DK1161449T3 - Modulatorer af beta-amyloidpeptidaggregering, der omfatter d-aminosyrer - Google Patents

Modulatorer af beta-amyloidpeptidaggregering, der omfatter d-aminosyrer

Info

Publication number: DK1161449T3
Authority: DK; Denmark
Prior art keywords: peptide; amyloid peptide; group; compounds; amino
Prior art date: 1999-03-04

Application number

DK00916028T

Other languages

Danish (da)

English (en)

Inventor

Mark A Findeis

Kathryn Phillips

Gary L Olson

Christopher Self

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-04

Filing date

2000-03-03

Publication date

2007-11-05

2000-03-03 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2007-11-05 Application granted granted Critical

2007-11-05 Publication of DK1161449T3 publication Critical patent/DK1161449T3/da

Links

150000008574 D-amino acids Chemical class 0.000 title abstract 4
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 4
230000006919 peptide aggregation Effects 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
125000003368 amide group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 1
229930182819 D-leucine Natural products 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
229930182832 D-phenylalanine Natural products 0.000 abstract 1
KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 abstract 1
229930182831 D-valine Natural products 0.000 abstract 1
230000003942 amyloidogenic effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK00916028T 1999-03-04 2000-03-03 Modulatorer af beta-amyloidpeptidaggregering, der omfatter d-aminosyrer DK1161449T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12273699P	1999-03-04	1999-03-04
PCT/US2000/005574 WO2000052048A1 (en)	1999-03-04	2000-03-03	Modulators of beta-amyloid peptide aggregation comprising d-amino acids

Publications (1)

Publication Number	Publication Date
DK1161449T3 true DK1161449T3 (da)	2007-11-05

Family

ID=22404455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00916028T DK1161449T3 (da)	1999-03-04	2000-03-03	Modulatorer af beta-amyloidpeptidaggregering, der omfatter d-aminosyrer

Country Status (19)

Country	Link
US (3)	US6610658B1 (ru)
EP (1)	EP1161449B1 (ru)
JP (2)	JP2002543043A (ru)
KR (1)	KR100771712B1 (ru)
CN (1)	CN1279053C (ru)
AT (1)	ATE366259T1 (ru)
AU (1)	AU781292B2 (ru)
BR (1)	BR0008738A (ru)
CA (1)	CA2362834C (ru)
CY (1)	CY1106899T1 (ru)
DE (1)	DE60035412T2 (ru)
DK (1)	DK1161449T3 (ru)
ES (1)	ES2290023T3 (ru)
HK (1)	HK1040722B (ru)
NZ (1)	NZ514414A (ru)
PT (1)	PT1161449E (ru)
RU (1)	RU2260599C2 (ru)
WO (1)	WO2000052048A1 (ru)
ZA (1)	ZA200107913B (ru)

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HK1040722B (en) *	1999-03-04	2008-02-22	Praecis Pharmaceuticals Incorporated	Modulators of beta-amyloid peptide aggregation comprising d-amino acids
US7060670B1 (en) *	1999-05-05	2006-06-13	Neurochem (International) Limited	Stereoselective antifibrillogenic peptides and peptidomimetics thereof
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US20070135337A2 (en) *	1999-11-29	2007-06-14	Neurochem (International) Limited	Vaccine for the Prevention and Treatment of Alzheimer's and Amyloid Related Diseases
US20020094335A1 (en) *	1999-11-29	2002-07-18	Robert Chalifour	Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
AU3808801A (en) *	2000-02-11	2001-08-20	Praecis Pharmaceuticals Incorporated	Methods for enhancing the bioavailability of a drug
AUPR215700A0 (en) *	2000-12-19	2001-01-25	Fujisawa Pharmaceutical Co., Ltd.	Carboxylic acid compound having cyclopropane ring
DE10117281A1 (de) *	2001-04-06	2002-10-24	Inst Molekulare Biotechnologie	Peptid zur Diagnose und Therapie der Alzheimer-Demenz
SI1499729T1 (sl)	2002-04-18	2011-11-30	Yeda Res & Dev	Derivati encima ki inducira nf-kappab njihova priprava in uporaba
JP2006512417A (ja) *	2002-12-24	2006-04-13	ニューロケム（インターナショナル）リミテッド	β−アミロイド関連疾患の治療のための治療用製剤
CN100340599C (zh) *	2003-06-09	2007-10-03	湖南大学	多聚赖氨酸淀粉纳米颗粒与制备方法及作为基因载体的应用
US7256002B2 (en) *	2003-08-12	2007-08-14	The Institute For Ethnomedicine	Screening for neurotoxic amino acid associated with neurological disorders
GB0503434D0 (en) *	2005-02-18	2005-03-30	Senexis Ltd	Amyloid-binding peptides, analogues and uses thereof
CN101351476B (zh) *	2005-12-12	2013-04-03	豪夫迈·罗氏有限公司	抗体可变区的糖基化
CA2676715A1 (en)	2007-02-12	2008-08-21	Merck & Co., Inc.	Piperazine derivatives for treatment of ad and related conditions
RU2372355C1 (ru) *	2008-06-27	2009-11-10	Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН	Пептид, обладающий защитным действием против болезни альцгеймера
DE102008037564A1 (de)	2008-11-19	2010-05-20	Forschungszentrum Jülich GmbH	Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden
EP3660510A3 (en) *	2009-12-07	2020-07-08	Pieris Pharmaceuticals GmbH	Muteins of human lipocalin 2 (lcn2, hngal) with affinity for a given target
US10653631B2 (en)	2011-09-07	2020-05-19	Roland SAUR-BROSCH	Optimal colon targeting technology
WO2013035081A2 (de)	2011-09-07	2013-03-14	JÄNISCH, Melisa	Optimale formulierung zur freisetzung eines wirkstoffes im dickdarm
KR101437354B1 (ko) *	2012-07-27	2014-09-05	한국과학기술연구원	고수율 및 고순도의 아밀로이드-베타 펩타이드의 제조방법
KR20230128606A (ko) *	2022-02-28	2023-09-05	경상국립대학교산학협력단	티로신을 유효성분으로 함유하는 알츠하이머병의 예방, 개선 또는 치료용 조성물
WO2023229445A1 (ko) *	2022-05-27	2023-11-30	주식회사 진큐어	신규 펩타이드 및 그의 용도
CN119403821A (zh) *	2022-05-27	2025-02-07	锌医疗公司	新型肽及其用途

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US6277826B1 (en) *	1996-08-27	2001-08-21	Praecis Pharmaceuticals, Inc.	Modulators of β-amyloid peptide aggregation comprising D-amino acids
US5985242A (en)	1995-10-27	1999-11-16	Praecis Pharmaceuticals, Inc.	Modulators of β-amyloid peptide aggregation comprising D-amino acids
WO1997021728A1 (en)	1995-12-12	1997-06-19	Karolinska Innovations Ab	PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b)
JP2001500852A (ja) *	1996-08-27	2001-01-23	プレーシスファーマスーティカルズインコーポレイテッド	Ｄ―アミノ酸を含むβ―アミロイドペプチド凝集のモジュレーター
HK1040722B (en)	1999-03-04	2008-02-22	Praecis Pharmaceuticals Incorporated	Modulators of beta-amyloid peptide aggregation comprising d-amino acids

2000
- 2000-03-03 HK HK02102235.9A patent/HK1040722B/en not_active IP Right Cessation
- 2000-03-03 NZ NZ514414A patent/NZ514414A/xx unknown
- 2000-03-03 WO PCT/US2000/005574 patent/WO2000052048A1/en not_active Ceased
- 2000-03-03 AT AT00916028T patent/ATE366259T1/de not_active IP Right Cessation
- 2000-03-03 DK DK00916028T patent/DK1161449T3/da active
- 2000-03-03 DE DE60035412T patent/DE60035412T2/de not_active Expired - Lifetime
- 2000-03-03 JP JP2000602272A patent/JP2002543043A/ja active Pending
- 2000-03-03 ES ES00916028T patent/ES2290023T3/es not_active Expired - Lifetime
- 2000-03-03 PT PT00916028T patent/PT1161449E/pt unknown
- 2000-03-03 CA CA002362834A patent/CA2362834C/en not_active Expired - Fee Related
- 2000-03-03 KR KR1020017011038A patent/KR100771712B1/ko not_active Expired - Fee Related
- 2000-03-03 AU AU37196/00A patent/AU781292B2/en not_active Ceased
- 2000-03-03 RU RU2001127246/04A patent/RU2260599C2/ru active
- 2000-03-03 US US09/519,019 patent/US6610658B1/en not_active Expired - Fee Related
- 2000-03-03 BR BR0008738-6A patent/BR0008738A/pt not_active Application Discontinuation
- 2000-03-03 EP EP00916028A patent/EP1161449B1/en not_active Expired - Lifetime
- 2000-03-03 CN CNB008071926A patent/CN1279053C/zh not_active Expired - Fee Related
2001
- 2001-09-26 ZA ZA200107913A patent/ZA200107913B/xx unknown
2003
- 2003-03-24 US US10/395,290 patent/US6831066B2/en not_active Expired - Fee Related
2004
- 2004-11-15 US US10/989,763 patent/US7803774B2/en not_active Expired - Fee Related
2007
- 2007-10-02 CY CY20071101254T patent/CY1106899T1/el unknown
2010
- 2010-12-24 JP JP2010287097A patent/JP2011121952A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO2000052048A9 (en)	2002-04-11
AU781292B2 (en)	2005-05-12
US7803774B2 (en)	2010-09-28
AU3719600A (en)	2000-09-21
NZ514414A (en)	2004-02-27
US20050137128A1 (en)	2005-06-23
ZA200107913B (en)	2002-11-27
HK1040722A1 (en)	2002-06-21
ATE366259T1 (de)	2007-07-15
HK1040722B (en)	2008-02-22
JP2011121952A (ja)	2011-06-23
CN1362967A (zh)	2002-08-07
DE60035412D1 (de)	2007-08-16
CN1279053C (zh)	2006-10-11
ES2290023T3 (es)	2008-02-16
CA2362834C (en)	2005-12-06
US6831066B2 (en)	2004-12-14
US20030236197A1 (en)	2003-12-25
KR20020007316A (ko)	2002-01-26
BR0008738A (pt)	2001-12-26
US6610658B1 (en)	2003-08-26
KR100771712B1 (ko)	2007-10-30
WO2000052048A1 (en)	2000-09-08
CY1106899T1 (el)	2012-09-26
RU2260599C2 (ru)	2005-09-20
DE60035412T2 (de)	2008-02-14
JP2002543043A (ja)	2002-12-17
CA2362834A1 (en)	2000-09-08
PT1161449E (pt)	2007-10-12
EP1161449A1 (en)	2001-12-12
EP1161449B1 (en)	2007-07-04

Publication	Publication Date	Title
DK1161449T3 (da)	2007-11-05	Modulatorer af beta-amyloidpeptidaggregering, der omfatter d-aminosyrer
DK0929574T3 (da)	2005-10-31	Modulatorer af beta-amyloidpeptidaggregering, som omfatter D-aminosyrer
DE69739035D1 (de)	2008-11-20	Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen
DK1521774T3 (da)	2008-10-27	Trunkerede Tau-proteiner
DE69635493D1 (de)	2005-12-29	Verfahren zur herstellung von l-aminosäuren
ATE417925T1 (de)	2009-01-15	Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen
BR9707819A (pt)	1999-07-27	Imunogenos peptidicos
DE69531204D1 (de)	2003-08-07	Formulierungen fuer faktor ix
DE69636453D1 (de)	2006-09-28	Modulation der aktivität des cholesteryl-ester-transfer-proteins (cetp)
WO2005060683A3 (en)	2007-04-12	Small peptides for the treatment of alzheimer’s disease and other beta-amyloid protein fibrillogenesis disorders
DE60023860D1 (de)	2005-12-15	Verfahren zur herstellung von rekombinanten peptiden
DE69636285D1 (de)	2006-08-03	ISOLIERTES FrpB NUKLEINSÄUREMOLEKÜL UND ENTSPRECHENDE IMPFSTOFF
ATE290315T1 (de)	2005-03-15	Von humanem hitzeschockprotein 60 hergeleitete peptide zur behandlung von diabetis, entsprechende zusammensetzungen, verfahren und kits
PT896615E (pt)	2003-01-31	Peptido proveniente de uma forma soluvel de acetilcolinesterase activo como modulador dos canais de calcio
DK1353948T3 (da)	2006-02-27	Oplöselige biologiske analoge til bata-amyloidpeptid
DK1077717T3 (da)	2003-11-17	Anvendelse af lipopeptider eller lipoproteiner til sårbehandling
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