovitrum Ab Compounds, their use and preparation
CA2723494C (fr) 2002-06-19 2013-04-16 Biovitrum Ab (Publ) Derives de la 2-methyl piperazine pour le traitement de troubles associes a la serotonine
SE0202287D0 (sv) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds
CN1305871C (zh) * 2002-07-19 2007-03-21 比奥维特罗姆股份公司 用于治疗与5－ht2a受体有关疾病的新哌嗪基－吡嗪酮衍生物
US8013156B2 (en) 2003-03-19 2011-09-06 Exelixis, Inc. Tie-2 modulators and methods of use
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
EP1670460B1 (fr) 2003-10-10 2014-11-26 Bristol-Myers Squibb Company Derives de pyrazole utilises comme modulateurs du recepteur de cannabinoide
MXPA06011414A (es) * 2004-03-31 2007-04-20 Johnson & Johnson Compuestos heterociclicos sin imidazol como ligandos del receptor de h3 histamina.
US8685924B2 (en) 2004-08-25 2014-04-01 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
GT200500317A (es) 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
ATE460415T1 (de) 2004-11-29 2010-03-15 Warner Lambert Co Therapeutische pyrazoloä3,4-büpyridine und - indazole
KR100894006B1 (ko) 2005-03-31 2009-04-17 화이자 프로덕츠 인코포레이티드 사이클로펜타피리딘 및 테트라하이드로퀴놀린 유도체
AR054849A1 (es) 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
WO2007112073A2 (fr) * 2006-03-24 2007-10-04 Wyeth Méthodes pour moduler la fonction de la vessie
US20070225277A1 (en) * 2006-03-24 2007-09-27 Wyeth Treatment of pain
EP2018863B9 (fr) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Composé hétérocyclique fusionné et utilisation
EA015555B1 (ru) 2006-05-30 2011-08-30 Янссен Фармацевтика Н.В. Замещенные пиридиламидные соединения в качестве модуляторов гистаминового h-рецептора
SI2209778T1 (sl) 2007-09-21 2012-12-31 Array Biopharma, Inc. Piridin-2-il-amino-I, 2,4-tiadiazol derivati kot aktivatorji glukokinaze za zdravljenje sladkorne bolezni
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
CN101868454A (zh) 2007-11-20 2010-10-20 詹森药业有限公司 作为组胺h3受体调节剂的环烷基氧基吡啶化合物和杂环烷基氧基吡啶化合物
EP2493878B1 (fr) 2009-10-30 2016-10-12 Janssen Pharmaceutica NV Pyrazines en tant que modulateurs du récepteur opioïde delta
BR112012010253A8 (pt) 2009-10-30 2016-10-04 Janssen Pharmaceutica Nv compostos de pirimidina como moduladores do receptor delta opioide
JP5770198B2 (ja) * 2009-10-30 2015-08-26 ヤンセン ファーマシューティカ エヌ．ベー． オピオイド受容体調節因子としてのフェノキシ置換ピリミジン
WO2011071136A1 (fr) 2009-12-11 2011-06-16 アステラス製薬株式会社 Agent thérapeutique pour la fibromyalgie
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
US20120245176A1 (en) 2010-09-28 2012-09-27 Bristol-Myers Squibb Company Novel piperazine analogs with substituted heteroaryl groups as broad-spectrum influenza antivirals
KR102047816B1 (ko) 2011-12-22 2019-11-22 칸세라 아베 염증 및 암 치료에 유용한 비스아릴술폰아미드
GB201312129D0 (en) * 2013-07-05 2013-08-21 Proximagen Ltd Drug combination and its use in therapy
GB201312131D0 (en) * 2013-07-05 2013-08-21 Proximagen Ltd Drug combination and its use in therapy
WO2015066344A1 (fr) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. Agonistes du récepteur 5-ht2c et compositions et procédés d'utilisation
CN105348204B (zh) * 2015-11-18 2018-09-14 乳源瑶族自治县大众药品贸易有限公司 1-杂环基-2-(杂芳基硫基)苯衍生物及其使用方法和用途
CN105461635B (zh) * 2015-11-18 2018-06-08 乳源瑶族自治县大众药品贸易有限公司 苯基哌嗪衍生物及其使用方法和用途
CN108409729B (zh) * 2017-02-09 2020-11-24 广东东阳光药业有限公司 苯基八氢-1H-吡啶并[1,2-a]吡嗪衍生物及其用途
WO2019131902A1 (fr) 2017-12-27 2019-07-04 武田薬品工業株式会社 Agent thérapeutique pour incontinence urinaire de stress et incontinence fécale
CN109111383B (zh) * 2018-09-14 2020-11-24 广东东阳光药业有限公司 2-取代的二苯硫醚衍生物及其用途
EP3853234B1 (fr) 2018-09-18 2025-04-23 Nikang Therapeutics, Inc. Dérivés d'anneaux tricycliques fusionnés utilisés en tant qu'inhibiteurs de la phosphatase src à homologie-2
CN114394887A (zh) * 2022-01-28 2022-04-26 江苏锐鸣材料科技有限公司 一种苯基氧乙醇化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI193974A7 (fr) * 1973-07-13 1975-01-14 Merck & Co Inc
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
GB9420999D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
AU4037699A (en) * 1998-05-08 1999-11-29 Akzo Nobel N.V. Novel aryl-hydro naphthalenal kanamines

Also Published As

Publication number Publication date
WO2000076984A3 (fr) 2001-02-08
EA200101223A1 (ru) 2002-06-27
EA005820B1 (ru) 2005-06-30
HK1048311A1 (en) 2003-03-28
KR20020016795A (ko) 2002-03-06
KR100722090B1 (ko) 2007-05-25
BR0010783A (pt) 2002-04-09
HK1048311B (zh) 2006-08-11
DE60024986D1 (de) 2006-01-26
WO2000076984A2 (fr) 2000-12-21
AU4969000A (en) 2001-01-02
CN1242995C (zh) 2006-02-22
EP1178973B1 (fr) 2005-12-21
AU777276B2 (en) 2004-10-07
NZ515786A (en) 2004-01-30
IL146582A (en) 2010-04-29
NO20015686D0 (no) 2001-11-21
WO2000076984A8 (fr) 2001-07-19
ES2252004T3 (es) 2006-05-16
CA2374898A1 (fr) 2000-12-21
NO322220B1 (no) 2006-08-28
NO20015686L (no) 2002-01-15
MXPA01011905A (es) 2004-03-19
IL146582A0 (en) 2002-07-25
ATE313535T1 (de) 2006-01-15
DE60024986T2 (de) 2006-07-27
CA2374898C (fr) 2009-12-08
CN1360583A (zh) 2002-07-24
AU777276C (en) 2005-07-07
EP1178973A2 (fr) 2002-02-13

Similar Documents

Publication Publication Date Title
DK1178973T3 (da) Pyrazinyl-piperazin-forbindelser, deres anvendelse og fremstilling
IS2293B (is) Arýl sambrædd asapólýsýklísk efnasambönd
SE0104332D0 (sv) Therapeutic agents
DK1678166T3 (da) Proteinkinaseinhibitorer
SG128491A1 (en) Heterocyclic sulfonamide inhibitors of beta amyloid production
MY136270A (en) Processes and intermediates for preparing anti-cancer compounds
MY126917A (en) Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
DK1270570T3 (da) Amidforbindelser og anvendelse deraf
PT1210320E (pt) Aminobenzofenonas como inibidores de il-1beta e tnf-alfa
DE60014394D1 (de) Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
ATE66913T1 (de) Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.
KR910015580A (ko) 신규 콜린에스테라제 억제제로서의 삼환-일환식 아민
SE9901884D0 (sv) Novel compounds their use and preparation
DK0732332T3 (da) Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf
MXPA04005077A (es) Derivados de benzotiazol.
MXPA06000892A (es) Compuestos azapoliciclicos arilo fusionados.
TH52204A (th) อนุพันธ์ (เบนโซไดออกเซน, เบนโซฟิวเรน หรือ เบนโซไพเรน) ที่มีคุณสมบัติฟันดิก รีแลกเซชั่น
MXPA04003688A (es) Compuestos azapoliciclicos condensados con arilo.